Randolph S Marshall, David S Liebeskind, John Huston Iii, Lloyd J Edwards, George Howard, James F Meschia, Thomas G Brott, Brajesh K Lal, Donald Heck, Giuseppe Lanzino, Navdeep Sangha, Vikram S Kashyap, Clarissa D Morales, Dejania Cotton-Samuel, Andres M Rivera, Adam M Brickman, Ronald M Lazar
BACKGROUND AND PURPOSE: High-grade carotid artery stenosis may alter hemodynamics in the ipsilateral hemisphere, but consequences of this effect are poorly understood. Cortical thinning is associated with cognitive impairment in dementia, head trauma, demyelination, and stroke. We hypothesized that hemodynamic impairment, as represented by a relative time-to-peak (TTP) delay on MRI in the hemisphere ipsilateral to the stenosis, would be associated with relative cortical thinning in that hemisphere...
January 2023: Journal of Stroke