journal
https://read.qxmd.com/read/38836285/cerebral-amyloid-angiopathy-an-undeniable-small-vessel-disease
#1
JOURNAL ARTICLE
Litao Wang, Qiong Liu, Dongqi Yue, Jun Liu, Yi Fu
No abstract text is available yet for this article.
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836284/sodium-glucose-cotransporter-2-inhibitor-improves-neurological-outcomes-in-diabetic-patients-with-acute-ischemic-stroke
#2
JOURNAL ARTICLE
Wookjin Yang, Jeong-Min Kim, Matthew Chung, Jiyeon Ha, Dong-Wan Kang, Eung-Joon Lee, Han-Yeong Jeong, Keun-Hwa Jung, Hyunpil Sung, Jin Chul Paeng, Seung-Hoon Lee
No abstract text is available yet for this article.
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836283/discrepancy-between-ischemic-changes-observed-on-non-enhanced-computed-tomography-and-perfusion-imaging-implications-for-decision-making-in-treatment
#3
JOURNAL ARTICLE
Gabriel Broocks, Jens Fiehler, Lukas Meyer
No abstract text is available yet for this article.
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836282/left-atrial-mechanical-dysfunction-is-associated-with-atrial-fibrillation-and-recurrent-stroke-after-cryptogenic-stroke
#4
JOURNAL ARTICLE
Joseph Raco, Ravi Shah, Michael Farbaniec, Faye L Norby, Megan Mann, Mario D Gonzalez, Gerald V Naccarelli, Ankit Maheshwari
No abstract text is available yet for this article.
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836281/the-role-of-atrial-cardiopathy-as-a-potential-cause-of-embolic-stroke-of-undetermined-source
#5
JOURNAL ARTICLE
Angelo Cascio Rizzo, Ghil Schwarz, Andrea Bonelli, Andrea Di Pietro, Martina Di Pietro, Francesco Aruta, Cristina Motto, Benedetta De Chiara, Antonella Moreo, Elio Clemente Agostoni
No abstract text is available yet for this article.
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836280/prevalence-and-associations-of-dural-arteriovenous-fistulae-in-cerebral-venous-thrombosis-analysis-of-action-cvt
#6
JOURNAL ARTICLE
Aaron Shoskes, Liqi Shu, Thanh N Nguyen, Mohamad Abdalkader, James Giles, Jordan Amar, James E Siegler, Nils Henninger, Marwa ElNazeir, Sami Al Kasab, Piers Klein, Mirjam R Heldner, Kateryna Antonenko, Marios Psychogios, David S Liebeskind, Thalia Field, Ava Liberman, Charles Esenwa, Alexis Simpkins, Grace Li, Jennifer Frontera, Lindsey Kuohn, Aaron Rothstein, Ossama Khazaal, Yasmin Aziz, Eva Mistry, Pooja Khatri, Setareh Salehi Omran, Adeel S Zubair, Richa Sharma, Robert M Starke, Jacques J Morcos, Jose G Romano, Shadi Yaghi, Negar Asdaghi
No abstract text is available yet for this article.
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836279/pupillometer-based-neurological-pupil-index-differential-a-potential-predictor-of-post-stroke-delirium
#7
JOURNAL ARTICLE
Kotaro Noda, Tomotaka Tanaka, Soichiro Abe, Ryo Usui, Misa Matsumoto, Yoshito Arakaki, Hiroyuki Kida, Ryoma Inui, Kaoru Kohama, Kazuo Washida, Sonu M M Bhaskar, Masatoshi Koga, Kazunori Toyoda, Masafumi Ihara
No abstract text is available yet for this article.
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836278/a-multimodal-ensemble-deep-learning-model-for-functional-outcome-prognosis-of-stroke-patients
#8
JOURNAL ARTICLE
Hye-Soo Jung, Eun-Jae Lee, Dae-Il Chang, Han Jin Cho, Jun Lee, Jae-Kwan Cha, Man-Seok Park, Kyung Ho Yu, Jin-Man Jung, Seong Hwan Ahn, Dong-Eog Kim, Ju Hun Lee, Keun-Sik Hong, Sung-Il Sohn, Kyung-Pil Park, Sun U Kwon, Jong S Kim, Jun Young Chang, Bum Joon Kim, Dong-Wha Kang
BACKGROUND AND PURPOSE: The accurate prediction of functional outcomes in patients with acute ischemic stroke (AIS) is crucial for informed clinical decision-making and optimal resource utilization. As such, this study aimed to construct an ensemble deep learning model that integrates multimodal imaging and clinical data to predict the 90-day functional outcomes after AIS. METHODS: We used data from the Korean Stroke Neuroimaging Initiative database, a prospective multicenter stroke registry to construct an ensemble model integrated individual 3D convolutional neural networks for diffusion-weighted imaging and fluid-attenuated inversion recovery (FLAIR), along with a deep neural network for clinical data, to predict 90-day functional independence after AIS using a modified Rankin Scale (mRS) of 3-6...
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836277/deep-learning-based-automatic-classification-of-ischemic-stroke-subtype-using-diffusion-weighted-images
#9
JOURNAL ARTICLE
Wi-Sun Ryu, Dawid Schellingerhout, Hoyoun Lee, Keon-Joo Lee, Chi Kyung Kim, Beom Joon Kim, Jong-Won Chung, Jae-Sung Lim, Joon-Tae Kim, Dae-Hyun Kim, Jae-Kwan Cha, Leonard Sunwoo, Dongmin Kim, Sang-Il Suh, Oh Young Bang, Hee-Joon Bae, Dong-Eog Kim
BACKGROUND AND PURPOSE: Accurate classification of ischemic stroke subtype is important for effective secondary prevention of stroke. We used diffusion-weighted image (DWI) and atrial fibrillation (AF) data to train a deep learning algorithm to classify stroke subtype. METHODS: Model development was done in 2,988 patients with ischemic stroke from three centers by using U-net for infarct segmentation and EfficientNetV2 for subtype classification. Experienced neurologists (n=5) determined subtypes for external test datasets, while establishing a consensus for clinical trial datasets...
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836276/endovascular-thrombectomy-versus-intravenous-thrombolysis-of-posterior-cerebral-artery-occlusion-stroke
#10
JOURNAL ARTICLE
Silja Räty, Thanh N Nguyen, Simon Nagel, Davide Strambo, Patrik Michel, Christian Herweh, Muhammad M Qureshi, Mohamad Abdalkader, Pekka Virtanen, Marta Olive-Gadea, Marc Ribo, Marios Psychogios, Anh Nguyen, Joji B Kuramatsu, David Haupenthal, Martin Köhrmann, Cornelius Deuschl, Jordi Kühne Escolà, Jelle Demeestere, Robin Lemmens, Lieselotte Vandewalle, Shadi Yaghi, Liqi Shu, Volker Puetz, Daniel P O Kaiser, Johannes Kaesmacher, Adnan Mujanovic, Dominique Cornelius Marterstoc, Tobias Engelhorn, Anne Berberich, Piers Klein, Diogo C Haussen, Mahmoud H Mohammaden, Hend Abdelhamid, Isabel Fragata, Bruno Cunha, Michele Romoli, Wei Hu, Jianlon Song, Johanna T Fifi, Stavros Matsoukas, Sunil A Sheth, Sergio A Salazar-Marioni, João Pedro Marto, João Nuno Ramos, Milena Miszczuk, Christoph Riegler, Sven Poli, Khouloud Poli, Ashutosh P Jadhav, Shashvat Desai, Volker Maus, Maximilian Kaeder, Adnan H Siddiqui, Andre Monteiro, Tatu Kokkonen, Francesco Diana, Hesham E Masoud, Neil Suryadareva, Maxim Mokin, Shail Thanki, Pauli Ylikotila, Kemal Alpay, James E Siegler, Italo Linfante, Guilherme Dabus, Dileep Yavaghal, Vasu Saini, Christian H Nolte, Eberhart Siebert, Markus A Möhlenbruch, Peter A Ringleb, Raul G Nogueira, Uta Hanning, Lukas Meyer, Urs Fischer, Daniel Strbian
BACKGROUND AND PURPOSE: Posterior cerebral artery occlusion (PCAo) can cause long-term disability, yet randomized controlled trials to guide optimal reperfusion strategy are lacking. We compared the outcomes of PCAo patients treated with endovascular thrombectomy (EVT) with or without intravenous thrombolysis (IVT) to patients treated with IVT alone. METHODS: From the multicenter retrospective Posterior cerebraL ArTery Occlusion (PLATO) registry, we included patients with isolated PCAo treated with reperfusion therapy within 24 hours of onset between January 2015 and August 2022...
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836275/tenecteplase-versus-alteplase-in-medium-vessel-occlusion-ischemic-stroke-a-secondary-analysis-of-the-alteplase-compared-to-tenecteplase-randomized-trial
#11
JOURNAL ARTICLE
Fouzi Bala, Nishita Singh, Katrina Ignacio, Ibrahim Alhabli, Ayoola Ademola, Anas Alrohimi, Houman Khosravani, Aleksander Tkach, Luciana Catanese, Dariush Dowlatshahi, Thalia Field, Gary Hunter, Faysal Benali, MacKenzie Horn, Andrew Demchuk, Michael Hill, Tolulope Sajobi, Brian Buck, Richard Swartz, Mohammed Almekhlafi, Bijoy K Menon
BACKGROUND AND PURPOSE: The safety and efficacy of tenecteplase in patients with ischemic stroke due to medium vessel occlusion (MeVO) are not well studied. We aimed to compare tenecteplase with alteplase in stroke due to MeVO. METHODS: Patients with baseline M2-middle cerebral artery (MCA), M3/M4-MCA, P2/P3/P4-posterior cerebral artery (PCA), A2/A3/A4-anterior cerebral artery (ACA) occlusions from the Alteplase Compared to Tenecteplase (AcT) trial were included...
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836274/endovascular-therapy-in-the-extended-time-window-for-large-vessel-occlusion-in-patients-with-pre-stroke-disability
#12
JOURNAL ARTICLE
Kanta Tanaka, Hiroshi Yamagami, Muhammad M Qureshi, Kazutaka Uchida, James E Siegler, Raul G Nogueira, Shinichi Yoshimura, Nobuyuki Sakai, Nicolas Martinez-Majander, Simon Nagel, Jelle Demeestere, Volker Puetz, Diogo C Haussen, Mohamad Abdalkader, Marta Olive-Gadea, Mahmoud H Mohammaden, João Pedro Marto, Anne Dusart, Simon Winzer, Liisa Tomppo, Francois Caparros, Hilde Henon, Flavio Bellante, João Nuno Ramos, Santiago Ortega-Gutierrez, Sunil A Sheth, Stefania Nannoni, Johannes Kaesmacher, Lieselotte Vandewalle, Sergio Salazar-Marioni, Mudassir Farooqui, Pekka Virtanen, Rita Ventura, Syed Zaidi, Alicia C Castonguay, Ajit S Puri, Behzad Farzin, Hesham E Masoud, Piers Klein, Jessica Jesser, Manuel Requena, Tomas Dobrocky, Daniel P O Kaiser, Erno Peltola, Davide Strambo, Markus A Möhlenbruch, Eugene Lin, Peter A Ringleb, Osama O Zaidat, Charlotte Cordonnier, Daniel Roy, Robin Lemmens, Marc Ribo, Daniel Strbian, Urs Fischer, Patrik Michel, Jean Raymond, Thanh N Nguyen
BACKGROUND AND PURPOSE: We compared the outcomes of endovascular therapy (EVT) in an extended time window in patients with large-vessel occlusion (LVO) between patients with and without pre-stroke disability. METHODS: In this prespecified analysis of the multinational CT for Late Endovascular Reperfusion study (66 participating sites, 10 countries between 2014 and 2022), we analyzed data from patients with acute ischemic stroke with a pre-stroke modified Rankin Scale (mRS) score of 0-4 and LVO who underwent EVT 6-24 hours from the time last seen well...
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836273/infarcts-due-to-large-vessel-occlusions-continue-to-grow-despite-near-complete-reperfusion-after-endovascular-treatment
#13
JOURNAL ARTICLE
Johanna M Ospel, Nathaniel Rex, Karim Oueidat, Rosalie McDonough, Leon Rinkel, Grayson Baird, Scott Collins, Gaurav Jindal, Matthew D Alvin, Jerrold Boxerman, Phil Barber, Mahesh Jayaraman, Wendy Smith, Amanda Amirault-Capuano, Michael D Hill, Mayank Goyal, Ryan McTaggart
BACKGROUND AND PURPOSE: Infarcts in acute ischemic stroke (AIS) patients may continue to grow even after reperfusion, due to mechanisms such as microvascular obstruction and reperfusion injury. We investigated whether and how much infarcts grow in AIS patients after near-complete (expanded Thrombolysis in Cerebral Infarction [eTICI] 2c/3) reperfusion following endovascular treatment (EVT), and to assess the association of post-reperfusion infarct growth with clinical outcomes. METHODS: Data are from a single-center retrospective observational cohort study that included AIS patients undergoing EVT with near-complete reperfusion who received diffusion-weighted magnetic resonance imaging (MRI) within 2 hours post-EVT and 24 hours after EVT...
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836272/how-do-quantitative-tissue-imaging-outcomes-in-acute-ischemic-stroke-relate-to-clinical-outcomes
#14
JOURNAL ARTICLE
Johanna M Ospel, Leon Rinkel, Aravind Ganesh, Andrew Demchuk, Manraj Heran, Eric Sauvageau, Manish Joshi, Diogo Haussen, Mahesh Jayaraman, Shelagh Coutts, Amy Yu, Volker Puetz, Dana Iancu, Oh Young Bang, Jason Tarpley, Staffan Holmin, Michael Kelly, Michael Tymianski, Michael Hill, Mayank Goyal
BACKGROUND AND PURPOSE: Infarct volume and other imaging markers are increasingly used as surrogate measures for clinical outcome in acute ischemic stroke research, but how improvements in these imaging surrogates translate into better clinical outcomes is currently unclear. We investigated how changes in infarct volume at 24 hours alter the probability of achieving good clinical outcome (modified Rankin Scale [mRS] 0-2). METHODS: Data are from endovascular thrombectomy patients from the randomized controlled ESCAPE-NA1 (Efficacy and Safety of Nerinetide for the Treatment of Acute Ischaemic Stroke) trial...
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836271/device-closure-or-antithrombotic-therapy-after-cryptogenic-stroke-in-elderly-patients-with-a-high-risk-patent-foramen-ovale
#15
JOURNAL ARTICLE
Pil Hyung Lee, Jung-Sun Kim, Jae-Kwan Song, Sun U Kwon, Bum Joon Kim, Ji Sung Lee, Byung Joo Sun, Jong Shin Woo, Soe Hee Ann, Jung-Won Suh, Jun Yup Kim, Kyusup Lee, Sang Yeub Lee, Ran Heo, Soo Jeong, Jeong Yoon Jang, Jang-Whan Bae, Young Dae Kim, Sung Hyuk Heo, Jong S Kim
BACKGROUND AND PURPOSE: In young patients (aged 18-60 years) with patent foramen ovale (PFO)-associated stroke, percutaneous closure has been found to be useful for preventing recurrent ischemic stroke or transient ischemic attack (TIA). However, it remains unknown whether PFO closure is also beneficial in older patients. METHODS: Patients aged ≥60 years who had a cryptogenic stroke and PFO from ten hospitals in South Korea were included. The effect of PFO closure plus medical therapy over medical therapy alone was assessed by a propensity-score matching method in the overall cohort and in those with a high-risk PFO, characterized by the presence of an atrial septal aneurysm or a large shunt...
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836270/the-influence-of-non-high-density-lipoprotein-cholesterol-on-the-efficacy-of-genotype-guided-dual-antiplatelet-therapy-in-preventing-stroke-recurrence
#16
JOURNAL ARTICLE
Qin Xu, Xia Meng, Hao Li, Xuewei Xie, Jing Jing, Jinxi Lin, Yong Jiang, Yilong Wang, Xingquan Zhao, Zixiao Li, Liping Liu, Anxin Wang, Yongjun Wang
BACKGROUND AND PURPOSE: Non-high-density lipoprotein cholesterol (non-HDL-C), which represents the total cholesterol content of all pro-atherogenic lipoproteins, has recently been included as a new target for lipid-lowering therapy in high-risk atherosclerotic patients in multiple guidelines. Herein, we aimed to explore the relationship between non-HDL-C level and the efficacy and safety of ticagrelor-aspirin versus clopidogrel-aspirin in preventing stroke recurrence. METHODS: This study comprised a post hoc analysis of the CHANCE-2 (Ticagrelor or Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events II) trial, from which 5,901 patients with complete data on non-HDL-C were included and categorized by median non-HDL-C levels, using a cutoff of 3...
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836269/neuroprotective-approaches-for-brain-injury-after-cardiac-arrest-current-trends-and-prospective-avenues
#17
REVIEW
Subash Marasini, Xiaofeng Jia
With the implementation of improved bystander cardiopulmonary resuscitation techniques and public-access defibrillation, survival after out-of-hospital cardiac arrest (OHCA) has increased significantly over the years. Nevertheless, OHCA survivors have residual anoxia/reperfusion brain damage and associated neurological impairment resulting in poor quality of life. Extracorporeal membrane oxygenation or targeted temperature management has proven effective in improving post-cardiac arrest (CA) neurological outcomes, yet considering the substantial healthcare costs and resources involved, there is an urgent need for alternative treatment strategies that are crucial to alleviate brain injury and promote recovery of neurological function after CA...
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836268/distal-medium-vessel-occlusion-strokes-understanding-the-present-and-paving-the-way-for-a-better-future
#18
REVIEW
Raul G Nogueira, Mohamed F Doheim, Alhamza R Al-Bayati, Jin Soo Lee, Diogo C Haussen, Mahmoud Mohammaden, Michael Lang, Matthew Starr, Marcelo Rocha, Catarina Perry da Câmara, Bradley A Gross, Nirav R Bhatt
Distal medium vessel occlusions (DMVOs) are thought to cause as many as 25% to 40% of all acute ischemic strokes and may result in substantial disability amongst survivors. Although intravenous thrombolysis (IVT) is more effective for distal than proximal vessel occlusions, the overall efficacy of IVT remains limited in DMVO with less than 50% of patients achieving reperfusion and about 1/3 to 1/4 of the patients failing to achieve functional independence. Data regarding mechanical thrombectomy (MT) among these patients remains limited...
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836267/prevalence-of-cerebral-amyloid-angiopathy-pathology-and-strictly-lobar-microbleeds-in-east-asian-versus-western-populations-a-systematic-review-and-meta-analysis
#19
REVIEW
Anna M De Kort, Marcel M Verbeek, Floris H B M Schreuder, Catharina J M Klijn, Lieke Jäkel
BACKGROUND AND PURPOSE: Possible differences in the prevalence of cerebral amyloid angiopathy (CAA) in East-Asian compared to Western populations have received little attention, and results so far have been ambiguous. Our aim is to compare the prevalence of CAA neuropathology and magnetic resonance imaging markers of CAA in East-Asian and Western cohorts reflecting the general population, cognitively normal elderly, patients with Alzheimer's disease (AD), and patients with (lobar) intracerebral hemorrhage (ICH)...
May 2024: Journal of Stroke
https://read.qxmd.com/read/38836266/cancer-associated-stroke-thrombosis-mechanism-diagnosis-outcome-and-therapeutic-strategies
#20
REVIEW
Ji Hoe Heo, Jaeseob Yun, Kwang Hyun Kim, Jae Wook Jung, Joonsang Yoo, Young Dae Kim, Hyo Suk Nam
Cancer can induce hypercoagulability, which may lead to stroke. This occurs when tumor cells activate platelets as part of their growth and metastasis. Tumor cells activate platelets by generating thrombin and expressing tissue factor, resulting in tumor cell-induced platelet aggregation. Histopathological studies of thrombi obtained during endovascular thrombectomy in patients with acute stroke and active cancer have shown a high proportion of platelets and thrombin. This underscores the crucial roles of platelets and thrombin in cancer-associated thrombosis...
May 2024: Journal of Stroke
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