journal
https://read.qxmd.com/read/36950809/endovascular-treatment-of-distal-m2-segment-occlusions-a-clinical-registry-and-meta-analysis
#1
JOURNAL ARTICLE
Sacha Bensoussan, Stephanos Nikolaos Finitsis, Bertrand Lapergue, Gaultier Marnat, Igor Sibon, Solène Moulin, Jean-Marc Olivot, Sébastien Richard, Charlotte Rosso, Benjamin Gory, Frédéric Clarençon
No abstract text is available yet for this article.
March 23, 2023: Journal of Stroke
https://read.qxmd.com/read/36916018/occurrence-of-ischemic-stroke-in-patients-with-atrial-fibrillation-receiving-non-vitamin-k-oral-anticoagulants-causes-and-prevention-strategies
#2
REVIEW
Oh Young Bang, Kyoung-Min Park, Dong Seop Jeong
Atrial fibrillation (AF) is a leading cause of cardioembolic stroke, which is often fatal or disabling. Prevention of stroke is crucial in AF management, and anticoagulation with non-vitamin K oral anticoagulants (NOACs) is the mainstay of AF management for stroke prevention. Because NOAC prescriptions have been surging worldwide, the development of acute ischemic stroke in patients with AF who receive NOAC treatment is an increasingly important issue in clinical practice. Moreover, these patients show a high risk of recurrence, with more than a 50% higher risk, than do patients with AF and no prior anticoagulation therapy...
March 15, 2023: Journal of Stroke
https://read.qxmd.com/read/36916017/genotype-phenotype-correlation-of-the-i-rnf213-i-r4810k-variant-in-moyamoya-disease
#3
JOURNAL ARTICLE
Taedong Ok, Yo Han Jung, Kyung-Yul Lee
No abstract text is available yet for this article.
March 15, 2023: Journal of Stroke
https://read.qxmd.com/read/36907186/collateral-circulation-in-ischemic-stroke-an-updated-review
#4
REVIEW
Gino Maguida, Ashfaq Shuaib
The collateral circulation plays a crucial role in maintaining perfusion to brain tissue in ischemic stroke, which prolongs the time window for effective therapies to be provided and ultimately avoids irreversible damage that may lead to worse clinical outcomes. The understanding of this complex vascular bypass system has advanced greatly in the past few years, yet effective treatments for its potentiation as a therapeutic target remain a challenge. The assessment of the collateral circulation is now part of the routine neuroimaging protocols for acute ischemic stroke, which provides a more complete pathophysiological picture in each patient that allows for a better selection for acute reperfusion therapies and a more accurate prognostication of outcomes, among other potential uses...
March 13, 2023: Journal of Stroke
https://read.qxmd.com/read/36907185/thrombus-enhancement-sign-for-differentiation-of-embolism-and-arteriosclerosis-related-acute-large-vessel-occlusion
#5
JOURNAL ARTICLE
Yan Zhang, Guangchen He, Jing Lu, Guihua Miao, Da Liang, Jiangliang Wang, Liming Wei, Jiangshan Deng, Yueqi Zhu
BACKGROUND AND PURPOSE: To evaluate whether the thrombus enhancement sign (TES) can be used to differentiate embolic large vessel occlusion (LVO) from in situ intracranial atherosclerotic stenosis (ICAS)-related LVO in the anterior circulation of patients with acute ischemic stroke (AIS). METHODS: Patients with LVO in the anterior circulation who underwent both non-contrast computed tomography (CT) and CT angiography and mechanical thrombectomy were retrospectively enrolled...
March 13, 2023: Journal of Stroke
https://read.qxmd.com/read/36592972/impact-of-left-atrial-or-left-atrial-appendage-thrombus-on-stroke-outcome-a-matched-control-analysis
#6
JOURNAL ARTICLE
JoonNyung Heo, Hyungwoo Lee, Il Hyung Lee, Hyo Suk Nam, Young Dae Kim
BACKGROUND AND PURPOSE: Left atrial or left atrial appendage (LA/LAA) thrombi are frequently observed during cardioembolic evaluation in patients with ischemic stroke. This study aimed to investigate stroke outcomes in patients with LA/LAA thrombus. METHODS: This retrospective study included patients admitted to a single tertiary center in Korea between January 2012 and December 2020. Patients with nonvalvular atrial fibrillation who underwent transesophageal echocardiography or multi-detector coronary computed tomography were included in the study...
January 3, 2023: Journal of Stroke
https://read.qxmd.com/read/36592971/the-heart-is-at-risk-understanding-stroke-heart-brain-interactions-with-focus-on-neurogenic-stress-cardiomyopathy-a-review
#7
REVIEW
Mairi Ziaka, Aristomenis Exadaktylos
In recent years, it has been convincingly demonstrated that acute brain injury may cause severe cardiac complications-such as neurogenic stress cardiomyopathy (NSC), a specific form of takotsubo cardiomyopathy. The pathophysiology of these brain-heart interactions is complex and involves sympathetic hyperactivity, activation of the hypothalamic-pituitary-adrenal axis, as well as immune and inflammatory pathways. There have been great strides in our understanding of the axis from the brain to the heart in patients with isolated acute brain injury and more specifically in patients with stroke...
January 3, 2023: Journal of Stroke
https://read.qxmd.com/read/36592970/trends-in-venous-thromboembolism-readmission-rates-after-ischemic-stroke-and-intracerebral-hemorrhage
#8
JOURNAL ARTICLE
Liqi Shu, Adam de Havenon, Ava L Liberman, Nils Henninger, Eric Goldstein, Michael E Reznik, Ali Mahta, Fawaz Al-Mufti, Jennifer Frontera, Karen Furie, Shadi Yaghi
BACKGROUND AND PURPOSE: Venous thromboembolism (VTE) is a life-threatening complication of stroke. We evaluated nationwide rates and risk factors for hospital readmissions with VTE after an intracerebral hemorrhage (ICH) or acute ischemic stroke (AIS) hospitalization. METHODS: Using the Healthcare Cost and Utilization Project (HCUP) Nationwide Readmission Database, we included patients with a principal discharge diagnosis of ICH or AIS from 2016 to 2019. Patients who had VTE diagnosis or history of VTE during the index admission were excluded...
January 3, 2023: Journal of Stroke
https://read.qxmd.com/read/36592969/cortical-thinning-in-high-grade-asymptomatic-carotid-stenosis
#9
JOURNAL ARTICLE
Randolph S Marshall, David S Liebeskind, John Huston Iii, Lloyd J Edwards, George Howard, James F Meschia, Thomas G Brott, Brajesh K Lal, Donald Heck, Giuseppe Lanzino, Navdeep Sangha, Vikram S Kashyap, Clarissa D Morales, Dejania Cotton-Samuel, Andres M Rivera, Adam M Brickman, Ronald M Lazar
BACKGROUND AND PURPOSE: High-grade carotid artery stenosis may alter hemodynamics in the ipsilateral hemisphere, but consequences of this effect are poorly understood. Cortical thinning is associated with cognitive impairment in dementia, head trauma, demyelination, and stroke. We hypothesized that hemodynamic impairment, as represented by a relative time-to-peak (TTP) delay on MRI in the hemisphere ipsilateral to the stenosis, would be associated with relative cortical thinning in that hemisphere...
January 3, 2023: Journal of Stroke
https://read.qxmd.com/read/36592968/diabetes-and-stroke-what-are-the-connections
#10
REVIEW
Ofri Mosenzon, Alice Yy Cheng, Alejandro A Rabinstein, Simona Sacco
Stroke is a major cause of death and long-term disability worldwide. Diabetes is associated with an increased risk of cardiovascular complications, including stroke. People with diabetes have a 1.5-2 times higher risk of stroke compared with people without diabetes, with risk increasing with diabetes duration. These risks may also differ according to sex, with a greater risk observed among women versus men. Several mechanisms associated with diabetes lead to stroke, including large artery atherosclerosis, cerebral small vessel disease, and cardiac embolism...
January 3, 2023: Journal of Stroke
https://read.qxmd.com/read/36592967/mechanical-thrombectomy-for-acute-ischemic-stroke-in-metastatic-cancer-patients-a-nationwide-cross-sectional-analysis
#11
JOURNAL ARTICLE
Hassan Aboul-Nour, Ahmed Maraey, Ammar Jumah, Mahmoud Khalil, Ahmed M Elzanaty, Hadeer Elsharnoby, Fawaz Al-Mufti, Alex Bou Chebl, Daniel J Miller, Stephan A Mayer
BACKGROUND AND PURPOSE: Mechanical thrombectomy (MT) is the standard treatment for large vessel occlusion (LVO) acute ischemic stroke. Patients with active malignancy have an increased risk of stroke but were excluded from MT trials. METHODS: We searched the National Readmission Database for LVO patients treated with MT between 2016-2018 and compared the characteristics and outcomes of cancer-free patients to those with metastatic cancer (MC). Primary outcomes were all-cause in-hospital mortality and favorable outcome, defined as a routine discharge to home (regardless of whether home services were provided or not)...
January 3, 2023: Journal of Stroke
https://read.qxmd.com/read/36592965/practical-nomogram-predicting-apixaban-or-rivaroxaban-concentrations-from-low-molecular-weight-heparin-anti-xa-values-special-interest-in-acute-ischemic-stroke-patients
#12
JOURNAL ARTICLE
Charlyne Brakta, Alain Stépanian, Peggy Reiner, Maxime Delrue, Mikaël Mazighi, Emmanuel Curis, Virginie Siguret
BACKGROUND AND PURPOSE: In patients with acute ischemic stroke (AIS) using a direct oral factor-Xa anticoagulant (DOAC) during the last 48 hours, a fixed plasma heparin-calibrated anti-Xa activity (0.5 IU/mL) was proposed as a threshold below which patients could be eligible for thrombolysis and/or thrombectomy. Besides, specific DOAC-calibrated anti-Xa thresholds up to 50 ng/mL have been proposed. However, specific DOAC assays are not widely available contrarily to low-molecularweight heparin (LMWH) anti-Xa activity...
January 3, 2023: Journal of Stroke
https://read.qxmd.com/read/36746386/the-10th-korea-japan-joint-stroke-conference-kjjsc-at-osaka-the-first-ever-and-hopefully-the-last-virtual-conference
#13
JOURNAL ARTICLE
Kazunori Toyoda, Sohei Yoshimura, Kanta Tanaka, Kuniaki Ogasawara, Joung-Ho Rha
No abstract text is available yet for this article.
January 2023: Journal of Stroke
https://read.qxmd.com/read/36746385/the-rescue-on-reperfusion-damage-in-cerebral-infarction-by-nelonemdaz-rodin-trial-protocol-for-a-double-blinded-clinical-trial-of-nelonemdaz-in-patients-with-hyperacute-ischemic-stroke-and-endovascular-thrombectomy
#14
JOURNAL ARTICLE
Jin Soo Lee, Ji Sung Lee, Byoung Joo Gwag, Dennis W Choi, Chun San An, Hyun Goo Kang, Tae-Jin Song, Seong Hwan Ahn, Chang Hun Kim, Dong-Ick Shin, Sun U Kwon
BACKGROUND AND PURPOSE: Nelonemdaz (Neu2000) has both selective antagonism against 2B subunit of N-methyl-D-aspartate receptor and antioxidant activity. This drug provides sufficient evidence of neuroprotection in acute cerebral ischemia/reperfusion models. This phase III trial aims to determine this effect in patients. DESIGN: The Rescue on Reperfusion Damage in Cerebral Infarction by Nelonemdaz is a multicenter, double-blinded clinical trial. A total of 496 patients will be randomly assigned into the nelonemdaz (a total of 5,250 mg divided by 10 times for 5 days) and placebo groups...
January 2023: Journal of Stroke
https://read.qxmd.com/read/36746384/explanatory-power-and-prognostic-implications-of-factors-associated-with-troponin-elevation-in-acute-ischemic-stroke
#15
JOURNAL ARTICLE
Sung-Ho Ahn, Ji-Sung Lee, Mi-Sook Yun, Jung-Hee Han, Soo-Young Kim, Young-Hak Kim, Sang-Hyun Lee, Min-Gyu Park, Kyung-Pil Park, Dong-Wha Kang, Jong S Kim, Sun U Kwon
BACKGROUND AND PURPOSE: We investigated the impact of comorbidity burden on troponin elevation, with separate consideration of neurological conditions, in patients with acute ischemic stroke (AIS). METHODS: This prospective, observational cohort study consecutively enrolled patients with AIS for 2 years. Serum cardiac troponin I was repeatedly measured, and disease-related biomarkers were collected for diagnosis of preassigned comorbidities, including atrial fibrillation (AF), ischemic heart disease (IHD), myocardial hypertrophy (MH), heart failure (HF), renal insufficiency (RI), and active cancer...
January 2023: Journal of Stroke
https://read.qxmd.com/read/36746383/wall-shear-stress-associated-with-stroke-occurrence-and-mechanisms-in-middle-cerebral-artery-atherosclerosis
#16
JOURNAL ARTICLE
Ho Geol Woo, Hyug-Gi Kim, Kyung Mi Lee, Sang Hee Ha, HangJin Jo, Sung Hyuk Heo, Dae-Il Chang, David S Liebeskind, Bum Joon Kim
BACKGROUND AND PURPOSE: Various mechanisms are involved in the etiology of stroke caused by atherosclerosis of the middle cerebral artery (MCA). Here, we compared differences in plaque nature and hemodynamic parameters according to stroke mechanism in patients with MCA atherosclerosis. METHODS: Consecutive patients with asymptomatic and symptomatic MCA atherosclerosis (≥50% stenosis) were enrolled. MCA plaque characteristics (location and plaque enhancement) and wall shear stress (WSS) were measured using high-resolution vessel wall and four-dimensional flow magnetic resonance imaging, respectively, at five points (initial, upstream, minimal lumen, downstream, and terminal)...
January 2023: Journal of Stroke
https://read.qxmd.com/read/36746382/endovascular-versus-medical-management-of-acute-basilar-artery-occlusion-a-systematic-review-and-meta-analysis-of-the-randomized-controlled-trials
#17
REVIEW
Mohamad Abdalkader, Stephanos Finitsis, Chuanhui Li, Wei Hu, Xinfeng Liu, Xunming Ji, Xiaochuan Huo, Fana Alemseged, Zhongming Qiu, Daniel Strbian, Volker Puetz, James E Siegler, Shadi Yaghi, Kaiz Asif, Piers Klein, Yuyou Zhu, Bruce C V Campbell, Hui-Sheng Chen, Simon Nagel, Georgios Tsivgoulis, Zhongrong Miao, Raul G Nogueira, Tudor G Jovin, Wouter J Schonewille, Thanh N Nguyen
BACKGROUND AND PURPOSE: The optimal management of patients with acute basilar artery occlusion (BAO) is uncertain. We aimed to evaluate the safety and efficacy of endovascular thrombectomy (EVT) compared to medical management (MM) for acute BAO through a meta-analysis of randomized controlled trials (RCTs). METHODS: We performed a systematic review and meta-analysis of RCTs of patients with acute BAO. We analyzed the pooled effect of EVT compared to MM on the primary outcome (modified Rankin Scale [mRS] of 0-3 at 3 months), secondary outcome (mRS 0-2 at 3 months), symptomatic intracranial hemorrhage (sICH), and 3-month mortality rates...
January 2023: Journal of Stroke
https://read.qxmd.com/read/36746381/replacing-alteplase-with-tenecteplase-is-the-time-ripe
#18
REVIEW
Nishita Singh, Bijoy K Menon, Adam A Dmytriw, Robert W Regenhardt, Joshua A Hirsch, Aravind Ganesh
Thrombolysis for acute ischemic stroke has predominantly been with alteplase for over a quarter of a century. In recent years, with trials showing evidence of higher rates of successful reperfusion, similar safety profile and efficacy of tenecteplase (TNK) as compared to alteplase, TNK has now emerged as another potential choice for thrombolysis in acute ischemic stroke. In this review, we will focus on these recent advances, aiming: (1) to provide a brief overview of thrombolysis in stroke; (2) to provide comparisons between alteplase and TNK for clinical, imaging, and safety outcomes; (3) to focus on key subgroups of interest to understand if there is an advantage of using TNK over alteplase or vice-versa, to review available evidence on role of TNK in intra-arterial thrombolysis, as bridging therapy and in mobile stroke units; and (4) to summarize what to expect in the near future from recently completed trials and propose areas for future research on this evolving topic...
January 2023: Journal of Stroke
https://read.qxmd.com/read/36746380/neuroimaging-of-acute-ischemic-stroke-multimodal-imaging-approach-for-acute-endovascular-therapy
#19
REVIEW
Mohamad Abdalkader, James E Siegler, Jin Soo Lee, Shadi Yaghi, Zhongming Qiu, Xiaochuan Huo, Zhongrong Miao, Bruce C V Campbell, Thanh N Nguyen
Advances in acute ischemic stroke (AIS) treatment have been contingent on innovations in neuroimaging. Neuroimaging plays a pivotal role in the diagnosis and prognosis of ischemic stroke and large vessel occlusion, enabling triage decisions in the emergent care of the stroke patient. Current imaging protocols for acute stroke are dependent on the available resources and clinicians' preferences and experiences. In addition, differential application of neuroimaging in medical decision-making, and the rapidly growing evidence to support varying paradigms have outpaced guideline-based recommendations for selecting patients to receive intravenous or endovascular treatment...
January 2023: Journal of Stroke
https://read.qxmd.com/read/36746379/sex-and-gender-differences-in-stroke-and-their-practical-implications-in-acute-care
#20
REVIEW
Johanna Ospel, Nishita Singh, Aravind Ganesh, Mayank Goyal
There are several controversies regarding the role of sex and gender in the pathophysiology and management of acute stroke. Assessing the role of sex, i.e., biological/pathophysiological factors, and gender, i.e., sociocultural factors, in isolation is often not possible since they are closely intertwined with each other. To complicate matters even more, the functional baseline status of women and men at the time of their first stroke is substantially different, whereby women have, on average, a poorer reported/ascertained baseline function compared to men...
January 2023: Journal of Stroke
journal
journal
47857
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.