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JOURNAL ARTICLE
Ana M Quintero, Diego A Cruz Vidal, Brett G Klamer, Monica I Ardura, Sophonie J Oyeniran
BACKGROUND: Levofloxacin prophylaxis (LVXp) is often used for patients with underlying leukemia and severe neutropenia to reduce the risk of fever and bacteremia. This study evaluated trends in viridans group streptococci (VGS) antibiotic susceptibilities over time and clinical outcomes of children with VGS bloodstream infections (BSIs) during institutional adoption of LVXp. METHODS: VGS blood culture isolates between 1/1/2010 and 12/31/2021 with susceptibility testing reported were included...
July 31, 2023: Journal of the Pediatric Infectious Diseases Society
#22
EDITORIAL
Karen P Acker
No abstract text is available yet for this article.
July 31, 2023: Journal of the Pediatric Infectious Diseases Society
#23
(no author information available yet)
No abstract text is available yet for this article.
July 31, 2023: Journal of the Pediatric Infectious Diseases Society
#24
JOURNAL ARTICLE
José Iván Castillo Bejarano, Jorge Llaca Díaz, Manuel Enrique de la O Cavazos, Hugo Sánchez Alanís, Abiel Homero Mascareñas de Los Santos, Fernando Espinosa Villaseñor, Rebeca Aguayo Samaniego, Daniel Siller Rodríguez, Nestor Casillas Vega
BACKGROUND: Acinetobacter baumannii has emerged as a threat to public health due to the high prevalence of multidrug-resistant isolates. Information regarding the clinical and molecular characterization of carbapenem-resistant A. baumannii (CRAB) infections in children is scarce. Our study aimed to describe the clinical and molecular characteristics of CRAB infections in children from third-level center in Mexico. METHODS: Consecutive cases of CRAB infections were documented during 2017-2022...
July 1, 2023: Journal of the Pediatric Infectious Diseases Society
#25
EDITORIAL
Michael L O'Byrne
No abstract text is available yet for this article.
June 30, 2023: Journal of the Pediatric Infectious Diseases Society
#26
JOURNAL ARTICLE
Thomas J Sferra, Tomas Merta, Michael Neely, Claudia Murta de Oliveira, Alvaro Lassaletta, Claudia Fortuny Guasch, Mary Beth Dorr, Gregory Winchell, Feng-Hsiu Su, Sarah Perko, Doreen Fernsler, Hetty Waskin, Stephen R Holden
BACKGROUND: Therapies to prevent recurrence of Clostridioides difficile infection (CDI) in pediatric patients are needed. Bezlotoxumab is a fully human monoclonal antibody approved for prevention of recurrent CDI in adults. We assessed the pharmacokinetics, safety, tolerability, and efficacy of bezlotoxumab in pediatric patients. METHODS: MODIFY III was a multicenter, double-blind, placebo-controlled study of bezlotoxumab in children (1 to <18 years) receiving antibacterial treatment for CDI...
June 30, 2023: Journal of the Pediatric Infectious Diseases Society
#27
JOURNAL ARTICLE
Hiroki Kato, Kensuke Shoji, Miyuki Jinguji, Nao Nishimura, Satoshi Nakagawa, Isao Miyairi
BACKGROUND: Several reports have suggested that routine use of anaerobic blood culture bottles together with aerobic bottles may improve blood culture positivity. However, the information is still limited regarding the utility of anaerobic blood culture bottles in the pediatric intensive care unit (PICU), where bacteremia due to anaerobic bacteria is relatively rare. METHODS: A retrospective observational study was conducted at a PICU in a tertiary children's hospital in Japan from May 2016 to January 2020...
June 30, 2023: Journal of the Pediatric Infectious Diseases Society
#28
JOURNAL ARTICLE
Sarah A Buchan, Hannah Chung, Teresa To, Nick Daneman, Astrid Guttmann, Jeffrey C Kwong, Michelle Murti, Garima Aryal, Aaron Campigotto, Pranesh Chakraborty, Jonathan Gubbay, Timothy Karnauchow, Kevin Katz, Allison J McGeer, J Dayre McNally, Samira Mubareka, David Richardson, Susan E Richardson, Marek Smieja, George Zahariadis, Shelley L Deeks
BACKGROUND: Respiratory syncytial virus (RSV) contributes significantly to morbidity in children, placing substantial burdens on health systems, thus RSV vaccine development and program implementation are a public health priority. More data on burden are needed by policymakers to identify priority populations and formulate prevention strategies as vaccines are developed and licensed. MATERIALS/METHODS: Using health administrative data, we calculated incidence rates of RSV hospitalization in a population-based birth cohort of all children born over a six-year period (May 2009 - June 2015) in Ontario, Canada...
June 19, 2023: Journal of the Pediatric Infectious Diseases Society
#29
JOURNAL ARTICLE
Trevon L Fuller, Leonardo Bastos, Marilia Sá Carvalho, Paola Cristina Resende, Luana Damasceno, Oswaldo Gonçalves Cruz, Fernando Medeiros, Guilherme Calvet, Lusiele Guaraldo, Karin Nielsen-Saines, James Whitworth, Christopher Smith, Marilda Siqueira, Patrícia Brasil
BACKGROUND: It is important to understand the dynamics of SARS-CoV-2 transmission in close-contact settings such as households. We hypothesized that children would most often acquire SARS-CoV-2 from a symptomatic adult caregiver. METHODS: This prospective cohort study was conducted from April 2020 to July 2022 in a low-resource, urban settlement in Brazil. We recruited families who brought their children to a public clinic. We collected nasopharyngeal and oral swabs from household members and tracked symptoms and vaccination...
June 16, 2023: Journal of the Pediatric Infectious Diseases Society
#30
JOURNAL ARTICLE
Holly M Biggs, Eric A F Simões, Ilham Abu Khader, Mark G Thompson, Aubree Gordon, Danielle R Hunt, Nicholas P DeGroote, Rachael M Porter, Silvia Bino, Basima I Marar, Lionel Gresh, Joanne de Jesus-Cornejo, Gayle Langley, Natalie J Thornburg, Teresa C T Peret, Brett Whitaker, Yange Zhang, Lijuan Wang, Mira C Patel, Meredith McMorrow, William Campbell, Iris Hasibra, Enkeleda Duka, Mahmoud Al-Gazo, John Kubale, Felix Sanchez, Marilla G Lucero, Veronica L Tallo, Eduardo Azziz-Baumgartner, Artan Simaku, Susan I Gerber
BACKGROUND: Understanding respiratory syncytial virus (RSV) global epidemiology is important to inform future prevention strategies. METHODS: Hospitalized infants <1-year-old with acute illness were enrolled prospectively in Albania, Jordan, Nicaragua, and Philippines during respiratory seasons in 2015-2017. Medical chart review, parental interview, and post-discharge follow up were conducted. Respiratory specimens were tested using real-time RT-PCR for RSV. Infant characteristics associated with very severe illness (intensive care unit [ICU] admission or receipt of supplemental oxygen) were assessed using logistic regression to adjust for potential confounders (age, sex, study site, preterm birth)...
June 14, 2023: Journal of the Pediatric Infectious Diseases Society
#31
JOURNAL ARTICLE
Olivia Leow, Rie Aoyama, Woei Shyang Loh, E'Ching Shih, Sok Yan Tay, Ka Lip Chew, Kean Lee Chew, Liang Shen, Si Min Chan
BACKGROUND: Lymphadenitis is the most common manifestation of non-tuberculous mycobacteria (NTM) infection in children. We describe the epidemiology and clinical characteristics of NTM lymphadenitis, determine diagnostic yield from tissue sampling, and review management and outcomes. METHODS: This was a 10-year retrospective review of children aged 0-16 years diagnosed with NTM cervicofacial lymphadenitis who were seen in a paediatric infectious disease clinic in a tertiary public hospital...
June 13, 2023: Journal of the Pediatric Infectious Diseases Society
#32
JOURNAL ARTICLE
Caitlin Naureckas Li, Simon Parzen-Johnson, Ravi Jhaveri
No abstract text is available yet for this article.
June 7, 2023: Journal of the Pediatric Infectious Diseases Society
#33
JOURNAL ARTICLE
Samoel A Khamadi, Emmanuel Bahemana, Nicole Dear, Caroline Mavere, Fredy George, Razack Kapene, Grace Papianus, Walidah Willoughby, Jillian Chambers, Kavitha Ganesan, Iman Mwakabanje, Jason M Bacha, Priyanka Desai, Shaban Almas, Peter D Coakley, Vanessa Wolfman, Elizabeth H Lee, Patrick W Hickey, Jeffrey Livezey, Patricia A Agaba
BACKGROUND: Achieving viral suppression (VS) for persons living with HIV is key to reaching epidemic control. We assessed the prevalence of VS and the frequency of HIV drug resistance mutations (HIVDRM) among children and adolescents living with HIV (CALHIV) in the Southern Highland zone of Tanzania. METHODS: From 2019-2021, we enrolled CALHIV aged 1-19 years on ART for >6 months in a cross-sectional study. Participants had viral load (VL) testing; those with VL ≥1000 copies/mL underwent HIVDRM testing...
June 3, 2023: Journal of the Pediatric Infectious Diseases Society
#34
JOURNAL ARTICLE
Benchmarking of Outpatient Pediatric Antibiotic Prescribing: Results of a Multicenter Collaborative.
Rana E El Feghaly, Joshua C Herigon, Matthew P Kronman, Bethany A Wattles, Nicole M Poole, Michael J Smith, Ana M Vaughan, Rosemary Olivero, Sameer J Patel, Ann Wirtz, Zachary Willis, Brian R Lee
BACKGROUND: Most antibiotic use occurs in ambulatory settings. No benchmarks exist for pediatric institutions to assess their outpatient antibiotic use and compare prescribing rates to peers. We aimed to share pediatric outpatient antibiotic use reports and benchmarking metrics nationally. METHODS: We invited institutions from the Sharing Antimicrobial Reports for Pediatric Stewardship OutPatient (SHARPS-OP) Collaborative to contribute quarterly aggregate reports on antibiotic use from January 2019 through June 2022...
June 1, 2023: Journal of the Pediatric Infectious Diseases Society
#35
JOURNAL ARTICLE
Heather R Jackson, Luca Miglietta, Dominic Habgood-Coote, Giselle D'Souza, Priyen Shah, Samuel Nichols, Ortensia Vito, Oliver Powell, Maisey Salina Davidson, Chisato Shimizu, Philipp K A Agyeman, Coco R Beudeker, Karen Brengel-Pesce, Enitan D Carrol, Michael J Carter, Tisham De, Irini Eleftheriou, Marieke Emonts, Cristina Epalza, Pantelis Georgiou, Ronald De Groot, Katy Fidler, Colin Fink, Daniëlle van Keulen, Taco Kuijpers, Henriette Moll, Irene Papatheodorou, Stephane Paulus, Marko Pokorn, Andrew J Pollard, Irene Rivero-Calle, Pablo Rojo, Fatou Secka, Luregn J Schlapbach, Adriana H Tremoulet, Maria Tsolia, Effua Usuf, Michiel Van Der Flier, Ulrich Von Both, Clementien Vermont, Shunmay Yeung, Dace Zavadska, Werner Zenz, Lachlan J M Coin, Aubrey Cunnington, Jane C Burns, Victoria Wright, Federico Martinon-Torres, Jethro A Herberg, Jesus Rodriguez Manzano, Myrsini Kaforou, Michael Levin
This article has been temporarily withdrawn due to a pending patent application. It will be re-published at this location shortly. The journal apologizes for any inconvenience.
May 31, 2023: Journal of the Pediatric Infectious Diseases Society
#36
REVIEW
Andrew S Haynes, Holly Maples, Sarah Parker
Vancomycin remains the standard of care for treating methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in pediatrics largely because no alternative antibiotic is definitively superior. Long-standing historical precedent and S. aureus' notable lack of vancomycin resistance are clear benefits, but vancomycin's use remains plagued by nephrotoxicity and the need for therapeutic drug monitoring, with inadequate consensus on how best to dose or monitor vancomycin in pediatrics. Daptomycin, ceftaroline, and linezolid are all promising alternatives, with improved safety relative to vancomycin...
May 31, 2023: Journal of the Pediatric Infectious Diseases Society
#37
JOURNAL ARTICLE
Katherine V Williams, Zhu-Nan Li, Bo Zhai, John F Alcorn, Mary Patricia Nowalk, Min Z Levine, Sara S Kim, Brendan Flannery, Krissy Moehling Geffel, Amanda Jaber Merranko, Mark Collins, Michael Susick, Karen S Clarke, Richard K Zimmerman, Judith M Martin
BACKGROUND: Few studies have focused on the immune response to more recent influenza vaccine formulations such as cell-cultured inactivated influenza vaccine (ccIIV4) or live attenuated influenza vaccine (LAIV4) in older children and young adults, or differences in immunoglobulin response using newer antibody landscape technology. METHODS: Participants ages 4-21 were randomized to receive ccIIV4 (n =112) or LAIV4 (n=118). A novel high-throughput multiplex influenza antibody detection assay (MIADA) was used to provide detailed IgG, IgA, and IgM antibody isotypes, along with hemagglutination inhibition levels (HAI), measured pre- and 28 days post vaccination...
May 26, 2023: Journal of the Pediatric Infectious Diseases Society
#38
JOURNAL ARTICLE
Lisa Saiman, Susan E Coffin, Larry K Kociolek, Danielle M Zerr, Aaron M Milstone, Margaret L Aldrich, Celibell Y Vargas, Giovanny Zapata, Morgan A Zalot, Megan E Reyna, Amanda Adler, Annie Voskertchian, Emily R Egbert, Luis Alba, Sonia Gollerkeri, Madelyn Ruggieri, Lyn Finelli, Yoonyoung Choi
BACKGROUND: Outbreaks of healthcare-associated respiratory syncytial virus (HA-RSV) infections in children are well described, but less is known about sporadic HA-RSV infections. We assessed the epidemiology and clinical outcomes associated with sporadic HA-RSV infections. METHODS: We retrospectively identified hospitalized children <18 years old with HA-RSV infections in six children's hospitals in the United States during the respiratory viral seasons October-April in 2016-2017, 2017-2018, and 2018-2019 and prospectively from October 2020 through November 2021...
May 5, 2023: Journal of the Pediatric Infectious Diseases Society
#39
JOURNAL ARTICLE
Janet A Englund, Rachel A Cohen, Veronique Bianco, Joseph B Domachowske, Joanne M Langley, Shabir A Madhi, Khalequ Zaman, Agustin Bueso, Ana Ceballos, Luis Cousin, Sanjay Gandhi, Olivier Gruselle, Lisa Jose, Nicola P Klein, Anthonet Koen, Thanyawee Puthanaki, Meng Shi, Peter Silas, Auchara Tangsathapornpong, Jamaree Teeratakulpisarn, Timo Vesikari, Gerco Haars, Amanda Leach, Sonia K Stoszek, Ilse Dieussaert
BACKGROUND: Various case definitions of respiratory syncytial virus lower respiratory tract infection (RSV-LRTI) are currently proposed. We assessed the performance of three clinical case definitions against the World Health Organization definition recommended in 2015 (WHO 2015). METHODS: In this prospective cohort study conducted in eight countries, 2401 children were followed up during 2 years from birth. Suspected LRTIs were detected via active and passive surveillance, followed by in-person clinical evaluation including single timepoint respiratory rate and oxygen saturation (by pulse oximetry) assessment, and nasopharyngeal sampling for RSV testing by polymerase chain reaction...
May 5, 2023: Journal of the Pediatric Infectious Diseases Society
#40
JOURNAL ARTICLE
Jeffrey I Cohen, Anne A Gershon, Charles Grose
No abstract text is available yet for this article.
April 29, 2023: Journal of the Pediatric Infectious Diseases Society
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