Read by QxMD icon Read

Journal of the Pediatric Infectious Diseases Society

Huong Q McLean, Jennifer P King, Pamela Talley, Brendan Flannery, Sarah Spencer, Min Z Levine, Thomas C Friedrich, Edward A Belongia
Background: The effects of repeated influenza vaccination in children are not well understood. In this study, we evaluated previous vaccination effects on antibody response after vaccination with trivalent inactivated influenza vaccine (IIV) or quadrivalent live-attenuated influenza vaccine (LAIV) among school-aged children (5-17 years) across 3 seasons. Methods: Children were enrolled in the fall of 2013, 2014, and 2015. The participants received IIV or LAIV according to parent preference (2013-2014) or our randomization scheme (2014-2015)...
February 13, 2019: Journal of the Pediatric Infectious Diseases Society
Yifan Joshua Li, Katalin A Wilkinson, Robert J Wilkinson, Anthony A Figaji, Ursula K Rohlwink
We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis.
February 12, 2019: Journal of the Pediatric Infectious Diseases Society
N Nashid, S Khan, M Loutfy, J MacGillivray, M H Yudin, D M Campbell, T Barozzino, M Baqi, S E Read, A Bitnun
The reduction in human immunodeficiency virus (HIV) transmission through breastmilk with maternal combination antiretroviral therapy (cART) has led many pregnant women living with HIV and healthcare providers to question exclusive formula feeding in resource-rich settings. Here, we describe cART prophylaxis in 3 breastfed infants whose mothers had sustained virologic suppression; all 3 of these infants remained uninfected.
February 8, 2019: Journal of the Pediatric Infectious Diseases Society
Mary E Wikswo, Umesh D Parashar, Benjamin Lopman, Rangaraj Selvarangan, Christopher J Harrison, Parvin H Azimi, Julie A Boom, Leila C Sahni, Janet A Englund, Eileen J Klein, Mary Allen Staat, Monica M McNeal, Natasha Halasa, James Chappell, Geoffrey A Weinberg, Peter G Szilagyi, Mathew D Esona, Michael D Bowen, Daniel C Payne
Background: Rotavirus is a leading cause of acute gastroenteritis (AGE) in children and is highly transmissible. In this study, we assessed the presence of AGE in household contacts (HHCs) of pediatric patients with laboratory-confirmed rotavirus. Methods: Between December 2011 and June 2016, children aged 14 days to 11 years with AGE were enrolled at 1 of 7 hospitals or emergency departments as part of the New Vaccine Surveillance Network. Parental interviews, medical and vaccination records, and stool specimens were collected at enrollment...
February 7, 2019: Journal of the Pediatric Infectious Diseases Society
Mike L T Berendsen, Christian Bjerregård Øland, Pauli Bles, Aksel Karl Georg Jensen, Poul-Erik Kofoed, Hilton Whittle, Charlotte De Bree, Mihai G Netea, Cesario Martins, Christine S Benn, Peter Aaby
Background and Hypothesis: Maternal priming might enhance the beneficial nonspecific effects (NSEs) of live measles vaccination (MV). Children with a bacillus Calmette-Guérin (BCG) vaccine scar have a lower mortality rate than those without a scar that is not explained by protection against tuberculosis. We examined the hypothesis that BCG scarring would have a stronger effect on a child if the mother also had a BCG scar. Methods: In a randomized controlled trial (RCT) of early MV in children aged 4...
February 3, 2019: Journal of the Pediatric Infectious Diseases Society
Silvia S Chiang, Sangshin Park, Emily I White, Jennifer F Friedman, Andrea T Cruz, Hernán Del Castillo, Leonid Lecca, Mercedes C Becerra, James A Seddon
Background: International guidelines recommend monitoring weight as an indicator of therapeutic response in childhood tuberculosis (TB) disease. This recommendation is based on observations in adults. In the current study, we evaluated the association between weight change and treatment outcome, the accuracy of using weight change to predict regimen efficacy, and whether successfully treated children achieve catch-up weight gain. Methods: We enrolled children treated for drug-susceptible TB disease (group 1) and multidrug-resistant TB disease (group 2) in Peru...
February 1, 2019: Journal of the Pediatric Infectious Diseases Society
Anna C Sick-Samuels, Katherine E Goodman, Glenn Rapsinski, Elizabeth Colantouni, Aaron M Milstone, Andrew J Nowalk, Pranita D Tamma
Background: As rates of multidrug-resistant gram-negative infections rise, it is critical to recognize children at high risk of bloodstream infections with organisms resistant to commonly used empiric broad-spectrum antibiotics. The objective of the current study was to develop a user-friendly clinical decision aid to predict the risk of resistance to commonly prescribed broad-spectrum empiric antibiotics for children with gram-negative bloodstream infections. Methods: This was a longitudinal retrospective cohort study of children with gram-negative bacteria cared for at a tertiary care pediatric hospital from June 2009 to June 2015...
January 25, 2019: Journal of the Pediatric Infectious Diseases Society
Fátima C P A Di Maio Ferreira, Anamaria S V da Silva, Ana M Bispo de Filippis, Patrícia Brasil
We report here a probable case of vertical transmission of chikungunya infection with confirmed maternal viremia close to labor that led to severe infection in the newborn. The newborn progressed with cutaneous lesions and irritability 2 months after vertical transmission, when chikungunya virus was detected in the infant's CSF by a molecular diagnostic test (real-time polymerase chain reaction).
January 18, 2019: Journal of the Pediatric Infectious Diseases Society
Beate Zoch-Lesniak, Robert S Ware, Keith Grimwood, Stephen B Lambert
Background: Most acute respiratory infection (ARI) research focuses on severe disease and overlooks the burden of community-managed illness. For community-based studies, home-based specimen collection by parents could be a resource-saving alternative to collection by healthcare workers (HCWs). In this study, we compared parent and HCW groups for their likelihood to collect specimens and the timeliness and quality of such collection. Methods: In this unblinded randomized controlled trial, parents from Brisbane, Australia, were taught to identify new ARI episodes in their children aged <2 years...
January 18, 2019: Journal of the Pediatric Infectious Diseases Society
Stanley A Plotkin
No abstract text is available yet for this article.
January 18, 2019: Journal of the Pediatric Infectious Diseases Society
Jesse Papenburg, Patricia S Fontela, Raphael R Freitas, Brett Burstein
One-fourth of patients with bronchiolitis seen in US emergency departments between 2007 and 2015 received antibiotics; 70% of them had no documented bacterial coinfection. Macrolides were prescribed in 38% of the cases. Antibiotic use did not decrease after national recommendations against routine prescribing. Efforts are needed to reduce unnecessary and inappropriate antibiotic use for bronchiolitis.
January 17, 2019: Journal of the Pediatric Infectious Diseases Society
Melissa S Nolan, Andrea T Cruz, Tim Erickson
Background: Trichomonas vaginalis infection causes significant morbidity in the United States. Despite its high national disease burden, the epidemiologic characteristics of child and adolescent cases are not well understood. In this study, we aimed to describe the socioeconomic, transmission risk factors, clinical manifestations, and geospatial variables associated with cases of T vaginalis infection in the Houston, Texas, metropolitan area. Methods: We performed a retrospective chart abstraction of all T vaginalis cases at 2 large pediatric hospitals in Houston between 2008 and 2016...
January 8, 2019: Journal of the Pediatric Infectious Diseases Society
Suchitra Rao, Jan Martin, M Alex Ahearn, Christina Osborne, Angela Moss, Amanda Dempsey, Samuel R Dominguez, Adriana Weinberg, Kevin B Messacar
Among 182 children with influenza infection in 2016-2017, 18% had neurologic manifestations of influenza (NMI), including seizures and encephalopathy; 85% of these children were infected with the H3N2 strain. Children with NMI had 3.5-times-higher odds of having a neurologic comorbidity than those without NMI and a 10-fold increased odds of hospitalization.
December 27, 2018: Journal of the Pediatric Infectious Diseases Society
Ryan H Rochat, Debra L Palazzi
No abstract text is available yet for this article.
December 27, 2018: Journal of the Pediatric Infectious Diseases Society
Laura Chappell-Campbell, Hayden T Schwenk, Nicole Capdarest-Arest, Alan R Schroeder
Background: Blood cultures are obtained routinely for infants and young children for the evaluation for serious bacterial infection. Isolation of organisms that represent possible contaminants poses a management challenge. The prevalence of bacteremia reported in this population is potentially biased by inconsistent contaminant categorization reported in the literature. Our aim was to systematically review the definition and reporting of contaminants within the literature regarding infant bacteremia...
December 13, 2018: Journal of the Pediatric Infectious Diseases Society
Jared Olson, Emily A Thorell, Adam L Hersh
We conducted a retrospective study to evaluate suboptimal discharge antibiotic prescribing at a children's hospital and found that 27% of the prescriptions were suboptimal. Thirty-three percent of the patients who might have qualified for solid dosage forms received liquid dosages instead. Our findings suggest that opportunities exist for discharge antibiotic-stewardship and pill-swallowing programs.
December 13, 2018: Journal of the Pediatric Infectious Diseases Society
Chris A Rees, Andrea T Cruz, Stephen B Freedman, Prashant Mahajan, Neil G Uspal, Pamela Okada, Paul L Aronson, Amy D Thompson, Paul T Ishimine, Suzanne M Schmidt, Nathan Kuppermann, Lise E Nigrovic
In 4292 infants aged ≤60 days with cerebrospinal fluid (CSF) pleocytosis, the bacterial meningitis score had excellent sensitivity (121 of 121 [100.0%] [95% confidence interval, 96.5%-100.0%]) but low specificity (66 of 4171 [1.6%] [95% confidence interval, 1.3%-2.0%]) and therefore should not be applied clinically to infants in this age group.
December 10, 2018: Journal of the Pediatric Infectious Diseases Society
Jovanka R King, Jezabel Varadé, Lennart Hammarström
Background: Single-nucleotide polymorphisms (SNPs) in the fucosyltransferase genes FUT2 and FUT3 have been associated with susceptibility to various infectious and inflammatory disorders. FUT variations influence the expression of human histo-blood group antigens (HBGAs) (H-type 1 and Lewis), which are highly expressed in the gut and play an important role in microbial attachment, metabolism, colonization, and shaping of the microbiome. In particular, FUT polymorphisms confer susceptibility to specific rotavirus and norovirus genotypes, which has important global health implications...
December 9, 2018: Journal of the Pediatric Infectious Diseases Society
Bahaa Abu-Raya, Julie A Bettinger, Otto G Vanderkooi, Wendy Vaudry, Scott A Halperin, Manish Sadarangani
Background: Recent increases in pertussis morbidity and mortality rates among young infants have led to a recommendation in some countries for vaccination against pertussis during pregnancy. Having data on the burden of pediatric pertussis in a large population over time is important for establishing the true burden of disease in the acellular pertussis (aP) vaccine era. Here, we describe age-specific epidemiology and morbidity and mortality rates in children hospitalized with pertussis over 17 years across Canada in the aP vaccine era...
December 8, 2018: Journal of the Pediatric Infectious Diseases Society
Liset Olarte
The use of empiric vancomycin plus a third-generation cephalosporin for suspected bacterial meningitis has been recommended since 1997. Although the prevalence of ceftriaxone-nonsusceptible pneumococcal meningitis has decreased, vancomycin should still be included as empiric therapy for bacterial meningitis.
November 29, 2018: Journal of the Pediatric Infectious Diseases Society
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"