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BioImpacts: BI

Zohreh Ebrahimnezhad, Nosratollah Zarghami, Manoutchehr Keyhani, Soumaye Amirsaadat, Abolfazl Akbarzadeh, Mohammad Rahmati, Zohreh Mohammad Taheri, Kazem Nejati-Koshki
[This retracts the article DOI: 10.5681/bi.2013.005.].
2018: BioImpacts: BI
Shahram Emami, Mohammadreza Siahi-Shadbad, Khosro Adibkia, Mohammad Barzegar-Jalali
Introduction : Oral drug delivery is the most favored route of drug administration. However, poor oral bioavailability is one of the leading reasons for insufficient clinical efficacy. Improving oral absorption of drugs with low water solubility and/or low intestinal membrane permeability is an active field of research. Cocrystallization of drugs with appropriate coformers is a promising approach for enhancing oral bioavailability. Methods : In the present review, we have focused on recent advances that have been made in improving oral absorption through cocrystallization...
2018: BioImpacts: BI
Bryson C Lochte, Sean A Guillory, Craig A H Richard, William M Kelley
Introduction : The "autonomous sensory meridian response" (ASMR) is a neologism used to describe an internal sensation of deep relaxation and pleasant head tingling which is often stimulated by gentle sounds, light touch, and personal attention. Methods : An fMRI-based methodology was employed to examine the brain activation of subjects prescreened for ASMR-receptivity (n=10) as they watched ASMR videos and identified specific moments of relaxation and tingling. Results : Subjects who experienced ASMR showed significant activation in regions associated with both reward (NAcc) and emotional arousal (dACC and Insula/IFG)...
2018: BioImpacts: BI
Hassan Rasouli, Amir Hossein Norooznezhad, Tahereh Rashidi, Zohreh Hoseinkhani, Azadeh Mahnam, Mitra Tarlan, Narges Moasefi, Ali Mostafaei, Kamran Mansouri
Introduction: Date palm pollen (DPP) is the male reproductive soft powder from date flowers widely used as the valuable dietary supplement to fortify the size of testis and ovarian to increase the power of sex. This part of date palm significantly exhibited anti-diabetic, anti-inflammation and protective effects against male and female infertility. Though the anticancer activity of date fruits was previously reported, the DPP anti-angiogenic effects were not reported, and as the first study, its inhibitory effects were examined in the current study...
2018: BioImpacts: BI
Mohammad T Shervani-Tabar, Babak Farzaneh, Reza Ahrabi, Seyed E Razavi
Introduction : Employing of gaseous plugs inside a vein for preventing of blood flow to the damaged or cancerous tissues has been known as a gas embolism in the medicine. In this research, a numerical investigation has been carried out on the delivery of the liquid drug DDFP, encapsulated in the microlipidcoated spheres (MLCSs), to target the human vein for construction of the gaseous plug inside the veins. Methods : The encapsulated liquid drug DDFP were delivered to the vein by injection of an emulsion. Releasing of the liquid drug DDFP results in an explosive growth of a gaseous plug inside the vein...
2018: BioImpacts: BI
Mohammad Johari-Ahar, Jaleh Barar, Pari Karami, Davoud Asgari, Soodabeh Davaran, Mohammad-Reza Rashidi
Introduction : Dopamine is one of the key neurotransmitters (NTs) in nature, which plays a crucial role in the mammalian central nervous system (CNS). Its selective determination in the biological fluids is an essential need in the field of biomedicine studies. Methods : In this work, an amperometric sensor was developed using Nafion-coated cadmium pentacyanonitrosylferrate (CdPCNF) modified glassy carbon (GC) electrode (Nafion|CdPCNF|GC electrode) as an electrocatalyst to detect dopamine (DA) in human serum samples...
2018: BioImpacts: BI
Ravi Ranjan Kumar, Vasantba J Jadeja
Introduction : The inevitable rise of antibiotic-resistant bacteria is a global health problem. These pathogens erode the utility of available antibiotics. Staphylococcus aureus is one of the major causes of community-acquired infections. The aim of work was to evaluate the marine actinomycetes for production of the antibacterial agent against pathogens. Methods : Halophilic actinomycetes were isolated, characterized and screened for production of antibacterial agent against pathogenic bacteria. The antibacterial compounds were extracted by solvent extraction and separated by TLC based bioautography...
2018: BioImpacts: BI
Maryam Monajati, Shirin Tavakoli, Samira Sadat Abolmaali, Gholamhossein Yousefi, AliMohammad Tamaddon
Introduction: Sorafenib (SFB) is an FDA-approved chemotherapeutic agent with a high partition coefficient (log P = 4.34) for monotherapy of hepatocellular carcinoma (HCC). The oral bioavailability is low and variable, so it was aimed to study the application of the polymeric nanoassembly of cholesterol conjugates of branched polyethyleneimine (PEI) for micellar solubilization of SFB and to investigate the impact of the polymer PEGylation on the physicochemical and cellular characteristics of the lipopolymeric dispersions...
2018: BioImpacts: BI
Abdollah Abdollahi-Aghdam, Mir Reza Majidi, Yadollah Omidi
Through the development of analytical techniques, microscaled devices have displayed attractive advantages, including ultrasensitive detection and analysis, cost-effectiveness, portability, process integrity, multi-process functionality, and in-situ analysis. In the last decade, a new generation of analytical devices has emerged based on the cellulose materials - so-called microfluidic paper-based analytical devices (µPADs) - a field that will change the face of the diagnosis of different diseases and sensing of a wide range of biological/chemical/biochemical phenomena...
2018: BioImpacts: BI
Sepideh Parvizpour, Jafar Razmara, Yadollah Omidi
Introduction: Breast cancer, as one of the major causes of cancer death among women, is the central focus of this study. The recent advances in the development and application of computational tools and bioinformatics in the field of immunotherapy of malignancies such as breast cancer have emerged the new dominion of immunoinformatics, and therefore, next generation of immunomedicines . Methods: Having reviewed the most recent works on the applications of computational tools, we provide comprehensive insights into the breast cancer incidence and its leading causes as well as immunotherapy approaches and the future trends...
2018: BioImpacts: BI
Ananda Mookerjee, Michele Graciotti, Lana Kandalaft
Introduction: Ovarian cancer is one of the most lethal gynecologic cancers. Relapses after remission are common, hence novel strategies are urgently needed. Our group has previously developed a vaccination approach based on dendritic cells pulsed with HOCl-oxidized tumor lysates. Here we investigate the improvement of this vaccine strategy using squaric acid treatment of cancer cells during tumor lysate preparation and by differentiating dendritic cells in the presence of GM-CSF and IFNα. Methods: Induction of cell death by squaric acid treatment was assessed with propidium iodide (PI) and Annexin V in ID8 tumor cells...
2018: BioImpacts: BI
Shaminder Singh, Sonam Bhatia
Introduction: Quorum sensing inhibition (QSI) is one of the vital tools to overcome emerging virulence of pathogenic bacteria which aims at curbing bacterial resistance. Targeting QS (quorum sensing) as chemotherapy is less likely to generate resistance among pathogens as it targets only the adaptation and not the survival mechanism of the pathogen. Several QS inhibitors were developed in the recent past but none of them managed to have clinical application due to known toxic effects for human consumption. A rapid development of QS inhibitor drugs could be achieved by verification of the QSI activity of drugs which are already in clinical use with known pharmacology...
2018: BioImpacts: BI
Seyed Esmail Razavi, Vahid Farhangmehr, Nafiseh Zendeali
Introduction: The middle cerebral artery (MCA) is one of the three major paired arteries that supply the blood to the cerebrum. In the present study, the three-dimensional (3D) blood flow in the left MCA was numerically simulated by using the medical imaging. Methods: The arterial geometry was obtained by applying the CT angiography of the MCA of a 75-year-old man. The blood flow was assumed to be laminar and unsteady. Numerical simulations were done by commercial software package COMSOL Multiphysics 5.2. In this software, the Galerkin's finite element method was applied to solve the governing equations...
2018: BioImpacts: BI
Hassan Moghtaderi, Houri Sepehri, Ladan Delphi, Farnoosh Attari
Introduction: Gallic acid (GA) and curcumin (Cur) are natural phenolic compounds that their anti-tumor effects on many types of cancers have been proved. In the current study, the effect of the combination of these agents on MDA-MB-231 breast cancer cells was investigated. Methods: Inhibition of cell proliferation (MTT assay), light microscopy, fluorescence microscopy, cell cycle analysis, nitrite detection, ROS levels, measurement of the mitochondrial membrane potential, GSH level, Annexin V assay, RT-PCR and Western blotting methods were applied...
2018: BioImpacts: BI
Sepideh Zununi Vahed, Mohammadreza Nakhjavani, Jalal Etemadi, Henghame Jamshidi, Nima Jadidian, Tala Pourlak, Sima Abediazar
Introduction: Lupus nephritis (LN) is a major cause of mortality and morbidity in the patients with lupus, a chronic autoimmune disease. The role of genetic and epigenetic factors is emphasized in the pathogenesis of LN. The aim of the present study was to evaluate the levels of immune-regulatory microRNAs (e.g., miR-31, miR-125a, miR-142-3p, miR-146a, and miR-155) in plasma samples of patients with LN. Methods: In this study, 26 patients with LN and 26 healthy individuals were included. The plasma levels of the microRNAs were evaluated by a quantitative real-time PCR...
2018: BioImpacts: BI
Hakimeh Moghaddas Sani, Maryam Hamzeh-Mivehroud, Ana P Silva, James L Walshe, S Abolghasem Mohammadi, Mahdyieh Rahbar-Shahrouziasl, Milad Abbasi, Omid Jamshidi, Jason Kk Low, Siavoush Dastmalchi, Joel P Mackay
Introduction: DOF proteins are a family of plant-specific transcription factors with a conserved zinc finger (ZF) DNA-binding domain. Although several studies have demonstrated their specific DNA binding, quantitative affinity data is not available for the binding of DOF domains to their binding sites. Methods: ZF domains of DOF2.1, DOF3.4, and DOF5.8 from Arabidopsis thaliana were expressed and purified. Their DNA binding affinities were assessed using gel retardation assays and microscale thermophoresis with two different oligonucleotide probes containing one and two copies of recognition sequence AAAG...
2018: BioImpacts: BI
Eric Tzyy Jiann Chong, Shawn Shi Erh Kuok, Ping-Chin Lee
Introduction: Obesity is commonly linked up with several life-threatening diseases. This study aims to investigate the association of fatty acid synthase ( FASN ) rs4246445, rs2229425, rs2228305, and rs2229422 single nucleotide polymorphisms (SNPs) with the risk of overweight and obesity in the Malaysian population. Methods: Blood samples were collected from 1030 individuals who were grouped into normal, overweight, and obese categories. Blood biochemistry test and lipid profiling were performed and genomic DNA was extracted...
2018: BioImpacts: BI
Azam Safary, Mostafa Akbarzadeh Khiavi, Rahimeh Mousavi, Jaleh Barar, Mohammad A Rafi
Despite many beneficial outcomes of the conventional enzyme replacement therapy (ERT), several limitations such as the high-cost of the treatment and various inadvertent side effects including the occurrence of an immunological response against the infused enzyme and development of resistance to enzymes persist. These issues may limit the desired therapeutic outcomes of a majority of the lysosomal storage diseases (LSDs). Furthermore, the biodistribution of the recombinant enzymes into the target cells within the central nervous system (CNS), bone, cartilage, cornea, and heart still remain unresolved...
2018: BioImpacts: BI
Hajie Lotfi, Roghayeh Sheervalilou, Nosratollah Zarghami
Introduction: Human immunodeficiency virus (HIV) is a debilitating challenge and concern worldwide. Accessibility to highly active antiretroviral drugs is little or none for developing countries. Production of cost-effective microbicides to prevent the infection with HIV is a requirement. Cyanovirin-N (CVN) is known as a promising cyanobacterial lectin, capable of inhibiting the HIV cell entry in a highly specific manner. Methods: This review article presents an overview of attempts conducted on different expression systems for the recombinant production of CVN...
2018: BioImpacts: BI
Fahsai Kantawong, Chanidapa Saksiriwisitkul, Chanakan Riyapa, Suchalinee Limpakdee, Phenphichar Wanachantararak, Thasaneeya Kuboki
Introduction: Induced neural stem cells (iNSCs) have the ability of differentiation into neurons, astrocytes and oligodendrocytes. iNSCs are very useful in terms of research and treatment. The present study offers an idea that biomaterials could be one of the tools that could modulate reprogramming process in the fibroblasts. Methods: Gelatin biomaterials were fabricated into 3 types, including (i) gelatin, (ii) gelatin with 1 mg/mL hydroxyapatite, and (iii) gelatin with hydroxyapatite and pig brain. NIH/3T3 fibroblasts were cultured on each type of biomaterial for 7, 9 and 14 days...
2018: BioImpacts: BI
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