journal
Journals Journal of Experimental Pharma...

Journal of Experimental Pharmacology

https://read.qxmd.com/read/38826848/ameliorative-effect-of-faidherbia-albida-against-2-4-dinitrophenylhydrazine-induced-hyperbilirubinemia-in-wistar-albino-rats
#1
JOURNAL ARTICLE
Maryam Ibrahim Tukur, Ibrahim Babangida Abubakar, Isah Musa Fakai, Jamilu Bala Danjuma, Ibrahim Malami, Aliyu Muhammad
BACKGROUND: Faidherbia albida, popularly known as gawo in Hausa, is traditionally used to treat jaundice in Zuru emirate of Kebbi State. Herein, the ameliorative effect of F. albida against 2.4-dinitrophenylhydrazine-induced hyperbilirubinemia in Wistar albino rats was investigated. METHODS: Thirty healthy rats were administered 75 mg of 2.4-dinitrophenylhydrazine to induce hyperbilirubinemia. Thereafter, groups 1-3 received 500, 750, and 1000 mg/kg body weight of the methanol stem-bark extract, and 15 mg/kg of phenobarbitone (standard drug) was administered to group 4...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38826847/in-vivo-anti-malarial-activity-of-80-methanol-leaf-extract-of-croton-dichogamus-pax-and-ehretia-cymosa-thonn-in-plasmodium-berghei-infected-mice
#2
JOURNAL ARTICLE
Desta Hashim, Shemsu Umer, Ariaya Hymete, Yalemtsehay Mekonnen
BACKGROUND: Malaria is causing high mortality and morbidity due to Plasmodium's resistance to currently available anti-malarial drugs and mosquito's resistance to insecticides. Thus, there is a critical need to search for novel anti-malarial drugs from natural sources. Therefore, this study investigated in vivo antimalarial activities of two Ethiopian medicinal plants, Croton dichogamus Pax and Ehretia cymosa Thonn, in Plasmodium berghei infected Swiss albino mice. METHODS: Soxhlet extraction method using 80% methanol as a solvent was used to prepare crude extracts of the two plants...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38745913/appetite-suppressing-activity-of-rumex-usambarensis-leaf-and-stem-aqueous-extract-in-wistar-albino-female-rats-an-in-vivo-experimental-study
#3
JOURNAL ARTICLE
Fredrick Atwiine, Albert Mwesigwa, Derick Mwesiga, Polly Mwesigwa, Lawrence Katumba, Patrick Engeu Ogwang
BACKGROUND: The burden of obesity and overweight associated morbidity and mortality is increasing in epidemic proportions worldwide. Suppression of appetite is one of the mechanisms that has been shown to reduce weight. Most of the drugs on the market currently for appetite suppression are not readily available or affordable in resource-limited settings. Additionally, previous studies have shown that most of these drugs are associated with significant adverse effects, which demonstrates a need for alternative or complementary options of drugs for appetite suppression...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38736464/the-nephroprotective-activity-of-boesenbergia-rotunda-rhizome-by-reducing-creatinine-urea-nitrogen-glutamic-pyruvic-transaminase-and-malondialdehyde-levels-in-the-blood-and-attenuating-the-expression-of-havcr1-kim-1-lcn2-ngal-casp3-and-casp7-genes-in-the-kidney
#4
JOURNAL ARTICLE
Dani Sujana, Sri Adi Sumiwi, Nyi Mekar Saptarini, Jutti Levita
BACKGROUND: Cisplatin chemotherapy induces nephrotoxicity by producing reactive oxygen species, hence, discovering add-on nephroprotective drugs for patients with cancer is challenging. Boesenbergia rotunda has been reported for its antioxidant properties. PURPOSE: This study aims to explore the nephroprotective mechanism of the ethanol extract of Boesenbergia rotunda rhizome (EEBR) in cisplatin-induced rats. METHODS: The rats were randomly assigned into 6 groups: the normal control (treated with saline); the negative control (cisplatin-induced without any treatment); the positive control (treated with quercetin 50 mg/kg BW); and 3 treatment EEBR (125 mg/kg BW; 250 mg/kg BW; 500 mg/kg BW) groups for 10 days...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38650861/evaluation-of-diuretic-activity-of-aqueous-and-hydro-methanolic-crude-extracts-and-solvent-fraction-of-the-hydromethanolic-flower-extract-of-erica-arborea-l-ericaceae-in-swiss-albino-mice
#5
JOURNAL ARTICLE
Nardos Lema Wondimu, Mestayet Geta Mengistie, Jibril Seid Yesuf
PURPOSE: To evaluate the diuretic effects of aqueous (AQ) and hydromethanolic crude extract (HM) the as well as the solvent fractions of the HM extract from Erica arborea flowers in mice. METHODS: Mice were administered AQ and HM crude extracts, along with solvent fractions of HM extracts of E. arborea flowers, including HXF (n-hexane fraction), EAF (ethyl acetate fraction), and AQF (aqueous fraction), at doses ranging from 100 to 400 mg/kg orally. The effects of these extracts and solvent fractions on urine and salt excretion over 5 hours were compared to the effects of the solvent used for reconstitution and a standard drug (furosemide 10 mg/kg), as well as to each other...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38623271/evaluation-of-the-in-vivo-laxative-effects-of-aqueous-leaf-and-stem-extracts-of-artemisia-abyssinica-in-mice-letter
#6
JOURNAL ARTICLE
Siti Hamidatul Aliyah, Rizky Yulion, Santi Perawati
No abstract text is available yet for this article.
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38596746/nephroprotective-effect-of-the-leaf-extract-of-ajuga-remota-benth-against-gentamicin-induced-nephrotoxicity-in-swiss-albino-mice
#7
JOURNAL ARTICLE
Metages Ayele Akinaw, Suresh Kumar P Nair, Rashed Edris Usure, Bati Leta, Abdo Kedir, Selam Ayele Mamo, Nuredin Chura Waritu, Mohammed Jemal, Berhane Kebede Mulat
BACKGROUND: Drug-induced kidney injury was among the most common renal damages, from which gentamicin occupies around 25% of this injury. Gentamicin-induced renal damage is caused by increased free radicals with subsequent amplified inflammation. Ajuga remota leaf extract has many phytochemicals with antioxidant activities, which may improve gentamicin-induced renal damage. Thus, we aimed to investigate the nephroprotective effect of Ajuga remota leaf methanolic extract on gentamicin-induced nephrotoxicity in Swiss Albino Mice...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38545334/evaluation-of-wound-healing-activity-of-hydromethanolic-crude-extract-and-solvent-fractions-of-the-root-of-verbascum-sinaiticum-benth-scrophulariaceae-in-swiss-albino-mice
#8
JOURNAL ARTICLE
Aziza M Essa, Kefyalew A Getahun, Zewdu Birhanu Wubneh
BACKGROUND: The roots of Verbascum sinaiticum have been used traditionally for the management of wound in different regions of Ethiopia. Despite the presence of several claims and in vitro studies regarding its role in wound healing, no scientific studies have been conducted so far. Therefore, this study aims to scientifically evaluate the wound healing activities of the crude extract and solvent fractions of the roots of Verbascum sinaiticum in Swiss albino mice. METHODS: The dried root powder of Verbascum sinaiticum was extracted using 80% methanol by maceration technique...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38528962/evaluations-of-the-in-vivo-laxative-effects-of-aqueous-leaf-and-stem-extracts-of-artemisia-abyssinica-in-mice
#9
JOURNAL ARTICLE
Akeberegn Gorems Ayele, Jeylan Sinba Kawet
BACKGROUND: People frequently complain of long-term constipation. The cost associated with using modern medications to treat constipation is significant, and the probability of encountering side effects is notably high. These limitations restrict their effectiveness in therapy, remain unresolved, and underscore the need for research on alternative therapeutic approaches. Plants of the genus Artemisia have been used to treat constipation. Therefore, the aim of this study was to evaluate the laxative effects of aqueous A...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38525051/dapagliflozin-pretreatment-prevents-cardiac-electrophysiological-changes-in-a-diet-and-streptozotocin-induction-of-type-2-diabetes-in-rats-a-potential-new-first-line
#10
JOURNAL ARTICLE
Prabhjot Kaur Juttla, Boniface Mwangi Chege, Peter Waweru Mwangi, Frederick Bukachi
PURPOSE: Dapagliflozin exerts cardioprotective effects in Type 2 Diabetes Mellitus (T2DM). However, whether these effects prevent electrocardiographic changes associated with T2DM altogether remain unknown. Our aim was to investigate the prophylactic effect of dapagliflozin pretreatment on the rat ECG using a high-fat, high-fructose (HFHf) diet and a low dose streptozotocin (STZ) model of T2DM. METHODS: Twenty-five (25) rats were randomized into five (5) groups: normal control receiving a normal diet while the other groups received an 8-week HFHf and 40mg/kg STZ on day 42, and either: saline for the diabetic control (1 mg/kg/d), low dose (1...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38504909/soyghurt-potentially-controls-the-level-of-sflt1-and-plgf-in-preeclampsia-maternal-serum-induced-placental-trophoblast-cell-in-vitro
#11
JOURNAL ARTICLE
Astrid Feinisa Khairani, Uci Ary Lantika, Julia Ramadhanti, Muhammad Hasan Bashari, Widad Aghnia Shalannandia, Tenny Putri Wikayani, Achadiyani Achadiyani, Mulyanusa Amarullah Ritonga
PURPOSE: To observe the effect of soya yoghurt (Soyghurt), which is high in flavonoid substance, on the expression of preeclampsia biomarkers (sFLT-1 and PLGF) on preeclampsia serum-induced trophoblast primary cell culture isolated from placental tissue. METHODS: The trophoblast primary culture was induced by preeclampsia serum (10%). The Soyghurt treatment was performed with 2.5%, 5%, and 7.5% Soyghurt supernatant concentrations in culture media. The expression of preeclampsia markers, sFLT-1 and PLGF, were evaluated using ELISA...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38476311/medicinal-plants-used-by-oromo-community-in-kofale-district-west-arsi-zone-oromia-regional-state-ethiopia
#12
JOURNAL ARTICLE
Geritu Bedasso Nuro, Ketema Tolossa, Mirutse Giday
PURPOSE: The purpose of this study was to record the utilization of medicinal plants by the Oromo people in the Kofale District, Oromia Regional State, Ethiopia, to control human and animal health problems. METHODS: Data regarding the use of medicinal plants were collected using ethnobotanical methods from 84 traditional medicine practitioners and 304 general informants sampled employing purposive and systematic random sampling methods, respectively, in the Kofale District...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38371428/phytochemical-investigation-and-in-vitro-antimicrobial-and-antioxidant-activities-evaluation-of-erianthemum-aethiopicum-wiens-and-polhill
#13
JOURNAL ARTICLE
Teshome Gonfa, Ayalew Temesgen, Tsegu Kiros, Sivasubramanian Muthusaravanan, Olyad Erba Urgessa, Tadele Teklu
BACKGROUND: Erianthemum aethiopicum Wiens and Polhill (Loranthaceae) is a parasitic plant native to north eastern Africa and Ethiopia. In Ethiopia, it is traditionally used to treat breast swelling, mastitis, morning illnesses and vomiting. OBJECTIVE: This study aimed to screen the main phytochemical constituents; determine the total amounts of phenolics, flavonoids, and tannins; and evaluate the antimicrobial (against Escherichia coli, Staphylococcus sciuri, Candida glaebosa and Cryptococcus albidus ) and antioxidant (against DPPH radical and ferric ion) activities of E...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38333887/pharmacological-activity-of-chemical-compounds-of-potato-peel-waste-solanum-tuberosum-l-in-vitro-a-scoping-review
#14
REVIEW
Wahyu Hidayat, Irna Sufiawati, Mieke Hemiawati Satari, Ronny Lesmana, Solachuddin Ichwan
INTRODUCTION: The potato ( Solanum tuberosum L .) is a short-lived tuber plant with a round to oval shape and varying colors, depending on the variety. It is known that only the inside of the potato is used, while the peel is generally discarded. However, recent studies have shown that potato peels contain many health-beneficial compounds. PURPOSE: This study aimed to investigate the compounds present in potato peels and their in vitro activities. METHODS: A scoping review following the PRISMA guidelines was conducted...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38317831/the-effect-of-physalis-angulata-l-administration-on-gene-expressions-related-to-lung-fibrosis-resolution-in-mice-induced-bleomycin
#15
JOURNAL ARTICLE
Ummul Khair Imaduddin, Afiat Berbudi, Enny Rohmawaty
PURPOSE: To explore the potential therapeutic effects of Physalis angulata L . (Ciplukan) extract on lung fibrosis resolution in a Bleomycin-induced mouse model, researchers conducted a comprehensive study. The study focused on key genes associated with fibrosis progression, including Nox4, Mmp8, Klf4, and FAS, and assessed their mRNA expression levels following the administration of Ciplukan extract. METHODS: A Bleomycin-induced mice model was divided into seven groups to investigate the effects of ciplukan extract on fibrosis-related gene expressions...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38312742/investigating-bioavailability-of-curcumin-and-piperine-combination-in-comparison-to-turmeric-rhizomes-an-in-vitro-study
#16
JOURNAL ARTICLE
Varalakshmi Lalithya Pratti, Muthumani Thomas, Rachana Bhoite, Vinita Satyavrat
PURPOSE: To assess the permeability of the test item (a combination of curcumin and piperine) and a reference item (dried and crushed turmeric rhizomes) using a combination of Caco-2 cell monolayer permeability assay and liquid chromatography-tandem mass spectrometry. METHODOLOGY: In the Caco-2 cell assay, a transport buffer was prepared, and stock solutions of test and reference items were made. Caco-2 cells were cultured on transwell plates. Permeability assays were conducted for 2 and 6 hours, followed by post-experiment testing for assessing the monolayer integrity...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38292834/the-effects-of-potato-solanum-tuberosum-l-vs-granola-solanaceae-peel-extract-gel-on-gingival-wound-healing-in-wistar-rats
#17
JOURNAL ARTICLE
Faradila Tiarasanti, Irna Sufiawati, Eri Amalia, Kartika Indah Sari, Cucu Zubaedah, Veni Takarini
PURPOSE: Phenolic compounds with antioxidant, antimicrobial, and anti-inflammatory properties have been identified in potatoes ( Solanum tuberosum L.; Solanaceae), which may potentially contribute to wound healing. The study aimed to evaluate the effect of potato peel extract gel Granola variety on oral gingival wound healing in Wistar Rats. METHODS: This research was a true experimental in vivo study, involving 30 male Wistar rats, aged 12-14 weeks and weighing approximately 150 to 200 grams...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38249320/viloxazine-increases-extracellular-concentrations-of-norepinephrine-dopamine-and-serotonin-in-the-rat-prefrontal-cortex-at-doses-relevant-for-the-treatment-of-attention-deficit-hyperactivity-disorder
#18
JOURNAL ARTICLE
Jennie Garcia-Olivares, Brittney Yegla, Frank P Bymaster, Jami Earnest, Jennifer Koch, Chungping Yu, Jonathan Rubin
BACKGROUND: Viloxazine ER (viloxazine extended-release capsules; Qelbree® ), a nonstimulant attention-deficit/hyperactivity disorder (ADHD) treatment, has known activity as a norepinephrine (NE) transporter (NET) inhibitor. In vitro studies have also shown direct pharmacological effects on specific serotonin (5-HT) receptors, but not on the serotonin transporter (SERT). An in vivo microdialysis study in rats showed viloxazine (50 mg/kg i.p.) increased extracellular 5-HT, NE, and dopamine (DA) in the prefrontal cortex (PFC), a key brain region in ADHD pathology...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38213945/methanol-crude-peel-extract-of-p-granatum-prevents-oxidative-damage-in-kidneys-of-rats-exposed-to-highly-active-antiretroviral-therapy
#19
JOURNAL ARTICLE
Eliah Kwizera, Kenneth Ssekatawa, Patrick Maduabuchi Aja, Conrad Ondieki Miruka, Allan Wandera, Jackie Rachael Mpumbya, Robert Siida, Dayyabu Shehu, Tijjani Shinkafi Salihu
BACKGROUND: Highly Active Antiretroviral Therapy (HAART) has been linked to oxidative damage to kidney cells leading to renal disease in people living with HIV/AIDS on HAART treatment. The toxic effects of HAART affect the patients' quality of life leading to poor adherence to their regimen. Therefore, the purpose of this study was to investigate the nephron-protective activity of methanol crude peel extract of Punica granatum (MPEPG) in HAART-administered Wistar rats. METHODS: Thirty male albino Wistar rats weighing between 180-200g were randomly divided into six groups of five rats each...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38148923/molecular-docking-study-of-phytosterols-in-lygodium-microphyllum-towards-sirt1-and-ampk-the-in-vitro-brine-shrimp-toxicity-test-and-the-phenols-and-sterols-levels-in-the-extract
#20
JOURNAL ARTICLE
Putri Anggreini, Hadi Kuncoro, Sri Adi Sumiwi, Jutti Levita
BACKGROUND: Lygodium microphyllum is a fern plant with various pharmacological activities, and phytosterols were reported contained in the n-hexane and ethyl acetate extract of this plant. Phytosterols are known to inhibit steatosis, oxidative stress, and inflammation. Sirtuin 1 (SIRT1) and adenosine monophosphate-activated protein kinase (AMPK) are the key proteins that control lipogenesis. However, information about L. microphyllum on SIRT1 and AMPK is still lacking. PURPOSE: This study aims to investigate the binding mode of phytosterols in L...
2023: Journal of Experimental Pharmacology
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