Walter J Lukiw, Theodore P A Kruck, Maire E Percy, Aileen I Pogue, Peter N Alexandrov, William J Walsh, Nathan M Sharfman, Vivian R Jaber, Yuhai Zhao, Wenhong Li, Catherine Bergeron, Frank Culicchia, Zhide Fang, Donald R C McLachlan
Aluminum is a ubiquitous neurotoxin highly enriched in our biosphere, and has been implicated in the etiology and pathology of multiple neurological diseases that involve inflammatory neural degeneration, behavioral impairment and cognitive decline. Over the last 36 years our group has analyzed the aluminum content of the temporal lobe neocortex of 511 high quality coded human brain samples from 18 diverse neurological and neurodegenerative disorders, including 2 groups of age-matched controls. Brodmann anatomical areas including the inferior, medial and superior temporal gyrus (A20-A22) were selected for analysis: (i) because of their essential functions in massive neural information processing operations including cognition and memory formation; and (ii) because subareas of these anatomical regions are unique to humans and are amongst the earliest areas affected by progressive neurodegenerative disorders such as Alzheimer's disease (AD)...
2019: Journal of Alzheimer's Disease and Parkinsonism