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JOURNAL ARTICLE
Miwa Kamatani, Nobuyasu Awano, Minoru Inomata, Naoyuki Kuse, Keita Sakamoto, Toshio Kumasaka, Takehiro Izumo
BACKGROUND: Thoracoscopy is useful for diagnosing unexplained pleural effusions. A sufficient specimen volume is often difficult to obtain using forceps biopsies (FBs) but can be obtained with pleural cryobiopsies (CBs). This study aimed to assess the utility and safety of CB during thoracoscopy in the Japanese population. METHODS: Patients who underwent thoracoscopic CBs at the Japanese Red Cross Medical Center between January 2017 and August 2023 were included in the study...
May 7, 2024: Respiratory Investigation
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JOURNAL ARTICLE
Keiichi Akasaka, Masako Amano, Tomohiko Nakamura, Tomotaka Nishizawa, Hideaki Yamakawa, Shintaro Sato, Ami Aoki, Kenjiro Shima, Hidekazu Matsushima, Toshinori Takada
BACKGROUND: Pulmonary alveolar proteinosis (PAP) is characterized by an abnormal accumulation of surfactants in the alveoli. Most cases are classified as autoimmune PAP (APAP) because they are associated with autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF). However, GM-CSF autoantibody levels are unlikely to correlate with the disease severity or prognosis of APAP. METHODS: We collected clinical records and measured 38 serum cytokine concentrations for consecutive patients with APAP...
May 4, 2024: Respiratory Investigation
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EDITORIAL
Sumito Inoue
No abstract text is available yet for this article.
May 3, 2024: Respiratory Investigation
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JOURNAL ARTICLE
Hideo Ishikawa, Yu Yamaguchi
No abstract text is available yet for this article.
May 3, 2024: Respiratory Investigation
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JOURNAL ARTICLE
Takayoshi Enokido, Yoshihisa Hiraishi, Taisuke Jo, Hirokazu Urushiyama, Akira Saito, Satoshi Noguchi, Keisuke Hosoki, Takashi Ishii, Naoya Miyashita, Kensuke Fukuda, Rei Matsuki, Chihiro Minatsuki, Takeshi Shimamoto, Hidenori Kage, Nobutake Yamamichi, Hirotaka Matsuzaki
BACKGROUND: The association between reflux esophagitis and pulmonary function remains controversial. Thus, evaluating the relationship between endoscopic reflux esophagitis and changes in pulmonary function over time in a nonsmoking population is an important clinical issue. METHODS: In this single-center retrospective cohort study, a medical examination database at Kameda Medical Center Makuhari was employed to identify nonsmokers who underwent upper gastrointestinal endoscopy and spirometry in 2010 and were followed up in 2015...
May 1, 2024: Respiratory Investigation
#6
JOURNAL ARTICLE
Lei-Lei Wu, Dong Xie
No abstract text is available yet for this article.
April 30, 2024: Respiratory Investigation
#7
JOURNAL ARTICLE
Yoshikazu Inoue, Hideya Kitamura, Masaki Okamoto, Takashi Ogura, Yasuhiko Nishioka, Masataka Kuwana, Atsushi Taniguchi, Tomohiro Ito, Klaus B Rohr, Takafumi Suda
BACKGROUND: In previous Japanese subgroup/subset analyses of the global INBUILD trial, nintedanib reduced the annual rate of forced vital capacity (FVC) decline and the risk of disease progression in patients with progressive fibrosing interstitial lung diseases (PF-ILDs). This exploratory subset analysis assessed the effect of nintedanib on symptoms and impacts of pulmonary fibrosis in Japanese patients with PF-ILDs, including those with usual interstitial pneumonia (UIP)-like fibrotic pattern on high-resolution computed tomography (HRCT)...
April 30, 2024: Respiratory Investigation
#8
JOURNAL ARTICLE
Takahiro Ando, Mirei Ka, Yuriko Sugiura, Masakatsu Tokunaga, Natsuki Nakagawa, Takahiro Iida, Yoko Matsumoto, Kousuke Watanabe, Masanori Kawakami, Masaaki Sato, Hidenori Kage
INTRODUCTION: NECTINs are transmembrane proteins mediating cell-to-cell adhesion. NECTINs interact with integrins or other membrane receptors to trigger multiple cellular functions. Aberrant NECTIN expression is associated with cancer progression and poor outcomes. While NECTIN2 is overexpressed in various cancer types, its role in lung cancer is not well understood. MATERIAL AND METHODS: We investigated the function of NECTIN2 in lung adenocarcinoma (LUAD) using the Cancer Genome Atlas (TCGA) dataset and clinical samples of 105 LUAD patients who had undergone surgical resection...
April 27, 2024: Respiratory Investigation
#9
EDITORIAL
Toru Oga
No abstract text is available yet for this article.
April 26, 2024: Respiratory Investigation
#10
JOURNAL ARTICLE
Hirofumi Kamata, Kazufumi Takamatsu, Koichi Fukunaga, Shotaro Chubachi, Kensuke Nakagawara, Ho Namkoong, Hideki Terai, Katsushi Tanaka, Susumu Sato, Eri Hagiwara, Reoto Takei, Yasuhiro Kondoh, Takahiro Takazono, Midori Hashimoto, Sadatomo Tasaka, Takashi Ohrui, Yoshinori Tanino, Masamichi Mineshita, Yuko Komase, Kazuhito Miyazaki, Masanori Nishikawa, Akira Ando, Hideo Kita, Eiki Ichihara, Shinichiro Ohshimo, Yoriyuki Murata, Masayuki Ishida, Seiichi Kobayashi, Takahiro Uchida, Hiroki Tateno, Jun Ikari, Takeshi Terashima, Yutaka Kozu, Tomoya Tateishi, Masaharu Shinkai, Hironori Sagara, Yasuo To, Yoko Ito, Masaki Yamamoto, Yoshihiro Yamamoto, Toshiyuki Kita, Yutaka Ito, Keisuke Tomii, Yukio Fujita, Yoshihiro Funaki, Kazuhiro Yatera, Mari Yamasue, Kosaku Komiya, Satoko Kozawa, Hideaki Manabe, Hironao Hozumi, Tomoya Horiguchi, Takamasa Kitajima, Yasushi Nakano, Tetsutaro Nagaoka, Masayuki Hojo, Akinori Ebihara, Masayoshi Kobayashi, Koji Takayama, Torahiko Jinta, Toyomitsu Sawai, Yuichi Fukuda, Takeshi Kaneko, Kazuo Chin, Takashi Ogura, Hiroshi Mukae, Makoto Ishii, Akihito Yokoyama
BACKGROUND: No comprehensive analysis of the pulmonary sequelae of coronavirus disease 2019 (COVID-19) in Japan based on respiratory function tests and chest computed tomography (CT) has been reported. We evaluated post-COVID-19 conditions, especially focusing on pulmonary sequelae assessed by pulmonary function tests and chest CT. METHODS: For this prospective cohort study, we enrolled 1069 patients who presented pneumonia at the time of admission in 55 hospitals from February 2020 to September 2021...
April 25, 2024: Respiratory Investigation
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JOURNAL ARTICLE
Rizwan Qaisar, Shah Hussain, Ayousha Burki, Asima Karim, Tahir Muhammad, Firdos Ahmad
BACKGROUND: Age-associated muscle decline, termed sarcopenia, is a common systemic effect of chronic obstructive pulmonary disease (COPD). Circulating Neurofilament light chain (NfL) levels reflect neuronal degradation and may be relevant to sarcopenia phenotype. However, such an association in COPD patients remains elusive. METHODS: We investigated male, 60-76 years old controls (n = 50) and COPD patients (n = 139) for plasma NfL levels in relation to sarcopenia and physical capacity markers...
April 24, 2024: Respiratory Investigation
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JOURNAL ARTICLE
Hideaki Yamakawa, Shintaro Sato, Hiroki Ohta, Kenji Kusano, Rie Kawabe, Tomohiro Oba, Chisa Uzuka, Hiroki Sasaki, Keiichi Akasaka, Masako Amano, Tamiko Takemura, Jun Araya, Hidekazu Matsushima
BACKGROUND: Nintedanib is generally safe and well tolerated and can improve prognosis in patients with various interstitial lung diseases (ILDs). Appropriate management of adverse events of nintedanib is important to ensure its long-term persistent use. Weight loss is a routinely assessed adverse event in clinical practice. This study aimed to elucidate whether body weight change in the first year of nintedanib therapy can indicate prognosis and predict tolerability in patients with ILD...
April 24, 2024: Respiratory Investigation
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JOURNAL ARTICLE
Chaiphichit Phayangkhe, Pornpimon Ek-Eudomsuk, Kitipong Soontrapa
BACKGROUND: Allergic asthma affects nearly 300 million people worldwide and causes ahigh burden of disability and death. Effective treatments rely heavily on corticosteroids, which are associated with various complications. So, the alternative treatment is of significance. Hispidulin is a bioflavonoid found in herbs that were used in traditional medicine to treat inflammatory diseases, including asthma. This study aims to investigate the efficacy of hispidulin compound in the treatment of allergic lung inflammation using the mouse model of allergic asthma...
April 23, 2024: Respiratory Investigation
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REVIEW
Xiangyang Liu, Biao Liu, Xin Luo, Zhenfang Liu, Xiaoli Tan, Ke Zhu, Fan Ouyang
PURPOSE OF REVIEW: Pulmonary arterial hypertension (PAH) is a devastating disease characterized by increased pulmonary vascular resistance and pulmonary arterial pressure. At present, the definitive pathology of PAH has not been elucidated and its effective treatment remains lacking. Despite PAHs having multiple pathogeneses, the cancer-like characteristics of cells have been considered the main reason for PAH progression. RECENT FINDINGS: p53 protein, an important tumor suppressor, regulates a multitude of gene expressions to maintain normal cellular functions and suppress the progression of malignant tumors...
April 20, 2024: Respiratory Investigation
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JOURNAL ARTICLE
Seiichi Kobayashi, Fumi Chiba, Masatsugu Ishida, Hikari Satoh, Manabu Ono, Masakazu Hanagama, Masaru Yanai
BACKGROUND: Physical activity (PA) is associated with the risk of mortality in patients with chronic obstructive pulmonary disease (COPD); however, evidence is limited to the Japanese population. This study aimed to evaluate the effects of PA on long-term mortality in Japanese patients with COPD. METHODS: We conducted a prospective observational study in a cohort of Japanese patients with COPD and assessed mortality during a 4-year follow-up period. The Cox proportional hazards model was used to evaluate the association between PA and mortality...
April 20, 2024: Respiratory Investigation
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JOURNAL ARTICLE
Hiroto Takiguchi, Kazuo Koyanagi, Soji Ozawa, Tsuyoshi Oguma, Koichiro Asano
BACKGROUD: Oesophageal cancer patients are prone to early- and late-onset pneumonia after oesophagectomy. We aimed to investigate the incidence rate and impact on the long-term prognosis of late-onset pneumonia in oesophageal cancer survivors who survived for at least one year after oesophagectomy without cancer recurrence. METHODS: We retrospectively reviewed 233 patients with thoracic oesophageal cancer who underwent oesophagectomy with gastric conduit reconstruction between September 2009 and June 2019 at a tertiary referral hospital in Japan...
April 19, 2024: Respiratory Investigation
#17
REVIEW
Kazufumi Yoshida, Yuko Morishima, Yukio Ishii, Takashi Mastuzaka, Hitoshi Shimano, Nobuyuki Hizawa
Recent advances in fatty acid analysis have highlighted the links between lipid disruption and disease development. Lipid abnormalities are well-established risk factors for many of the most common chronic illnesses, and their involvement in asthma is also becoming clear. Here, we review research demonstrating the role of abnormal lipid metabolism in asthma, with a focus on saturated fatty acids and sphingolipids. High levels of palmitic acid, the most abundant saturated fatty acid in the human body, have been found in the airways of asthmatic patients with obesity, and were shown to worsen eosinophilic airway inflammation in asthma model mice on a high-fat diet...
April 18, 2024: Respiratory Investigation
#18
JOURNAL ARTICLE
Jumpei Taniguchi, Shotaro Aso, Taisuke Jo, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
BACKGROUND: Miliary tuberculosis (TB) is a fatal disease; thus, prompt diagnosis and immediate intervention are indispensable. However, the risk factors for in-hospital mortality in patients with miliary TB remain unclear. Therefore, this study aimed to identify the factors associated with in-hospital mortality in patients with miliary TB using a Japanese nationwide inpatient database. METHODS: Patients diagnosed with miliary TB between July 2010 and March 2022 were enrolled from the Diagnosis Procedure Combination database...
April 17, 2024: Respiratory Investigation
#19
Taichi Kaneko, Akimasa Sekine, Shigeru Komatsu, Ryota Otoshi, Sanshiro Haga, Yoichi Tagami, Takeshi Kaneko, Takashi Ogura
Microsatellite instability (MSI) is a valuable biomarker for immune checkpoint inhibitors. We report the first case of MSI-high thymoma successfully treated with pembrolizumab. This patient had pleural dissemination and was treated with two cytotoxic chemotherapy regimens including carboplatin and paclitaxel combination therapy and pemetrexed, which did not have the desired effect. Because MSI status was high by using the surgical specimen, pembrolizumab was administered as 3rd line chemotherapy. After three courses, the pleural lesions dramatically shrunk, which confirmed a partial response...
April 16, 2024: Respiratory Investigation
#20
JOURNAL ARTICLE
Taichi Kaneko, Ryota Otoshi, Akimasa Sekine, Tomohisa Baba, Chieri Yamada, Sanshiro Haga, Yoichi Tagami, Tomoe Sawazumi, Tamiko Takemura, Shigeru Komatsu, Eri Hagiwara, Takashi Ogura
Amikacin liposome inhalation suspension (ALIS) is known to cause drug-related pneumonitis, which has been described as "hypersensitivity pneumonitis (HP)". However, its clinical and pathological characteristics have never been reported. We retrospectively evaluated 18 patients treated with ALIS. Three (16.7%) patients developed HP-pattern pneumonitis on high-resolution computed tomography. Serum eosinophil counts were elevated up to above 1000/μL in these three patients, which decreased with ALIS discontinuation only...
April 13, 2024: Respiratory Investigation
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