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Respiratory Investigation

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https://read.qxmd.com/read/30773474/impact-of-reduced-pulmonary-function-in-the-japanese-general-population-lessons-from-the-yamagata-takahata-study
#1
REVIEW
Yoko Shibata, Sumito Inoue, Masafumi Watanabe
Regional epidemiological studies for respiratory diseases have been rarely performed in Japan, because spirometry is not regularly conducted in the standard annual health checks. The Yamagata-Takahata Study is an epidemiological study utilizing regional characteristics based on the 21st Century Centers of Excellence (COE) Program and the Global COE Program. Spirometric examination and other specific measurements via blood sampling were performed for the study participants in annual health check-ups held in Takahata, a town in Yamagata Prefecture...
February 14, 2019: Respiratory Investigation
https://read.qxmd.com/read/30772264/low-starting-dosage-of-nintedanib-for-the-reduction-of-early-termination
#2
Satoshi Ikeda, Akimasa Sekine, Tomohisa Baba, Takuma Katano, Erina Tabata, Ryota Shintani, Hideaki Yamakawa, Takashi Niwa, Tsuneyuki Oda, Ryo Okuda, Hideya Kitamura, Takashi Ogura
No abstract text is available yet for this article.
February 13, 2019: Respiratory Investigation
https://read.qxmd.com/read/30770233/respiratory-resistance-among-adults-in-a-population-based-cohort-study-in-northern-japan
#3
Emiri Miura, Naho Tsuchiya, Yu Igarashi, Ritsuko Arakawa, Etsuhiro Nikkuni, Tokiwa Tamai, Masao Tabata, Shinya Ohkouchi, Toshiya Irokawa, Hiromasa Ogawa, Takako Takai-Igarashi, Yoichi Suzuki, Shinichi Kuriyama, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto, Hajime Kurosawa
BACKGROUND: Forced oscillation technique (FOT) is a noninvasive method used to measure respiratory system resistance (Rrs) and reactance (Xrs) during quiet breathing, which has been extensively studied in clinical settings. The distribution of measured FOT values was previously assessed in a community-based cohort study. In this study, we aimed to confirm the distribution of measured FOT values in a different cohort in order to investigate the relationship between these values and patient clinical and biological data...
February 12, 2019: Respiratory Investigation
https://read.qxmd.com/read/30770232/obesity-is-strongly-and-independently-associated-with-a-higher-prevalence-of-pulmonary-embolism
#4
Mohammad Reza Movahed, Rostam Khoubyari, Mehrnoosh Hashemzadeh, Mehrtash Hashemzadeh
BACKGROUND: Obesity is associated with many cardiovascular risk factors. This study aimed to evaluate the independent association between obesity and pulmonary embolism. METHODS: We used the International Classification of Diseases, Ninth Revision, Codes for obesity and pulmonary embolism from the Nationwide Inpatient Sample database. We randomly selected the 1992 and 2002 databases, which are 10 years apart, as the two independent population samples. We performed uni- and multivariate analyses to evaluate any association between obesity and pulmonary embolism...
February 12, 2019: Respiratory Investigation
https://read.qxmd.com/read/30760407/coexistence-of-dementia-with-smear-positive-pulmonary-tuberculosis-is-associated-with-patient-in-hospital-mortality
#5
Masafumi Saiki, Yuki Iijima, Takayuki Honda, Sayaka Mori, Toshiharu Tsutsui, Yoshinori Uchida, Yoichi Kobayashi, Yumiko Kakizaki, Hiroyuki Sakashita, Yasunari Miyazaki, Yoshihiro Miyashita
BACKGROUND: The impact of dementia on the survival of patients with pulmonary tuberculosis (TB) remains unclear. This study sought to describe the risk factors influencing in-hospital mortality in patients with pulmonary TB and comorbid dementia. METHODS: A 9-y, medical record-based retrospective study of hospitalized adult patients with newly diagnosed, smear-positive, non-multidrug-resistant pulmonary TB without human immunodeficiency virus infection was performed...
February 11, 2019: Respiratory Investigation
https://read.qxmd.com/read/30745273/management-and-utility-of-transbronchial-lung-cryobiopsy-in-japan
#6
Naoyuki Kuse, Minoru Inomata, Nobuyasu Awano, Hanako Yoshimura, Tatsunori Jo, Mari Tone, Atsuko Moriya, Yuan Bae, Toshio Kumasaka, Tamiko Takemura, Takehiro Izumo
BACKGROUND: Transbronchial lung cryobiopsy (TBLC), which is transbronchial lung biopsy performed using a cryoprobe, has emerged as a new method for obtaining lung tissue specimens for diagnosing pulmonary diseases. TBLC has been widely performed, and many reports have documented its safety and feasibility in diagnosing pulmonary diseases such as lung cancer and diffuse parenchymal lung disease. However, to date, no reports have yet been published from Japan. Therefore, the purpose of this study was to describe our experience with TBLC in daily practice in Japan and compare it with those reported in previous studies from other countries...
February 8, 2019: Respiratory Investigation
https://read.qxmd.com/read/30745177/safety-efficacy-and-pharmacokinetics-of-bedaquiline-in-japanese-patients-with-pulmonary-multidrug-resistant-tuberculosis-an-interim-analysis-of-an-open-label-phase-2-study
#7
Kazunari Tsuyuguchi, Yuka Sasaki, Satoshi Mitarai, Ken Kurosawa, Yuki Saito, Tadaishi Koh
BACKGROUND: Bedaquiline, a diarylquinoline with a novel mode of action that specifically inhibits mycobacterial adenosine 5׳-triphosphate (ATP) synthase, has been approved in over 50 countries including the USA and EU for the treatment of pulmonary multidrug-resistant tuberculosis (pMDR-TB) in adults. METHODS: This study was conducted to evaluate the safety, efficacy, and pharmacokinetics of bedaquiline in adult Japanese patients with pMDR-TB. In this study, patients received bedaquiline for 24 weeks or more (maximum 48 weeks) with an individualized background regimen (BR)...
February 7, 2019: Respiratory Investigation
https://read.qxmd.com/read/30738923/improved-cough-and-sputum-related-quality-of-life-after-initiation-of-treatment-in-pulmonary-tuberculosis
#8
Takahito Suzuki, Toshihiro Shirai, Keita Hirai, Yuko Tanaka, Hirofumi Watanabe, Yoshinari Endo, Yukiko Shimoda, Mika Saigusa, Taisuke Akamatsu, Akito Yamamoto, Satoru Morita, Kazuhiro Asada
BACKGROUND: Cough and sputum are the major symptoms of pulmonary tuberculosis (TB). However, the relationship between these symptoms and treatment for TB is not fully understood. The aim of this prospective study was to clarify the cough- and sputum-related quality of life (QOL) in patients with pulmonary TB before and after initiation of treatment. METHODS: The study included 85 patients with active pulmonary TB who were hospitalized from July 2014 to August 2015...
February 6, 2019: Respiratory Investigation
https://read.qxmd.com/read/30738922/current-status-of-diagnostic-and-therapeutic-bronchoscopy-in-japan-2016-national-survey-of-bronchoscopy
#9
Hirohisa Horinouchi, Fumihiro Asano, Kenichi Okubo, Yoshinori Okada, Yoshinobu Ohsaki, Yuko Komase, Toshinori Hashizume, Mitsutomo Kohno, Motoi Aoe
BACKGROUND: The safety management committee of the Japan Society for Respiratory Endoscopy (JSRE) conducted national surveys to clarify the state of diagnostic and therapeutic bronchoscopy in 2016. METHODS: Questionnaire forms were mailed to 532 JSRE-accredited facilities throughout Japan. We surveyed the actual condition of clinical practice and cases of bronchoscopy during 2016. RESULTS: Four hundred and thirty-three facilities responded giving a response rate of 81...
February 6, 2019: Respiratory Investigation
https://read.qxmd.com/read/30718103/radiological-patterns-of-pulmonary-involvement-may-predict-treatment-response-in-rheumatoid-arthritis-a-retrospective-study
#10
Tetsuya Hanaka, Takashi Kido, Hiroshi Ishimoto, Keishi Oda, Shingo Noguchi, Aya Nawata, Shingo Nakayamada, Noriho Sakamoto, Yoshiya Tanaka, Kazuhiro Yatera, Hiroshi Mukae
BACKGROUND: There have been no reports on the relationship between lung radiological patterns and rheumatoid arthritis (RA) disease activity or RA treatment response in patients with RA-associated lung disease (RA-LD). METHODS: Patients with RA-LD who underwent treatment for RA from April 2005 to March 2015 were retrospectively evaluated. RA-LD patients were divided into three groups based on high-resolution computed tomography (HRCT) patterns [usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), and bronchiolitis]...
February 1, 2019: Respiratory Investigation
https://read.qxmd.com/read/30692051/exacerbation-of-chronic-pulmonary-aspergillosis-was-associated-with-a-high-rebleeding-rate-after-bronchial-artery-embolization
#11
Takahiro Ando, Masahiro Kawashima, Kimihiko Masuda, Keita Takeda, Kenichi Okuda, Junko Suzuki, Nobuharu Ohshima, Mitsuko Horibe, Atsuhisa Tamura, Hideaki Nagai, Hirotoshi Matsui, Ken Ohta
BACKGROUND: Hemoptysis is a common symptom associated with chronic pulmonary aspergillosis (CPA). While surgery is the primary choice to manage hemoptysis, it is often avoided because patients with CPA are more likely to have complications such as respiratory insufficiency and low pulmonary function. Bronchial artery embolization (BAE) may be considered one of the treatments of massive and persistent hemoptysis for such patients. METHODS: We retrospectively reviewed medical records of 41 patients, admitted to National Hospital Organization Tokyo National Hospital, Tokyo, Japan with hemoptysis arising from CPA between January 2011 to December 2016, who were considered inoperable and had undergone BAE...
January 25, 2019: Respiratory Investigation
https://read.qxmd.com/read/30639082/germline-mutations-in-lung-cancer
#12
REVIEW
Takehito Shukuya, Kazuhisa Takahashi
Genetic testing for alterations in oncogenic driver genes has become essential and standard in the clinical practice of the treatment of lung cancer. Germline mutations potentially predisposing patients to lung cancer are rare; however, with the introduction of next-generation sequencing in the clinical practice of lung cancer, the identification of potentially predisposing germline abnormalities is becoming more common. In addition, liquid biopsy, which analyzes cell-free DNA in blood, increases the possibility of detecting these germline mutations...
January 10, 2019: Respiratory Investigation
https://read.qxmd.com/read/30639081/a-mini-systematic-review-of-prognostic-factors-in-elderly-patients-with-tuberculosis
#13
REVIEW
Sonoe Uchida, Kosaku Komiya, Kokoro Honjo, Kenji Umeki, Shin-Ichi Nureki, Shuichi Takikawa, Masaru Ando, Kazufumi Hiramatsu, Jun-Ichi Kadota
BACKGROUND: While advanced age has been suggested as a prognostic factor in patients with tuberculosis, the characteristics associated with a poor outcome in elderly patients have remained unclear. The aim of this systematic review was to describe the risk factors for a poor outcome in elderly patients with tuberculosis. METHODS: We identified 1255 studies published between 1919 and 2017 from the PubMed database by using combinations of the keywords "tuberculosis [Title/Abstract]" and "elderly [Title/Abstract]"...
January 10, 2019: Respiratory Investigation
https://read.qxmd.com/read/30630751/dna-repair-as-an-emerging-target-for-copd-lung-cancer-overlap
#14
REVIEW
Catherine R Sears
Cigarette smoking is the leading cause of lung cancer and chronic obstructive pulmonary disease (COPD). Many of the detrimental effects of cigarette smoke have been attributed to the development of DNA damage, either directly from chemicals contained in cigarette smoke or as a product of cigarette smoke-induced inflammation and oxidative stress. In this review, we discuss the environmental, epidemiological, and physiological links between COPD and lung cancer and the likely role of DNA damage and repair in COPD and lung cancer development...
January 7, 2019: Respiratory Investigation
https://read.qxmd.com/read/30612948/combination-of-assist-use-of-short-acting-beta-2-agonists-inhalation-and-guidance-based-on-patient-specific-restrictions-in-daily-behavior-impact-on-physical-activity-of-japanese-patients-with-chronic-obstructive-pulmonary-disease
#15
Tsunahiko Hirano, Kazuto Matsunaga, Kazuki Hamada, Sho Uehara, Ryo Suetake, Yoshikazu Yamaji, Keiji Oishi, Maki Asami, Nobutaka Edakuni, Hiromasa Ogawa, Masakazu Ichinose
BACKGROUND: Assist use of inhaled short-acting beta 2 agonists (SABAs) is reportedly effective for preventing shortness of breath on exertion in chronic obstructive pulmonary disease (COPD) patients. However, it is unclear what strategy would be useful for improving physical activity in such patients. The aim is to investigate the effects of assisted use of SABA (procaterol) on physical activity in Japanese COPD patients targeting patient-specific restrictions in daily behavior. METHODS: Fourteen patients with stable COPD (age: 72...
January 3, 2019: Respiratory Investigation
https://read.qxmd.com/read/30600175/lung-transplant-candidates-with-idiopathic-pulmonary-fibrosis-and-long-term-pirfenidone-therapy-treatment-feasibility-influences-waitlist-survival
#16
Shin Tanaka, Kentaroh Miyoshi, Hisao Higo, Takeshi Kurosaki, Shinji Otani, Seiichiro Sugimoto, Masaomi Yamane, Katsuyuki Kiura, Shinichi Toyooka, Takahiro Oto
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronically progressive lung disease with exceptionally poor prognosis. While lung transplantation (LTx) is considered the last-resort therapeutic option, dismal waitlist mortality still hampers the salvage of patients with IPF. Pirfenidone, originally designed for IPF treatment, has increasingly been utilized. This study aimed to evaluate whether Pirfenidone could influence outcomes of patients with IPF on the Japanese LTx waitlist...
December 29, 2018: Respiratory Investigation
https://read.qxmd.com/read/30600174/leukotrienes-one-step-in-our-understanding-of-asthma
#17
REVIEW
Pierre Sirois
The steps leading to the discovery of leukotrienes and the researchers that played a major part in this long process are presented. The pharmacology of these exquisitely potent compounds shows that they express bronchoconstrictor activity and numerous cellular effects via very specific receptors. Experimental evidence strongly suggests that these mediators play a significant role in asthma physiopathology. Numerous approaches were taken to block their effects on the lungs and this led to the discovery of selected drugs used for asthma treatment...
December 29, 2018: Respiratory Investigation
https://read.qxmd.com/read/30598398/development-of-lung-cancer-in-patients-with-nontuberculous-mycobacterial-lung-disease
#18
Tatsuya Kusumoto, Takanori Asakura, Shoji Suzuki, Satoshi Okamori, Ho Namkoong, Hiroshi Fujiwara, Kazuma Yagi, Hirofumi Kamata, Makoto Ishii, Tomoko Betsuyaku, Naoki Hasegawa
BACKGROUND: As lung cancer development in patients with nontuberculous mycobacterial lung disease (NTM-LD) has never been reported, we investigated its incidence and clinical characteristics. METHODS: Prospective observational cohort registry (from June 2012 to June 2017), and retrospective identification by the International Classification of Diseases, tenth revision (between March 2010 and March 2018), were used to identify NTM-LD patients aged ≥20 years who developed lung cancer...
December 28, 2018: Respiratory Investigation
https://read.qxmd.com/read/30553784/elevated-serum-periostin-level-in-patients-with-chronic-cough-and-airway-hyperresponsiveness
#19
Yuta Kono, Masako To, Ryuta Tsuzuki, Kosuke Haruki, Yasuo To
No abstract text is available yet for this article.
December 12, 2018: Respiratory Investigation
https://read.qxmd.com/read/30552073/smaller-erector-spinae-muscle-size-is-associated-with-inability-to-recover-activities-of-daily-living-after-pneumonia-treatment
#20
Yukihiro Minegishi, Sumito Inoue, Kento Sato, Koya Abe, Hiroaki Murano, Kodai Furuyama, Sujeong Yang, Hiroyoshi Machida, Hiroshi Nakano, Masamichi Sato, Takako Nemoto, Chisa Sato, Michiko Nishiwaki, Tomomi Kimura, Keiko Yamauchi, Akira Igarashi, Yoshikane Tokairin, Yoko Shibata, Masafumi Watanabe
BACKGROUND: Elderly patients who are hospitalized due to pneumonia experience deterioration of their activities of daily living (ADL) during this period; in some cases, this loss of ADL is not recovered at the end of antibiotic treatment. In this study, we examined whether erector spinae muscle cross-sectional area (ESMCSA) measured by computed tomography (CT) could predict a low level of ADL at the end of antibiotic treatment for pneumonia. METHODS: Eighty patients (mean age 74...
December 11, 2018: Respiratory Investigation
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