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Natural Products and Bioprospecting

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https://read.qxmd.com/read/30652264/anti-oral-microbial-flavanes-from-broussonetia-papyrifera-under-the-guidance-of-bioassay
#1
Chang-An Geng, Meng-Hong Yan, Xue-Mei Zhang, Ji-Jun Chen
A new flavane, bropapyriferol (1), and eleven known ones were isolated from the EtOAc part of Broussonetia papyrifera under the guidance of bioassay. The structure of compound 1 was determined by extensive 1D and 2D NMR, [α]D spectroscopic data and quantum computation. Daphnegiravan F (2) and 5,7,3',4'-tetrahydroxy-3-methoxy-8,5'-diprenylflavone (3) showed significantly anti-oral microbial activity against five Gram-positive strains and three Gram-negative strains in vitro. Especially, compound 3 was more potent in suppressing Actinomyces naeslundii and Porphyromonas gingivalis (MIC = 1...
January 16, 2019: Natural Products and Bioprospecting
https://read.qxmd.com/read/30607860/isolation-structural-assignment-of-isoselagintamarlin-a-from-selaginella-tamariscina-and-its-biomimetic-synthesis
#2
Qin-Feng Zhu, Li-Dong Shao, Xing-De Wu, Jiang-Xin Liu, Qin-Shi Zhao
Isoselagintamarlin A (1), a selaginellin analogue featured a rare benzofuran unit, was isolated from Selaginella tamariscina. Its complete structural assignment was established through a combination of high-field NMR technique and biomimetic synthesis. Notably, isoselagintamarlin A (1) was successfully synthesized via sequential oxidations and intramolecular cyclization.
January 3, 2019: Natural Products and Bioprospecting
https://read.qxmd.com/read/30582134/correction-to-structurally-diverse-polymethylated-phloroglucinol-meroterpenoids-from-baeckea-frutescens
#3
Yin-E Zhi, Xu-Jie Qin, Hui Liu, Yuan Zeng, Wei Ni, Li He, Zu-Ding Wang, Hai-Yang Liu
In the original publication, two errors have occurred. The corrected texts are provided below.
December 24, 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/30511136/brevipedicelones-d-and-e-two-c-o-c-flavonoid-dimmers-from-the-leaves-of-garcinia-brevipedicellata-and-anti-onchocercal-activity
#4
Mirabel Akongwi, Anastasie E Tih, Kennedy D Nyongbela, Moses Samje, Raphael T Ghogomu, Bernard Bodo
A novel isoflavone-chromone flavonoid C-O-C dimmer, brevipedicelone D (1), along with one new C-O-C biflavonoid derivative, brevipedicelone E (2), were isolated from the ethyl acetate extract of the leaves of Garcinia brevipedicellata, a medicinal plant used in folk medicine in parts of Cameroon. Their structures were elucidated by extensive spectroscopic techniques, including 1D- and 2D- NMR, MS experiments, as well as comparing their spectral data with those of known analogues. Anti-onchocercal screening of 1 showed moderate inhibition of adult worm motility of Onchocerca ochengi by 60% at the highest concentration (20 µg/mL) and inhibited motility of both the juvenile worms of O...
December 3, 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/30488317/synthesis-urease-inhibition-and-molecular-modelling-studies-of-novel-derivatives-of-the-naturally-occurring-%C3%AE-amyrenone
#5
Jean J K Bankeu, Hira Sattar, Yannick S F Fongang, Syeda W Muhammadi, Conrad V Simoben, Fidele Ntie-Kang, Guy R T Feuya, Marthe A T Tchuenmogne, Mehreen Lateef, Bruno N Lenta, Muhammad S Ali, Augustin S Ngouela
Urease enzyme (UE) has been reported to be a potent virulence factor for Helicobacter pylori (HP) bacteria indicated to be responsible for various gastrointestinal diseases. Therefore, the spread of HP, currently regarded by the World Health Organization as a class 1 carcinogen, could be better controlled by targeting UE. It is in this line that we have synthesized three new derivatives (2-4) of the naturally occurring olean-12-en-3-one (1), which was previously isolated from the figs of Ficus vallis-choudae Delile (Moraceae)...
November 28, 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/30484065/medicinal-and-aromatic-plants-used-in-traditional-treatment-of-the-oral-pathology-the-ethnobotanical-survey-in-the-economic-capital-casablanca-morocco-north-africa
#6
Sophia Zougagh, Ayoub Belghiti, Tarik Rochd, Ilham Zerdani, Jamal Mouslim
In order to identify the medicinal and aromatic plants most requested for the treatment of the most common oral pathology, an ethnobotanical survey was carried out in the economic capital Casablanca, Morocco. The data basis was obtained draw selected traditional herbalists based on the semi-structured questionnaire. Quantitative indices such as use value (UV), family UV (FUV), fidelity level and informant consensus factor (ICF) were intended to evaluate the importance of plant species. A total of 46 plants species belonging to 22 families that were used...
November 27, 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/30387083/codonopsis-tangshen-oliv-amelioration-effect-on-diabetic-kidney-disease-rats-induced-by-high-fat-diet-feeding-combined-with-streptozotocin
#7
Xian-Yuan Lu, Feng-Hua Zhou, Ya-Qian Dong, Lin-Na Gong, Qing-Yun Li, Lan Tang, Zheng Cai, Jing-Yu He, Meng-Hua Liu
Diabetic kidney disease (DKD) is the most serious microvascular complication during the development of diabetes with the characterizations of glomerular basement membrane thickening, mesangial expansion, and glomerular sclerosis, eventually leading to end-stage renal disease. This study aimed to investigate the melioration effect of Codonopisis tangshen Oliv. (COD) on the DKD model, which was established by unilateral nephrectomy (UN)-high fat diet feeding (HFD) combined with streptozotocin (STZ). After the DKD rats were oral treated with COD at a dose of 2...
December 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/30374905/structurally-diverse-polymethylated-phloroglucinol-meroterpenoids-from-baeckea-frutescens
#8
Yin-E Zhi, Xu-Jie Qi, Hui Liu, Yuan Zeng, Wei Ni, Li He, Zu-Ding Wang, Hai-Yang Liu
Phytochemical investigation of the MeOH extract of twigs and leaves of Baeckea frutescens led to the isolation of seven new polymethylated phloroglucinol meroterpenoids (PPMs), named baeckfrutones M-S (1-7). Their structures and absolute configurations were determined by spectroscopic analyses, chiral-phase HPLC analysis, and electronic circular dichroism (ECD) calculations. PPM 1 is a novel meroterpenoid possessing a 6/6/5/3 tetracyclic skeleton in PPMs, whereas 3 and 4 are the first hydroxytasmanone type phloroglucinol-monoterpene hybrids...
December 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/30151716/progress-on-the-chemical-constituents-derived-from-glucosinolates-in-maca-lepidium-meyenii
#9
REVIEW
Yan-Jie Huang, Xing-Rong Peng, Ming-Hua Qiu
Maca (Lepidium meyenii Walp.), a famous food supplement, has drawn an unprecedented international interest over the last two decades. It was assumed that glucosinolates, macamides, macaenes, and alkaloids are the main bioactive components of Maca before. Recently, a series of novel thiohydantoins which generally exhibit a variety of activities have been isolated from Maca. This review focuses on the progress on the main bioactive components of Maca and their biosynthetic pathway, which indicates that macamides, thiohydantoins, and some alkaloids may originate from glucosinolates...
December 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/30128843/new-dammarane-triterpenoids-caffruones-a-d-from-the-cherries-of-coffea-arabica
#10
Xia Wang, Xing-Rong Peng, Jing Lu, Gui-Lin Hu, Ming-Hua Qiu
In present study, four new dammarane-type triterpenoids, namely caffruones A-D (1-4), were isolated from the cherries of Coffea arabica. Their structures were elucidated by extensive spectroscopic analysis including 1D, 2D NMR (HSQC, HMBC, 1 H-1 H COSY, and ROESY), HRMS and IR spectra. This is the first time that tetracyclic triterpenes have been reported in genus Coffea.
December 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/30073582/amides-isoquinoline-alkaloids-and-dipeptides-from-the-aerial-parts-of-piper-mullesua
#11
Meng-Yuan Xia, Jun Yang, Pan-Hua Zhang, Xiao-Nian Li, Ji-Feng Luo, Chun-Lin Long, Yue-Hu Wang
One undescribed amide, pipermullesine A, two undescribed isoquinoline alkaloids, pipermullesines B and C, and six undescribed dipeptides, pipermullamides A-F, along with 28 known compounds, were isolated from the aerial parts of Piper mullesua. The structures of the undescribed compounds were elucidated based on the analysis of 1D and 2D NMR and MS data. Furthermore, the structures of pipermullesines A-C were confirmed by single crystal X-ray diffraction analysis. All isolates were evaluated for inhibitory activity against platelet aggregation induced by thrombin (IIa) or platelet-activating factor (PAF)...
December 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/30430388/lc-esi-it-ms-ms-and-maldi-tof-approach-identification-of-natural-polymers-from-rhizophora-mangle-barks-and-determination-of-their-analgesic-and-anti-inflammatory-properties
#12
Leonardo Mendes de Souza Mesquita, Caroline Fabri Bittencourt Rodrigues, Cláudia Quintino da Rocha, Mayara Silveira Bianchim, Clenilson Martins Rodrigues, Vanda Maria de Oliveira, Henrique Hessel Gaeta, Mariana Novo Belchor, Marcos Hikari Toyama, Wagner Vilegas
We recognize the chemical composition of the acetonic extract of Rhizophora mangle barks (AERM) using mass spectrometry analysis [liquid chromatography (LC)-ESI-IT-MS/MS and matrix-assisted laser desorption/ionization-time of flight-MS (MALDI-TOF)]. Analgesic activity was evaluated by formalin and tail-flick experimental assays. Anti-inflammatory activity was performed by paw edema test induced by carrageenan and 48/80 compounds. The first series of experiments involved [LC]-FIA-IT-MS/MS with 11 separated catechins derivatives until degree of polymerization 3 (DP3)...
November 14, 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/30387082/a-fluorescent-glucose-transport-assay-for-screening-sglt2-inhibitors-in-endogenous-sglt2-expressing-hk-2-cells
#13
Yan-Ting Lu, Xiu-Li Ma, Yu-Hui Xu, Jing Hu, Fang Wang, Wan-Ying Qin, Wen-Yong Xiong
The sodium-dependent glucose transporters 2 (SGLT2) plays important role in renal reabsorption of urinal glucose back to plasma for maintaining glucose homeostasis. The approval of SGLT2 inhibitors for treatment of type 2 diabetes highlights the SGLT2 as a feasible and promising drug target in recent years. Current methods for screening SGLT2 inhibitors are complex, expensive and labor intensive. Particularly, these methods cannot directly measure nonradioactive glucose uptake in endogenous SGLT2-expressing kidney cells...
November 1, 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/30374904/caraway-as-important-medicinal-plants-in-management-of-diseases
#14
REVIEW
Mohaddese Mahboubi
Carum carvi or caraway is traditionally used for treatment of indigestion, pneumonia, and as appetizer, galactagogue, and carminative. Essential oil, fixed oil and many other valuable extractive compounds with industrial applications are prepared from caraway. This review article has new deep research on caraway as medicinal plant. For preparing the manuscript, the information was extracted from accessible international databases (Google scholar, PubMed, Science direct, Springer, and Wiley), electronic resources and traditional books by key word of caraway or Carum carvi...
October 29, 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/30069678/fruits-as-prospective-reserves-of-bioactive-compounds-a-review
#15
REVIEW
Marines Marli Gniech Karasawa, Chakravarthi Mohan
Bioactive natural products have always played a significant role as novel therapeutical agents irrespective of their source of origin. They have a profound effect on human health by both direct and indirect means and also possess immense medicinal properties. Fruit species are largely appreciated and highly consumed throughout the world. Epidemiologic information supports the association between high intake of fruits and low risk of chronic diseases. There are several biological reasons why the consumption of fruits might reduce or prevent chronic diseases...
October 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/29855857/-%C3%A2-zanthonitidine-a-a-pair-of-enantiomeric-furoquinoline-alkaloids-from-zanthoxylum-nitidum-with-antibacterial-activity
#16
Li-Na Zhao, Xi-Xi Guo, Shuai Liu, Li Feng, Qi-Rui Bi, Zhe Wang, Ning-Hua Tan
A pair of new enantiomeric furoquinoline alkaloids, (±)-zanthonitidine A (1), together with nine known ones (2-10) were isolated from the radix of Zanthoxylum nitidum. Their chemical structures were elucidated based on the extensive spectroscopic analysis. The racemic mixture of 1 was separated by chiral column chromatography, and the absolute configurations of (+)-1 and (-)-1 were determined by the comparison of experimental and calculated electronic circular dichroism spectra. Antibacterial activities of compounds 1-9 were evaluated, and compounds (+)-1, (-)-1, 3, 7 and 8 showed antibacterial activities against Bacillus subtilis, Enterococcus faecalis or Staphylococcus aureus...
October 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/29802619/antitumor-triterpenoid-saponin-from-the-fruits-of-avicennia-marina
#17
Xiong-Wu Yang, Zhi Dai, Bei Wang, Ya-Ping Liu, Xu-Dong Zhao, Xiao-Dong Luo
The fruits of Avicennia marina are widely used for both medicine and food in Guangxi of China. As a part of our continuous effort to search for bioactive molecules from the plant, the fruits of A. marina were investigated, which has led to one new triterpenoid saponin (1) and 29 known compounds been isolated and their structures were established by using spectroscopic methods and comparing with literature data. The new triterpenoid saponin showed cytotoxicity against GSC-3# and GSC-18# with the IC50 values were 12...
October 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/29790088/three-new-heptelidic-acid-derivatives-from-the-culture-of-mushroom-lentinellus-ursinus
#18
Li Liu, Jun-Jie Han, Tian-Shun Xu, Rui-Xing Liu, Li Bao, Hong-Wei Liu
Three new heptelidic acid derivatives (1-3) including two new dimeric esters and two known heptelidic acid analogues (4 and 5) were isolated from the solid culture of mushroom Lentinellus ursinus. The structures of new compounds were confirmed by the analysis of NMR and HRESIMS spectroscopic data. The biosynthetic origin of compounds 1-5 was postulated. Compounds 1-5 exhibited no antibacterial activity against Staphylococcus aureus and Escherichia coli at the dose of 100 μM.
October 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/30032475/an-explorer-of-chemical-biology-of-plant-natural-products-in-southwest-china-xiaojiang-hao
#19
REVIEW
Yue-Mao Shen, Duo-Zhi Chen
Xiaojiang Hao, who obtained Master Degree from Kunming Institute of Botany (KIB), Chinese Academy of Sciences (CAS) in 1985, and Doctor in Pharmacy degree in Pharmacy from Institute for Chemical Research, Kyoto University, in 1990, was born in Chongqing in July, 1951. In 1991, he returned to KIB, CAS, as an Associate professor and served as the chair of the Department of Phytochemistry. In 1994, he was promoted to a full professor at the current institute. He served as the Deputy Director of KIB and the Director of Open Laboratory of Phytochemistry from 1995 to 1997, and the Director of KIB from 1997 to 2005...
August 2018: Natural Products and Bioprospecting
https://read.qxmd.com/read/30027529/harvest-after-50-years-of-sowing
#20
REVIEW
Pema-Tenzin Puno
No abstract text is available yet for this article.
August 2018: Natural Products and Bioprospecting
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