Use the journals feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#41
JOURNAL ARTICLE
Marius-Ionuţ Iuraşcu, Zsuzsanna Balla, Catarina Pereira, Noémi Andrási, Lilian Varga, Dorottya Csuka, Ágnes Szilágyi, Kornelia Tripolszki, Suliman Khan, Iuliana Susnea, Peter Bauer, Claudia Cozma, Henriette Farkas
BACKGROUND: Hereditary angioedema (HAE) with C1-inhibitor deficiency (C1-INH-HAE) is a rare disease caused by low level (type I) or dysfunction (type II) of the C1-inhibitor protein with subsequent reduction of certain complement protein levels. METHODS: To develop and test the reliability of a two-tier method based on C1-INH and C4 quantitation followed by genetic analysis from dried blood spot (DBS) for establishing the diagnosis of C1-INH-HAE. C1-INH and C4 proteins have been quantified in human plasma using a classical immuno-assay and in DBS using a newly developed proteolytic liquid chromatography-mass spectrometry method...
November 2023: Clinical and Translational Allergy
#42
LETTER
Fleur A C Jansen, Klaske van Norren, Joseph L Baumert, Annegeet van den Bos, Joannes F M Jacobs, Stef J Koppelman
No abstract text is available yet for this article.
November 2023: Clinical and Translational Allergy
#43
JOURNAL ARTICLE
Idun Holmdahl, Sandip Chakraborty, Angela Hoyer, Anastasia Filiou, Anna Asarnoj, Anders Sjölander, Magnus P Borres, Marianne van Hage, Gunilla Hedlin, Jon R Konradsen, Cilla Söderhäll
BACKGROUND: Preschool wheeze is a risk factor for asthma development. However, the molecular mechanism behind a wheezing episode is not well understood. OBJECTIVE: Our aims were to assess the association of plasma proteins with acute preschool wheeze and to study the proteins with differential expression at the acute phase at revisit after 3 months. Additionally, to investigate the relationship between protein expression and clinical parameters. METHOD: We measured 92 inflammatory proteins in plasma and clinical parameters from 145 children during an episode of preschool wheeze (PW) and at the revisit after 3 months (PW-R, n = 113/145) and 101 healthy controls (HC) aged 6-48 months in the GEWAC cohort using the antibody-mediated proximity extension-based assay (Olink Proteomics, Uppsala)...
November 2023: Clinical and Translational Allergy
#44
JOURNAL ARTICLE
Pekka Hurme, Reetta Sahla, Beate Rückert, Tero Vahlberg, Riitta Turunen, Tytti Vuorinen, Mübeccel Akdis, Maria Söderlund-Venermo, Cezmi Akdis, Tuomas Jartti
BACKGROUND: Rhinovirus (RV)-induced first wheezing episodes in children are associated with a markedly increased risk of asthma. Previous studies have suggested that human bocavirus 1 (HBoV1) may modify RV-induced immune responses in young children. We investigated cytokine profiles of sole RV- and dual RV-HBoV1-induced first wheezing episodes, and their association with severity and prognosis. METHODS: Fifty-two children infected with only RV and nine children infected with dual RV-HBoV1, aged 3-23 months, with severe first wheezing episodes were recruited...
November 2023: Clinical and Translational Allergy
#45
JOURNAL ARTICLE
Freerk Prenzel, Susanne Abraham, Christoph Hirche, Gerrit Müller, Stephan Kaiser, Leonarda Serdani-Neuhaus, Rebecca Zingel, Inmaculada Martinez-Saguer
BACKGROUND: Hereditary angioedema (HAE) is a potentially life-threatening inherited disease that causes recurrent, serious, and debilitating episodes of swelling. While evidence has improved in adult patients, data on the epidemiology and treatment of pediatric patients with HAE remain very limited. The aim of this study was to determine the incidence and prevalence of pediatric patients with HAE aged <12 years, as well as treatment patterns, co-medication, and specialties involved...
November 2023: Clinical and Translational Allergy
#46
LETTER
Bernard N Jukema, Thomas C Pelgrim, Sylvan L J E Janssen, Thijs M H Eijsvogels, Alma Mingels, Wim Vroemen, Nienke Vrisekoop, Leo Koenderman
No abstract text is available yet for this article.
November 2023: Clinical and Translational Allergy
#47
JOURNAL ARTICLE
Oliver Pfaar, Angelika Sager, Ralph Mösges, Margitta Worm
BACKGROUND: Subcutaneous allergen immunotherapy (SCIT) with depigmented, polymerized (DPP) birch pollen extract has been marketed at doses of up to 1000 DPP units/mL since 2001. We sought to determine the dose-dependent efficacy of a DPP birch pollen extract formulation in patients suffering from birch-pollen-induced allergic rhinitis or rhinoconjunctivitis with or without intermittent asthma. METHODS: A titrated conjunctival provocation test (CPT) was applied as a surrogate marker...
November 2023: Clinical and Translational Allergy
#48
JOURNAL ARTICLE
Nanike Esterhuizen, Dilys M Berman, Frank H Neumann, Linus Ajikah, Lynne J Quick, Erin Hilmer, Andri Van Aardt, Juanette John, Rebecca Garland, Trevor Hill, Jemma Finch, Werner Hoek, Marion Bamford, Riaz Y Seedat, Ahmed I Manjra, Jonny Peter
BACKGROUND: Pollen monitoring has been discontinuously undertaken in South Africa, a country with high biodiversity, a seasonal rainfall gradient, and nine biomes from arid to subtropical. The South African Pollen Monitoring Network was set up in 2019 to conduct the first long-term national aerospora monitoring across multiple biomes, providing weekly reports to allergy sufferers and healthcare providers. METHODS: Daily airborne pollen concentrations were measured from August 2019 to August 2021 in seven cities across South Africa...
November 2023: Clinical and Translational Allergy
#49
JOURNAL ARTICLE
Marine Savouré, Jean Bousquet, Bénédicte Leynaert, Céline Ribet, Marcel Goldberg, Marie Zins, Bénédicte Jacquemin, Rachel Nadif
BACKGROUND: Few population-based studies have described allergic rhinitis (AR) according to the Allergic Rhinitis and its Impact on Asthma (ARIA) classification, and none have assessed the impact of asthma on this classification. Our aims were to 1) describe AR according to four ARIA classes and 2) within each of the four ARIA classes, compare participants with AR alone versus those with AR and asthma. METHODS: Cross-sectional analyses were performed using data from the 2014 annual follow-up questionnaire of the French adult population-based cohort Constances...
November 2023: Clinical and Translational Allergy
#50
JOURNAL ARTICLE
Michael A Portelli, Sangita Bhaker, Vincent Pang, David O Bates, Simon R Johnson, Andrew P Mazar, Dominick Shaw, Christopher Brightling, Ian Sayers
BACKGROUND: Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown. OBJECTIVES: To determine (i) the expression profile of uPAR in cultured human bronchial epithelial cells (HBEC) from asthma patients, (ii) the relationship between uPAR and the epithelial barrier, including blocking uPAR functions and (iii) the function of different uPAR isoforms...
October 2023: Clinical and Translational Allergy
#51
REVIEW
Anna Szylling, Filip Raciborski, Oksana Wojas, Konrad Furmańczyk, Edyta Krzych-Fałta, Jean Bousquet, Boleslaw Samoliński
BACKGROUND: Allergic diseases-rhinitis and asthma-are the most common chronic conditions affecting adults. Traditional approaches to allergy diagnosis and treatment do not meet the health needs of all patients. Treatment adherence remains a challenge for physicians. The ubiquity of Internet access paired with limited in-person contact with medical personnel in the course of the COVID-19 pandemic demonstrated the potential of mHealth in communicating health information. BODY: The abundance of new applications dedicated to various medical specialties encourages reflection on the informed use of such tools...
October 2023: Clinical and Translational Allergy
#52
JOURNAL ARTICLE
Jan Hubert, Susanne Vrtala, Bruno Sopko, Scot E Dowd, Qixin He, Pavel B Klimov, Karel Harant, Pavel Talacko, Tomas Erban
BACKGROUND: The domestic mite Blomia tropicalis is a major source of allergens in tropical and subtropical regions. Despite its great medical importance, the allergome of this mite has not been sufficiently studied. Only 14 allergen groups have been identified in B. tropicalis thus far, even though early radioimmunoelectrophoresis techniques (27 uncharacterized allergen complexes) and comparative data based on 40 allergen groups officially recognized by the World Health Organization (WHO)/IUIS in domestic astigmatid mites suggest the presence of a large set of additional allergens...
October 2023: Clinical and Translational Allergy
#53
JOURNAL ARTICLE
Adel H Mansur, Julie Marsh, Ali Bahron, Maximillian Thomas, Gareth Walters, John Busby, Liam G Heaney, Mamidipudi Thirumala Krishna
BACKGROUND: House dust mite (HDM) is the most common sensitising allergen in asthma. Ethnic minority groups (EMGs) in the UK are more likely to live in deprived conditionings with a greater exposure to HDM and other aero-allergens. AIM: To compare the ethnicity-based patterns of sensitisation to aero-allergens and the impact of ethnicity on clinical outcomes in patients with difficult-to-treat asthma (DTA). METHODS: Data of patients with DTA were extracted from the registry of the Birmingham Regional Severe Asthma Service (BRSAS), which have a catchment population of 7...
October 2023: Clinical and Translational Allergy
#54
JOURNAL ARTICLE
Karoline Krause, Hanna Bonnekoh, Jannis Jelden-Thurm, Riccardo Asero, Ana Maria Gimenez-Arnau, José C Cardoso, Clive Grattan, Emek Kocatürk, Undine Lippert, Marcus Maurer, Martin Metz, Petra Staubach, Margarida Goncalo, Pavel Kolkhir
BACKGROUND: Urticarial vasculitis (UV) should be differentiated from chronic spontaneous urticaria (CSU) in patients initially presenting with recurrent wheals, although criteria for differential diagnosis remain ill-defined. OBJECTIVES: To set the goals, define criteria and unmet needs in UV diagnosis and differential diagnosis with CSU, and explore the possibility of coexistence of both diseases. METHODS: Thirteen experts experienced in UV research participated in a Delphi survey of European Academy of Allergy and Clinical Immunology taskforce...
October 2023: Clinical and Translational Allergy
#55
JOURNAL ARTICLE
Rebecca Czolk, Maria Ruiz-Castell, Oliver Hunewald, Naphisabet Wanniang, Gwenaëlle Le Coroller, Christiane Hilger, Michel Vaillant, Guy Fagherazzi, Françoise Morel-Codreanu, Markus Ollert, Annette Kuehn
BACKGROUND: Even though the prevalence of allergies is increasing, population-based data are still scarce. As a read-out for chronic inflammatory information, new methods are needed to integrate individual biological measurements and lifestyle parameters to mitigate the consequences and costs of allergic burden for society. METHODS: More than 480.000 data points were collected from 1462 Luxembourg adults during the representative, cross-sectional European Health Examination Survey, spanning health and lifestyle reports...
September 2023: Clinical and Translational Allergy
#56
JOURNAL ARTICLE
Lauré M Fijen, Carolina Vera, Thomas Buttgereit, Hanna Bonnekoh, Marcus Maurer, Markus Magerl, Karsten Weller
BACKGROUND: The Angioedema Control Test (AECT) is a patient-reported outcome measure developed and validated for the assessment of disease control in patients with recurrent angioedema. Its sensitivity to change and minimal clinically important difference (MCID) have hitherto not been established. METHODS: Patients with recurrent angioedema due to chronic spontaneous urticaria, hereditary angioedema, or acquired C1-inhibitor deficiency were repeatedly asked to complete the AECT along with the Angioedema Quality of Life Questionnaire (AE-QoL), Dermatology Life Quality Index (DLQI), and anchors for disease control and whether treatment was sufficient during routine care visits...
September 2023: Clinical and Translational Allergy
#57
LETTER
Andy Ka Chun Kan, Valerie Chiang, Wai Ki Ip, Elaine Y L Au, Philip H Li
No abstract text is available yet for this article.
September 2023: Clinical and Translational Allergy
#58
REVIEW
Markus Magerl, Anna Sala-Cunill, Christina Weber-Chrysochoou, Susanne Trainotti, Ilaria Mormile, Giuseppe Spadaro
Hereditary angioedema (HAE) is a rare autosomal dominant disease, with patients often suffering with associated symptoms for many years before receiving a correct diagnosis. The symptoms greatly impact a patient's quality of life (QoL) and include excruciating abdominal pain and angioedema of the skin and submucosa. Angioedema of the larynx represents a significant mortality risk in undiagnosed patients, and a large proportion of patients with HAE receive incorrect diagnoses and undergo unnecessary surgery...
September 2023: Clinical and Translational Allergy
#59
JOURNAL ARTICLE
Danny M Cohn, Emel Aygören-Pürsün, Jonathan A Bernstein, Henriette Farkas, William R Lumry, Marcus Maurer, Andrea Zanichelli, Matthew Iverson, James Hao, Michael D Smith, Christopher M Yea, Paul K Audhya, Marc A Riedl
BACKGROUND: Hereditary angioedema (HAE) with C1-inhibitor deficiency (HAE-C1-INH) is characterized by recurrent, debilitating episodes of swelling. Sebetralstat, an investigational oral plasma kallikrein inhibitor, demonstrated promising efficacy for on-demand treatment of HAE-C1-INH in a phase 2 trial. We describe the multipronged approach informing the design of KONFIDENT, a phase 3 randomized, placebo-controlled, three-way crossover trial evaluating the efficacy and safety of sebetralstat in patients aged ≥12 years with HAE-C1-INH...
September 2023: Clinical and Translational Allergy
#60
REVIEW
Torsten Zuberbier, Amir Abdul Latiff, Xenofon Aggelidis, Matthias Augustin, Radu-Gheorghe Balan, Christine Bangert, Lisa Beck, Thomas Bieber, Jonathan A Bernstein, Marta Bertolin Colilla, Alejandro Berardi, Anna Bedbrook, Carsten Bindslev-Jensen, Jean Bousquet, Marjolein de Bruin-Weller, Dayanne Bruscky, Betul Buyuktiryaki, Giorgio Walter Canonica, Carla Castro, Natia Chanturidze, Herberto Jose Chong-Neto, Chia-Yu Chu, Leena Chularojanamontri, Michael Cork, Roberta F J Criado, Laia Curto Barredo, Adnan Custovic, Ulf Darsow, Arben Emurlai, Ana de Pablo, Stefano Del Giacco, Giampiero Girolomoni, Tanja Deleva Jovanova, Mette Deleuran, Nikolaos Douladiris, Bruno Duarte, Ruta Dubakiene, Esben Eller, Batya Engel-Yeger, Luis Felipe Ensina, Nelson Rosario Filho, Carsten Flohr, Daria Fomina, Wojciech Francuzik, Maria Laura Galimberti, Ana M Giménez-Arnau, Kiran Godse, Charlotte Gotthard Mortz, Maia Gotua, Michihiro Hide, Wolfram Hoetzenecker, Nicolas Hunzelmann, Alan Irvine, Carolyn Jack, Ioanna Kanavarou, Norito Katoh, Tamar Kinaciyan, Emek Kocatürk, Kanokvalai Kulthanan, Hilde Lapeere, Susanne Lau, Mariana Machado Forti Nastri, Michael Makris, Eli Mansour, Alexander Marsland, Mara Morelo Rocha Felix, Ana Paula Moschione Castro, Eustachio Nettis, J F Nicolas, Audrey Nosbaum, Mikaela Odemyr, Niki Papapostolou, Claudio A S Parisi, Sushil Paudel, Jonny Peter, Prakash Pokharel, Luis Puig, Tamara Quint, German Dario Ramon, Frederico Regateiro, Giampaolo Ricci, Cristine Rosario, Cansin Sackesen, Peter Schmid-Grendelmeier, Esther Serra-Baldrich, Kristina Siemens, Cathrine Smith, Petra Staubach, Katarina Stevanovic, Özlem Su-Kücük, Gordon Sussman, Simona Tavecchio, Natasa Teovska Mitrevska, Diamant Thaci, Elias Toubi, Claudia Traidl-Hoffmann, Regina Treudler, Zahava Vadasz, Ingrid van Hofman, Maria Teresa Ventura, Zhao Wang, Thomas Werfel, Andreas Wollenberg, Ariana Yang, Yik Weng Yew, Zuotao Zhao, Ricardo Zwiener, Margitta Worm
INTRODUCTION: The integrated care pathways for atopic dermatitis (AD-ICPs) aim to bridge the gap between existing AD treatment evidence-based guidelines and expert opinion based on daily practice by offering a structured multidisciplinary plan for patient management of AD. ICPs have the potential to enhance guideline recommendations by combining interventions and aspects from different guidelines, integrating quality assurance, and describing co-ordination of care. Most importantly, patients can enter the ICPs at any level depending on AD severity, resources available in their country, and economic factors such as differences in insurance reimbursement systems...
September 2023: Clinical and Translational Allergy
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
