journal
https://read.qxmd.com/read/38779783/utility-of-silver-birch-and-house-dust-mite-extracts-derived-from-licensed-sublingual-tablets-for-nasal-allergen-challenge
#1
JOURNAL ARTICLE
Bianca Olivieri, Ana Jimenez Gil, Kostadin Stoenchev, Stephen R Durham, Guy Scadding
BACKGROUND: Nasal allergen challenge (NAC) is used to investigate the effects of allergen exposure and assess treatment efficacy in allergic rhinitis (AR). This study aims to establish dose-responses to NAC using licensed silver birch (SB) pollen and house dust mite (HDM) sublingual tablets as sources of the allergen extracts in participants with AR. METHODS: Sixteen volunteers with HDM-induced perennial AR and 15 volunteers with SB pollen-induced seasonal rhinitis underwent a graded up-dosing NAC with extracts derived from HDM allergen (Acarizax®) and SB (Itulazax®) tablets, respectively...
May 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38730525/proteomic-analysis-reveals-potential-therapeutic-targets-for-childhood-asthma-through-mendelian-randomization
#2
JOURNAL ARTICLE
Yi-Qing Wu, Yi-Xin Cai, Xiao-Li Chen, Shang-Qin Chen, Xiu-Feng Huang, Zhen-Lang Lin
BACKGROUND: Asthma is the most common chronic disease among children and poses a significant threat to their health. This study aims to assess the relationship between various plasma proteins and childhood asthma, thereby identifying potential therapeutic targets. METHODS: Based on publicly available genome-wide association study summary statistics, we employed a two-sample Mendelian randomization (MR) approach to elucidate the causal relationship between plasma proteins and asthma...
May 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38687096/gut-lung-axis-and-asthma-a-historical-review-on-mechanism-and-future-perspective
#3
REVIEW
Xiu-Ling Song, Juan Liang, Shao-Zhu Lin, Yu-Wei Xie, Chuang-Hong Ke, Dang Ao, Jun Lu, Xue-Mei Chen, Ying-Zhi He, Xiao-Hua Liu, Wen Li
BACKGROUND: Gut microbiota are closely related to the development and regulation of the host immune system by regulating the maturation of immune cells and the resistance to pathogens, which affects the host immunity. Early use of antibiotics disrupts the homeostasis of gut microbiota and increases the risk of asthma. Gut microbiota actively interact with the host immune system via the gut-lung axis, a bidirectional communication pathway between the gut and lung. The manipulation of gut microbiota through probiotics, helminth therapy, and fecal microbiota transplantation (FMT) to combat asthma has become a hot research topic...
May 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38676659/proof-of-concept-study-of-anti-fel-d-1-igy-antibodies-in-cat-food-using-the-mask-air-%C3%A2-app
#4
JOURNAL ARTICLE
Jean Bousquet, Alina Gherasim, Frédéric de Blay, Eve Mathieu-Dupas, Géraldine Batot, Daniel Laune, Bernardo Sousa-Pinto, Torsten Zuberbier, Nhân Pham-Thi
BACKGROUND: An innovation to better manage cat-allergic patients utilises anti-Fel d 1 IgY antibodies to neutralise Fel d 1 after its production by the cat. However, there is no published study showing its clinical efficacy in humans in a home setting. A longitudinal, open-label, proof-of-concept study was carried out to approach clinical efficacy of the cat food in cat-allergic patients. METHODS: After a baseline evaluation, the cats ate only the cat food for the following 4 months...
May 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38658181/comorbidities-of-chronic-rhinosinusitis-in-children-and-adults
#5
JOURNAL ARTICLE
Aada Murtomäki, Alma Helevä, Paulus Torkki, Jari Haukka, Anna Julkunen-Iivari, Riikka Lemmetyinen, Mika Mäkelä, Aarno Dietz, Mikko Nuutinen, Sanna Toppila-Salmi
BACKGROUND: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nose and paranasal sinuses lasting ≥12 weeks. CRS may exist with (CRSwNP) or without (CRSsNP) nasal polyps. The aim was to evaluate conditions associated with CRS in a randomized hospital cohort. We hypothesized that comorbidities and surgical procedures differ between pediatric and adult patients. METHODS: This study consisted of hospital registry data of a random sample of rhinosinusitis patients (age range 0-89 years) with the diagnosis of J32 or J33, correspondingly, registered during outpatient visits from 2005 to 2019 (n = 1461)...
April 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38613160/consumption-of-cow-s-milk-formula-in-the-nursery-and-the-development-of-milk-allergy
#6
JOURNAL ARTICLE
Arnon Elizur, Shirel Rachel-Jossefi, Marianna Rachmiel, Eli Eisenberg, Yitzhak Katz
BACKGROUND: The effect of the amount of transient cow's milk formula (CMF) consumed during the first days of life on IgE-cow's milk allergy (IgE-CMA) is unknown. METHODS: A cohort of 58 patients with IgE-CMA was identified from a large scale population-based study of 13,019 infants followed from birth. A group of 116 infants matched for sex and breastfeeding only duration (beyond the nursery period), and another random group of 259 healthy infants were used as controls...
April 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38613147/dilemmas-of-nomenclature-web-search-analysis-reveals-european-preferences-in-atopic-skin-diseases
#7
LETTER
Hannah Wecker, Stefanie Ziehfreund, Sebastian Sitaru, Emma K Johansson, Jesper Elberling, Anaïs Doll, Electra Nicolaidou, Emanuele Scala, Michael J Boffa, Lea Schmidt, Mariusz Sikora, Tiago Torres, Pavel V Chernyshov, Alexander Zink
No abstract text is available yet for this article.
April 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38578246/correction-to-hla-a-24-02-increase-the-risk-of-allopurinol-induced-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-in-hla-b-58-01-carriers-in-korean-population-a-multicenter-cross-sectional-case-control-study
#8
https://read.qxmd.com/read/38573314/identification-of-potential-drug-targets-for-allergic-diseases-from-a-genetic-perspective-a-mendelian-randomization-study
#9
JOURNAL ARTICLE
Hui Wang, Jianyu Pang, Yuguan Zhou, Qi Qi, Yuheng Tang, Samina Gul, Miaomiao Sheng, Juhua Dan, Wenru Tang
BACKGROUND: Allergic diseases typically refer to a heterogeneous group of conditions primarily caused by the activation of mast cells or eosinophils, including atopic dermatitis (AD), allergic rhinitis (AR), and asthma. Asthma, AR, and AD collectively affect approximately one-fifth of the global population, imposing a significant economic burden on society. Despite the availability of drugs to treat allergic diseases, they have been shown to be insufficient in controlling relapses and halting disease progression...
April 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38558358/real-world-drug-use-in-asthma-chronic-obstructive-pulmonary-disease-rhinitis-cough-and-cold-in-finland-from-1990-to-2021-association-with-reduced-disease-burden
#10
EDITORIAL
Tiina Mattila, Vesa Jormanainen, Marina Erhola, Tuula Vasankari, Sanna Toppila-Salmi, Fredrik Herse, Riikka-Leena Leskelä, Tari Haahtela
No abstract text is available yet for this article.
April 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38554237/regional-sex-and-age-inequities-in-asthma-hospital-admissions-in-spain-and-portugal
#11
LETTER
Rafael José Vieira, Ana Margarida Pereira, Luís Taborda-Barata, Frederico S Regateiro, Manuel Marques-Cruz, Carlos Robalo Cordeiro, Cláudia Chaves Loureiro, Ignacio J Dávila, Jean Bousquet, João A Fonseca, Bernardo Sousa-Pinto
BACKGROUND: Asthma presents a significant health challenge, imposing a considerable burden on healthcare services. Discrepancies in asthma-related hospitalisations may reflect underlying health disparities. We aimed to analyse inequities in asthma hospital admissions in mainland Portugal and Spain, from a regional perspective and considering sex and age. METHODS: We conducted a retrospective study using data from the Spanish and Portuguese national hospitalisations databases...
April 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38526449/ethnic-differences-in-depression-and-anxiety-among-adults-with-atopic-eczema-population-based-matched-cohort-studies-within-uk-primary-care
#12
JOURNAL ARTICLE
Elizabeth I Adesanya, Alasdair Henderson, Joseph F Hayes, Alexandra Lewin, Rohini Mathur, Amy Mulick, Caroline Morton, Catherine Smith, Sinéad M Langan, Kathryn E Mansfield
BACKGROUND: Evidence demonstrates that individuals with atopic eczema (eczema) have increased depression and anxiety; however, the role of ethnicity in these associations is poorly understood. We aimed to investigate whether associations between eczema and depression or anxiety differed between adults from white and minority ethnic groups in the UK. METHODS: We used UK Clinical Practice Research Datalink GOLD to conduct matched cohort studies of adults (≥18 years) with ethnicity recorded in primary care electronic health records (April 2006-January 2020)...
March 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38497844/a-survey-study-on-antibiotic-prescription-practices-for-acute-asthma-exacerbations-an-european-academy-of-allergy-and-clinical-immunology-task-force-report
#13
JOURNAL ARTICLE
Anne-Lotte Redel, Wojciech Feleszko, Alessandra Arcolaci, Francesca Cefaloni, Marina Atanaskovic-Markovic, Gert-Jan Braunstahl, Cristina Boccabella, Matteo Bonini, Aspasia Karavelia, Eefje Louwers, Norbert Mülleneisen, Liam O'Mahony, Laura Pini, Anna Rapiejko, Esmeralda Shehu, Milena Sokolowska, Eva Untersmayr, Gerdien Tramper-Stranders
INTRODUCTION: Guidelines recommend treating asthma exacerbations (AAEs) with bronchodilators combined with inhaled and/or systemic corticosteroids. Indications for antibiotic prescriptions for AAEs are usually not incorporated although the literature shows antibiotics are frequently prescribed. AIM: To investigate the antibiotic prescription rates in AAEs and explore the possible determining factors of those practices. METHODS: A digital survey was created to determine the antibiotic prescription rates in AAEs and the influencing factors for the prescription practices...
March 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38488856/early-exposure-to-maternal-stress-and-risk-for-atopic-dermatitis-in-children-a-systematic-review-and-meta-analysis
#14
REVIEW
Yuan Ai, Jichong Huang, Ting Ting Zhu
BACKGROUND: The incidence of atopic dermatitis (AD) in children is increasing. Early exposure to stress factors may be associated with the AD development. This study aimed to summarize studies that reported an association between stress exposure and AD development in later life. METHODS AND FINDINGS: A comprehensive literature search was performed using online databases (PubMed, EMBASE, PsycINFO, and Web of Science) for articles published up to May 1, 2023. Eligible studies were screened and selected based on the inclusion criteria...
March 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38462526/delayed-neutrophil-shedding-of-cd62l-in-patients-with-chronic-rhinosinusitis-with-nasal-polyps-and-asthma-implications-for-staphylococcus-aureus-colonization-and-corticosteroid-treatment
#15
LETTER
Maryam Jafari, Eduardo I Cardenas, Sandra Ekstedt, Julia Arebro, Marianne Petro, Agnetha Karlsson, Eric Hjalmarsson, Daniel Arnarson, Monika Ezerskyte, Susanna Kumlien Georén, Lars Olaf Cardell
No abstract text is available yet for this article.
March 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38423800/non-pharmacological-interventions-for-asthma-prevention-and-management-across-the-life-course-umbrella-review
#16
REVIEW
Xunliang Tong, Xinyue Zhang, Mengyuan Wang, Zijun Wang, Fawu Dong, Enying Gong, Torsten Zuberbier, Yanming Li
BACKGROUND: The impact of non-pharmacological interventions (NPIs) on asthma prevention and management is insufficiently examined. We aim to comprehensively evaluate and synthesize existing evidence regarding the effectiveness of various NPIs throughout the life course. METHODS: We conducted a systematic search and screening of reviews that examined the effectiveness of various NPIs on asthma prevention and control in the Cochrane Library, PubMed, Embase, and Ovid databases...
March 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38415974/monitoring-recurrent-angioedema-findings-from-the-turkish-angioedema-control-test-validation-study
#17
JOURNAL ARTICLE
Semra Demir, Deniz Eyice-Karabacak, Emek Kocatürk, Derya Ünal, İlkim Deniz Toprak, Pelin Korkmaz, Ayşe Feyza Aslan, Işıl Göğem İmren, Bahar Dikicier, Nevzat Kahveci, Nida Öztop, Rabia Öztaş Kara, Halim İşsever, Marcus Maurer, Karsten Weller, Aslı Gelincik
BACKGROUND: Determination of control level in recurrent angioedema (RAE) is necessary to guide management. Here, we validated a Turkish version of the angioedema control test (AECT) for 4-week (AECT-4wk) and for 3-month (AECT-3mth) and assessed their utility in monitoring RAE. METHOD: The recommended structured translation process for patient-reported outcome measures was completed. The final versions were administered to 51 patients with mast cell-mediated angioedema (MMAE) and 38 patients with hereditary angioedema, and the minimal clinically important difference (MCID) was determined...
March 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38353300/a-global-perspective-on-stepping-down-chronic-spontaneous-urticaria-treatment-results-of-the-urticaria-centers-of-reference-and-excellence-sdown-csu-study
#18
JOURNAL ARTICLE
Murat Türk, Emek Kocatürk, Ragıp Ertaş, Luis Felipe Ensina, Silvia Mariel Ferrucci, Clive Grattan, Christian Vestergaard, Torsten Zuberbier, Marcus Maurer, Ana Maria Giménez-Arnau
BACKGROUND: Although there have been significant advances in the treatment of chronic spontaneous urticaria (CSU) in recent years, there remains a lack of clear guidance on when and how to step down treatment in responders. This study aims to investigate stepping down approaches of different steps of CSU treatment from a global perspective. METHODS: "Stepping down chronic spontaneous urticaria treatment" (SDown-CSU) is an international, multicenter, observational, cross-sectional, survey-based study of the Urticaria Centers of Reference and Excellence (UCARE) network...
February 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38343066/the-long-term-efficacy-of-intra-cervical-lymphatic-immunotherapy-on-adults-with-allergic-rhinitis-a-randomized-controlled-study
#19
JOURNAL ARTICLE
Yang Qin, Weijun Huang, Rui Zheng, Qixing Wang, Qingqing Yu, Yin Li, Kai Wang, Jun Tang
BACKGROUND: The efficacy and safety of the novel immunotherapy method, intra-cervical lymphatic immunotherapy (ICLIT), need to be investigated. Comparing it with subcutaneous immunotherapy (SCIT), we clarified the long-term efficacy and safety of intra-cervical lymphatic immunotherapy on allergic rhinitis (AR), and investigated the improvement of clinical efficacy of the booster injection at 1 year after ICLIT treatment. METHODS: Ninety adult patients with dust mite allergy were randomly divided into 3 groups: 30 in the SCIT group, 30 in the ILCLIT group, and 30 in ICLIT booster group...
February 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38342758/a-cross-talk-between-microbial-metabolites-and-host-immunity-its-relevance-for-allergic-diseases
#20
REVIEW
Purevsuren Losol, Magdalena Wolska, Tomasz P Wypych, Lu Yao, Liam O'Mahony, Milena Sokolowska
BACKGROUND: Allergic diseases, including respiratory and food allergies, as well as allergic skin conditions have surged in prevalence in recent decades. In allergic diseases, the gut microbiome is dysbiotic, with reduced diversity of beneficial bacteria and increased abundance of potential pathogens. Research findings suggest that the microbiome, which is highly influenced by environmental and dietary factors, plays a central role in the development, progression, and severity of allergic diseases...
February 2024: Clinical and Translational Allergy
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