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Clinical and Translational Allergy

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https://read.qxmd.com/read/30858968/two-grass-pollen-tablets-commercially-available-for-allergy-immunotherapy-display-different-ige-epitope-repertoires
#1
Thierry Batard, Amparo Sanjuan, Laure Denis, Hélène Nguyen, Armelle Montagut, Joaquín Sastre, Sabina Rak, Jean F Cuiné
Background: The distribution of Pooideae species varies across Europe. Especially, Timothy is less represented in Southern than in Northern Europe. Since allergenic cross-reactivity between pollens from different grasses is only partial, grass pollen-allergic patients are expected to display different sensitization profiles, with specific IgE directed against different combinations of allergenic epitopes, depending on their living places in Europe and the grasses they are exposed to. In this context, this study aimed at comparing two tablets commercially available for allergy immunotherapy, namely a 5-grass (Cocksfoot, Meadow-grass, Rye-grass, Sweet vernal-grass and Timothy) and a 1-grass (Timothy) pollen tablets, for their ability to represent the sensitization profiles of patients, depending on whether they live in Southern or Northern Europe...
2019: Clinical and Translational Allergy
https://read.qxmd.com/read/30834110/characterization-of-a-subgroup-of-non-type-2-asthma-with-cow-s-milk-hypersensitivity-in-young-subjects
#2
N Tsolakis, L Nordvall, C Janson, N Rydell, A Malinovschi, K Alving
Background: Asthma with atopy is often characterized by type 2 inflammation but less progress has been made in defining non-type 2 asthma. We have previously identified a subgroup of young non-atopic asthmatics with perceived food hypersensitivity and poor asthma control. Objective: Our aim was to further characterize this subgroup of non-type 2 asthmatics, including the use of a broad panel of inflammation-related proteins. Methods: Sex- and age-matched subjects (10-35 years old) were divided into three groups with regard to history of asthma and atopy: non-atopic asthmatics with perceived cow's milk hypersensitivity but with IgE antibodies < 0...
2019: Clinical and Translational Allergy
https://read.qxmd.com/read/30828418/evaluation-of-basophil-activation-caused-by-transgenic-rice-seeds-expressing-whole-t-cell-epitopes-of-the-major-japanese-cedar-pollen-allergens
#3
Shinya Takaishi, Saburo Saito, Minori Kamada, Nobuyoshi Otori, Hiromi Kojima, Kenjiro Ozawa, Fumio Takaiwa
Background: Japanese cedar (JC) pollinosis is a serious type I allergic disease in Japan. Although subcutaneous immunotherapy and sublingual immunotherapy have been applied to treat JC pollinosis, high doses of allergens may cause IgE-mediated allergic reactions. The transgenic rice seeds that contain genetically modified Cry j 1 and Cry j 2, the two major allergens of JC pollen, have been developed as candidates for oral immunotherapy. Although the antigens in the transgenic rice seeds (Tg-rice seeds) were engineered such that they decrease binding ability with IgE and they are of insufficient length to cross-link IgE on the surface of mast cells or basophils, the safety of Tg-rice seeds for patients with JC pollinosis was unclear...
2019: Clinical and Translational Allergy
https://read.qxmd.com/read/30820315/sensitivity-and-specificity-of-standardised-allergen-extracts-in-skin-prick-test-for-diagnoses-of-ige-mediated-respiratory-allergies
#4
Nicola Wagner, Michael Rudert
Background: Skin prick tests (SPTs) are essential for the diagnosis of IgE-mediated allergy and are influenced by extract quality, biological potency and concentration of allergen. Methods: In this open multicentre study 431 patients, aged 18-64 years were enrolled. Patients had a history of IgE-mediated allergy and a sensitisation (previous positive SPT of any manufacturer) against at least one of the investigated allergens: 6-grass pollen, house dust mite, birch and mugwort pollen...
2019: Clinical and Translational Allergy
https://read.qxmd.com/read/30809376/identification-of-the-recently-described-plasminogen-gene-mutation-p-lys330glu-in-a-family-from-northern-germany-with-hereditary-angioedema
#5
Andreas Recke, Elisabeth G Massalme, Uta Jappe, Lars Steinmüller-Magin, Julia Schmidt, Yorck Hellenbroich, Irina Hüning, Gabriele Gillessen-Kaesbach, Detlef Zillikens, Karin Hartmann
Hereditary angioedema (HAE) is a life-threatening disease characterized by recurrent episodes of subcutaneous and mucosal swellings and abdominal cramping. Corticosteroids and antihistamines, which are usually beneficial in histamine-induced acquired angioedema, are not effective in HAE. Therefore, diagnosing HAE correctly is crucial for affected patients. We report a family from Northern Germany with six individuals suffering from recurrent swellings, indicating HAE. Laboratory tests and genetic diagnostics of the genes SERPING1 , encoding C1 esterase inhibitor (C1-INH), and F12, encoding coagulation factor XII, were unremarkable...
2019: Clinical and Translational Allergy
https://read.qxmd.com/read/30792849/dissociating-polysensitization-and-multimorbidity-in-children-and-adults-from-a-polish-general-population-cohort
#6
Filip Raciborski, Jean Bousqet, Andrzej Namysłowski, Edyta Krzych-Fałta, Aneta Tomaszewska, Barbara Piekarska, Piotr Samel-Kowalik, Artur Z Białoszewski, Artur Walkiewicz, Agnieszka Lipiec, Oksana Wojas, Krzysztof Samoliński, Anna Szylling, Wojciech Zieliński, Adam Sybilski, Aleksandra Grąbczewska, Bolesław Samoliński
Background: Links between multimorbidity of allergic diseases and allergen sensitization are still under debate, especially in adults. This study aimed to establish a relationship between polysensitization and allergic multimorbidity in children and adults and the allergens involved in multimorbidity. Material and method: A cross-sectional multicentre study enrolled children aged 6-7 and 13-14 years and adults aged 20-44 years from a Polish national cohort. The diagnosis of allergic diseases was made by a physician...
2019: Clinical and Translational Allergy
https://read.qxmd.com/read/30774928/health-related-quality-of-life-worsens-by-school-age-amongst-children-with-food-allergy
#7
Victoria Thörnqvist, Roelinde Middelveld, Hay Mar Wai, Natalia Ballardini, Evalill Nilsson, Jennie Strömquist, Staffan Ahlstedt, Lennart Jan Nilsson, Jennifer L P Protudjer
Background: Food allergy is negatively associated with health-related quality of life (HRQL). Although differences exist between parents and children, less is known about age-specific differences amongst children. As such, we aimed to identify if age, as well as other factors, are associated with food allergy-specific HRQL in an objectively defined population of children. Methods: Overall, 63 children (boys: n = 36; 57.1%) with specialist-diagnosed food allergy to 1 + foods were included...
2019: Clinical and Translational Allergy
https://read.qxmd.com/read/30740211/stepwise-approach-towards-adoption-of-allergen-immunotherapy-for-allergic-rhinitis-and-asthma-patients-in-daily-practice-in-belgium-a-belsaci-abeforcal-euforea-statement
#8
REVIEW
P W Hellings, B Pugin, G Mariën, C Bachert, C Breynaert, D M Bullens, J L Ceuppens, G Clement, T Cox, D Ebo, P Gevaert, S Halewyck, V Hox, K Ladha, R Jacobs, P Rombaux, R Schrijvers, K Speleman, X Van der Brempt, L Van Gerven, O Vanderveken, B Verhaeghe, K Vierstraete, S Vlaminck, J-B Watelet, J Bousquet, S F Seys
Allergic rhinitis (AR) affects 23-30% of the European population with equal prevalence reported in Belgium. Despite guidelines on the correct use of effective treatment, up to 40% of AR patients remain uncontrolled. Allergen immunotherapy (AIT) has been shown to improve the level of control up to 84% of patients being controlled by AIT. Recently, new guidelines for AIT have been published, supporting the clinical evidence for effectiveness of various subcutaneous and sublingual products for AIT in patients who are allergic to airborne allergens...
2019: Clinical and Translational Allergy
https://read.qxmd.com/read/30728947/the-antimicrobial-protein-s100a12-identified-as-a-potential-autoantigen-in-a-subgroup-of-atopic-dermatitis-patients
#9
Maria Mikus, Catharina Johansson, Nathalie Acevedo, Peter Nilsson, Annika Scheynius
Background: Atopic dermatitis (AD) is a complex heterogeneous chronic inflammatory skin disease. Specific IgE antibodies against autoantigens have been observed in a subgroup of AD patients, however, little is known about IgG-auto-reactivity in AD. To investigate the presence of autoreactive IgG antibodies, we performed autoantibody profiling of IgG in patients with AD of different severities and in healthy controls (HC). Methods: First, we performed an untargeted screening in plasma samples from 40 severe AD (sAD) patients and 40 HC towards 1152 protein fragments on planar antigen microarrays...
2019: Clinical and Translational Allergy
https://read.qxmd.com/read/30705747/vilnius-declaration-on-chronic-respiratory-diseases-multisectoral-care-pathways-embedding-guided-self-management-mhealth-and-air-pollution-in-chronic-respiratory-diseases
#10
REVIEW
A Valiulis, J Bousquet, A Veryga, U Suprun, D Sergeenko, S Cebotari, D Borelli, S Pietikainen, J Banys, I Agache, N E Billo, A Bush, I Chkhaidze, L Dubey, W J Fokkens, J Grigg, T Haahtela, K Julge, O Katilov, N Khaltaev, M Odemyr, S Palkonen, R Savli, A Utkus, V Vilc, T Alasevicius, A Bedbrook, M Bewick, J Chorostowska-Wynimko, E Danila, A Hadjipanayis, R Karseladze, V Kvedariene, E Lesinskas, L Münter, B Samolinski, S Sargsyan, B Sitkauskiene, D Somekh, L Vaideliene, A Valiulis, P W Hellings
Background: Over 1 billion people suffer from chronic respiratory diseases such as asthma, COPD, rhinitis and rhinosinusitis. They cause an enormous burden and are considered as major non-communicable diseases. Many patients are still uncontrolled and the cost of inaction is unacceptable. A meeting was held in Vilnius, Lithuania (March 23, 2018) under the patronage of the Ministry of Health and several scientific societies to propose multisectoral care pathways embedding guided self-management, mHealth and air pollution in selected chronic respiratory diseases (rhinitis, chronic rhinosinusitis, asthma and COPD)...
2019: Clinical and Translational Allergy
https://read.qxmd.com/read/30697418/the-roadmap-for-the-allergology-specialty-and-allergy-care-in-europe-and-adjacent-countries-an-eaaci-position-paper
#11
REVIEW
N Fyhrquist, T Werfel, M B Bilò, N Mülleneisen, R Gerth van Wijk
The high prevalence of allergic diseases warrants for sufficient health care provisions available to patients with allergic diseases. Allergy care should be delivered by well-trained specialists. However, the current status of allergy care is not well documented. For this reason a survey among European and a few non-European countries was launched by the National Allergy Society Committee from the European Academy of Allergy and Clinical Immunology and the Union Européenne des Médecins Spécialistes section and board of Allergology...
2019: Clinical and Translational Allergy
https://read.qxmd.com/read/30651972/a-specific-synbiotic-containing-amino-acid-based-formula-in-dietary-management-of-cow-s-milk-allergy-a-randomized-controlled-trial
#12
Adam T Fox, Harm Wopereis, Marleen T J Van Ampting, Manon M Oude Nijhuis, Assad M Butt, Diego G Peroni, Yvan Vandenplas, David C A Candy, Neil Shah, Christina E West, Johan Garssen, Lucien F Harthoorn, Jan Knol, Louise J Michaelis
Background: Here we report follow-up data from a double-blind, randomized, controlled multicenter trial, which investigated fecal microbiota changes with a new amino acid-based formula (AAF) including synbiotics in infants with non-immunoglobulin E (IgE)-mediated cow's milk allergy (CMA). Methods: Subjects were randomized to receive test product (AAF including fructo-oligosaccharides and Bifidobacterium breve M-16V) or control product (AAF) for 8 weeks, after which infants could continue study product until 26 weeks...
2019: Clinical and Translational Allergy
https://read.qxmd.com/read/30647901/genetic-associations-of-the-response-to-inhaled-corticosteroids-in-asthma-a-systematic-review
#13
REVIEW
Ozlem Keskin, Niloufar Farzan, Esra Birben, Hayriye Akel, Cagatay Karaaslan, Anke H Maitland-van der Zee, Michael E Wechsler, Susanne J Vijverberg, Omer Kalayci
There is wide variability in the response to inhaled corticosteroids (ICS) in asthma. While some of this heterogeneity of response is due to adherence and environmental causes, genetic variation also influences response to treatment and genetic markers may help guide treatment. Over the past years, researchers have investigated the relationship between a large number of genetic variations and response to ICS by performing pharmacogenomic studies. In this systematic review we will provide a summary of recent pharmacogenomic studies on ICS and discuss the latest insight into the potential functional role of identified genetic variants...
2019: Clinical and Translational Allergy
https://read.qxmd.com/read/30555680/dual-exposure-to-smoking-and-household-air-pollution-is-associated-with-an-increased-risk-of-severe-asthma-in-adults-in-brazil
#14
Andréia Guedes Oliva Fernandes, Carolina de Souza-Machado, Gabriela Pimentel Pinheiro, Sergio Telles de Oliva, Raquel Cristina Lins Mota, Valmar Bião de Lima, Constança Sampaio Cruz, José Miguel Chatkin, Álvaro A Cruz
Background: The relationship between smoking, household pollution, dual exposure and severity of asthma in adults has not been sufficiently studied. We examined and compared the effects of cigarette smoking, domestic wood burning pollution and dual exposure (tobacco and wood burning) upon asthma severity in adults. Methods: This was a cross-sectional study performed with 452 individuals with mild to moderate asthma and 544 patients with severe asthma (previously untreated)...
2018: Clinical and Translational Allergy
https://read.qxmd.com/read/30534360/relationship-between-vitamin-d-and-chronic-spontaneous-urticaria-a-systematic-review
#15
Papapit Tuchinda, Kanokvalai Kulthanan, Leena Chularojanamontri, Sittiroj Arunkajohnsak, Sutin Sriussadaporn
Background: Vitamin D has been reported to be associated with many allergic diseases. There are a limited number of the studies of vitamin D supplementation in patients with chronic spontaneous urticaria (CSU). This study aims to study the relationship between vitamin D and CSU in terms of serum vitamin D levels, and the outcomes of vitamin D supplementation. Methods: A literature search of electronic databases for all relevant articles published between 1966 and 2018 was performed...
2018: Clinical and Translational Allergy
https://read.qxmd.com/read/30519393/elevated-expression-of-il-17rb-and-st2-on-myeloid-dendritic-cells-is-associated-with-a-th2-skewed-eosinophilic-inflammation-in-nasal-polyps
#16
Rui Zheng, Dan Wang, Kai Wang, Wen-Xiang Gao, Qin-Tai Yang, Li-Jie Jiang, Min Zhou, Yu-Jie Cao, Jianbo Shi, Yueqi Sun
Background: Interleukin(IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) underlie the crosstalk between epithelial cells and dendritic cells (DCs) during the development of Th2 responses. This study aimed to measure the expressions of IL-17RB, ST2 and TSLPR, receptor of IL-25, IL-33, and TSLP respectively, on myeloid DCs in nasal polyps (NP) and evaluate their association with local Th2 inflammation and disease severity in patients with NP. Methods: Samples were collected from 30 NP patients and 16 control subjects recruited prospectively...
2018: Clinical and Translational Allergy
https://read.qxmd.com/read/30498567/highlights-and-recent-developments-in-airway-diseases-in-eaaci-journals-2017
#17
REVIEW
J Bousquet, C A Akdis, C Grattan, P A Eigenmann, K Hoffmann-Sommergruber, P W Hellings, I Agache
The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to support health promotion in which prevention of allergy and asthma plays a critical role and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members. There was substantial progress in 2017 in the identification of basic mechanisms of allergic and respiratory disease and the translation of these mechanisms into clinics...
2018: Clinical and Translational Allergy
https://read.qxmd.com/read/30479743/early-aggressive-intervention-for-infantile-atopic-dermatitis-to-prevent-development-of-food-allergy-a-multicenter-investigator-blinded-randomized-parallel-group-controlled-trial-paci-study-protocol-for-a-randomized-controlled-trial
#18
Kiwako Yamamoto-Hanada, Tohru Kobayashi, Hywel C Williams, Masashi Mikami, Mayako Saito-Abe, Kumiko Morita, Osamu Natsume, Miori Sato, Motoko Iwama, Yumiko Miyaji, Makiko Miyata, Shinichiro Inagaki, Fukuie Tatsuki, Narita Masami, Shoji F Nakayama, Hiroshi Kido, Hirohisa Saito, Yukihiro Ohya
Background: Atopic dermatitis is the first clinical manifestation of the atopic march, with the highest incidence in the first year of life. Those affected often go on to develop other allergic diseases including food allergy, asthma, and allergic rhinitis. Recent evidence suggests that sensitization to foods may occur through a defective skin barrier which is common in atopic dermatitis in early life. We hypothesize that therapeutic aggressive intervention to treat new onset atopic dermatitis may prevent the development of later allergen sensitization, and associated food allergy, asthma, and allergic rhinitis...
2018: Clinical and Translational Allergy
https://read.qxmd.com/read/30455865/identification-of-pen-m-4-as-a-potential-cause-of-occupational-asthma-to-gammarus-shrimp
#19
A Sogo, M J Cruz, M J Amengual, X Muñoz
We present the case of a 34-year-old male patient employed for 8 years in a company manufacturing and packaging animal feed. The patient developed occupational asthma to dry Gammarus powder. The diagnosis was confirmed by specific bronchial provocation test. The determination of specific IgE antibodies was positive for Pen m 4, a sarcoplasmic calcium binding protein, with a level of 6.7 ISU-E. The sensitization to Pen m 4 described here may identify a new allergen causing occupational asthma in these workers...
2018: Clinical and Translational Allergy
https://read.qxmd.com/read/30410723/alpha-1-antitrypsin-distribution-in-an-allergic-asthmatic-population-sensitized-to-house-dust-mites
#20
I Suárez-Lorenzo, F Rodríguez de Castro, D Cruz-Niesvaara, E Herrera-Ramos, C Rodríguez-Gallego, T Carrillo-Diaz
Background and objective: Severe alpha1 antitrypsin deficiency has been clearly associated with pulmonary emphysema, but its relationship with bronchial asthma remains controversial. Some deficient alpha 1 antitrypsin (AAT) genotypes seem to be associated with asthma development. The objective of this study was to analyze the distribution of AAT genotypes in asthmatic patients allergic to house dust mites (HDM), and to asses a possible association between these genotypes and severe asthma...
2018: Clinical and Translational Allergy
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