journal
https://read.qxmd.com/read/38646441/profiling-of-serum-metabolome-of-breast-cancer-multi-cancer-features-discriminate-between-healthy-women-and-patients-with-breast-cancer
#1
JOURNAL ARTICLE
Katarzyna Mrowiec, Julia Debik, Karol Jelonek, Agata Kurczyk, Lucyna Ponge, Agata Wilk, Marcela Krzempek, Guro F Giskeødegård, Tone F Bathen, Piotr Widłak
INTRODUCTION: The progression of solid cancers is manifested at the systemic level as molecular changes in the metabolome of body fluids, an emerging source of cancer biomarkers. METHODS: We analyzed quantitatively the serum metabolite profile using high-resolution mass spectrometry. Metabolic profiles were compared between breast cancer patients (n=112) and two groups of healthy women (from Poland and Norway; n=95 and n=112, respectively) with similar age distributions...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38646440/macrophage-colony-stimulating-factor-and-its-role-in-the-tumor-microenvironment-novel-therapeutic-avenues-and-mechanistic-insights
#2
REVIEW
Li Yi, Yihan Gai, Zhuo Chen, Kecan Tian, Pengfei Liu, Hongrui Liang, Xinyu Xu, Qiuyi Peng, Xiaoqing Luo
The tumor microenvironment is a complex ecosystem where various cellular and molecular interactions shape the course of cancer progression. Macrophage colony-stimulating factor (M-CSF) plays a pivotal role in this context. This study delves into the biological properties and functions of M-CSF in regulating tumor-associated macrophages (TAMs) and its role in modulating host immune responses. Through the specific binding to its receptor colony-stimulating factor 1 receptor (CSF-1R), M-CSF orchestrates a cascade of downstream signaling pathways to modulate macrophage activation, polarization, and proliferation...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38646439/diversity-of-extracellular-hsp70-in-cancer-advancing-from-a-molecular-biomarker-to-a-novel-therapeutic-target
#3
REVIEW
Binbin Hu, Guihong Liu, Kejia Zhao, Gao Zhang
Heat shock protein 70 (HSP70) is a highly conserved protein functioning as a "molecular chaperone", which is integral to protein folding and maturation. In addition to its high expression within cells upon stressful challenges, HSP70 can be translocated to the cell membrane or released from cells in free form or within extracellular vesicles (EVs). Such trafficking of HSP70 is also present in cancer cells, as HSP70 is overexpressed in various types of patient samples across a range of common malignancies, signifying that extracellular HSP70 (eHSP70) can serve as a tumor biomarker...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38646438/transarterial-chemoembolization-combined-with-radiofrequency-ablation-for-medium-and-large-hepatocellular-carcinoma-insufficient-ablation-is-associated-with-intrahepatic-distant-metastasis-and-extrahepatic-metastasis
#4
JOURNAL ARTICLE
Peng Guo, Junjun Zheng, Xingtao Pi, Feng Gao, Yushan Zhao, Chunming Xie, Wendong Cao
PURPOSE: To compare the prognosis of complete and insufficient ablation of transarterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) in treating medium and large hepatocellular carcinoma (HCC) and to explore the differences in recurrence patterns between the two groups. PATIENTS AND METHODS: Patients´ medical records and imaging data of patients with confirmed HCC from January 2014 to January 2022 were collected. These patients were divided into 2 groups: complete ablation (n=172) and insufficient ablation (n=171)...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38646437/editorial-overcoming-obstacles-of-cancer-immunotherapy-the-important-role-of-emerging-nanomedicine
#5
EDITORIAL
Aimin Jiang, Wangxiao He, Yu Yao
No abstract text is available yet for this article.
2024: Frontiers in Oncology
https://read.qxmd.com/read/38646436/paratesticular-metastasis-from-colorectal-adenocarcinoma-presenting-as-hydrocele-a-rare-case-report-and-literature-review
#6
XiaoJun Huang, KeLi Xu, Yin Zhao, MinHui Chen, ZheYang Li
Colorectal cancer, with the liver being the most common site of distant metastasis, followed by the lungs and bones. Although reports of metastasis to the testis exist, paratesticular metastasis is extremely rare. A 37-year-old male presented with scrotal swelling. Ultrasound revealed hydrocele of the tunica vaginalis. The patient underwent routine surgical treatment, and postoperative pathology of the tunica vaginalis indicated adenocarcinoma of gastrointestinal origin. Colonoscopic biopsy confirmed adenocarcinoma of the sigmoid colon...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38646435/retreatment-with-immunotherapy-in-a-patient-with-hepatocellular-carcinoma-who-received-immune-checkpoint-inhibitors-after-primary-curative-treatment-a-case-report
#7
Tao Wang, Fei Tang, Fenghui Li, Weili Yin, Jing Liang
Hepatocellular carcinoma (HCC) presents a malignant pathology known for its high early recurrence rate following curative treatment, significantly impacting patient prognosis. Currently, effective strategies to mitigate early HCC recurrence remain undetermined. In this report, we document a case of HCC managed with curative radiofrequency ablation (RFA), particularly in a patient facing a high risk of early recurrence due to a substantial tumor size. In an effort to forestall recurrence, immune checkpoint inhibitors (ICIs) were preemptively administered for 6 months post-RFA...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38646434/case-report-unusual-breast-cancer-metastasis-manifesting-as-a-scalp-lesion-in-a-patient-with-invasive-lobular-carcinoma
#8
Nam Hee Koh, Ha Yeun Oh
Breast cancer is the most prevalent cancer in women globally, often leading to distant metastasis in the lung, liver, or bones. Cutaneous metastasis represents an uncommon pattern in breast cancer, but when observed, it tends to manifest in the thorax and upper abdomen, primarily due to lymph node involvement. Therefore, occurrences of cutaneous metastasis on the scalp and extremities are infrequent. Moreover, invasive lobular carcinoma metastasizing to remote skin is rare among the breast cancer. This report presents a case of cutaneous metastasis of invasive lobular carcinoma to the scalp in a patient treated for breast cancer six years ago, with no signs of local recurrence or metastasis to other organs...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38646433/commentary-case-report-lenvatinib-for-the-treatment-of-recurrent-hepatocellular-carcinoma-in-people-living-with-hiv-a-report-of-two-cases
#9
COMMENT
Cuiming Sun, Ying Wen, Jin Zhou
No abstract text is available yet for this article.
2024: Frontiers in Oncology
https://read.qxmd.com/read/38646432/tace-assisted-multi-image-guided-radiofrequency-ablation-for-the-treatment-of-single-hepatocellular-carcinoma-%C3%A2-5%C3%A2-cm-a-retrospective-study
#10
JOURNAL ARTICLE
Yong Xie, Tianshi Lyu, Li Song, Xiaoqiang Tong, Jian Wang, Yinghua Zou
BACKGROUND/OBJECTIVE: Treatment of hepatocellular carcinoma (HCC) with ablation alone often results in high rates of recurrence and metastasis, reaching up to 25.9% within two years. Therefore, this study aimed to examine the efficacy and safety of transarterial chemoembolization (TACE)-assisted multi-image guided radiofrequency ablation (RFA) for the treatment of stage Ia HCC according to the China liver cancer staging (CNLC). METHODS: This study enrolled and analyzed a total of 118 patients diagnosed with HCC, each with a single nodular lesion no larger than 5 cm, who received TACE-RFA as first-line therapy between February 1, 2014, and December 31, 2021...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38646431/case-report-navigating-treatment-pathways-for-cardiac-intimal-sarcoma-with-pdgfr%C3%AE-n666k-mutation
#11
Akihiro Nishiyama, Shigeki Sato, Hiroyuki Sakaguchi, Hiroshi Kotani, Kaname Yamashita, Koushiro Ohtsubo, Keishi Mizuguchi, Hiroko Ikeda, Kenji Iino, Hirofumi Takemura, Shinji Takeuchi
In the realm of rare cardiac tumors, intimal sarcoma presents a formidable challenge, often requiring innovative treatment approaches. This case report presents a unique instance of primary intimal sarcoma in the left atrium, underscoring the critical role of genomic profiling in guiding treatment. Initial genomic testing unveiled a somatic, active mutation in PDGFRβ ( PDGFRβ N666K), accompanied by MDM2 and CDK4 amplifications. This discovery directed the treatment course toward pazopanib, a PDGFRβ inhibitor, following irradiation...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38646430/oral-cancer-in-young-adults-should-we-approach-these-patients-differently
#12
JOURNAL ARTICLE
Mateusz Szewczyk, Jakub Pazdrowski, Paweł Golusiński, Barbara Więckowska, Wojciech Golusiński
OBJECTIVE: The influence of age on treatment outcomes in oral cancer is unclear. We aimed to determine the prevalence of oral cancer in adults under age 45 and to compare treatment outcomes by age. METHODS: Retrospective study of 284 patients treated for oral cancer from 2010 to 2021. The primary analysis involved the full cohort stratified by age (< vs. ≥ 45y). The second analysis included all patients under age 45 (n=44) matched 1:1 by sex and stage to older patients (age 55-70)...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38646429/optimal-surgical-population-for-cervical-lymph-node-dissection-in-ptc
#13
JOURNAL ARTICLE
Yongkun Wang, Zhen Wu, Jinqiang Yan, Yumin Yao, Lin Han
OBJECTIVE: There is still controversy about whether cervical lymph node dissection should be performed in surgical treatment of PTC. Based on the data of thyroid cancer patients from Liaocheng People's Hospital from 2015 to 2018, this study focused on appropriate indications for cervical lymph node dissection surgery. METHODS: The clinical and pathological data of patients with initial treatment of PTC in thyroid surgery department from 2015 to 2018 were collected...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38646428/application-of-nano-radiosensitizers-in-non-small-cell-lung-cancer
#14
REVIEW
Xiao Hu, Jiamiao Hu, Yuke Pang, Mengjia Wang, Weiwen Zhou, Xuyun Xie, Chu Zhu, Xuanxuan Wang, Xiaonan Sun
Radiotherapy stands as a cornerstone in the treatment of numerous malignant tumors, including non-small cell lung cancer. However, the critical challenge of amplifying the tumoricidal effectiveness of radiotherapy while minimizing collateral damage to healthy tissues remains an area of significant research interest. Radiosensitizers, by methods such as amplifying DNA damage and fostering the creation of free radicals, play a pivotal role in enhancing the destructive impact of radiotherapy on tumors. Over recent decades, nano-dimensional radiosensitizers have emerged as a notable advancement...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38638862/clinical-outcomes-of-intermittent-panitumumab-based-therapy-for-previously-treated-older-patient-with-metastatic-colorectal-cancer-a-case-report-and-review-of-literature
#15
Gerardo Rosati, Luigi Annunziata, Enrico Scarano, Francesca Dapoto, Domenico Bilancia
BACKGROUND: Metastatic colorectal cancer is one of the most common causes of cancer death worldwide, and its incidence increases with age. Treating an older RAS and BRAF wild-type patient represents a challenge for the medical oncologist, even more so for those patients defined as "vulnerable" and undergoing at least two lines of therapy. In this context, recent evidence supports the role of retreatment with anti-EGFR inhibitors and the use of liquid biopsy. However, frequent skin toxicity constitutes a limitation of therapy, especially in older people...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38638861/clinicopathologic-and-endoscopic-features-of-sessile-serrated-lesions-and-conventional-adenomas-a-large-inpatient-population-based-study-in-china
#16
JOURNAL ARTICLE
Chang Tan, Geng Qin, Qian-Qian Wang, Yuan-Chen Zhou, Shu-Kun Yao
OBJECTIVES: Sessile serrated lesions (SSLs) are precursors of sporadic colorectal cancer (CRC) and have distinct characteristics compared with conventional adenomas (CAs). Several lifestyle and environmental factors may play critical roles in the development of advanced lesions. Our aim is to describe the features of SSLs and CAs and further explore risk factors for advanced lesions. METHODS: This is an observational study that collected demographic, endoscopic, and histological data from the China-Japan Friendship Hospital among the inpatient population with pathologically reported as SSL or CA between 2015 and 2022...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38638860/efficacy-of-befotertinib-in-non-small-cell-lung-cancer-harboring-uncommon-compound-egfr-mutations-g719x-and-s768i-a-case-report
#17
Zhedong Zhang, Yu Huang, Haihua Gu, Lufeng Zhao, Baiqin Zhao
The discovery of epidermal growth factor receptor (EGFR) somatic mutations and the availability of tyrosine kinase inhibitors (TKIs) as targeted therapies have transformed the treatment landscape for advanced non-small cell lung cancer (NSCLC). p. G719X and p. S768I mutations, often present in the form of complex mutations, are considered rare. This study firstly reported the treatment outcome of a locally advanced unresectable NSCLC patient with a rare complex EGFR p. G719X/ p. S768I mutations who received befotertinib...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38638859/case-report-envafolimab-combined-with-endostar-in-the-treatment-of-advanced-non-small-cell-lung-cancer-with-malignant-pleural-effusion
#18
Changhong Dong, Chenxi Hu, Yanting Jiang, Kaiyuan Hui, Xiaodong Jiang
Malignant pleural effusion (MPE) is one of the common complications of lung cancer. The quality of life and prognoses for MPE patients are significantly compromised. Controlling the production of MPE can relieve patients' symptoms, improve their quality of life, and prolong their survival. This article presents a case of advanced non-small cell lung cancer (NSCLC) with MPE and negative driver genes. The patient received envafolimab and Endostar in combination, resulting in a complete reduction of MPE and durable clinical benefits...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38638858/tumor-regression-and-safe-distance-of-distal-margin-after-neoadjuvant-therapy-for-rectal-cancer
#19
REVIEW
Guilin Yu, Huanyu Chi, Guohua Zhao, Yue Wang
Neoadjuvant therapy has been widely employed in the treatment of rectal cancer, demonstrating its utility in reducing tumor volume, downstaging tumors, and improving patient prognosis. It has become the standard preoperative treatment modality for locally advanced rectal cancer. However, the efficacy of neoadjuvant therapy varies significantly among patients, with notable differences in tumor regression outcomes. In some cases, patients exhibit substantial tumor regression, even achieving pathological complete response...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38638857/editorial-epigenomic-drivers-of-cancer-disparities
#20
EDITORIAL
Luciane R Cavalli, Rachel E Ellsworth, Ritu Aneja
No abstract text is available yet for this article.
2024: Frontiers in Oncology
journal
journal
43752
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.