journal
https://read.qxmd.com/read/37736552/influence-of-body-composition-assessment-with-bioelectrical-impedance-vector-analysis-in-cancer-patients-undergoing-surgery
#1
JOURNAL ARTICLE
Bin Cai, Lan Luo, Chenping Zhu, Liping Meng, Qing Shen, Yafei Fu, Mingjie Wang, Sue Chen
BACKGROUND: Malnutrition is common in patients undergoing surgery for cancers and is a risk factor for postoperative outcomes. Body composition provides information for precise nutrition intervention in perioperative period for improving patients' postoperative outcomes. OBJECTION: The aim was to determine changes in parameters of body composition and nutritional status of cancer patients during perioperative period. METHODS: A total of 92 patients diagnosed with cancer were divided into gastrointestinal and non-gastrointestinal cancer group according to different cancer types...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37736551/regulation-of-iron-metabolism-and-ferroptosis-in-cancer-stem-cells
#2
REVIEW
Hailiang Wang, Zhongyan Zhang, Shiye Ruan, Qian Yan, Yubin Chen, Jinwei Cui, Xinjian Wang, Shanzhou Huang, Baohua Hou
The ability of cancer stem cells (CSCs) to self-renew, differentiate, and generate new tumors is a significant contributor to drug resistance, relapse, and metastasis. Therefore, the targeting of CSCs for treatment is particularly important. Recent studies have demonstrated that CSCs are more susceptible to ferroptosis than non-CSCs, indicating that this could be an effective strategy for treating tumors. Ferroptosis is a type of programmed cell death that results from the accumulation of lipid peroxides caused by intracellular iron-mediated processes...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37736550/exopd-l1-an-assistant-for-tumor-progression-and-potential-diagnostic-marker
#3
REVIEW
Rong Hu, Md Shoykot Jahan, Lijun Tang
The proliferation and function of immune cells are often inhibited by the binding of programmed cell-death ligand 1 (PD-L1) to programmed cell-death 1 (PD-1). So far, many studies have shown that this combination poses significant difficulties for cancer treatment. Fortunately, PD-L1/PD-1 blocking therapy has achieved satisfactory results. Exosomes are tiny extracellular vesicle particles with a diameter of 40~160 nm, formed by cells through endocytosis. The exosomes are a natural shelter for many molecules and an important medium for information transmission...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37736549/erratum-extracellular-volume-fraction-using-contrast-enhanced-ct-is-useful-in-differentiating-intrahepatic-cholangiocellular-carcinoma-from-hepatocellular-carcinoma
#4
(no author information available yet)
[This corrects the article DOI: 10.3389/fonc.2023.1214977.].
2023: Frontiers in Oncology
https://read.qxmd.com/read/37736548/prognostic-and-therapeutic-implications-of-iron-related-cell-death-pathways-in-acute-myeloid-leukemia
#5
JOURNAL ARTICLE
Tongyu Li, Tongtong Lin, Jiahao Zhu, Miao Zhou, Shufang Fan, Hao Zhou, Qitian Mu, Lixia Sheng, Guifang Ouyang
Acute myeloid leukemia (AML) is a blood cancer that is diverse in terms of its molecular abnormalities and clinical outcomes. Iron homeostasis and cell death pathways play crucial roles in cancer pathogenesis, including AML. The objective of this study was to examine the clinical significance of genes involved in iron-related cell death and apoptotic pathways in AML, with the intention of providing insights that could have prognostic implications and facilitate the development of targeted therapeutic interventions...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37736547/size-and-depth-of-residual-tumor-after-neoadjuvant-chemoradiotherapy-in-rectal-cancer-implications-for-the-development-of-new-imaging-modalities-for-response-assessment
#6
JOURNAL ARTICLE
Stefan D van der Stel, Jose G van den Berg, Petur Snaebjornsson, Iris M Seignette, Mark Witteveen, Brechtje A Grotenhuis, Geerard L Beets, Anouk L Post, Theo J M Ruers
With the shift towards organ preserving treatment strategies in rectal cancer it has become increasingly important to accurately discriminate between a complete and good clinical response after neoadjuvant chemoradiotherapy (CRT). Standard of care imaging techniques such as CT and MRI are well equipped for initial staging of rectal tumors, but discrimination between a good clinical and complete response remains difficult due to their limited ability to detect small residual vital tumor fragments. To identify new promising imaging techniques that could fill this gap, it is crucial to know the size and invasion depth of residual vital tumor tissue since this determines the requirements with regard to the resolution and imaging depth of potential new optical imaging techniques...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37736546/distribution-pattern-of-medial-group-retropharyngeal-lymph-nodes-and-its-implication-in-optimizing-clinical-target-volume-in-nasopharyngeal-carcinoma
#7
JOURNAL ARTICLE
Dan Zong, Ning Jiang, Cheng Kong, Jing Wen, Li-Jun Wang, Ye-Song Guo, Lan-Fang Zhang, Xia He, Zhen-Zhang Chen, Sheng-Fu Huang
PURPOSE: This study aimed to determine the diagnostic value of diffusion-weighted imaging (DWI) and to elucidate the clinical characteristics of medial group retropharyngeal lymph nodes (RLNs) based on multi-modal imaging. Also, we intended to explore the feasibility of optimizing the CTV60 boundary based on the characteristics of medial group RLNs. METHODS: A total of 549 patients with nasopharyngeal carcinoma received magnetic resonance imaging (MRI), DWI, and contrast-enhanced computed tomography (CT) to detect and evaluate clinical characteristics of medial group RLNs...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37736545/network-pharmacology-and-experimental-verification-reveal-the-mechanism-of-safranal-against-glioblastoma-gbm
#8
JOURNAL ARTICLE
Xiaobing Yang, Di Lu, Yanfei Sun, Tiandi Wei, Dulegeqi Man, Anbin Chen, Tao Luo, Feihu Zhao, Xuemeng Liu, Bo Cheng, Xu Wang, Peng Zhao, Donghai Wang, Xingang Li
INTRODUCTION: Safranal is an active component of the traditional Tibetan medicine (TTM) saffron, which has potential anticancer activity. METHODS AND RESULTS: Here, we studied the therapeutic effect and mechanism of safranal on GBM. CCK-8, GBM-brain organoid coculture experiments and 3D tumour spheroid invasion assays showed that safranal inhibited GBM cell proliferation and invasion in vitro . Network pharmacology, RNA-seq, molecular docking analysis, western blotting, apoptosis, and cell cycle assays predicted and verified that safranal could promote GBM cell apoptosis and G2/M phase arrest and inhibit the PI3K/AKT/mTOR axis...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37736544/editorial-prognostic-research-and-precision-oncology-in-upper-tract-urothelial-carcinoma-volume-ii
#9
EDITORIAL
Tsung-Mu Yang, Nirmish Singla, Chung-Hsin Chen, Jer-Tsong Hsieh, Hsin-Chih Yeh
No abstract text is available yet for this article.
2023: Frontiers in Oncology
https://read.qxmd.com/read/37736543/argon-helium-knife-cryoablation-plus-programmed-cell-death-protein-1-inhibitor-in-the-treatment-of-advanced-soft-tissue-sarcomas-there-is-no-evidence-of-the-synergistic-effects-of-this-combination-therapy
#10
JOURNAL ARTICLE
Jiaqiang Wang, Dengwei Zong, Shuping Dong, Shilei Gao, Yonghao Yang, Peng Zhang, Xin Wang, Weitao Yao, Zhichao Tian
BACKGROUND: Effective treatment for advanced soft tissue sarcomas (STSs) is necessary for improved outcomes. Previous studies have suggested that cryoablation can have a synergistic effect with programmed cell death protein-1 (PD-1) inhibitor in the treatment of malignancy. This study aimed to clarify the efficacy and safety of argon-helium knife cryoablation in combination with PD-1 inhibitor in the treatment of STSs. METHODS: Retrospectively collected and analyzed the clinical data of patients with advanced STS who underwent cryoablation and PD-1 inhibitor between March 2018 and December 2021...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37736542/phenotypic-characteristics-of-circulating-tumor-cells-and-predictive-impact-for-efficacy-of-chemotherapy-in-patients-with-pancreatic-cancer-a-prospective-study
#11
JOURNAL ARTICLE
Hee Seung Lee, Eun Hye Jung, Hyejung Shin, Chan Su Park, Soo Been Park, Dawoon E Jung, Galam Leem, So Jung Kim, Jung Hyun Jo, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Si Young Song
OBJECTIVE: Early chemoresistance and tumor mass progression are associated with poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Circulating tumor cells (CTCs) have been studied as potential predictors of treatment response and prognosis in PDAC; however, this approach has yet to be applied in clinical practice. The aim of our study was to investigate the phenotypic characteristics of CTCs and determine their predictive value for PDAC progression. METHODS: We prospectively enrolled 40 patients who were pathologically diagnosed with PDAC and collected blood samples at diagnosis, 2 months after diagnosis, and during disease progression or recurrence...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37731647/lifestyle-habits-and-gastric-cancer-in-an-east-asian-population-a-mendelian-randomization-study
#12
JOURNAL ARTICLE
Yuegui Tan, Zhao Wei, Kun Liu, Yuzhen Qin, Wenqi Hui
BACKGROUND: Epidemiological evidence suggests an association between lifestyle habits (smoking, alcohol consumption, tea, coffee intake, etc.) and gastric cancer (GC). However, the causal relationship remains uncertain. Therefore, the purpose of this study was to ascertain whether there is a causal connection between them. METHODS: Two-sample Mendelian randomization (MR) analysis was performed using the publicly available Genome Wide Association Study summary datasets using six methods: inverse variance weighting (IVW), weighted median, MR using a Robust Adjusted Profile Score (MR...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37731646/duplication-of-the-transverse-colon-in-adults-a-case-report-and-literature-review
#13
Xiaochun Zhang, Guangci Di, Wei Cheng, Cuizhong Wang, Guanwen Gong, Zhiwei Jiang
BACKGROUND: Duplication of the transverse colon is a rare gastrointestinal malformation. Its pathogenesis is still unclear, and it is extremely rare in adults. Patients often present with symptoms of tumor compression such as abdominal mass, abdominal pain, and constipation as the first manifestation. METHODS AND RESULT: A patient with a duplication of the transverse colon was admitted to the Department of General Surgery of our hospital. Laparoscopic exploration found a mass at the rear of the transverse colon near the splenic flexure, and the root was connected to the middle portion of the transverse colon...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37731645/neoadjuvant-chemoimmunotherapy-cycle-number-selection-for-non-small-cell-lung-cancer-and-clinical-outcomes-a-real-world-analysis
#14
JOURNAL ARTICLE
Baihua Zhang, Xiaotong Guo, Ran Jia, Zhan Wang, Jie Wu, Xiaoyan Chen, Jigang Li, Desong Yang, Xu Li, Wenxiang Wang, Qin Xiao
OBJECTIVES: Neoadjuvant chemoimmunotherapy is the optimal choice in the treatment of NSCLC; however, the optimal number of therapeutic cycles remains unclear. The primary aim of this study was to determine the optimal number of neoadjuvant therapeutic cycles in NSCLC. METHODS: This study was a real-world clinical analysis that included patients who received neoadjuvant chemoimmunotherapy followed by surgery from January 2020 to August 2022. Patients were divided into two groups based on the number of therapeutic cycles: 2-cycle group and 3-4-cycles group...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37731644/editorial-women-in-molecular-and-cellular-oncology
#15
EDITORIAL
Petranel T Ferrao, Laura RosanĂ², Valeria Poli, Shilpa S Dhar, Ana Paula Lepique
No abstract text is available yet for this article.
2023: Frontiers in Oncology
https://read.qxmd.com/read/37731643/applications-of-large-language-models-in-cancer-care-current-evidence-and-future-perspectives
#16
REVIEW
Giovanni Maria Iannantuono, Dara Bracken-Clarke, Charalampos S Floudas, Mario Roselli, James L Gulley, Fatima Karzai
The development of large language models (LLMs) is a recent success in the field of generative artificial intelligence (AI). They are computer models able to perform a wide range of natural language processing tasks, including content generation, question answering, or language translation. In recent months, a growing number of studies aimed to assess their potential applications in the field of medicine, including cancer care. In this mini review, we described the present published evidence for using LLMs in oncology...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37731642/prognostic-significance-of-c-reactive-protein-in-patients-with-cervical-cancer-a-meta-analysis
#17
Sheng Yang, Zongxin Zhang, Linglong Shen
BACKGROUND: Numerous studies have investigated the significance of pretreatment C-reactive protein (CRP) levels for determining the prognosis of cervical cancer (CC). The results of these studies, however, have been inconsistent. The present meta-analysis, therefore, focused on identifying the exact relationship of CRP levels with CC prognoses. METHODS: We searched the following databases from their inception until April 18, 2023: PubMed; Web of Science; Embase; and Cochrane Library...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37731641/clinical-outcomes-of-ramucirumab-plus-docetaxel-in-the-treatment-of-patients-with-non-small-cell-lung-cancer-after-immunotherapy-a-systematic-literature-review
#18
Edward B Garon, Carla Visseren-Grul, Maria Teresa Rizzo, Tarun Puri, Suresh Chenji, Martin Reck
INTRODUCTION: In the REVEL trial, ramucirumab plus docetaxel demonstrated significant improvements in overall survival (OS), progression-free survival (PFS), and overall response rate (ORR) compared with placebo plus docetaxel for treatment of metastatic non-small cell lung cancer (NSCLC) that progressed during or after platinum-based chemotherapy. Since the approval of ramucirumab plus docetaxel, immune checkpoint inhibitors (ICIs), either as single agents or in combination with chemotherapy, have become the standard of care for first-line treatment of patients with advanced NSCLC...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37731640/multiple-cardiac-myxofibrosarcomas-with-complete-right-pulmonary-artery-occlusion-a-case-report
#19
Weimin Zhang, Qi Tang, Balhen Bolathan, Yan Xing, Xiaoxin Sun, Qiang Huo
Primary cardiac myxofibrosarcoma is a rare form of cardiac malignant tumors. MFS usually involves the left atrium and presents as a unicentric or multicentric tumor mass. We reported on a 37-year-old female who presented with chest tightness and dyspnea for a month, dry cough, and occasionally having blood streak sputum for half a month. Echocardiography, cardiac computed tomography and cardiac positron emission tomography revealed multiple tumors in the heart. The right ventricle and right pulmonary artery were involved, with occlusion of the right pulmonary artery...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37731639/case-report-misdiagnosis-of-primary-mucinous-cystadenoma-of-the-testicle-by-ultrasound
#20
Linlin Zhang, Jianyuan Xuan, Manxi Li, Mei Zhang, Yu Song, Ziang Pan, Bo Fan, Lin Lu, Hongyan Zhou, Yang Li
Testicular mucinous cystadenoma is a rare benign testicular tumor with the characteristics of being potentially malignant and showing atypical clinical symptoms; this article reports a case of a primary testicular mucinous cystadenoma misdiagnosed as testicular teratoma by ultrasound. A 69-year-old man was admitted to the hospital because of a 1-year history of left-sided testicular enlargement with scrotal swelling and no obvious abnormalities on laboratory tests. Ultrasound examination revealed solid-mass lesions in the left testicle, suggesting a high probability of teratoma, and contrast-enhanced magnetic resonance imaging (MRI) examination suggested an increased possibility of epidermoid cysts...
2023: Frontiers in Oncology
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