Mojtaba Abrishami, Majid Abrishami, Asma Mahmoudi, Navid Mosallaei, Mohammad Vakili Ahrari Roodi, Bizhan Malaekeh-Nikouei
Purpose. In order to improve the drug availability after intravitreal administration, solid lipid nanoparticles (SLNs) containing diclofenac were prepared. Methods. In this experimental study, 18 albino rabbits were included. In right and left eyes of all rabbits, SLNs containing diclofenac and commercial form of diclofenac (0.3 mg drug) were intravitreally injected, respectively. One, four, twelve, twenty-four, and forty-eight hours after injection, vitreous and aqueous humor samples were obtained in all cases...
2016: Journal of Drug Delivery