Itzia Z Arroyo, Clarissa Gomez, Hugo Alarcon, Araceli Jimenez, Andrew Pardo, Gabriel Montaño, Rodrigo X Armijos, Juan C Noveron
[This corrects the article DOI: 10.1155/2018/2851579.].
2020: Journal of Drug Delivery
Norihide Murayama, Kei Asai, Kikuno Murayama, Satoru Doi, Makoto Kameda
Steroid inhalation is the standard bronchial asthma therapy and it includes powdered metered doses, dry powder, and nebulizer suspension. However, particle sizes vary widely. The research goal was to demonstrate that different budesonide administration forms and devices have various deposition rates in the airway obstruction region. Here, we compared relative inhalation therapy efficacies and identified therapies that delivered the highest drug doses to the airway obstruction region. Weibel's anatomy data were used to identify the airway obstruction region in asthma...
2019: Journal of Drug Delivery
Miguel A Lopez-Toledano, Vaibhav Saxena, Jason D Legassie, Haiyang Liu, Ajay Ghanta, Stephen Riseman, Courtney Cocilova, Ahmed Daak, Thorsteinn Thorsteinsson, Adrian L Rabinowicz, Frederick D Sancilio
Despite recent advances, the drug development process continues to face significant challenges to efficiently improve the poor solubility of active pharmaceutical ingredients (API) in aqueous media or to improve the bioavailability of lipid-based formulations. The inherent high intra- and interindividual variability of absorption of oral lipophilic drug leads to inconsistent and unpredictable bioavailability and magnitude of the therapeutic effect. For this reason, the development of lipid-based drugs remains a challenging endeavour with a high risk of failure...
2019: Journal of Drug Delivery
Juan F Granada, Renu Virmani, Daniel Schulz-Jander, Stefan Tunev, Robert J Melder
Two different drug-coated balloons (DCBs) possessing different coating formulations were compared for rate of coating dissolution in vitro, in addition to tissue drug concentration and histological responses of treated vascular tissue in vivo, to determine if the rate of drug bioavailability to vascular tissue can impact the degree and duration of the observed pharmacological response to locally delivered drug. In vitro dissolution comparison demonstrated that a urea/paclitaxel-based coating formulation (IN...
2019: Journal of Drug Delivery
Itizia Z Arroyo, Clarissa Gomez, Hugo Alarcon, Araceli Jimenez, Andrew Pardo, Gabriel Montaño, Rodrigo X Armijos, Juan C Noveron
Cationic liposomes with DNA-transportation properties have attracted considerable attention for their ability to deliver medicinal oligonucleotides to mammalian cells. Amongst these are metalloliposomes that use transition metal ions to confer the lipid molecules cationic charge and unique advantages such as redox- and ligand-exchange triggered DNA-release properties. In this study, lipophilic copper (II) and zinc (II) complexes of 1-alkyl-1,4,7-triazacyclononane were prepared to investigate their ability to bind and transfect double stranded DNA with mammalian cells in vitro and in vivo...
2018: Journal of Drug Delivery
Ofosua Adi-Dako, Kwabena Ofori-Kwakye, Seth Kwabena Amponsah, Isaac Boamah, Noble Kuntworbe, Esther Eshun Oppong
The potential of cocoa pod husk (CPH) pectin-based modified release (MR) capsules as a carrier for chronodelivery of hydrocortisone in Sprague-Dawley rats was assessed. Extemporaneously formulated CPH pectin-based hydrocortisone (10 mg) capsules crosslinked with calcium chloride (Formulation A) or zinc (Formulation B) and a commercial immediate release hydrocortisone formulation were administered orally to Sprague-Dawley rats and the pharmacokinetic parameters were evaluated using noncompartmental analysis...
2018: Journal of Drug Delivery
James R Stegman, Jill K Badin, Kaitlyn A Biles, Thamar Etienne, Sogand Fartash-Naini, Ariel D Gordon, Zachary W Greeley, Benjamin W Harding, Ricardo J Mack, Danielle Masica, Ashley N Nelson, Amandeep K Samra, Sarah E Smith, Gabrielle P Thomas, Haley J Zack, Timothy J Brunker, Barry J Margulies
Treatment for herpes simplex virus-1 and -2 (HSV-1 and -2) patients who suffer from recurrent outbreaks consists of multiple daily doses of the antiviral drugs acyclovir (ACV), penciclovir, or their more orally bioavailable derivatives valacyclovir or famciclovir. Drug troughs caused by missed doses may result in viral replication, which can generate drug-resistant mutants along with clinical sequelae. We developed a molecularly homogeneous mixture of ACV with the bioerodable polymer polycaprolactone. Through scanning electron microscopy, infrared spectroscopy, gel permeation chromatography, 1H NMR, and differential scanning calorimetry, our method of combining drug and polymer, termed Volatile Acid-Solvent Evaporation (VASE), does not compromise the integrity of polymer or drug...
2018: Journal of Drug Delivery
P Vijayanand, V Jyothi, N Aditya, A Mounika
In alternate systems of medicine like Ayurveda and traditional Chinese medicine, Hibiscus rosa sinensis and its extracts have been traditionally prescribed for their antidepressant activity. Crude extracts and rudimentary formulations approaches are good for proof-of-concept studies; however, these formulations are fraught with problems like poor oral bioavailability and high variability between subjects. Systematic drug delivery approaches could prove effective in addressing some of these problems. In this study, we report the development of Hibiscus rosa sinensis extract loaded solid lipid nanoparticles (HSLNs) using glycerol monostearate or beeswax as lipids...
2018: Journal of Drug Delivery
Asra Parveen, Manjunath S Yalagatti, Venkataraman Abbaraju, Raghunandan Deshpande
Antimicrobial study of biofunctionalized silver nanoparticles has been done with the emphasis on its mechanism on both gram positive and negative bacteria. The biofunctionalized silver nanoparticles are employed considering their importance in green chemistry with respect to easy synthesis, usefulness, and economic synthetic procedure involved. The stability of these nanoparticles was determined by zeta potential analyzer. The probable mechanism of antibacterial activity was performed on Proteus mirabilis by field emission scanning electron microscopy (FESEM) and energy dispersive spectroscopy (EDAX) study which does not show the presence of silver...
2018: Journal of Drug Delivery
Wadzanayi L Masiiwa, Louis L Gadaga
Background: Artesunate is one of the most potent, rapidly acting and therapeutically versatile antimalarial drugs. Its efficacy is hampered by poor aqueous solubility and stability resulting in low oral bioavailability. Recent efforts to nanoformulate artesunate have shown great potential of improving its dissolution profile and bioavailability. However, no study has yet been done to investigate the intestinal permeability of these nanoformulations, which is a critical determinant of systemic absorption...
2018: Journal of Drug Delivery
Piyush Mehta
Inhalation therapy has strong history of more than 4000 years and it is well recognized around the globe within every culture. In early days, inhalation therapy was designed for treatment of local disorders such as asthma and other pulmonary diseases. Almost all inhalation products composed a simple formulation of a carrier, usually α -lactose monohydrate orderly mixed with micronized therapeutic agent. Most of these formulations lacked satisfactory pulmonary deposition and dispersion. Thus, various alternative carrier's molecules and powder processing techniques are increasingly investigated to achieve suitable aerodynamic performance...
2018: Journal of Drug Delivery
Sheikh Tasnim Jahan, Sams M A Sadat, Matthew Walliser, Azita Haddadi
In nanomedicine, targeted therapeutic nanoparticle (NP) is a virtual outcome of nanotechnology taking the advantage of cancer propagation pattern. Tying up all elements such as therapeutic or imaging agent, targeting ligand, and cross-linking agent with the NPs is the key concept to deliver the payload selectively where it intends to reach. The microenvironment of tumor tissues in lymphatic vessels can also help targeted NPs to achieve their anticipated accumulation depending on the formulation objectives. This review accumulates the application of poly(lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) based NP systems, with a specific perspective in cancer...
2017: Journal of Drug Delivery
Ofosua Adi-Dako, Kwabena Ofori-Kwakye, Mariam El Boakye-Gyasi, Samuel Oppong Bekoe, Samuel Okyem
This study evaluated the in vitro potential of cocoa pod husk (CPH) pectin as a carrier for chronodelivery of hydrocortisone intended for adrenal insufficiency. FTIR studies found no drug-CPH pectin interactions, and chemometric analysis showed that pure hydrocortisone bears closer similarity to hydrocortisone in hot water soluble pectin (HWSP) than hydrocortisone in citric acid soluble pectin (CASP). CPH pectin-based hydrocortisone matrix tablets (~300 mg) were prepared by direct compression and wet granulation techniques, and the tablet cores were film-coated with a 15% HPMC formulation for timed release, followed by a 12...
2017: Journal of Drug Delivery
Emmanuel O Olorunsola, Grace A Akpan, Michael U Adikwu
This study was aimed at evaluating chitosan-microcrystalline cellulose blends as direct compression excipients. Crab shell chitosan, α -lactose monohydrate, and microcrystalline cellulose powders were characterized. Blends of the microcrystalline cellulose and chitosan in ratios 9 : 1, 4 : 1, 2 : 1, and 1 : 1 as direct compression excipients were made to constitute 60% of metronidazole tablets. Similar tablets containing blends of the microcrystalline cellulose and α -lactose monohydrate as well as those containing pure microcrystalline cellulose were also produced...
2017: Journal of Drug Delivery
Michael T Eadon, Ying-Hua Cheng, Takashi Hato, Eric A Benson, Joseph Ipe, Kimberly S Collins, Thomas De Luca, Tarek M El-Achkar, Robert L Bacallao, Todd C Skaar, Pierre C Dagher
siRNA stabilized for in vivo applications is filtered and reabsorbed in the renal proximal tubule (PT), reducing mRNA expression transiently. Prior siRNA efforts have successfully prevented upregulation of mRNA in response to injury. We proposed reducing constitutive gene and protein expression of LRP2 (megalin) in order to understand its molecular regulation in mice. Using siRNA targeting mouse LRP2 (si LRP2 ), reduction of LRP2 mRNA expression was compared to scrambled siRNA (siSCR) in mouse PT cells. Mice received si LRP2 administration optimized for dose, administration site, carrier solution, administration frequency, and administration duration...
2017: Journal of Drug Delivery
Nidhi Sandal, Gaurav Mittal, Aseem Bhatnagar, Dharam Pal Pathak, Ajay Kumar Singh
Background: Prussian blue (PB, ferric hexacyanoferrate) is approved by US-FDA for internal decorporation of Cesium-137 (137 Cs) and Thallium-201 (201 Tl). Aim: Since PB is a costly drug, pH-dependent oral delivery system of PB was developed using calcium alginate matrix system. Methods: Alginate (Alg) beads containing PB were optimized by gelation of sodium alginate with calcium ions and effect of varying polymer concentration on encapsulation efficiency and release profile was investigated...
2017: Journal of Drug Delivery
Jirapornchai Suksaeree, Patsakorn Siripornpinyo, Somruethai Chaiprasit
The crystallization of mefenamic acid in transdermal patch is a major problem that makes the patch unstable and decreases the drug release. The additive was used to inhibit crystallization of a mefenamic acid. Among the different types of additives, polyvinylpyrrolidone (PVP) K30 and PVP K90 were studied and found to be highly effective in inhibiting the crystallization of the drug. The PVP presented as a solubilizer agent for mefenamic acid in matrix patches at the different ratio between drug : PVP, 1 : 2 and 1 : 2...
2017: Journal of Drug Delivery
Qixin Leng, Martin C Woodle, A James Mixson
Over the past 20 years, a diverse group of ligands targeting surface biomarkers or receptors has been identified with several investigated to target siRNA to tumors. Many approaches to developing tumor-homing peptides, RNA and DNA aptamers, and single-chain variable fragment antibodies by using phage display, in vitro evolution, and recombinant antibody methods could not have been imagined by researchers in the 1980s. Despite these many scientific advances, there is no reason to expect that the ligand field will not continue to evolve...
2017: Journal of Drug Delivery
Sowmya Vishnubhakthula, Ravinder Elupula, Esteban F Durán-Lara
The purpose of this study is to describe some of the latest advances in using hydrogels for cancer melanoma therapy. Hydrogel formulations of polymeric material from natural or synthetic sources combined with therapeutic agents have gained great attention in the recent years for treating various maladies. These formulations can be categorized according to the strategies that induce cancer cell death in melanoma. First of all, we should note that these formulations can only play a supporting role that releases bioactive agents against cancer cells rather than the main role...
2017: Journal of Drug Delivery
Naren Subbiah, Jesus Campagna, Patricia Spilman, Mohammad Parvez Alam, Shivani Sharma, Akishige Hokugo, Ichiro Nishimura, Varghese John
Phospholipid-based deformable nanovesicles (DNVs) that have flexibility in shape offer an adaptable and facile method to encapsulate diverse classes of therapeutics and facilitate localized transdermal delivery while minimizing systemic exposure. Here we report the use of a microfluidic reactor for the synthesis of DNVs and show that alteration of input parameters such as flow speeds as well as molar and flow rate ratios increases entrapment efficiency of drugs and allows fine-tuning of DNV size, elasticity, and surface charge...
2017: Journal of Drug Delivery
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