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Journals International Forum of Allergy...

International Forum of Allergy & Rhinology

https://read.qxmd.com/read/38409897/medication-utilization-for-patients-with-chronic-rhinosinusitis-with-nasal-polyposis-and-asthma-in-12-months-pre-and-post-dupilumab-initiation
#1
LETTER
Emily Garvey, Bita Naimi, Alexander Duffy, Chase Kahn, Douglas Farquhar, Marc Rosen, Mindy Rabinowitz, Damaris Pena Evertz, Jessica Most, Elina Toskala, Gurston G Nyquist
This study examines the impact of dupilumab on medication use for chronic rhinosinusitis with nasal polyposis (CRSwNP) and asthma patients. Patients on dupilumab had a reduction in oral/inhaled/topical steroids, antibiotics, and leukotriene receptor antagonists (LTRAs). The reduction in medication use had no impact on total polyp or SNOT-22 scores.
February 26, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38400591/the-effect-of-pm2-5-on-acute-sinusitis-a-population-based-study
#2
JOURNAL ARTICLE
David Grimm, Z Jason Qian, Michael Yong, Peter H Hwang
PM2.5 exposure is a risk factor for the development of acute sinusitis. PM2.5 exposure affects acute sinusitis in a dose response fashion.
February 23, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38372441/snot-22-subdomain-outcomes-following-treatment-for-sinonasal-malignancy-a-prospective-multicenter-study
#3
JOURNAL ARTICLE
David R Grimm, Daniel M Beswick, Sabrina L Maoz, Eric W Wang, Garret W Choby, Edward C Kuan, Erik P Chan, Nithin D Adappa, Mathew Geltzeiler, Anne E Getz, Ian M Humphreys, Christopher H Le, Waleed M Abuzeid, Eugene H Chang, Aria Jafari, Todd T Kingdom, Michael A Kohanski, Jivianne K Lee, Jayakar V Nayak, James N Palmer, Zara M Patel, Carlos D Pinheiro-Neto, Adam C Resnick, Myung S Sim, Timothy L Smith, Carl H Snyderman, Maie A John, Phillip Storm, Jeffrey D Suh, Marilene B Wang, Peter H Hwang
BACKGROUND: Patients with sinonasal malignancy (SNM) present with significant sinonasal quality of life (QOL) impairment. Global sinonasal QOL as measured by the 22-item Sinonasal Outcomes Test (SNOT-22) has been shown to improve with treatment. This study aims to characterize SNOT-22 subdomain outcomes in SNM. METHODS: Patients diagnosed with SNM were prospectively enrolled in a multi-center patient registry. SNOT-22 scores were collected at the time of diagnosis and through the post-treatment period for up to 5 years...
February 19, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38372028/severe-epistaxis-after-posterior-nasal-nerve-ablation-requiring-surgical-intervention-a-multi-center-case-series
#4
LETTER
Najm S Khan, Yuki Yoshiyasu, Brian S Wang, Antoine Khoudari, Dean M Clerico, Jackson M King, Toby O Steele, Aatin K Dhanda, Masayoshi Takashima, Omar G Ahmed
Severe epistaxis occurs in 2% of PNN ablation cases, independent of method or device type. Major epistaxis requiring intervention after PNN ablation can occur on average 20 days post-procedure.
February 19, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38367249/health-care-disparities-and-chronic-rhinosinusitis-does-neighborhood-disadvantage-impact-outcomes-in-sinonasal-disease
#5
JOURNAL ARTICLE
Amarbir S Gill, Benton Tullis, Jess C Mace, Conner Massey, Vivek C Pandrangi, Jorge A Gutierrez, Vijay R Ramakrishnan, Daniel M Beswick, Zachary M Soler, Timothy L Smith, Jeremiah A Alt
OBJECTIVE: Socioeconomic status (SES) is linked to health outcomes but has not been well studied in patients with chronic rhinosinusitis (CRS). The area deprivation index (ADI) is a comprehensive measure of geographic SES that ranks neighborhood disadvantage. This investigation used ADI to understand the impact of neighborhood disadvantage on CRS treatment outcomes. METHODS: A total of 642 study participants with CRS were prospectively enrolled and self-selected endoscopic sinus surgery (ESS) or continued appropriate medical therapy as treatment...
February 17, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38353285/severe-unilateral-refractory-epistaxis-arising-from-the-septal-branch-of-the-anterior-ethmoid-artery
#6
JOURNAL ARTICLE
Theodore V Nguyen, Benjamin F Bitner, Ellen M Hong, Jonathan C Pang, Leo Li Tang Meller, Cecilia Nguyen, Edward C Kuan
The septal branch of the anterior ethmoid artery (sbAEA) is an underrecognized source of severe refractory epistaxis. Herein, we describe the presentation, predisposing factors, treatment strategies, and outcomes of a series of patients with this condition.
February 14, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38343308/ensuring-the-appropriate-use-of-biologics-a-call-for-specialty-evaluation
#7
LETTER
Aurelia Monk, Brian D Thorp, Brent A Senior, Adam J Kimple, Cristine Klatt-Cromwell, Charles S Ebert
No abstract text is available yet for this article.
February 11, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38343306/comparison-between-upper-and-lower-airway-microbiome-profiles-in-chronic-rhinosinusitis-patients
#8
JOURNAL ARTICLE
Juan Carlos Hernaiz-Leonardo, Changwan Ryu, Athenea Pascual, Judy Fan, Maria Caray, Rogério Pezato, Julia Yang, Don Sin, Andrew Thamboo
BACKGROUND: Dysregulation of the airway microbiota is thought to contribute to airway inflammation in both chronic rhinosinusitis (CRS) and asthma. However, the relationship between the upper and lower airway microbiome remains unclear. METHODS: Sinus and lung brushes were collected from 29 CRS participants undergoing sinus surgery. DNA was extracted and submitted for 16s rRNA microbiome sequencing. Alpha and beta diversity metrics, taxonomic composition, and differences between individual taxa were compared for paired sinus and bronchial samples...
February 11, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38343159/assessment-of-social-vulnerability-impact-in-care-and-prognosis-of-sinonasal-cancers-in-the-united-states
#9
JOURNAL ARTICLE
Achilles A Kanaris, David J Fei-Zhang, Lily B Fletcher, Stephanie S Smith, Urjeet A Patel, Jill N D'Souza, Daniel C Chelius, Anthony M Sheyn, Jeffrey C Rastatter
Social determinants of health interactively influence sinonasal cancer care and prognosis. Housing-transportation and socioeconomic status showed the largest associations with disparities. The social vulnerability index can reveal the social determinants of sinonasal cancers.
February 11, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38343156/decoding-chronic-rhinosinusitis-a-metabolomics-based-approach
#10
REVIEW
Xinru Gong, Yijie Fu, Lei Zhou, Aiming Wei, Chongsheng Pan, Tianmin Zhu, Hui Li
BACKGROUND: Chronic rhinosinusitis (CRS) is a common and intractable disease in otorhinolaryngology, laying a heavy burden on healthcare systems. The worldwide researchers are making efforts to find solutions to this disease. Metabolomics has recently gained more and more traction, and might become a promising tool to unravel the complexity of CRS. This paper provides an overview of current studies on the metabolomics of various CRS subtypes. METHODS: We conducted a comprehensive literature search in PubMed, Web of Science, EMBASE, Google Scholar, and Cochrane Library, up to May 25, 2023...
February 11, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38343143/patient-perspectives-on-chronic-rhinosinusitis-in-cystic-fibrosis-symptom-prioritization-in-the-era-of-highly-effective-modulator-therapy
#11
JOURNAL ARTICLE
Christine M Liu, Ethan J Han, Jakob L Fischer, Jess C Mace, Jose L Mattos, Karolin Markarian, Jeremiah A Alt, Todd E Bodner, Naweed I Chowdhury, Patricia H Eshaghian, Anne E Getz, Peter H Hwang, Ashoke Khanwalkar, Adam J Kimple, Jivianne T Lee, Douglas A Li, Meghan Norris, Jayakar V Nayak, Cameran Owens, Zara M Patel, Katie Poch, Rodney J Schlosser, Kristine A Smith, Timothy L Smith, Zachary M Soler, Jeffrey D Suh, Grant A Turner, Marilene B Wang, Jennifer L Taylor-Cousar, Milene T Saavedra, Daniel M Beswick
BACKGROUND: Chronic rhinosinusitis (CRS) is common in people with cystic fibrosis (PwCF). Rhinologic symptom prioritization and areas that influence CRS treatment choices, including pursuing endoscopic sinus surgery (ESS), remain understudied. METHODS: Adult PwCF + CRS were enrolled at eight centers into a prospective, observational study (2019-2023). Participants were administered the 22-SinoNasal Outcome Test (SNOT-22) survey and a modified SNOT-22 instrument examining symptom importance...
February 11, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38297486/impact-of-dupilumab-prescribing-on-utilization-of-medical-and-surgical-therapies-for-chronic-rhinosinusitis-with-nasal-polyps
#12
JOURNAL ARTICLE
Christopher M Low, Allan R Wang, Michael Yong, Jayakar Nayak, Zara Patel, Peter H Hwang
Increased dupilumab utilization coincided with decreased ESS in patients with CRSwNP between 2019 and 2021. One potential confounder was the concurrent COVID-19 pandemic, which may have negatively impacted surgery utilization rates.
January 31, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38297443/which-intranasal-corticosteroids-can-be-used-in-patients-on-highly-active-antiretroviral-therapy-or-pre-exposure-prophylactic
#13
LETTER
Meghan Norris, Erin Lopez, Daniel Alicea Delgado, Brian Thorp, Christine Klatt-Cromwell, Brent Senior, Adam Kimple, Charles S Ebert
All intranasal corticosteroid spray formulations are safe to use in patients on pre-exposure prophylaxis. Beclomethasone nasal spray can be used safely with all HAART and PrEP regimens.
January 31, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38268115/cognition-and-saccadic-eye-movement-performance-are-impaired-in-chronic-rhinosinusitis
#14
JOURNAL ARTICLE
David J Cvancara, Heather A Wood, Mohamed Aboueisha, Thomas B Marshall, Tzu-Cheg Kao, James O Phillips, Ian M Humphreys, Waleed M Abuzeid, Ashton E Lehmann, Yoshiko Kojima, Aria Jafari
BACKGROUND: Patients with chronic rhinosinusitis (CRS) can experience cognitive dysfunction. The literature on this topic mostly reflects patient-reported measurements. Our goal was to assess cognitive function in patients with CRS using objective measures, including saccadic eye movements-a behavioral response reflecting cognitive and sensory information integration that is often compromised in conditions with impaired cognition. METHODS: Participants (N = 24 with CRS, N = 23 non-CRS healthy controls) enrolled from rhinology clinic underwent sinonasal evaluation, quality of life assessment (Sino-nasal Outcome Test 22 [SNOT-22]), and cognitive assessment with the Neuro-QOL Cognitive Function-Short Form, the Montreal Cognitive Assessment (MoCA), and recording of eye movements using video-oculography...
January 24, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38268107/tissue-specific-early-and-late-activated-lymphocytes-immunophenotype-in%C3%A2-chronic-rhinosinusitis-with-nasal%C3%A2-polyps
#15
JOURNAL ARTICLE
Soledad López-Enríquez, Cristina Porras-González, Ramón Moreno-Luna, Francisca Palomares, José Luis Muñoz-Bravo, Gonzalo Alba, Consuelo Santa-María, Juan Maza-Solano, Daniel Iván Martín-Jiménez, Antonio Pérez-Pérez, Rafael Moreno-Luna, Víctor Sánchez-Margalet, Serafín Sánchez-Gómez
T-cell activation in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) is enriched by late cytotoxic T cells. The proportion of early and intermediate activated cytotoxic T cells decreases in nasal polyps of patients with CRSwNP. Our results identify late activated cytotoxic T cells as potential biomarkers or therapeutic targets for patients with CRSwNP.
January 24, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38268100/nasoseptal-flap-with-extended-pedicle-dissection-based-on-the-maxillary-artery-clinical-series-of-55-cases
#16
JOURNAL ARTICLE
Alessandro Vinciguerra, Mario Turri-Zanoni, Marco Ferrari, Davide Mattavelli, Giorgio Sileo, Vittorio Rampinelli, Vincenzo Abbate, Benjamin Verillaud, Alberto Schreiber, Paolo Battaglia, Maurizio Bignami, Piero Nicolai, Paolo Castelnuovo, Philippe Herman
Nasoseptal flap with extended pedicle dissection is a low morbidity and high success rate flap. It is a flap that can be applied to reconstruct a wide range of ipsilateral skull base defects.
January 24, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38268099/chatgpt-4-performance-in-rhinology-a-clinical-case-series
#17
JOURNAL ARTICLE
Thomas Radulesco, Alberto Maria Saibene, Justin Michel, Luigi Angelo Vaira, Jérôme R Lechien
Chatbot Generative Pre-trained Transformer (ChatGPT)-4 indicated more than twice additional examinations than practitioners in the management of clinical cases in rhinology. The consistency between ChatGPT-4 and practitioner in the indication of additional examinations may significantly vary from one examination to another. The ChatGPT-4 proposed a plausible and correct primary diagnosis in 62.5% cases, while pertinent and necessary additional examinations and therapeutic regimen were indicated in 7.5%-30.0% and 7...
January 24, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38268092/frailty-is-an-independent-predictor-of-postoperative-rescue-medication-use-after-endoscopic-sinus-surgery
#18
JOURNAL ARTICLE
Kolin E Rubel, Andrea Lopez, Rory J Lubner, Diane L Lee, Kristen Yancey, Rakesh K Chandra, Naweed I Chowdhury, Justin H Turner
INTRODUCTION: The modified five-item frailty index (mFI-5) is a validated risk stratification tool with the ability to predict adverse outcomes following surgery. In this study, we sought to use mFI-5 to assess the potential relationship between unhealthy aging and postoperative endoscopic sinus surgery (ESS) outcomes. METHODS: Patients who underwent sinus surgery at Vanderbilt between 2014 and 2018 were identified and assessed using the mFI-5, which is calculated based on the presence of five comorbidities: diabetes mellitus, hypertension requiring medication, chronic obstructive pulmonary disease, congestive heart failure, and non-independent functional status...
January 24, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38266636/temperature-controlled-radiofrequency-ablation-for-the-treatment-of-chronic-rhinitis-two-year-outcomes-from-a-prospective-multicenter-trial
#19
JOURNAL ARTICLE
Masayoshi Takashima, J Pablo Stolovitzky, Randall A Ow, Stacey L Silvers, Chad M McDuffie, Marc Dean, Ahmad R Sedaghat, Bobby A Tajudeen
BACKGROUND: Minimally invasive temperature-controlled radiofrequency (TCRF) ablation of the posterior nasal nerve (PNN) demonstrated a significant larger treatment effect on the symptom burden of chronic rhinitis patients than a sham control (no energy delivery) at the 3-month primary endpoint of this trial. METHODS: Two-year posttreatment outcomes for patients treated in a prospective, multicenter, patient-blinded randomized controlled trial were determined by combining the index active treatment-arm and index control-arm crossover patients into a single group (after the primary endpoint) to evaluate the treatment effect durability and long-term effects on concomitant chronic rhinitis medication usage...
January 24, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38266634/correlation-between-inflammatory-biomarkers-and-disease-control-in-chronic-rhinosinusitis-with-nasal-polyps
#20
JOURNAL ARTICLE
Eugenio De Corso, Silvia Baroni, Stefano Settimi, Maria Elisabetta Onori, Tiziana di Cesare, Rodolfo Francesco Mastrapasqua, Francesca Sarlo, Daniele Penazzi, Giuseppe D'Agostino, Leandro Maria D'Auria, Gabriele De Maio, Anna Rita Fetoni, Jacopo Galli
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) may have a heterogeneous response to medical/surgical treatments based on endotypes. Data correlating biomarkers and severity of the disease are lacking. We aimed to determine if IL-5 and calprotectin may be useful in defining severity of disease and identifying uncontrolled patients. METHODS: This was a case-control study including 81 patients with diffuse CRSwNP who underwent at least one previous surgery and treated with intranasal steroids...
January 24, 2024: International Forum of Allergy & Rhinology
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