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International Forum of Allergy & Rhinology

Neil N Patel, Vasiliki Triantafillou, Ivy W Maina, Alan D Workman, Charles C L Tong, Edward C Kuan, Peter Papagiannopoulos, John V Bosso, Nithin D Adappa, James N Palmer, Michael A Kohanski, De'Broski R Herbert, Noam A Cohen
BACKGROUND: Solitary chemosensory cells (SCCs) are rare epithelial cells enriched in nasal polyps and are the primary source of interleukin-25 (IL-25), an innate cytokine eliciting T-helper 2 (Th2) immune response. Although it is proposed that SCCs are stimulated by antigens released by upper airway pathogens, the exogenous triggers of human SCCs remain elusive. We studied patients with noninvasive fungal rhinosinusitis to determine whether extracts of Aspergillus fumigatus and Alternaria alternata stimulate SCC proliferation as an early event in type 2 inflammation...
March 20, 2019: International Forum of Allergy & Rhinology
Riyadh Alhedaithy, Ahmed Alhussien, Ahmad Alroqi, Saud Alromaih, Mohammad Aloulah, Saad Alsaleh
BACKGROUND: Preserving the L-shaped strut during septoplasty is a crucial step in the prevention of several types of postoperative nasal deformities. In this study, we aimed to identify the intranasal anatomic landmarks to establish reliable and feasible measurements to preserve an adequate L-strut during an endoscopic septoplasty. METHODS: A prospective study was conducted on 20 cadaver heads. Three measurements were studied within each side of the nasal cavity...
March 18, 2019: International Forum of Allergy & Rhinology
Daniel A Donoho, Cali E Johnson, Kevin T Hur, Ian A Buchanan, Vance L Fredrickson, Michael Minneti, Gabriel Zada, Bozena B Wrobel
BACKGROUND: Internal carotid artery injury (ICAI) is a rare, life-threatening complication of endoscopic endonasal approaches (EEAs). High-fidelity simulation methods exist, but optimization of the training cohort, training paradigm, and costs of simulation training remain unknown. METHODS: Using our previously validated, high-fidelity, perfused-cadaver model, participants attempted to manage a simulated ICAI. After a brief instructional video and coaching, the simulation was repeated...
March 18, 2019: International Forum of Allergy & Rhinology
Lauren F Tracy, Saikat Basu, Parth V Shah, Dennis O Frank-Ito, Snigdha Das, Adam M Zanation, Julia S Kimbell
BACKGROUND: Endoscopic craniofacial resections (CFR) are performed for extensive anterior skull base lesions. This surgery involves removal of multiple intranasal structures, potentially leading to empty nose syndrome (ENS). However, many patients remain asymptomatic postoperatively. Our objective was to analyze the impact of CFR on nasal physiology and airflow using computational fluid dynamics (CFD). This is the first CFD analysis of post-CFR patients. METHODS: Three-dimensional sinonasal models were constructed from 3 postoperative images using MimicsTM ...
March 12, 2019: International Forum of Allergy & Rhinology
David W Kennedy
No abstract text is available yet for this article.
March 8, 2019: International Forum of Allergy & Rhinology
Zainab Farzal, Saikat Basu, Alyssa Burke, Olulade O Fasanmade, Erin M Lopez, William D Bennett, Charles S Ebert, Adam M Zanation, Brent A Senior, Julia S Kimbell
BACKGROUND: Topical intranasal drugs are widely prescribed for chronic rhinosinusitis (CRS), although delivery can vary with device type and droplet size. The study objective was to compare nebulized and sprayed droplet deposition in the paranasal sinuses and ostiomeatal complex (OMC) across multiple droplet sizes in CRS patients using computational fluid dynamics (CFD). METHODS: Three-dimensional models of sinonasal cavities were constructed from computed tomography (CT) scans of 3 subjects with CRS refractory to medical therapy using imaging software...
March 1, 2019: International Forum of Allergy & Rhinology
Nicholas R Rowan, Rodney J Schlosser, Kristina A Storck, Kimia G Ganjaei, Zachary M Soler
BACKGROUND: Cognitive dysfunction in chronic rhinosinusitis (CRS) is often overlooked despite potentially broad implications. Earlier work has demonstrated decreased cognitive function in CRS patients at baseline. In this study we sought to prospectively evaluate the impact of initial, appropriate medical therapy on subjective and objective cognitive function, fatigue, and workplace productivity. METHODS: Adult patients with CRS were prospectively enrolled and completed a robust battery of pretreatment quality-of-life and neurocognitive testing, before undergoing appropriate medical therapy with follow-up testing at 6 weeks...
February 27, 2019: International Forum of Allergy & Rhinology
Edward El Rassi, Nithin D Adappa, Paolo Battaglia, Paolo Castelnuovo, Iacopo Dallan, Suzanne K Freitag, Paul A Gardner, Ricardo Lenzi, Darlene Lubbe, Ralph Metson, Kris S Moe, Luca Muscatello, Hamzah Mustak, João Flávio Nogueira, James N Palmer, Narayanan Prepageran, Vijay R Ramakirshnan, Raymond Sacks, Carl H Snyderman, S Tonya Stefko, Mario Turri-Zanoni, Eric W Wang, Bing Zhou, Benjamin S Bleier
BACKGROUND: Orbital cavernous hemangiomas (OCH) are the most common adult orbital tumor and represent an ideal index lesion for endonasal orbital tumor surgery. In order to standardize outcomes reporting, an anatomic-based staging system was developed. METHODS: An international, multidisciplinary panel of 23 experts in orbital tumor surgery was formed. A modified Delphi method was used to develop the cavernous hemangioma exclusively endonasal resection (CHEER) staging system with a total of 2 rounds being completed...
February 27, 2019: International Forum of Allergy & Rhinology
Boo-Young Kim, Ju Yeon Park, Eui Jin Kim, Byung Guk Kim, Sung Won Kim, Soo Whan Kim
BACKGROUND: Several studies have reported the benefits of olfactory training (OT) in the olfactory nervous system of mouse models. Therefore, in this study we performed next-generation sequencing to evaluate the effects of OT on mRNA sequencing in the olfactory area. METHODS: Mice in each group were administered 300 mg of 3-methylindole per kilogram of mouse weight. The olfactory function was evaluated by a food-finding test once a week. The olfactory neuroepithelium was harvested for histologic examination and protein analysis...
February 21, 2019: International Forum of Allergy & Rhinology
Giuseppe Brescia, Lara Alessandrini, Claudia Zanotti, Daniela Parrino, Giulia Tealdo, Miriam Torsello, Vladislav Zybine, Luciano Giacomelli, Umberto Barion, Gino Marioni
BACKGROUND: There is a dearth of information regarding the histological and hematological differences between primary and recurrent chronic rhinosinusitis with nasal polyps (CRSwNP). The present study analyzed the histological changes in recurrent CRSwNP in terms of eosinophilic infiltrate, subepithelial edema, goblet cell hyperplasia, and basement membrane thickness. Blood levels of eosinophils and basophils were also measured prior to surgery on both primary and recurrent disease. METHODS: Thirty-two consecutive adult patients with nasal polyposis treated with primary surgery who subsequently underwent revision surgery were retrospectively enrolled...
February 20, 2019: International Forum of Allergy & Rhinology
Spencer C Payne, Jose L Mattos, Ashwini Tilak, Heather Koehn
No abstract text is available yet for this article.
February 18, 2019: International Forum of Allergy & Rhinology
Alan D Workman, Angela L Nocera, Sarina K Mueller, Hasan H Otu, Towia A Libermann, Benjamin S Bleier
BACKGROUND: Much of the literature examining chronic rhinosinusitis with nasal polyps (CRSwNP) immunopathology has been predicated on messenger RNA (mRNA) analysis with the assumption that transcriptional changes would reflect end-effector protein expression. The purpose of this study was to test this hypothesis using matched transcriptomic and proteomic data sets. METHODS: Matched tissue proteomic and transcriptomic arrays were quantified in CRSwNP polyp tissue and control inferior turbinate tissue (n = 10/group)...
February 18, 2019: International Forum of Allergy & Rhinology
Alan D Workman, Nathalia Velasquez, Nayel I Khan, Nicole A Borchard, Edward C Kuan, James N Palmer, Eric W Wang, Zara M Patel, Nithin D Adappa
BACKGROUND: Sinonasal malignancies are a rare subset of head and neck tumors, and surveillance strategies after definitive tumor treatment are often generalized from those for overall head and neck cancer outcomes data. However, recent literature suggests that the posttreatment period in sinonasal cancer is fundamentally different and a more tailored surveillance approach may be beneficial. Although rates of symptomatology are high in head and neck cancer recurrence and patient-driven follow-up is common, rates of symptomatology are unknown in sinonasal cancer specifically...
February 15, 2019: International Forum of Allergy & Rhinology
Sandra Y Lin
No abstract text is available yet for this article.
February 14, 2019: International Forum of Allergy & Rhinology
Mathew Geltzeiler, Ricardo Carrau, Rakesh Chandra, James Palmer, Rodney Schlosser, Timothy Smith, Sarah Wise, Bradford Woodworth
No abstract text is available yet for this article.
February 13, 2019: International Forum of Allergy & Rhinology
Dong Chang Lee, Hyunsu Choi, Jeong-Min Oh, Do Hee Lee, Sung Won Kim, Soo Whan Kim, Byung Guk Kim, Jin Hee Cho, Joohyung Lee
BACKGROUND: Exposure to urban particulate matter (UPM) has been studied as a cause of various health problems. Although the association between UPM and the respiratory tract has been well studied, further research is required to characterize the effects of UPM on the upper respiratory tract. We investigated the effects of UPM-induced reactive oxygen species (ROS) production on cultured human nasal fibroblasts, as well as the protective effects of α-lipoic acid (ALA) on ROS production and the underlying signaling pathways involved in ROS inhibition...
February 13, 2019: International Forum of Allergy & Rhinology
Chandala Chitguppi, Ryan A Rimmer, Hermes G Garcia, Ian J Koszewski, Judd H Fastenberg, Gurston G Nyquist, Marc R Rosen, Colin Huntley, Mindy R Rabinowitz, James J Evans
BACKGROUND: Although recent guidelines for obstructive sleep apnea recommend early postoperative use of continuous positive airway pressure (CPAP) after endonasal skull base surgery, the time of initiation of CPAP is unclear. In this study we used a novel, previously validated cadaveric model to analyze the pressures delivered to the cranial base and evaluate the effectiveness of various repair techniques to withstand positive pressure. METHODS: Skull base defects were surgically created in 3 fresh human cadaver heads and repaired using 3 commonly used repair techniques: (1) Surgicel™ onlay; (2) dural substitute underlay with dural sealant onlay; and (3) dural substitute underlay with nasoseptal flap onlay with dural sealant...
February 12, 2019: International Forum of Allergy & Rhinology
Nam-Kyung Yeo, Woo Joo Park, Daeo-Woon Eom, Mi Young Oh, Ji Hwan Lee
BACKGROUND: Oral steroids are recommended for the treatment of nasal polyps (NPs), but prolonged use is avoided because of side effects. Topical steroids can also control NPs without significant complications; however, the response to this is partially successful, and additional therapies are needed to treat glucocorticoid-resistant NPs. Azathioprine (AZA) and its first metabolite 6-mercaptopurine (6-MP) are important immunosuppressants used for the therapy of various diseases. The aim of this study was to investigate the effects of AZA and 6-MP on inflammatory cytokines in organ-cultured NPs...
February 12, 2019: International Forum of Allergy & Rhinology
Chen Zhuo, Lyu Lei, Zhao Yulin, Liu Wentao, Wu Shuangxia, Wang Chao, Zhang Yaqian, Huang Shuman, Dong Dong
BACKGROUND: Three-dimensional (3D) printed models have been shown to be promising in surgical training in rhinology. The objectives of this study were to develop a set of 3D-printed models including the pediatric and adult nasal cavity, and the postsurgical paranasal sinuses, and to assess the face and content validity in endoscopic training. METHODS: The computed tomography (CT) data of a pediatric patient without nasal disorders and an adult patient with nasal septal deviation were selected to produce the models of the pediatric and adult nasal cavity, and the CT data of an adult patient who underwent endoscopic sinus surgery 4 months ago was chosen to create the paranasal sinus model...
February 12, 2019: International Forum of Allergy & Rhinology
Lisa Mary Cherian, Clare Cooksley, Katharina Richter, Mahnaz Ramezanpour, Sathish Paramasivan, Peter-John Wormald, Sarah Vreugde, Alkis James Psaltis
BACKGROUND: Topical budesonide (Pulmicort; AstraZeneca AB, Sodertalje, Sweden) is commonly used in the management of chronic rhinosinusitis (CRS). Although its use is due to its perceived anti-inflammatory effect, studies have suggested that it may also have antibacterial properties. To make the hydrophobic steroid molecule suitable for topical administration, pharmaceutical excipients are used in commercial steroid formulations. Herein we investigated the antibacterial action of commercial budesonide and its excipients...
February 12, 2019: International Forum of Allergy & Rhinology
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