journal
https://read.qxmd.com/read/36926660/exposure-to-proton-pump-inhibitors-and-risk-of-diabetes-a-systematic-review-and-meta-analysis
#1
JOURNAL ARTICLE
Yun-Ran Guo, Xin-Ming Liu, Gui-Xia Wang
BACKGROUND: Exposure to proton pump inhibitors (PPIs) has been reported to have a potential role in the development of diabetes. AIM: To determine the association between PPIs and diabetes. METHODS: This meta-analysis is registered on PROSPERO (CRD42022352704). In August 2022, eligible studies were identified through a comprehensive literature search. In this study, odds ratios were combined with 95% confidence intervals using a random-effects model...
February 15, 2023: World Journal of Diabetes
https://read.qxmd.com/read/36926659/insulin-a-connection-between-pancreatic-%C3%AE-cells-and-the-hypothalamus
#2
REVIEW
Brenda De la Cruz Concepción, Yaccil Adilene Flores Cortez, Martha Isela Barragán Bonilla, Juan Miguel Mendoza Bello, Monica Espinoza Rojo
Insulin is a hormone secreted by pancreatic β cells. The concentration of glucose in circulation is proportional to the secretion of insulin by these cells. In target cells, insulin binds to its receptors and activates phosphatidylinositol-3-kinase/protein kinase B, inducing different mechanisms depending on the cell type. In the liver it activates the synthesis of glycogen, in adipose tissue and muscle it allows the capture of glucose, and in the hypothalamus, it regulates thermogenesis and appetite...
February 15, 2023: World Journal of Diabetes
https://read.qxmd.com/read/36926658/diabetes-and-cognitive-function-an-evidence-based-current-perspective
#3
REVIEW
Meghna Julian Sebastian, Shahanas Ka Khan, Joseph M Pappachan, Mohammad Sadiq Jeeyavudeen
Several epidemiological studies have clearly identified diabetes mellitus (DM) as a major risk factor for cognitive dysfunction, and it is going to be a major public health issue in the coming years because of the alarming rise in diabetes prevalence across the world. Brain and neural tissues predominantly depend on glucose as energy substrate and hence, any alterations in carbohydrate meta-bolism can directly impact on cerebral functional output including cognition, executive capacity, and memory. DM affects neuronal function and mental capacity in several ways, some of which include hypoperfusion of the brain tissues from cerebrovascular disease, diabetes-related alterations of glucose transporters causing abnormalities in neuronal glucose uptake and metabolism, local hyper- and hypometabolism of brain areas from insulin resistance, and recurrent hypoglycemic episodes inherent to pharmacotherapy of diabetes resulting in neuronal damage...
February 15, 2023: World Journal of Diabetes
https://read.qxmd.com/read/36926657/protective-effect-of-liraglutide-on-the-myocardium-of-type-2-diabetic-rats-by-inhibiting-polyadenosine-diphosphate-ribose-polymerase-1
#4
JOURNAL ARTICLE
Dong-Dong Xue, Xiang Zhang, De-Wei Li, Yan-Lan Yang, Jing-Jin Liu
BACKGROUND: In recent years, studies have found that the occurrence and development of diabetic cardiomyopathy (DCM) is closely related to an increase in polyadenosine diphosphate-ribose polymerase-1 (PARP-1) activity. PARP-1 activation could be involved in the pathophysiological process of DCM by promoting oxidative stress, the inflammatory response, apoptosis and myocardial fibrosis. AIM: To investigate the mechanism of liraglutide in improving myocardial injury in type 2 diabetic rats, further clarified the protective effect of liraglutide on the heart, and provided a new option for the treatment of DCM...
February 15, 2023: World Journal of Diabetes
https://read.qxmd.com/read/36926656/modulatory-effect-of-caffeic-acid-in-alleviating-diabetes-and-associated-complications
#5
REVIEW
Risha Ganguly, Shiv Vardan Singh, Kritika Jaiswal, Ramesh Kumar, Abhay K Pandey
Diabetes mellitus (DM) is one of the most common metabolic disorders characterized by elevated blood glucose levels. Prolonged uncontrolled hyperglycemia often leads to multi-organ damage including diabetic neuropathy, nephropathy, retinopathy, cardiovascular disorders, and diabetic foot ulcers. Excess production of free radicals causing oxidative stress in tissues is often considered to be the primary cause of onset and progression of DM and associated complications. Natural polyphenols can be used to induce or inhibit the expression of antioxidant enzymes such as glutathione peroxidase, heme oxygenase-1, superoxide dismutase, and catalase that are essential in maintaining redox balance, and ameliorate oxidative stress...
February 15, 2023: World Journal of Diabetes
https://read.qxmd.com/read/36684386/association-of-vitamin-d-and-magnesium-with-insulin-sensitivity-and-their-influence-on-glycemic-control
#6
REVIEW
Wan Nor Fazila Hafizan Wan Nik, Hani Ajrina Zulkeflee, Siti Nadirah Ab Rahim, Tuan Salwani Tuan Ismail
Insulin resistance increases the risk of developing diabetes, and the degree of resistance influences the glycemic control of patients with diabetes. Numerous researchers have focused on improving insulin sensitivity in order to prevent diabetes-related complications and other chronic diseases. Several studies have also linked vitamin D levels to insulin secretion and resistance, given that both vitamin D and its receptor complex play important roles in regulating pancreatic β-cells. It has been suggested that vitamin D supplementation improves vitamin D levels, but further research is needed to confirm this as neither insulin function nor glycemic control improves when vitamin D levels increase...
January 15, 2023: World Journal of Diabetes
https://read.qxmd.com/read/36684385/advances-in-microfluidic-chips-based-on-islet-hormone-sensing-techniques
#7
REVIEW
Wei Li, You-Fan Peng
Diabetes mellitus is a global health problem resulting from islet dysfunction or insulin resistance. The mechanisms of islet dysfunction are still under investigation. Islet hormone secretion is the main function of islets, and serves an important role in the homeostasis of blood glucose. Elucidating the detailed mechanism of islet hormone secretome distortion can provide clues for the treatment of diabetes. Therefore, it is crucial to develop accurate, real-time, labor-saving, high-throughput, automated, and cost-effective techniques for the sensing of islet secretome...
January 15, 2023: World Journal of Diabetes
https://read.qxmd.com/read/36684384/future-applications-of-exosomes-delivering-resolvins-and-cytokines-in-facilitating-diabetic-foot-ulcer-healing
#8
REVIEW
Joshua P B Littig, Rebecca Moellmer, Devendra K Agrawal, Vikrant Rai
Type 2 diabetes mellitus (T2DM) increases the risk of many lethal and debilitating conditions. Among them, foot ulceration due to neuropathy, vascular disease, or trauma affects the quality of life of millions in the United States and around the world. Physiological wound healing is stalled in the inflammatory phase by the chronicity of inflammation without proceeding to the resolution phase. Despite advanced treatment, diabetic foot ulcers (DFUs) are associated with a risk of amputation. Thus, there is a need for novel therapies to address chronic inflammation, decreased angiogenesis, and impaired granulation tissue formation contributing to the non-healing of DFUs...
January 15, 2023: World Journal of Diabetes
https://read.qxmd.com/read/36684383/gut-region-specific-tnfr-expression-tnfr2-is-more-affected-than-tnfr1-in-duodenal-myenteric-ganglia-of-diabetic-rats
#9
JOURNAL ARTICLE
Bence Pál Barta, Benita Onhausz, Afnan Al Doghmi, Zita Szalai, János Balázs, Mária Bagyánszki, Nikolett Bódi
BACKGROUND: Cytokines are essential in autoimmune inflammatory processes that accompany type 1 diabetes. Tumor necrosis factor alpha plays a key role among others in modulating enteric neuroinflammation, however, it has a dual role in cell degeneration or survival depending on different TNFRs. In general, TNFR1 is believed to trigger apoptosis, while TNFR2 promotes cell regeneration. The importance of the neuronal microenvironment has been recently highlighted in gut region-specific diabetic enteric neuropathy, however, the expression and alterations of different TNFRs in the gastrointestinal tract has not been reported...
January 15, 2023: World Journal of Diabetes
https://read.qxmd.com/read/36684382/current-scenario-of-traditional-medicines-in-management-of-diabetic-foot-ulcers-a-review
#10
REVIEW
Abhijit S Rayate, Basavraj S Nagoba, Sachin S Mumbre, Hardi B Mavani, Ajay M Gavkare, Advait S Deshpande
Diabetic foot infections and diabetic foot ulcers (DFU) cause significant suffering and are often recurring. DFU have three important pathogenic factors, namely, microangiopathy causing local tissue anoxia, neuropathy making the foot prone to injuries from trivial trauma, and local tissue hyperglycaemia favouring infection and delaying the wound healing. DFU have been the leading cause for non-traumatic amputations of part or whole of the limb. Western medicines focus mainly on euglycaemia, antimicrobials, debridement and wound cover with grafts, and off-loading techniques...
January 15, 2023: World Journal of Diabetes
https://read.qxmd.com/read/36578875/the-role-of-artificial-intelligence-technology-in-the-care-of-diabetic-foot-ulcers-the-past-the-present-and-the-future
#11
REVIEW
Joseph M Pappachan, Bill Cassidy, Cornelius James Fernandez, Vishnu Chandrabalan, Moi Hoon Yap
Foot ulcers are common complications of diabetes mellitus and substantially increase the morbidity and mortality due to this disease. Wound care by regular monitoring of the progress of healing with clinical review of the ulcers, dressing changes, appropriate antibiotic therapy for infection and proper offloading of the ulcer are the cornerstones of the management of foot ulcers. Assessing the progress of foot ulcers can be a challenge for the clinician and patient due to logistic issues such as regular attendance in the clinic...
December 15, 2022: World Journal of Diabetes
https://read.qxmd.com/read/36578874/keeping-an-eye-on-the-diabetic-foot-the-connection-between-diabetic-eye-disease-and-wound-healing-in-the-lower-extremity
#12
REVIEW
David J Ramsey, James T Kwan, Arjun Sharma
Diabetic eye disease is strongly associated with the development of diabetic foot ulcers (DFUs). DFUs are a common and significant complication of diabetes mellitus (DM) that arise from a combination of micro- and macrovascular compromise. Hyperglycemia and associated metabolic dysfunction in DM lead to impaired wound healing, immune dysregulation, peripheral vascular disease, and diabetic neuropathy that predisposes the lower extremities to repetitive injury and progressive tissue damage that may ultimately necessitate amputation...
December 15, 2022: World Journal of Diabetes
https://read.qxmd.com/read/36578873/hyperbaric-oxygen-therapy-and-chemokine-administration-a-combination-with-potential-therapeutic-value-for-treating-diabetic-wounds
#13
REVIEW
Jagannathan Venkataseshan, Pragasam Viswanathan
Non-healing wounds impart serious medical problems to people with diabetes. Amongst 15% of diabetic patients, the incidence of foot ulcer is the most prevailing, which confers a significant risk of limb amputation, mainly due to hypoxia and impairment in cell signaling. Alteration in the expression of chemokines and the related factors in diabetic conditions delays the recruitment of different cell types, including fibroblasts, keratinocytes, and immune cells such as macrophages to the site of injury, further impairing neovasculogenesis, re-epithelialization, and extracellular matrix formation...
December 15, 2022: World Journal of Diabetes
https://read.qxmd.com/read/36578872/comparison-of-gliclazide-vs-linagliptin-on-hypoglycemia-and-cardiovascular-events-in-type-2-diabetes-mellitus-a-systematic-review
#14
JOURNAL ARTICLE
Viswanathan Mohan, Subhash Wangnoo, Sambit Das, Rajnish Dhediya, Kumar Gaurav
BACKGROUND: Cardiovascular outcome trials have demonstrated cardiovascular safety of glimepiride (a sulfonylureas) against dipeptidyl peptidase-4 inhibitor linagliptin. Gliclazide (another newer sulfonylureas) has shown similar glycemic efficacy and 50% decreased risk of hypoglycemia compared to glimepiride. AIM: Considering the absence of cardiovascular outcome trials for gliclazide, we decided to conduct a systematic review of the literature to assess the car-diovascular (CV) safety by assessing the risk for major adverse CV events and hypoglycemia risk of gliclazide vs linagliptin in patients with type 2 diabetes (T2D)...
December 15, 2022: World Journal of Diabetes
https://read.qxmd.com/read/36578871/diabetic-foot-ulcers-classification-risk-factors-and-management
#15
REVIEW
Xuan Wang, Chong-Xi Yuan, Bin Xu, Zhi Yu
Diabetic foot ulceration is a devastating complication of diabetes that is associated with infection, amputation, and death, and is affecting increasing numbers of patients with diabetes mellitus. The pathogenesis of foot ulcers is complex, and different factors play major roles in different stages. The refractory nature of foot ulcer is reflected in that even after healing there is still a high recurrence rate and amputation rate, which means that management and nursing plans need to be considered carefully...
December 15, 2022: World Journal of Diabetes
https://read.qxmd.com/read/36578870/diabetic-foot-ulcer-challenges-and-future
#16
REVIEW
Li Yang, Gui-Chuan Rong, Qi-Nan Wu
Diabetic foot ulcers (DFUs) have become one of the important causes of mortality and morbidity in patients with diabetes, and they are also a common cause of hospitalization, which places a heavy burden on patients and society. The prevention and treatment of DFUs requires multidisciplinary management. By controlling various risk factors, such as blood glucose levels, blood pressure, lipid levels and smoking cessation, local management of DFUs should be strengthened, such as debridement, dressing, revascularization, stem cell decompression and oxygen therapy...
December 15, 2022: World Journal of Diabetes
https://read.qxmd.com/read/36578869/single-nucleotide-variations-in-the-development-of-diabetic-foot-ulcer-a-narrative-review
#17
REVIEW
Yan-Jun Hu, Chen-Sheng Song, Nan Jiang
Diabetes mellitus has become a global health problem, and the number of patients with diabetic foot ulcers (DFU) is rapidly increasing. Currently, DFU still poses great challenges to physicians, as the treatment is complex, with high risks of infection, recurrence, limb amputation, and even death. Therefore, a comprehensive understanding of DFU pathogenesis is of great importance. In this review, we summarized recent findings regarding the DFU development from the perspective of single-nucleotide variations (SNVs)...
December 15, 2022: World Journal of Diabetes
https://read.qxmd.com/read/36578868/baseline-moderate-range-albuminuria-is-associated-with-protection-against-severe-covid-19-pneumonia
#18
JOURNAL ARTICLE
Amir Bashkin, Mona Shehadeh, Lina Shbita, Kamil Namoura, Ronza Haiek, Elena Kuyantseva, Yousef Boulos, Orly Yakir, Etty Kruzel-Davila
BACKGROUND: Diabetes mellitus is considered a leading contributor to severe coronavirus disease 2019 (COVID-19). AIM: To characterize differences between hospitalized diabetic patients with vs without COVID-19, and parameters associated with COVID-19 severity for prediction. METHODS: This case-control study included 209 patients with type 2 diabetic mellitus hospitalized at the Galilee Medical Center (Nahariya, Israel) and recruited between September 2020 and May 2021, 65 patients with COVID-19 infection in dedicated wards and 144 COVID-19-negative patients in internal medicine wards hospitalized due to other reasons...
December 15, 2022: World Journal of Diabetes
https://read.qxmd.com/read/36578867/mesenchymal-stem-cell-derived-exosomes-the-dawn-of-diabetic-wound-healing
#19
REVIEW
Jing Wu, Li-Hong Chen, Shi-Yi Sun, Yan Li, Xing-Wu Ran
Chronic wound healing has long been an unmet medical need in the field of wound repair, with diabetes being one of the major etiologies. Diabetic chronic wounds (DCWs), especially diabetic foot ulcers, are one of the most threatening chronic complications of diabetes. Although the treatment strategies, drugs, and dressings for DCWs have made great progress, they remain ineffective in some patients with refractory wounds. Stem cell-based therapies have achieved specific efficacy in various fields, with mesenchymal stem cells (MSCs) being the most widely used...
December 15, 2022: World Journal of Diabetes
https://read.qxmd.com/read/36578866/prehabilitation-of-overweight-and-obese-patients-with-dysglycemia-awaiting-bariatric-surgery-predicting-the-success-of-obesity-treatment
#20
REVIEW
Maja Cigrovski Berkovic, Ines Bilic-Curcic, Anna Mrzljak, Silvija Canecki Varzic, Vjekoslav Cigrovski
Bariatric surgery offers the best health results in overweight and obese patients but is not a risk and/or complication-free treatment. In cases with additional hyperglycemia, the burden of surgery can be even higher and alter both short-term and long-term outcomes. Although bariatric surgery offers glycemic improvements and in the case of early onset diabetes disease remission, weight loss results are lower than for obese patients without diabetes. Different multimodal programs, usually including interventions related to patients' performance, nutritional and psychological status as well as currently available pharmacotherapy before the surgery itself might considerably improve the immediate and late postoperative course...
December 15, 2022: World Journal of Diabetes
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