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Frontiers in Neurology

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https://read.qxmd.com/read/30766509/triple-drug-therapy-with-bevacizumab-irinotecan-and-temozolomide-plus-tumor-treating-fields-for-recurrent-glioblastoma-a-retrospective-study
#1
Guangrong Lu, Mayank Rao, Ping Zhu, Buqing Liang, Rasheda T El-Nazer, Ekokobe Fonkem, Meenakshi B Bhattacharjee, Jay-Jiguang Zhu
Clinical studies treating pediatric and adult solid tumors, such as glioblastoma (GBM), with a triple-drug regimen of temozolomide (TMZ), bevacizumab (BEV), and irinotecan (IRI) [TBI] have demonstrated various efficacies, but with no unexpected toxicities. The TBI regimen has never been studied in recurrent GBM (rGBM) patients. In this retrospective study, we investigated the outcomes and side effects of rGBM patients who had received the TBI regimen. We identified 48 adult rGBM patients with a median age of 56 years (range: 26-76), who received Tumor Treating Fields (TTFields) treatment for 30 days or longer, and concurrent salvage chemotherapies...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30766508/effectiveness-of-robot-assisted-upper-limb-training-on-spasticity-function-and-muscle-activity-in-chronic-stroke-patients-treated-with-botulinum-toxin-a-randomized-single-blinded-controlled-trial
#2
Marialuisa Gandolfi, Nicola Valè, Eleonora Kirilova Dimitrova, Stefano Mazzoleni, Elena Battini, Mirko Filippetti, Alessandro Picelli, Andrea Santamato, Michele Gravina, Leopold Saltuari, Nicola Smania
Background: The combined use of Robot-assisted UL training and Botulinum toxin (BoNT) appear to be a promising therapeutic synergism to improve UL function in chronic stroke patients. Objective: To evaluate the effects of Robot-assisted UL training on UL spasticity, function, muscle strength and the electromyographic UL muscles activity in chronic stroke patients treated with Botulinum toxin. Methods: This single-blind, randomized, controlled trial involved 32 chronic stroke outpatients with UL spastic hemiparesis...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30766507/can-intestinal-pseudo-obstruction-drive-recurrent-stroke-like-episodes-in-late-onset-melas-syndrome-a-case-report-and-review-of-the-literature
#3
Delia Gagliardi, Eleonora Mauri, Francesca Magri, Daniele Velardo, Megi Meneri, Elena Abati, Roberta Brusa, Irene Faravelli, Daniela Piga, Dario Ronchi, Fabio Triulzi, Lorenzo Peverelli, Monica Sciacco, Nereo Bresolin, Giacomo Pietro Comi, Stefania Corti, Alessandra Govoni
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a maternally inherited mitochondrial disorder that is most commonly caused by the m. 3243A>G mutation in the MT-TL1 mitochondrial DNA gene, resulting in impairment of mitochondrial energy metabolism. Although childhood is the typical age of onset, a small fraction (1-6%) of individuals manifest the disease after 40 years of age and usually have a less aggressive disease course. The clinical manifestations are variable and mainly depend on the degree of heteroplasmy in the patient's tissues and organs...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761078/a-smart-device-system-to-identify-new-phenotypical-characteristics-in-movement-disorders
#4
Julian Varghese, Stephan Niewöhner, Iñaki Soto-Rey, Stephanie Schipmann-Miletić, Nils Warneke, Tobias Warnecke, Martin Dugas
Parkinson's disease and Essential Tremor are two of the most common movement disorders and are still associated with high rates of misdiagnosis. Collected data by technology-based objective measures (TOMs) has the potential to provide new promising and highly accurate movement data for a better understanding of phenotypical characteristics and diagnostic support. A technology-based system called Smart Device System (SDS) is going to be implemented for multi-modal high-resolution acceleration measurement of patients with PD or ET within a clinical setting...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761077/vestibule-middle-ear-dehiscence-tested-with-perilymph-specific-protein-cochlin-tomoprotein-ctp-detection-test
#5
Takeshi Fujita, Takaaki Kobayashi, Kazuya Saito, Toru Seo, Tetsuo Ikezono, Katsumi Doi
An 8-year-old boy was referred to the ENT department for further evaluation of right-sided conductive hearing loss. A small cyst anterior to the oval window and fixation of the stapes footplate were observed during an exploratory tympanotomy. The concentration of a perilymph-specific protein, cochlin-tomoprotein (CTP), in the middle ear lavage fluid was measured with an ELISA-based CTP detection kit. The level of CTP in the middle ear lavage fluid before fenestration of the cyst was 0.26 ng/ml (negative), and its level after fenestration was 2...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761076/comparison-of-clopidogrel-and-ticlopidine-ginkgo-biloba-in-patients-with-clopidogrel-resistance-and-carotid-stenting
#6
Jong-Won Chung, Suk Jae Kim, Jaechun Hwang, Mi Ji Lee, Jun Lee, Kyung-Yul Lee, Man-Seok Park, Sang Min Sung, Keon Ha Kim, Pyoung Jeon, Oh Young Bang
Background and Purpose: Patients undergoing carotid artery stenting (CAS) who show low responsiveness to clopidogrel may have a higher risk of peri-procedural embolic events. This study aimed to compare the effectiveness and safety of clopidogrel and ticlopidine plus Ginkgo biloba in clopidogrel-resistant patients undergoing CAS. Methods: In this multi-center, randomized, controlled trial, we used platelet reactivity test to select patients undergoing CAS who showed clopidogrel resistance, and compared treatments using clopidogrel and ticlopidine plus ginkgo...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761075/short-term-surgical-outcome-for-vestibular-schwannoma-in-sweden-a-nation-wide-registry-study
#7
Jiri Bartek, Petter Förander, Erik Thurin, Theresa Wangerid, Roger Henriksson, Göran Hesselager, Asgeir Store Jakola
Background: Vestibular Schwannoma (VS) is a benign neoplasm arising from the 8th cranial nerve, with surgery one of the treatment modalities. In a nation-wide registry study, we describe the baseline, treatment characteristics, and short-term outcome in patients surgically treated for VS. Methods: We performed a nationwide study with data from the Swedish Brain Tumor Registry (SBTR) for all adults diagnosed with VS 2009-2015. Patient symptoms, tumor characteristics, and postoperative complications were analyzed...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761074/quality-of-life-in-brain-cancer-clinical-validation-of-the-mexican-spanish-version-of-the-eortc-qlq-bn20-questionnaire
#8
Bernardo Cacho-Díaz, Nydia A Lorenzana-Mendoza, Luis F Oñate-Ocaña
Background: Overall survival (OS) of patients with Brain Cancer (BC) is slowly increasing. The disease itself and its treatments deeply impact patient Health-related quality of life (HRQL). Therefore, valid and reliable instruments are needed. In this study, the Mexican-Spanish version of the QLQ-BN20 instrument is psychometrically and clinically validated. Methods: Patients with brain cancer (BC) (primary or metastatic) evaluated at a tertiary cancer center, were invited to respond to the questionnaire, as well as the core-module QLQ-C30...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761073/commentary-idiopathic-intracranial-hypertension-without-papilledema-iihwop-in-chronic-refractory-headache
#9
COMMENT
Roberto De Simone, Angelo Ranieri
No abstract text is available yet for this article.
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761072/association-of-two-polymorphisms-in-ccl2-with-parkinson-s-disease-a-case-control-study
#10
Ruinan Shen, Suzhen Lin, Lu He, Xue Zhu, Zhekun Zhou, Shengdi Chen, Ying Wang, Jianqing Ding
Background: Parkinson's disease (PD) is the most common neurodegenerative movement disorder that is known to be related to neuro-inflammation. Chemokines participate in this process usually through upregulation of expression levels, which are closely related to the polymorphisms in their genes. Recent studies have further revealed the association between these polymorphisms and the risk of PD in multiple populations, but not the Chinese Han population. Methods: The promoter region of CCL2 was sequenced in 411 PD patients and 422 gender-age matched control from a Chinese Han population using PCR-RFLP method...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761071/burden-of-care-implications-and-association-of-intracranial-hypertension-with-extremely-severe-post-traumatic-amnesia-after-traumatic-brain-injury-a-5-year-retrospective-longitudinal-study
#11
Nhung T Quach, Reza Ehsanian, Benjamin Dirlikov, Samantha Sechrist, Jyodi Mohole, Stephen McKenna, Linda Isaac, Thao T Duong
Post-traumatic amnesia (PTA) is characterized by a state of disorientation and confusion following traumatic brain injury (TBI). Few studies have looked at the effect of prolonged PTA on the functional outcomes beyond 1 year post-injury. This study aims to evaluate the burden of care in individuals with extremely severe PTA (esPTA; PTA >28 days) from acute inpatient rehabilitation admission to 5 years post-injury as well as the association between intracranial hypertension (ICH; Intracranial pressure (ICP) ≥20 mmHg) and esPTA status...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761070/functional-network-based-statistics-reveal-abnormal-resting-state-functional-connectivity-in-minimal-hepatic-encephalopathy
#12
Chuanyin Zhan, Hua-Jun Chen, Yong-Qing Gao, Tian-Xiu Zou
Purpose: Whole-brain functional network analysis is an emerging methodology for exploring the mechanisms underlying hepatic encephalopathy (HE). This study aimed to identify the brain subnetwork that is significantly altered within the functional connectome in minimal HE (MHE), the earliest stage of HE. Materials and Methods: The study enrolled 19 cirrhotic patients with MHE and 19 controls who underwent the resting-state functional magnetic resonance imaging and cognitive assessment based on the Psychometric Hepatic Encephalopathy Score (PHES)...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761069/transient-receptor-potential-vanilloid-1-modulates-central-inflammation-in-multiple-sclerosis
#13
Mario Stampanoni Bassi, Antonietta Gentile, Ennio Iezzi, Sara Zagaglia, Alessandra Musella, Ilaria Simonelli, Luana Gilio, Roberto Furlan, Annamaria Finardi, Girolama A Marfia, Livia Guadalupi, Silvia Bullitta, Georgia Mandolesi, Diego Centonze, Fabio Buttari
Introduction: Disease course of multiple sclerosis (MS) is negatively influenced by proinflammatory molecules released by activated T and B lymphocytes and local immune cells. The endovanilloid system plays different physiological functions, and preclinical data suggest that transient receptor potential vanilloid type 1 (TRPV1) could modulate neuroinflammation in this disorder. Methods: The effect of TRPV1 activation on the release of two main proinflammatory cytokines, tumor necrosis factor (TNF) and interleukin (IL)-6, was explored in activated microglial cells...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761068/biomarkers-in-spinal-cord-injury-prognostic-insights-and-future-potentials
#14
REVIEW
Ahmed A Albayar, Abigail Roche, Przemyslaw Swiatkowski, Sarah Antar, Nouran Ouda, Eman Emara, Douglas H Smith, Ali K Ozturk, Basem I Awad
Spinal Cord Injury (SCI) is a major challenge in Neurotrauma research. Complex pathophysiological processes take place immediately after the injury and later on as the chronic injury develops. Moreover, SCI is usually accompanied by traumatic injuries because the most common modality of injury is road traffic accidents and falls. Patients develop significant permanent neurological deficits that depend on the extent and the location of the injury itself and in time they develop further neurological and body changes that may risk their mere survival...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761067/ultrasound-evaluation-of-transient-ischemic-attack-caused-by-styloid-process-elongation-a-case-report
#15
Zhaoqiang Li, Yang Hua, Jie Yang, Jingzhi Li
Stylocarotid artery syndrome (SAS) is a type of Eagle syndrome, which is caused by the compression of the internal or external carotid artery (along with their perivascular sympathetic fibers) by an elongated styloid process, resulting in neurological symptoms including transient ischemic attack (TIA) and cervicofacial pain along the distribution of the artery. The authors describe the case of a 56-year-old man with a history of TIA of unknown origin, who underwent color Doppler flow imaging (CDFI) that detected an elongated styloid process and transcranial Doppler (TCD) monitoring that revealed changes in intracranial blood flow when turning his head...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761066/analysis-of-different-device-interactions-in-a-virtual-reality-task-in-individuals-with-duchenne-muscular-dystrophy-a-randomized-controlled-trial
#16
Bruna Leal de Freitas, Talita Dias da Silva, Tânia Brusque Crocetta, Thais Massetti, Luciano Vieira de Araújo, Shelly Coe, Helen Dawes, Fatima Aparecida Caromano, Carlos Bandeira de Mello Monteiro
There is a need to support individuals with Duchenne Muscular Dystrophy (DMD) to achieve optimal functionality in everyday life and with meaningful tasks and activities, throughout stages of the disease progression. Thus, technological developments have created an exciting opportunity for the use of affordable virtual reality (VR) systems with different kinds of interaction devices, providing an efficient and fun tool for enabling improvement in motor performance. Objective: To compare performance on a virtual task using interfaces with and without physical contact in order to identify functionality by using different devices in individuals with DMD...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761065/role-of-sonification-and-rhythmic-auditory-cueing-for-enhancing-gait-associated-deficits-induced-by-neurotoxic-cancer-therapies-a-perspective-on-auditory-neuroprosthetics
#17
Shashank Ghai, Ishan Ghai
Patients undergoing chemotherapy, radiotherapy, and immunotherapy experience neurotoxic changes in the central and peripheral nervous system. These neurotoxic changes adversely affect functioning in the sensory, motor, and cognitive domains. Thereby, considerably affecting autonomic activities like gait and posture. Recent evidence from a range of systematic reviews and meta-analyses have suggested the beneficial influence of music-based external auditory stimulations i.e., rhythmic auditory cueing and real-time auditory feedback (sonification) on gait and postural stability in population groups will balance disorders...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761064/probing-corticospinal-control-during-different-locomotor-tasks-using-detailed-time-frequency-analysis-of-electromyograms
#18
Linard Filli, Christian Meyer, Tim Killeen, Lilla Lörincz, Beat Göpfert, Michael Linnebank, Vinzenz von Tscharner, Armin Curt, Marc Bolliger, Björn Zörner
Locomotion relies on the fine-tuned coordination of different muscles which are controlled by particular neural circuits. Depending on the attendant conditions, walking patterns must be modified to optimally meet the demands of the task. Assessing neuromuscular control during dynamic conditions is methodologically highly challenging and prone to artifacts. Here we aim at assessing corticospinal involvement during different locomotor tasks using non-invasive surface electromyography. Activity in tibialis anterior (TA) and gastrocnemius medialis (GM) muscles was monitored by electromyograms (EMGs) in 27 healthy volunteers (11 female) during regular walking, walking while engaged in simultaneous cognitive dual tasks, walking with partial visual restriction, and skilled, targeted locomotion...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761063/stroke-severity-versus-dysphagia-screen-as-driver-for-post-stroke-pneumonia
#19
Thanh G Phan, Talvika Kooblal, Chelsea Matley, Shaloo Singhal, Benjamin Clissold, John Ly, Amanda G Thrift, Velandai Srikanth, Henry Ma
Background and Purpose: Post-stroke pneumonia is a feared complication of stroke as it is associated with greater mortality and disability than in those without pneumonia. Patients are often kept "Nil By Mouth" (NBM) after stroke until after receiving a screen for dysphagia and declared safe to resume oral intake. We aimed to assess the proportional contribution of stroke severity and dysphagia screen to pneumonia by borrowing idea from coalition game theory on fair distribution of marginal profit (Shapley value)...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30761062/association-between-cortical-superficial-siderosis-and-dementia-in-patients-with-cognitive-impairment-a-meta-analysis
#20
Chenheng Zhou, Keqin Liu, Shenqiang Yan, Ying Jin
Background: It remains unclear whether cortical superficial siderosis (cSS) is associated with dementia and its subtypes. We thus performed a meta-analysis to evaluate the relationship between dementia and cSS. Methods: We searched EMBASE, PubMed, and Web of Science for relevant studies assessing risk of dementia and prevalence of cSS in patients with cognitive impairment. Fixed-effects and random-effects models were performed. Results: Seven eligible studies including 3,218 patients with definite cognitive impairment were pooled in meta-analysis...
2019: Frontiers in Neurology
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