Bolanle M Famakin, Orest Tsymbalyuk, Natalia Tsymbalyuk, Svetlana Ivanova, Seung Kyoon Woo, Min Seong Kwon, Volodymyr Gerzanich, J Marc Simard
Limited, and underutilized, therapeutic options for acute stroke require new approaches to treatment. One such potential approach involves better understanding of innate immune response to brain injury such as acute focal cerebral ischemia. This includes understanding the temporal profile, and specificity, of Toll-like receptor 4 (TLR4) signaling in brain cell types, such as astrocytes, following focal cerebral ischemia. This study evaluated TLR4 signaling, and downstream mediators, in astrocytes, during acute and chronic phases post transient middle cerebral artery occlusion (MCAO)...
2020: Neurology Research International