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Neurology Research International

Vijay Renga
Dizziness is a common reason for outpatient neurology consultation. Oftentimes, a complete workup by general practitioner, including MRI brain fails to reveal a cause. Some patients would have also undergone an ENT evaluation before approaching neurology for an answer. Such scenarios provide a challenge as well as opportunity for the neurologist to exercise their knowledge and clinical skills in arriving at a diagnosis. Conditions like 'Unspecified Vestibular Dysfunction' and 'Presbyvertigo' are often the underlying causes, which are either not recognized or misdiagnosed as BPPV, psychogenic or perceptive dizziness...
2019: Neurology Research International
Abdul-Ganiyu Fuseini, Patience Aniteye, Afizu Alhassan
Background: Although several studies have been conducted on the lived experiences of persons with spinal cord injury (SCI) in high income countries, there is no published data on such experiences in Ghana. The purpose of this study was to explore the lived experiences of persons with SCI in the Tamale Metropolis of the Northern Region of Ghana. Material and Methods: A qualitative descriptive design involving thirteen participants was conducted at the Tamale Metropolis-Ghana...
2019: Neurology Research International
Jacques De Reuck
Purpose: The Boston criteria for cerebral amyloid angiopathy (CAA) have to be confirmed by postmortem examination. The present study investigates the incidence and the cerebrovascular impact of the severity of CAA in various neurodegenerative dementia diseases. Material and Methods: 208 patients underwent an autopsy. They consisted of 92 brains with Alzheimer's disease (AD), 46 with frontotemporal lobar degeneration (FTLD), 24 with progressive supranuclear palsy (PSP), 21 with Lewy body dementia (LBD), 5 with corticobasal degeneration (CBD), and 20 controls...
2019: Neurology Research International
Astri Budikayanti, Lubna Muhammad Qadri, Zakiah Syeban, Luh Ari Indrawati, Fitri Octaviana
Introduction: Adverse events (AEs) associated with antiepileptic drugs (AEDs) affect people with epilepsy's (PWE) quality of life. A study conducted in 15 European countries showed that the AEs prevalence of AEDs in PWE was up to 80%. To date, there are no validated screening instruments to detect AEs of AEDs in Indonesian PWE. Therefore its epidemiology is currently unknown. This study aimed to validate the Indonesian version of Liverpool Adverse Events Profile (LAEP), consequently increasing physicians' awareness toward the probability of AEs and its necessary evaluation...
2018: Neurology Research International
HamidReza Naderi, Fereshte Sheybani, Omid Khosravi, Mehdi Jabbari Nooghabi
Objectives: To assess the frequency of different types of diagnostic errors in patients with central nervous system (CNS) infection from the onset of symptoms to admission to the hospital, where the correct diagnosis was made. Methods: A cross-sectional observational design was used, and the information was collected by interviewing patients and/or their knowledgeable relatives as well as reviewing the accompanying medical record documents and hospital records. Results: Of 169 adult patients with CNS infection, 129 (76...
2018: Neurology Research International
Jegan Sakthivel Nadar, Pravin Popatrao Kale, Pramod Kerunath Kadu, Kedar Prabhavalkar, Ruchita Dhangar
Hesperidin, a well-known flavanone glycoside mostly found in citrus fruits, showed neuroprotective and antidepressant activity. Agomelatine, a melatonergic MT1 /MT2 agonist and 5-HT2C receptor antagonist, exhibits good antidepressant efficacy. Bupropion has been widely used for the treatment of depression because of its dopamine and norepinephrine reuptake inhibition. The objective of present study was to assess the antidepressant effects of hesperidin combination with agomelatine or bupropion. Male Swiss Albino mice received treatment of saline, vehicle, 'hesperidin alone', 'agomelatine alone', hesperidin+agomelatine, 'bupropion alone', hesperidin+bupropion, and agomelatine+bupropion for 14 days...
2018: Neurology Research International
Emily R Rosario, Stephanie E Kaplan, Sepehr Khonsari, Garrett Vazquez, Niyant Solanki, Melanie Lane, Hiriam Brownell, Sheila S Rosenberg
Background: While research suggests a benefit of hyperbaric oxygen therapy (HBOT) for neurologic injury, controlled clinical trials have not been able to clearly define the benefits. Objective: To investigate the effects of HBOT on physical and cognitive impairments resulting from an ischemic stroke. Methods: Using a within-subject design a baseline for current functional abilities was established over a 3-month period for all subjects (n=7)...
2018: Neurology Research International
Ali M Al Khathaami, Haya Aloraini, S Almudlej, Haifa Al Issa, Nourhan Elshammaa, Sami Alsolamy
Background and Objectives: Tissue plasminogen activator (t-PA) within 4.5 hours from onset improves outcome in patients with ischemic stroke and has been recommended by several international guidelines. Since its approval in 1996, the debate among emergency physicians continues particularly around the result interpretation of the first positive randomized controlled trial, the National Institute of Neurological Disorders and Stroke (NINDS) clinical trial. This lack of consensus might negatively affect the delivery of effective stroke care...
2018: Neurology Research International
Jean-Baptiste Delmotte, Abdulkarim Tutakhail, Kahina Abdallah, Pauline Reach, Marguerite D'Ussel, Gael Deplanque, Hélène Beaussier, François Coudoré
Purpose: Oxaliplatin is a platinum compound widely used in gastrointestinal cancer treatment but produces dose-limiting peripheral neuropathy. New insights into oxaliplatin-induced peripheral neuropathy (OIPN) assessment are needed to detect more effectively this condition. In this context, we conducted Canaloxa study, a prospective preliminary clinical trial that aimed to investigate how Electrochemical Skin Conductance (ESC), a parameter used in small fiber neuropathy assessment, could be helpful in OIPN diagnosis...
2018: Neurology Research International
Mohammed Saeed Alqahtani, Ahmad Ayed Alshbriqe, Ahmed A Awwadh, Turki Ali Alyami, Mohammed Saad Alshomrani, Adel Alhazzani
Objectives: To identify prevalence and risk factors of depression among caregivers of Alzheimer' disease (AD) patients. Methods: In a cross-sectional study, 110 caregivers of AD patients participated in this study (51 males and 59 females). Patients data were obtained from patients' records at Aseer Central Hospital. Depression among caregivers was assessed by using the Hamilton Rating Scale for Depression. Results: The age of caregivers ranged from 17 to 85 years (Mean±SD: 41...
2018: Neurology Research International
Gizachew Kassahun, Getachew Moges, Yitayew Demessie
An epileptic seizure is a clinical event presumed to result from an abnormal and excessive neuronal discharge. The clinical symptoms are paroxysmal and may include impaired consciousness and motor, sensory, autonomic, or psychic events perceived by the subject or an observer. Epilepsy occurs when 2 or more epileptic seizures occur unprovoked by any immediately identifiable cause. And in the majority of patients with epilepsy, antiepileptic drugs effectively control their illness. However, more than 30% of people with epilepsy do not attain full seizure control, even with the best available treatment regimen...
2018: Neurology Research International
Jocelyn Y Cheng
Purpose: Positive airway pressure remains the gold-standard treatment for OSA, but many are intolerant. The neurotransmitter serotonin is involved in respiratory control. Evidence exists for SRIs in reducing OSA severity in the general population and ictal hypoxemia and seizure-induced respiratory arrest in people with epilepsy (PWE). However, the association between SRIs and OSA severity has not been studied in populations consisting of both groups. This study aims to determine if SRIs are associated with OSA severity in both PWE and people without epilepsy (PWO) and whether differences exist between the two groups...
2018: Neurology Research International
Stephen Albano, Blake Berman, Glenn Fischberg, Javed Siddiqi, Bolin Liu, Yasir Khan, Atif Zafar, Syed A Quadri, Mudassir Farooqui
Background: Nosocomial EVD-related ventriculitis is a major complication and a significant cause of morbidity and mortality in critically ill neurological patients. Questions remain about best management of EVDs. The purpose of this study is to compare our incidence of ventriculitis to studies using different catheters and/or antibiotic coverage schemes and determine whether c-EVD with prolonged antibiotics given for the duration of drain placement is inferior to ac-EVD with pp-abx or ac-EVD with prolonged antibiotics for prevention of ventriculitis...
2018: Neurology Research International
Osama A Khairoalsindi, Ahmad R Abuzinadah
Amyotrophic lateral sclerosis is a neurodegenerative disease that leads to loss of the upper and lower motor neurons. Almost 90% of all cases occur in the sporadic form, with the rest occurring in the familial form. The disease has a poor prognosis, with only two disease-modifying drugs approved by the United States Food and Drug Administration (FDA). The approved drugs for the disease have very limited survival benefits. Edaravone is a new FDA-approved medication that may slow the disease progression by 33% in a selected subgroup of ALS patients...
2018: Neurology Research International
Hanan Amer, Hatem Shehata, Laila Ahmed Rashed, Hanan Helmy, Shaimaa El-Jaafary, Asmaa Sabbah, Wael Ibrahim
No abstract text is available yet for this article.
2018: Neurology Research International
Mahdi Habibi-Koolaee, Leila Shahmoradi, Sharareh R Niakan Kalhori, Hossein Ghannadan, Erfan Younesi
Background: Stroke is a leading cause of death and disability worldwide. According to the Iranian Ministry of Medical Health and Education, out of 100,000 stroke incidents in the country, 25,000 lead to death. Thus, identifying risk factors of stroke can help healthcare providers to establish prevention strategies. This study was conducted to investigate the prevalence of stroke risk factors and their distribution based on stroke subtypes in Sayad Shirazi Hospital, Gorgan, Northeastern Iran...
2018: Neurology Research International
Mohamed E Khallaf
Background: In individuals with hemiparetic stroke, reaching with the paretic arm can be impaired by abnormal muscle coactivation. Prior trails for improving upper extremity functions after stroke have underestimated the role of gravitational force in motor planning and execution. Objective: The aims this trial were to study the effect of gravity as a facilitator for elbow extension and to estimate the immediate and retention effects of task specific training of elbow extensors on upper extremity function after stroke...
2018: Neurology Research International
Cansu Köseoğlu Toksoy, Cem Bölük, Ülkü Türk Börü, Seydahmet Akın, Abdullah Yasir Yılmaz, Sanem Coşkun Duman, Mustafa Taşdemir
Background: This study aims to determine the stroke prevalence in Akçakoca which is a rural area in Turkey. Methods: The study was designed as a cross-sectional, door-to-door survey. The stroke questionnaire was completed by a trained team in the presence of the participants according to their answers. Based on the screenings, patients who had been diagnosed with stroke previously were reexamined by a neurologist and determined the prevalence values, risk factors, and stroke types...
2018: Neurology Research International
Jisu Elsa Jacob, Gopakumar Kuttappan Nair, Thomas Iype, Ajith Cherian
EEG analysis in the field of neurology is customarily done using frequency domain methods like fast Fourier transform. A complex biomedical signal such as EEG is best analysed using a time-frequency algorithm. Wavelet decomposition based analysis is a relatively novel area in EEG analysis and for extracting its subbands. This work aims at exploring the use of discrete wavelet transform for extracting EEG subbands in encephalopathy. The subband energies were then calculated and given as feature sets to SVM classifier for identifying cases of encephalopathy from normal healthy subjects...
2018: Neurology Research International
Marcelo de Lima Oliveira, Angela Macedo Salinet, Ricardo de Carvalho Nogueira, Alessandro Rodrigo Belon, Wellingson Silva Paiva, Brasil Chian Ping Jeng, Manoel Jacobsen Teixeira, Edson Bor-Seng-Shu
Background: This study aimed to analyse cerebral autoregulation (CA) during induction and treatment of intracranial hypertension (ICH) in an experimental model. Materials and Methods: Landrace and Duroc piglets were divided into mild and severe ICH groups. Four or seven millilitres of saline solution was infused into paediatric bladder catheter inserted in the parietal lobe (balloon inflation). After 1.5 h, a 3% saline solution was infused via venous catheter, and 30 min later, the bladder catheter balloon was deflated (surgery)...
2018: Neurology Research International
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