Rashid Jahangirnejad, Mehdi Goudarzi, Heibatullah Kalantari, Hossein Najafzadeh, Mohsen Rezaei
BACKGROUND: Arsenic, an environmental pollutant, is a carcinogenic metalloid and also an anticancer agent. OBJECTIVE: To evaluate the toxicity of arsenic nanoparticles in rat hepatocytes. METHODS: Freshly isolated rat hepatocytes were exposed to 0, 20, 40, and 100 μM of arsenic nanoparticles and its bulk counterpart. Their viability, reactive oxygen species level, glutathione depletion, mitochondrial and lysosomal damage, and apoptosis were evaluated...
January 2020: International Journal of Occupational and Environmental Medicine