Ming-Zi Zhang, Xin-Hang Dong, Wen-Chao Zhang, De-Li Pan, Li Ding, Hao-Ran Li, Peng-Xiang Zhao, Meng-Yu Liu, Lou-Bin Si, Xiao-Jun Wang, Xiao Long, Yi-Fang Liu
Photodynamic therapy (PDT) is a new therapy for treating cancer with less toxicity, high selectivity, good cooperativity, and repetitive usability. However, keloid treatment by PDT is mainly focused on clinical appearance, and few studies have been conducted on the mechanisms of PDT. In this study, key factors of the classical mitochondrial apoptosis signaling pathway were measured to assess the effect of a new PDT photosensitizer (p1). A specific inhibitor of caspase-8 (Z-IETD-FMK) was also used to verify the possible mechanisms...
May 6, 2022: Journal of Plastic Surgery and Hand Surgery