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Science China. Life Sciences

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https://read.qxmd.com/read/30701456/novel-hepacivirus-in-asian-house-shrew-china
#1
LETTER
Hua Guo, Chunlin Cai, Bo Wang, Fei Zhuo, Rendi Jiang, Ning Wang, Bei Li, Wei Zhang, Yan Zhu, Yi Fan, Wushen Chen, Weihong Chen, Xinglou Yang, Zhengli Shi
No abstract text is available yet for this article.
January 28, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30701455/chitosan-licl-composite-scaffolds-promote-skin-regeneration-in-full-thickness-loss
#2
Jifang Yuan, Qian Hou, Deyun Chen, Lingzhi Zhong, Xin Dai, Ziying Zhu, Meirong Li, Xiaobing Fu
Small molecules loaded into biological materials present a promising strategy for stimulating endogenous repair mechanisms for in situ skin regeneration. Lithium can modulate various biologic processes, promoting proliferation, angiogenesis, and decreasing inflammation. However, its role in skin repair is rarely reported. In this study, we loaded lithium chloride (LiCl) into the chitosan (CHI) hydrogel and develop a sterile and biocompatible sponge scaffold through freeze-drying. In-vitro assessment demonstrated that the CHI-LiCl composite scaffolds (CLiS) possessed favorable cytocompatibility, swelling and biodegradation...
January 28, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30685827/profile-of-dr-hefeng-huang
#3
(no author information available yet)
No abstract text is available yet for this article.
January 26, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30694431/an-map-kinase-interacts-with-lhk1-and-regulates-nodule-organogenesis-in-lotus-japonicus
#4
Jun Yin, Xiaomin Guan, Heng Zhang, Longxiang Wang, Hao Li, Qing Zhang, Tao Chen, Zeyuan Xu, Zonglie Hong, Yangrong Cao, Zhongming Zhang
Symbiosis receptor-like kinase (SymRK) is a key protein mediating the legume-Rhizobium symbiosis. Our previous work has identified an MAP kinase kinase, SIP2, as a SymRK-interacting protein to positively regulate nodule organogenesis in Lotus japonicus, suggesting that an MAPK cascade might be involved in Rhizobium-legume symbiosis. In this study, LjMPK6 was identified as a phosphorylation target of SIP2. Stable transgenic L. japonicus with RNAi silencing of LjMPK6 decreased the numbers of nodule primordia (NP) and nodule, while plants overexpressing LjMPK6 increased the numbers of nodule, infection threads (ITs), and NP, indicating that LjMPK6 plays a positive role in nodulation...
January 25, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30685829/in-depth-analysis-of-the-genome-of-trypanosoma-evansi-an-etiologic-agent-of-surra
#5
Lili Zheng, Ning Jiang, Xiaoyu Sang, Naiwen Zhang, Kai Zhang, Hongyu Chen, Na Yang, Ying Feng, Ran Chen, Xun Suo, Qijun Chen
Trypanosoma evansi is the causative agent of the animal trypanosomiasis surra, a disease with serious economic burden worldwide. The availability of the genome of its closely related parasite Trypanosoma brucei allows us to compare their genetic and evolutionarily shared and distinct biological features. The complete genomic sequence of the T. evansi YNB strain was obtained using a combination of genomic and transcriptomic sequencing, de novo assembly, and bioinformatic analysis. The genome size of the T. evansi YNB strain was 35...
January 24, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30685828/advances-in-research-into-gamete-and-embryo-fetal-origins-of-adult-diseases
#6
REVIEW
Kexin Zou, Guolian Ding, Hefeng Huang
The fetal and infant origins of adult disease hypothesis proposed that the roots of adult chronic disease lie in the effects of adverse environments in fetal life and early infancy. In addition to the fetal period, fertilization and early embryonic stages, the critical time windows of epigenetic reprogramming, rapid cell differentiation and organogenesis, are the most sensitive stages to environmental disturbances. Compared with embryo and fetal development, gametogenesis and maturation take decades and are more vulnerable to potential damage for a longer exposure period...
January 24, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30671887/seasonal-and-reproductive-variation-in-chemical-constituents-of-scent-signals-in-wild-giant-pandas
#7
Wenliang Zhou, Yonggang Nie, Yibo Hu, Ronald R Swaisgood, Yaohua Zhang, Dingzhen Liu, Fuwen Wei
Seasonally reproducing animals show many behavioral and physiological changes during the mating period, including increased signaling for intrasexual competition and mate attraction. We collected 102 anogenital gland secretions (AGS) from marking trees in Foping Nature Reserve, and used gas chromatography mass spectrometry analyze these chemical composition. Of these marks, all but one were from males, confirmed with DNA analysis. We found that several chemical constituents, especially volatile compounds, is present only during the mating season and that the relative abundance of many compounds changed as a function of breeding season, whereas nonvolatile compounds were lower in the mating season...
January 21, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30671886/further-analyses-of-variation-of-ribosome-dna-copy-number-and-polymorphism-in-ciliates-provide-insights-relevant-to-studies-of-both-molecular-ecology-and-phylogeny
#8
Yurui Wang, Chundi Wang, Yaohan Jiang, Laura A Katz, Feng Gao, Ying Yan
Sequence-based approaches, such as analyses of ribosome DNA (rDNA) clone libraries and high-throughput amplicon sequencing, have been used extensively to infer evolutionary relationships and elucidate the biodiversity in microbial communities. However, recent studies demonstrate both rDNA copy number variation and intra-individual (intra-genomic) sequence variation in many organisms, which challenges the application of the rDNA-based surveys. In ciliates, an ecologically important clade of microbial eukaryotes, rDNA copy number and sequence variation are rarely studied...
January 21, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30671885/spatial-patterns-and-effects-of-air-pollution-and-meteorological-factors-on-hospitalization-for-chronic-lung-diseases-in-beijing-china
#9
Lin Tian, Chuan Yang, Zijun Zhou, Ziting Wu, Xiaochuan Pan, Archie C A Clements
Chronic obstructive pulmonary disease (COPD), lung cancer (LC) and tuberculosis (TB) are common chronic lung diseases that generate a large disease burden and significant health care resource use in China. The aim of this study was to quantify spatial patterns and effects of air pollution and meteorological factors on hospitalization of COPD, LC and TB in Beijing. Daily counts of hospitalization for 2010 were obtained from the Beijing Urban Employees Basic Medical Insurance (UEBMI) system. Bayesian hierarchical Poisson regression models were applied to identify spatial patterns of hospitalization for COPD, LC and TB at the district level and explore associations with inhalable particulate matter (aerodynamic diameter <10 μm, PM10 ), sulfur dioxide (SO2 ), nitrogen dioxide (NO2 ), mean temperature and relative humidity...
January 21, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30661181/de-novo-assembly-of-white-poplar-genome-and-genetic-diversity-of-white-poplar-population-in-irtysh-river-basin-in-china
#10
Yan-Jing Liu, Xiao-Ru Wang, Qing-Yin Zeng
The white poplar (Populus alba) is widely distributed in Central Asia and Europe. There are natural populations of white poplar in Irtysh River basin in China. It also can be cultivated and grown well in northern China. In this study, we sequenced the genome of P. alba by single-molecule real-time technology. De novo assembly of P. alba had a genome size of 415.99 Mb with a contig N50 of 1.18 Mb. A total of 32,963 protein-coding genes were identified. 45.16% of the genome was annotated as repetitive elements...
January 17, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30659450/enhancement-of-salinomycin-production-by-ribosome-engineering-in-streptomyces-albus
#11
LETTER
Dong Li, Jihui Zhang, Yuqing Tian, Huarong Tan
No abstract text is available yet for this article.
January 16, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30689104/characterization-of-a-lal-type-regulator-nemr-in-nemadectin-biosynthesis-and-its-application-for-increasing-nemadectin-production-in-streptomyces-cyaneogriseus
#12
Chuang Li, Hairong He, Jiabin Wang, Hui Liu, Haiyan Wang, Yajie Zhu, Xiangjing Wang, Yanyan Zhang, Wensheng Xiang
Nemadectin, a macrocyclic lactone antibiotic, is produced by Streptomyces cyaneogriseus ssp. noncyanogenus. A methoxime derivative of nemadectin, moxdectin, has been widely used to control insect and helminth in animal health. Despite the importance of nemadectin, little attention has been paid to the regulation of nemadectin biosynthesis, which has hindered efforts to improve nemadectin production via genetic manipulation of regulatory genes. Here, we characterize the function of nemR, the cluster-situated regulatory gene encoding a LAL-family transcriptional regulator, in the nemadectin biosynthesis gene cluster of S...
January 15, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30645723/profile-of-dr-fuwen-wei
#13
(no author information available yet)
No abstract text is available yet for this article.
January 15, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30635833/differentiated-super-enhancers-in-lung-cancer-cells
#14
Xin Li, Chengjun Lu, Qijue Lu, Chunguang Li, Ji Zhu, Tiejun Zhao, Hezhong Chen, Hai Jin
Super-enhancers (SEs) are regulatory elements with enriched accumulation of key transcription factors. Few studies were done investigating SEs in lung cancers. Here we analyzed epigenetic profiling data to identify SEs in lung cancer cell lines. Enhancers were classified as SEs and typical enhancers (TEs). Most of the TEs were overlapped between normal cell and cancer cells. A great portion of SEs were differentiated comparing these cells. Analysis of GO terms associated with SEs revealed SE remodeling (lost on some sites while gain on others) between normal and lung cancer cells...
January 9, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30628009/china-s-treatment-regimen-for-fulminant-myocarditis-is-bringing-wonderful-achievement-to-the-world
#15
Jing Zhang, Weijian Hang, Rutai Hui, Qiong Zhao, Shashank S Desai
No abstract text is available yet for this article.
January 8, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30610537/the-function-and-potential-drug-targets-of-tumour-associated-tregs-for-cancer-immunotherapy
#16
REVIEW
Shanshan Yan, Yaguang Zhang, Bing Sun
Regulatory T cells (Tregs) play an important role in maintaining self-tolerance and immune homeostasis, but they also play a negative role in evoking effective antitumour immune responses. There is ample evidence indicating that the depletion of Tregs or the inhibition of Treg function will enhance antitumour effects. However, it is unclear which surface molecules of Tregs are suitable targets for tumour immunotherapy with minimal toxic side effects, which is a central theme in the field of Treg-targeted immunotherapy...
January 3, 2019: Science China. Life Sciences
https://read.qxmd.com/read/30593611/targeted-disruption-of-tyrosinase-causes-melanin-reduction-in-carassius-auratus-cuvieri-and-its-hybrid-progeny
#17
Qingfeng Liu, Yanhua Qi, Qiuli Liang, Jia Song, Junmei Liu, Wuhui Li, Yuqin Shu, Min Tao, Chun Zhang, Qinbo Qin, Jing Wang, Shaojun Liu
The white crucian carp (Carassius auratus cuvieri, WCC) not only is one of the most economically important fish in Asia, characterized by strong reproductive ability and rapid growth rates, but also represents a good germplasm to produce hybrid progenies with heterosis. Gene knockout technique provides a safe and acceptant way for fish breeding. Achieving gene knockout in WCC and its hybrid progeny will be of great importance for both genetic studies and hybridization breeding. Tyrosinase (TYR) is a key enzyme in melanin synthesis...
December 27, 2018: Science China. Life Sciences
https://read.qxmd.com/read/30593613/enhancer-rnas-a-missing-regulatory-layer-in-gene-transcription
#18
REVIEW
Renfang Mao, Yuanyuan Wu, Yue Ming, Yuanpei Xu, Shouyan Wang, Xia Chen, Xiaoying Wang, Yihui Fan
Enhancers and super-enhancers exert indispensable roles in maintaining cell identity through spatiotemporally regulating gene transcription. Meanwhile, active enhancers and super-enhancers also produce transcripts termed enhancer RNAs (eRNAs) from their DNA elements. Although enhancers have been identified for more than 30 years, widespread transcription from enhancers are just discovered by genome-wide sequencing and considered as the key to understand longstanding questions in gene transcription. RNA-transcribed enhancers are marked by histone modifications such as H3K4m1/2 and H3K27Ac, and enriched with transcription regulatory factors such as LDTFs, P300, CBP, BRD4 and MED1...
December 26, 2018: Science China. Life Sciences
https://read.qxmd.com/read/30588567/conservation-metagenomics-a-new-branch-of-conservation-biology
#19
REVIEW
Fuwen Wei, Qi Wu, Yibo Hu, Guangping Huang, Yonggang Nie, Li Yan
Multifaceted approaches are required to monitor wildlife populations and improve conservation efforts. In the last decade, increasing evidence suggests that metagenomic analysis offers valuable perspectives and tools for identifying microbial communities and functions. It has become clear that gut microbiome plays a critical role in health, nutrition, and physiology of wildlife, including numerous endangered animals in the wild and in captivity. In this review, we first introduce the human microbiome and metagenomics, highlighting the importance of microbiome for host fitness...
December 25, 2018: Science China. Life Sciences
https://read.qxmd.com/read/30591961/genome-wide-analysis-identified-17-new-loci-influencing-intraocular-pressure-in-chinese-population
#20
Lulin Huang, Yuhong Chen, Ying Lin, Pancy O S Tam, Yilian Cheng, Yi Shi, Bo Gong, Fang Lu, Jialiang Yang, Haixin Wang, Yi Yin, Yong Cao, Dan Jiang, Ling Zhong, Bai Xue, Jing Wang, Fang Hao, Dean-Yao Lee, Chi-Pui Pang, Xinghuai Sun, Zhenglin Yang
Intraocular pressure (IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new avenues for therapeutic intervention. We performed a genome-wide association study and replication analysis of 8,552 Chinese participants. In the genome-wide association study, we identified 51 loci that surpassed the significance of P<9×10-7 , and we formally replicated these loci. A combined discovery and replication meta-analysis identified 21 genome-wide loci that surpassed the genome-wide significance of P<5×10-8 , including 4 previously reported loci: rs145063132 (7p21...
December 24, 2018: Science China. Life Sciences
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