Aifan Li, Tianyi Han, Yongfang Li, Gaiqing Yang, Yuchao Zhang, Yanyang Huang, Baixue Zhou, Guoying Song, Ying He
BACKGROUND AND PURPOSE: Studies have shown that matrix metalloproteinase (MMP-2,3,9) plays an important role in the pathologic process of ischemic stroke (IS). The aim of this study was to investigate the relationship between C1306T, 1612-5A/6A, C-1562T polymorphisms of MMP -2,3,9 genes and IS in Chinese Han population. METHODS: The polymorphisms of MMP -2(C1306T), -3(1612-5A/6A), -9(C-1562T) gene were detected by PCR-RFLP and SNaPshot sequencing. Then, stratified analysis was used to study the relationship between IS subtypes and MMP-2,3,9 polymorphisms...
2023: International Journal of General Medicine