journal
https://read.qxmd.com/read/38646146/pre-and-post-treatment-quality-of-life-among-patients-with-advanced-stage-cervical-cancer-at-tikur-anbessa-specialized-hospital-ethiopia
#1
JOURNAL ARTICLE
Roza Teshome, Irene Yang, Edom Woldetsadik, Eshetu Girma, Melinda Higgins, Jessica Wells
BACKGROUND: The development of health concepts beyond traditional markers of illness and death has made the evaluation of quality of life (QoL) crucial to patient care. Yet, there is little research evaluating the pre- and post-treatment QoL of cervical cancer survivors in Ethiopia. OBJECTIVE: This study aimed to assess the pre- and post-treatment QoL of women diagnosed with advanced-stage cervical cancer. METHODS AND MATERIALS: A cohort design was conducted at the Tikur Anbessa Specialized Hospital Oncology Center...
2024: Cancer Management and Research
https://read.qxmd.com/read/38617188/serum-biochemical-markers-for-medullary-thyroid-carcinoma-an-update
#2
REVIEW
Shuzhou Liu, Hao Zhao, Xiaoyi Li
INTRODUCTION: Medullary thyroid carcinoma (MTC), a rare malignancy, requires early diagnosis for optimal patient outcomes. An important aspect of MTC diagnosis is the assessment of serum biomarkers. This review aimed to evaluate the use of serum biomarkers in the diagnosis, prognosis, and follow-up of MTC. METHODS: A thorough search of PubMed covering 1975 to 2022 was conducted to identify English-language articles on MTC serum biomarkers. RESULTS: The review revealed that calcitonin (Ctn) and carcinoembryonic antigen (CEA) remain the most important serum biomarkers for MTC diagnosis and management...
2024: Cancer Management and Research
https://read.qxmd.com/read/38617187/risk-factors-associated-with-chemotherapy-induced-nausea-and-vomiting-among-women-with-breast-cancer-receiving-highly-emetogenic-chemotherapy-individual-patient-based-analysis-of-three-prospective-antiemetic-trials
#3
JOURNAL ARTICLE
Winnie Yeo, Nicole T Y Ngai, Christopher C H Yip, Frankie K F Mo, Victoria A Yeo, Jonathan W H Ko, Leung V Li, Thomas K H Lau, Kwai Tung Lai, Elizabeth Pang, Claudia H W Yip, Horatio L Yeo, Carol Chi Hei Kwok, Stephanie W Y Ko, Alex Molassiotis
PURPOSE: Although risk factors related to chemotherapy-induced nausea and vomiting (CINV) have been identified in previous studies, only a few studies have evaluated the risk factors associated with contemporary antiemetic prophylaxis, including olanzapine/aprepitant- or NEPA-containing regimens. This study aimed to identify the risk factors associated with CINV development in Chinese breast cancer patients receiving doxorubicin and cyclophosphamide chemotherapy. METHODS: Data from 304 patients enrolled in 3 previously reported prospective antiemetic studies were included...
2024: Cancer Management and Research
https://read.qxmd.com/read/38601904/oct4-accelerates-tumorigenesis-through-activating-jak-stat-signaling-in-ovarian-cancer-side-population-cells-retraction
#4
(no author information available yet)
[This retracts the article DOI: 10.2147/CMAR.S180418.].
2024: Cancer Management and Research
https://read.qxmd.com/read/38585434/comparative-analysis-of-oncologic-outcomes-in-patients-with-squamous-cell-carcinoma-of-the-uterine-cervix-with-high-risk-features-for-para-aortic-recurrence-prophylactic-extended-field-versus-pelvic-chemoradiotherapy
#5
JOURNAL ARTICLE
Chung-Shih Chen, Yu-Ming Wang, Eng-Yen Huang
PURPOSE: To compare the oncologic outcomes of prophylactic extended-field radiation therapy (EFRT) and whole pelvic radiation therapy (WPRT) in cervical patients at high risk of para-aortic lymph node (PALN) recurrence. PATIENTS AND METHODS: From July 1999 to May 2022, a total of 115 patients with cervical cancer and high-risk features of PALN recurrence based on tumor markers, positive LNs and extensive parametrial invasion were retrospectively analyzed. All patients had received EFRT or WPRT at a dose of 39...
2024: Cancer Management and Research
https://read.qxmd.com/read/38585433/effects-of-metformin-on-jnk-signaling-pathway-and-pd-l1-expression-in-triple-negative-breast-cancer
#6
JOURNAL ARTICLE
Ruibin Wang, Yanjie Zhao
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. Metformin has been shown to have the potential to inhibit the proliferation of malignant cells. This study aimed to investigate the regulatory effect of metformin on the expression of programmed death protein ligand 1(PD-L1) and mechanisms in TNBC. METHODS: Mouse breast cancer cell line 4T1 was co-cultured with metformin, and the effect of metformin on cell proliferation was detected by MTT assay...
2024: Cancer Management and Research
https://read.qxmd.com/read/38560662/induction-of-hepatocellular-carcinoma-in-conventional-domestic-swine-using-n-diethylnitrosamine-and-phenobarbital
#7
JOURNAL ARTICLE
Angela Giselvania, Vetnizah Juniantito, Heri Wibowo, Trifonia Pingkan Siregar, Soehartati Gondhowiardjo
PURPOSE: Large animal models are still used in many studies because of their likeness to humans. It has not been documented that regular-sized conventional farm-breed pigs, generally bred for meat production, can be used to generate hepatocellular carcinoma (HCC) animal models. The goal of this study was to investigate how N-diethylnitrosamine (DENA) and phenobarbital (PB) together can generate HCC in ordinary farmed pigs. MATERIALS AND METHODS: Conventional domestic swine ( Sus scrofa domesticus ) were used...
2024: Cancer Management and Research
https://read.qxmd.com/read/38525374/extensive-stage-small-cell-lung-cancer-with-cystic-brain-metastases-a-report-of-two-cases
#8
Fei Cai, Di Wu, Junling Liu, Shuxi Song, Jingyu Li, Zhendong Zheng, Long Xu
OBJECTIVE: Cystic brain metastases (BMs) are rare in small cell lung cancer (SCLC), and there are limited data on the treatment and prognosis of cystic BMs. Whole brain radiotherapy has been the mainstay for BMs since several years. Immune checkpoint inhibitors in extensive stage small cell lung cancer (ES-SCLC) have been shown to be suitable for patients who experienced better overall survival and progress-free survival and have been approved as the first-line treatment for ES-SCLC. In this report, we described two ES-SCLC patients developed cystic BMs after immunotherapy, after which the patients continued to treat the primary lesion with immune checkpoint inhibitors and the cystic BMs with radiotherapy...
2024: Cancer Management and Research
https://read.qxmd.com/read/38525373/seed-and-soil-consensus-molecular-subgroups-cms-and-tumor-microenvironment-features-between-primary-lesions-and-metastases-of-different-organ-sites-in-colorectal-cancer
#9
JOURNAL ARTICLE
Qingqing Luo, Yibo Quan, Wei Liu, Zixin Wu, Wenjing Qiu, Wenlong Liang, Ping Yang, Qing Huang, Guanwei Li, Jianchang Wei, Qiang Wang, Fei Shen, Wanglin Li, Feng He, Jie Cao
PURPOSE: Consensus molecular subtypes (CMS) are mainly used for biological interpretability and clinical stratification of colorectal cancer (CRC) in primary tumors (PT) but few in metastases. The heterogeneity of CMS distribution in metastases and the concordance of CMS between PT and metastases still lack sufficient study. We used CMS to classify CRC metastases and combine it with histopathological analysis to explore differences between PT and distant metastases. PATIENTS AND METHODS: We obtained gene expression profiles for 942 PT samples from TCGA database (n=376) and GEO database (n=566), as well as 442 metastasis samples from GEO database...
2024: Cancer Management and Research
https://read.qxmd.com/read/38525372/the-prognostic-value-of-serum-sialic-acid-in-patients-with-nasopharyngeal-carcinoma-a-propensity-score-matching-study
#10
JOURNAL ARTICLE
Zetan Chen, Gang Wu, Xiangying Lin, Xiaopeng Huang, Shuai Zhang, Kaihua Chen, Zhongguo Liang, Xiaodong Zhu
PURPOSE: Elevated serum sialic acid (SA) is one of the indicators of poor prognosis in various malignant tumors. This study intends to determine the relationship between serum SA levels and survival prognosis in nasopharyngeal carcinoma (NPC). PATIENTS AND METHODS: From 2014 to 2016, NPC patients with no distance metastasis undergoing intensity-modulated radiotherapy (IMRT) were retrospectively analyzed. The serum SA levels before initial treatment were measured, and an optimal cut-off level was determined by X-tile software...
2024: Cancer Management and Research
https://read.qxmd.com/read/38525371/efficacy-and-safety-of-maintenance-therapy-using-cetuximab-in-patients-with-metastatic-colorectal-cancer-retrospective-study
#11
JOURNAL ARTICLE
Tiantian Xuan, Zhanmei Wang, Sibo Meng, Jiaxin Li, Jisheng Li, Fangli Cao, Linli Qu
PURPOSE: Cetuximab (CET) combined with chemotherapy significantly improved the survival in RAS and RAF wild-type metastatic colorectal cancer (mCRC) patients, while clinical evidence was lacking on the use of maintenance therapy (MT). The study aimed to explore the role of maintenance therapy following Cetuximab + chemotherapy and the optimal Cetuximab-based maintenance therapy regimen. PATIENTS AND METHODS: We retrospectively reviewed data on the efficacy and safety of CET-based MT in patients with mCRC who achieved disease control after induction therapy...
2024: Cancer Management and Research
https://read.qxmd.com/read/38525370/perp-may-affect-the-prognosis-of-lung-adenocarcinoma-by-inhibiting-apoptosis
#12
JOURNAL ARTICLE
Zhongxiang Liu, Shuhua Han, Yuhong Luo, Zhangyan Zhao, Lingyu Ni, Linlin Chai, Haicheng Tang
BACKGROUND: PERP, a member of the peripheral myelin protein gene family, is a new therapeutic target in cancer. The relationships between PERP and immune cell infiltration in lung cancer have not been studied. Therefore, the role of PERP in the tumour microenvironment (TME) of lung cancer needs to be further explored. METHODS: In this study, we explored the association between PERP expression and clinical characteristics by analysing data from the TCGA database...
2024: Cancer Management and Research
https://read.qxmd.com/read/38505102/efficacy-and-safety-of-hepatic-arterial-infusion-therapy-with-cinobufacini-in-advanced-hepatocellular-carcinoma-with-macrovascular-invasion-a-retrospective-cohort-study
#13
JOURNAL ARTICLE
Tao Xue, Hongbin Yu, Wenming Feng, Yao Wang, Shiyong Wu, Lili Wang, Peiqin Zhu, Jianming Guan, Quan Sun
BACKGROUND: The presence of macrovascular invasion (MVI) is associated with poor prognosis in advanced hepatocellular carcinoma (HCC). This study aims to evaluate the efficacy and safety of Cinobufacini therapy via hepatic arterial infusion (HAI) in advanced HCC patients with MVI. METHODS: The clinical records of 130 consecutive patients with unresectable advanced HCC and MVI who had received Cinobufacini or cisplatin plus 5-fluorouracil (CF) treatment via HAI were retrospectively analyzed...
2024: Cancer Management and Research
https://read.qxmd.com/read/38501053/immune-related-adverse-event-related-adrenal-insufficiency-mediates-immune-checkpoint-inhibitors-efficacy-in-cancer-treatment
#14
JOURNAL ARTICLE
Shasha Zhang, Jianhua Wu, Yue Zhao, Jingjing Zhang, Xiaoyun Zhang, Chensi Wu, Zhidong Zhang, Zhanjun Guo
PURPOSE: Immune checkpoint inhibitors (ICIs) have significantly improved the outcomes of patients with cancer; however, these agents may initiate immune-related adverse events (irAEs). Previous studies have demonstrated a robust correlation between disease prognosis and the occurrence of irAEs, specifically skin or endocrine irAEs. Herein, we aimed to evaluate the correlation between irAE-related adrenal insufficiency (AI) and ICI treatment efficacy. PATIENTS AND METHODS: Patients diagnosed with gastrointestinal, respiratory, head and neck, urological, skin and gynecologic cancers treated with anti-programmed cell death 1 (PD-1)/anti-programmed cell death ligand 1 (PD-L1) antibody as monotherapy or combined therapy (combined with chemotherapy or targeted therapy) were divided into irAE-A (patients with irAE-related AI), irAE-B (patients with other irAEs) and non-irAE groups...
2024: Cancer Management and Research
https://read.qxmd.com/read/38476973/sirt3-expression-predicts-overall-survival-and-neoadjuvant-chemosensitivity-in-triple-negative-breast-cancer
#15
JOURNAL ARTICLE
Lvwen Ning, Ni Xie
BACKGROUND: The Sirtuin (SIRT) family consists of seven evolutionary conserved NAD-dependent deacetylases that play important roles in various cancers, including breast cancer (BC). SIRTs expression has been reported to have prognostic value in BC, but these studies used limited sample size and yielded inconsistent conclusions. This study evaluated the association of SIRT3 and other SIRT family members with survival and neoadjuvant chemotherapy outcomes. METHODS: BC patients' data was obtained from the TCGA-BRCA, METABRIC and GEO databases, comprising 4336 samples...
2024: Cancer Management and Research
https://read.qxmd.com/read/38476972/high-expression-of-wt1-and-low-expression-of-p53-in-archived-blocks-of-children-with-wilms-tumor-in-south-western-uganda
#16
JOURNAL ARTICLE
Brian Ssenkumba, Barnabas Atwiine, Yekosani Mitala, Janet Adongo, Samuel Olowo, Rita Nabulya, Amnia Diaz Anaya, Raymond Atwine
PURPOSE: The determination of the presence or absence of anaplasia in Wilms tumor is difficult sometimes creating diagnostic errors and is worsened by the use of neoadjuvant chemotherapy, which causes cellular alterations that may mimic anaplasia. This study described the histological features of Wilms tumor and their association with WT1 and p53 expression in archived specimens in South Western Uganda. PATIENTS AND METHODS: A series of 308 formalin-fixed paraffin-embedded tissue blocks belonging to 85 children were retrospectively recruited in the only public Histopathology laboratory in South Western Uganda...
2024: Cancer Management and Research
https://read.qxmd.com/read/38463556/the-clinical-and-pathological-characteristics-of-pole-mutated-endometrial-cancer-a-comprehensive-review
#17
REVIEW
Xiaohong Yao, Min Feng, Wei Wang
Endometrial cancer shows high histological and molecular heterogeneity. The POLE mutation is a significant molecular alteration in endometrial cancer, leading to the identification of a specific subtype known as POLE -mutated endometrial cancer. This subtype exhibits a high tumor mutation burden, abundant lymphocyte infiltration, and a favorable prognosis, making it a promising candidate for immune checkpoint inhibitor therapy. This paper presents a comprehensive review of the clinical and pathological characteristics, outcomes, treatment advancements, pathogenic POLE gene detection, and alternative testing methods for POLE -mutated endometrial cancer...
2024: Cancer Management and Research
https://read.qxmd.com/read/38419857/shp-2-interacts-with-cd81-and-regulates-the-malignant-evolution-of-colorectal-cancer-by-inhibiting-epithelial-mesenchymal-transition-retraction
#18
(no author information available yet)
[This retracts the article DOI: 10.2147/CMAR.S270813.].
2024: Cancer Management and Research
https://read.qxmd.com/read/38419856/microrna-506-regulates-apoptosis-in-retinoblastoma-cells-by-targeting-sirtuin-1-retraction
#19
(no author information available yet)
[This retracts the article DOI: 10.2147/CMAR.S211122.].
2024: Cancer Management and Research
https://read.qxmd.com/read/38370535/investigation-of-the-proteasome-26s-subunit-atpase-family-genes-as-potential-prognostic-biomarkers-and-therapeutic-targets-for-hepatocellular-carcinoma
#20
JOURNAL ARTICLE
Lei Feng, Ning Zhang, Lan Luo, Jie Liu, Yong Yao, Ming-Sheng Gao, Jin Pan, Cai He
BACKGROUND: Several studies suggest that Proteasome 26S Subunit, ATPase (PSMC) family genes are of great importance in tumor progression and spreading, but the study for systematic evaluation of the function of PSMC genes in hepatocellular carcinoma (HCC) is currently lacking. METHODS: The functions of PSMC genes in HCC were analyzed using multiple online databases, including the TCGA database, GEO database, HPA database, cBioPortal database, DAVID, and KEGG pathway...
2024: Cancer Management and Research
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