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Cancer Management and Research

Hongfei Yan, Chunlei Zheng, Zhi Li, Bowen Bao, Bowen Yang, Kezuo Hou, Xiujuan Qu, Jiawen Xiao, Xiaofang Che, Yunpeng Liu
Purpose: This study aimed to investigate the effect of NPTX1 on the prognosis of gastric cancer (GC), as well as the metastatic process in GC. Materials and methods: The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were used to analyze the association between NPTX1 expression and prognosis in GC. Quantitative real-time polymerase chain reaction and Western blots were applied to examine the expression of NPTX1 in GC cell lines and expression of genes in downstream pathways...
2019: Cancer Management and Research
Yongli Yang, Zhiwei Cheng, Xiaocan Jia, Nian Shi, Zhenhua Xia, Weiping Zhang, Xuezhong Shi
Purpose: The effects of age, period, and cohort on mortality rates of bladder cancer in China remained vague. This study aimed to analyze the secular trends of bladder cancer mortality in China and estimate the independent effects of age, period, and cohort. Methods: Data for bladder cancer mortality from 1991 to 2015 was obtained from the WHO Mortality Database and China Health Statistical Yearbook. The age-period-cohort model was used to estimate the effect of age, period, and cohort...
2019: Cancer Management and Research
Fei Ji, Wei-Kai Xiao, Ci-Qiu Yang, Mei Yang, Liu-Lu Zhang, Hong-Fei Gao, Yu-Feng Lin, Teng Zhu, Min-Yi Cheng, Wei-Ping Li, Wei-Jun Pan, Xiao-Sheng Zhuang, Kun Wang
Background: Tumor location in the breast varies, with the highest frequency in the upper outer quadrant and lowest frequency in the lower inner quadrant. Nevertheless, tumors in the central and nipple portion (TCNP) are poorly studied types of breast cancer; therefore, we aimed to clarify the clinicopathological characteristics and prognostic features of TCNP. Methods: Using the Surveillance, Epidemiology, and End Results database, we identifed 105,037 patients diagnosed with tumor in the breast peripheral quadrant (TBPQ) (n=97,046) or TCNP (n=7,991)...
2019: Cancer Management and Research
Tao Ma, Jin Zhang
Background: Family of forkhead box transcription factors has been found to play key roles in multiple types of cancer. Materials and methods: Our study is to decipher the effects of FOXP4 in human breast cancer (BC). Quantitative real-time polymerase chain reaction and Western blot analyses were performed to determine the mRNA and protein expressions of FOXP4 in BC tissue samples and cell lines. The gain and loss of function assay were used to explore the detailed roles of FOXP4 in breast cell lines, including MDA-MB-231 and MCF-7 cells...
2019: Cancer Management and Research
Chao Wu, Xudong Ren, Quanbao Zhang
Aims: The study aims to explore the incidence, risk factors, and prognosis in patients with primary hepatocellular carcinoma (HCC) and synchronous lung metastasis using a large-scale population-based cancer registry database. Patients and methods: Data of 33,177 HCC patients were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. Multivariate logistic and Cox regression model analysis were applied for the recognition of risk factors and prognostic factors associated with lung metastasis among HCC patients...
2019: Cancer Management and Research
Yiqun Huang, Yong Zou, Luhui Lin, Xudong Ma, Ruiji Zheng
Background: miR-101 is reported to be associated with cell proliferation and apoptosis. However, it is unknown whether miR-101 expression affects cell proliferation and apoptosis in diffuse large B cell lymphoma (DLBCL). The aim of the present study was to investigate the expression of miR-101 and its effect on cell proliferation and apoptosis in DLBCL. Methods: miR-101 expression was detected in 30 cases of patients with DLBCL and normal lymph node by qRT-PCR. Then, miR-101 expression was up-regulated and down-regulated in Originated Cell Line-Large Lymphoma 8 (OCL-LY8) cell line, respectively...
2019: Cancer Management and Research
Leung Li, Stephen L Chan, Frankie Mo, Edwin P Hui, Jane Koh, Allen K C Chan, Nelson L S Tang, Kit F Lee, Paul B S Lai, Simon C H Yu, Winnie Yeo
Purpose: Health-related quality of life (HRQoL) is a significant prognostic factor for overall survival in hepatocellular carcinoma (HCC) patients, and this is independent of stage and liver function. Inflammation plays a significant role in HCC development and progression. It was hypothesized that the inflammatory status of HCC patients may affect their HRQoL. The relationship between HRQoL and inflammatory status was explored using indicators IL-8 level and modified inflammation-based index (mIBI, based on IL-8, C-reactive protein, and albumin)...
2019: Cancer Management and Research
Di Lu, Zhizhi Wang, Xiguang Liu, Siyang Feng, Xiaoying Dong, Xiaoshun Shi, He Wang, Hua Wu, Gang Xiong, Haofei Wang, Kaican Cai
Purpose: A survival improvement was achieved with adjuvant chemotherapy in non-small-cell lung cancer (NSCLC) patients, but its differential effects among patients with different stages remained controversial. This study aimed to compare the beneficial effects of adjuvant tyrosine kinase inhibitor (TKI) therapy with those of traditional therapy on NSCLC patients, specifically on EGFR-mutant and stage II-IIIA patients, who might benefit most from such treatment. Methods: MEDLINE, Embase, and the Cochrane Library were searched, and the results were screened independently according to certain criteria by two authors...
2019: Cancer Management and Research
K Groen, Nwcj van de Donk, Cam Stege, S Zweegman, I S Nijhof
Although the prognosis of multiple myeloma (MM) patients has dramatically improved during recent years, virtually all patients eventually develop relapsed refractory disease. Several new therapeutics have been developed in the last few years, including carfilzomib, a second-generation proteasome inhibitor (PI) that has been approved by the US Food and Drug Administration (FDA) in the setting of relapsed and/or refractory MM, as a single agent with or without dexamethasone, and in combination with lenalidomide in 2012 and 2015, respectively...
2019: Cancer Management and Research
Zhongyu Ren, Jing Liang, Peng Zhang, Jianjiao Chen, Jian Wen
Background: Glioblastoma (GBM) is the most severe brain cancer due to its ability to invade surrounding brain tissue. Iron oxide nanoparticles (ION) could effectively induce a decrease of cell migration/invasion. Also IONs could generate ROS stress which induces autophagy elevation. Autophagy is associated with both anti-tumorigenesis and protumorigenesis. Objective: To explore the effect of PEGylated IONs (PION@E6) on the GBM cell invasion and its mechanism based on autophagy...
2019: Cancer Management and Research
Noor-Ul-Ain Tariq, Mairéad G McNamara, Juan W Valle
Biliary tract cancers (BTCs) are rare with poor prognosis. Due to the advent of genomic sequencing, new data have emerged regarding the molecular makeup of this disease. To add to the complexity, various subtypes also harbor a varied genetic composition. The commonly mutated genes associated with this cancer are KRAS , EGFR , IDH , FGFR and BAP1 . Various clinical studies are looking at targeting these genetic mutations. Another therapeutic area of note is the potential for the use of immunotherapy in patients with BTC...
2019: Cancer Management and Research
Gangjian Wang, Yu Chang, Xiaolong Wu, Xin Li, Ling Li, Lei Zhang, Xiaorui Fu, Zhenchang Sun, Xudong Zhang, Mingzh Zhang
Background: Primary bone marrow lymphoma (PBML) is a very uncommon neoplasm originally arising in the bone marrow system, and the most common pathological type is diffuse large B-cell lymphoma. Patients and methods: To describe the clinical characteristics of PBML and evaluate the risk factors related to prognosis, we recruited and studied 66 patients from our center and the current published literature. Various symptoms are present at the onset of PBML, the most important of which is cytopenia, followed by fever...
2019: Cancer Management and Research
Ranliang Cui, Yichao Wang, Ying Li, Yueguo Li
Objectives: The role of retrospective analysis has evolved greatly in cancer research. We undertook this network meta-analysis to evaluate retrospectively the diagnostic value of ROMA in ovarian cancer. Materials and methods: We systematically retrieved 56 relevant articles published about ROMA index from 2009-2018 and about ovarian cancer from China National Knowledge Infrastructure (CNKI), PubMed and EMBASE. Data were comprehensively analyzed by Rev-Man 5.3 and MetaDisc 12...
2019: Cancer Management and Research
Gilles Houvenaeghel, Eric Lambaudie, Marie Bannier, Sandrine Rua, Julien Barrou, Mellie Heinemann, Max Buttarelli, Jeanne Thomassin Piana, Monique Cohen
Introduction: Reoperation after breast-conserving surgery (BCS) could be proposed for positive or close margins. Reoperation type, re-excision or mastectomy, depends on several factors in relation to patient's and tumor's characteristics. We have analyzed our breast cancer (BC) database in order to determine second and third attempts for BCS and mastectomy rates, as well as associated factors for type of surgery. Methods: All patients with BCS between 1995 and 2017 were included...
2019: Cancer Management and Research
Dan Zhou, Weiwei Tang, Yun Zhang, Han-Xiang An
Purpose: JAM3, an adhesion and transmigration regulatory element, is abundantly expressed in intestinal epithelial cells. However, its expression and function in colorectal cancer (CRC) remain unknown. In this study, we explored its epigenetic mechanism and biological role in CRC. Patients and methods: Bioinformatics analysis was used to analyze the expression and methylation level of JAM3 in CRC. Methylation and expression status of JAM3 were then validated by quantitative methylation-specific PCR (qMSP) and quantitative PCR in tissues, plasma samples, and cell lines...
2019: Cancer Management and Research
Pengbo Deng, Chengping Hu, Zeng Xiong, Yuanyuan Li, Juan Jiang, Huaping Yang, Yongjun Tang, Liming Cao, Rongli Lu
Purpose: Large-scale studies have revealed that appropriate antiangiogenic treatment enables the recovery of the normal structure and function of solid tumor vessels. Epigallocatechin-3-gallate (EGCG), a natural extract of green tea, has multiple effects on angiogenesis. However, normalization of blood vessels due to natural ingredients has not yet been reported. Therefore, we examined the microvasculature, microenvironment, and efficacy of EGCG combined with chemotherapy in a xenograft model...
2019: Cancer Management and Research
JinHui Liu, SiYue Li, JunYa Liang, Yi Jiang, YiCong Wan, ShuLin Zhou, WenJun Cheng
Background: Epithelial ovarian cancer (EOC) is a female malignant tumor. Bioinformatics has been widely utilized to analyze genes related to cancer progression. Targeted therapy for specific biological factors has become more valuable. Materials and methods: Gene expression profiles of GSE18520 and GSE27651 were downloaded from Gene Expression Omnibus. We used the "limma" package to screen differentially expressed genes (DEGs) between EOC and normal ovarian tissue samples and then used Clusterprofiler to do functional and pathway enrichment analyses...
2019: Cancer Management and Research
Ruifeng Zhang, Xuhong Dang, Zhongxin Zhang, Yayi Yuan, Yue Ren, Zhikai Duan, Yahui Zuo
Objective: Heavy ions have contributed to tumor site-specific radiotherapy and are a major health risk for astronauts. The purpose of this study was to investigate the changes in gene expression in peripheral lymphocytes of cancer patients and astronauts exposed to 12 C ions, and identify suitable molecular biomarkers for health monitoring. We also aimed to observe the effects of treatment and the level of damage, by comparing the transcriptional profiles of human lymphocyte cell lines exposed to 12 C ion beams at doses of 0-2...
2019: Cancer Management and Research
Xiaoxue Wang, Zhimin Liu, Hong Tong, Hui Peng, Zhenyu Xian, Li Li, Bang Hu, Shangkui Xie
Background: The incidence of colorectal cancer ranks among the top three malignant tumors, attributing to more than 50,000 deaths in the United States every year. Survival rate is directly correlated with TNM stage at diagnosis, and identifying the molecules involved in the cancer development process will provide directions to better investigate the mechanisms of colorectal cancer. Materials and methods: Bioinformatics analysis of differentially expressed long noncoding RNAs (lncRNAs), survival analysis, cell proliferation assay, migration assay, and Western blot analysis were performed...
2019: Cancer Management and Research
Yingyi Ye, Shuhong Huang, Yingying Wu
Background: Human melanoma is a malignant tumor originated from melanocytes with high invasion, metastasis, and poor prognosis. In this study, the effects of naphthalimides UNBS5162 and amonafide on the properties of proliferation and apoptosis in human melanoma cells were confirmed. Methods: Cell proliferation was determined by CCK8 and clone formation assay. Transwell assay was performed to detect the migration and invasion of M14 and A375 cells. Cell apoptosis was estimated using flow cytometry...
2019: Cancer Management and Research
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