Ye Cao, Fansu Meng, Tiange Cai, Lanwen Gao, Jaiwoo Lee, Sergey O Solomevich, Uladzislau E Aharodnikau, Tingting Guo, Meng Lan, Fengjie Liu, Qianwen Li, Timoshenko Viktor, Detang Li, Yu Cai
The conventional therapeutic treatment of triple-negative breast cancer (TNBC) is negatively influenced by the development of tumor cell drug resistant, and systemic toxicity of therapeutic agents due to off-target activity. In accordance with research findings, nanoparticles (NPs) responsive to the tumor microenvironment (TME) have been discovered for providing opportunities to selectively target tumor cells via active targeting or Enhanced Permeability and Retention (EPR) effect. The combination of the TME control and therapeutic NPs offers promising solutions for improving the prognosis of the TNBC because the TME actively participates in tumor growth, metastasis, and drug resistance...
2024: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology