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JOURNAL ARTICLE
Claire Greenhill
No abstract text is available yet for this article.
January 11, 2024: Nature Reviews. Endocrinology
#62
JOURNAL ARTICLE
Anil K Agarwal, Abhimanyu Garg
No abstract text is available yet for this article.
January 8, 2024: Nature Reviews. Endocrinology
#63
JOURNAL ARTICLE
Shimona Starling
No abstract text is available yet for this article.
January 5, 2024: Nature Reviews. Endocrinology
#64
JOURNAL ARTICLE
Penney M Gilbert, Sandra Hofmann, Huck-Hui Ng, Hugo Vankelecom, James M Wells
No abstract text is available yet for this article.
January 5, 2024: Nature Reviews. Endocrinology
#65
JOURNAL ARTICLE
Olivia Tysoe
No abstract text is available yet for this article.
January 5, 2024: Nature Reviews. Endocrinology
#66
JOURNAL ARTICLE
Steffen H Raun
No abstract text is available yet for this article.
January 5, 2024: Nature Reviews. Endocrinology
#67
JOURNAL ARTICLE
Olivia Tysoe
No abstract text is available yet for this article.
January 2024: Nature Reviews. Endocrinology
#68
JOURNAL ARTICLE
Shimona Starling
No abstract text is available yet for this article.
January 2024: Nature Reviews. Endocrinology
#69
REVIEW
Diana van Heemst
Thyroid hormones have vital roles in development, growth and energy metabolism. Within the past two decades, disturbances in thyroid hormone action have been implicated in ageing and the development of age-related diseases. This Review will consider results from biomedical studies that have identified the importance of precise temporospatial regulation of thyroid hormone action for local tissue maintenance and repair. Age-related disturbances in the maintenance of tissue homeostasis are thought to be important drivers of age-related disease...
January 2024: Nature Reviews. Endocrinology
#70
REVIEW
Ramiah D Jacks, Carey N Lumeng
The signals and structure of the tissues in which leukocytes reside critically mould leukocyte function and development and have challenged our fundamental understanding of how to define and categorize tissue-resident immune cells. One specialized tissue niche that has a powerful effect on immune cell function is adipose tissue. The field of adipose tissue leukocyte biology has expanded dramatically and has revealed how tissue niches can shape immune cell function and reshape them in a setting of metabolic stress, such as obesity...
January 2024: Nature Reviews. Endocrinology
#71
Stephan Petersenn, Maria Fleseriu, Felipe F Casanueva, Andrea Giustina, Nienke Biermasz, Beverly M K Biller, Marcello Bronstein, Philippe Chanson, Hidenori Fukuoka, Monica Gadelha, Yona Greenman, Mark Gurnell, Ken K Y Ho, Jürgen Honegger, Adriana G Ioachimescu, Ursula B Kaiser, Niki Karavitaki, Laurence Katznelson, Maya Lodish, Dominique Maiter, Hani J Marcus, Ann McCormack, Mark Molitch, Christopher A Muir, Sebastian Neggers, Alberto M Pereira, Rosario Pivonello, Kalmon Post, Gerald Raverot, Roberto Salvatori, Susan L Samson, Ilan Shimon, Joanna Spencer-Segal, Greisa Vila, John Wass, Shlomo Melmed
No abstract text is available yet for this article.
January 2024: Nature Reviews. Endocrinology
#72
REVIEW
Georgia Xourafa, Melis Korbmacher, Michael Roden
Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within different tissues and systemic dysregulation of tissue crosstalk. The main local mechanisms comprise metabolic (lipid) signalling, altered mitochondrial metabolism with oxidative stress, endoplasmic reticulum stress and local inflammation. While the role of endocrine dysregulation in T2DM pathogenesis is well established, other forms of inter-organ crosstalk deserve closer investigation to better understand the multifactorial transition from normoglycaemia to hyperglycaemia...
January 2024: Nature Reviews. Endocrinology
#73
REVIEW
Saame Raza Shaikh, Melinda A Beck, Yazan Alwarawrah, Nancie J MacIver
Obesity is associated with a wide range of complications, including type 2 diabetes mellitus, cardiovascular disease, hypertension and nonalcoholic fatty liver disease. Obesity also increases the incidence and progression of cancers, autoimmunity and infections, as well as lowering vaccine responsiveness. A unifying concept across these differing diseases is dysregulated immunity, particularly inflammation, in response to metabolic overload. Herein, we review emerging mechanisms by which obesity drives inflammation and autoimmunity, as well as impairing tumour immunosurveillance and the response to infections...
December 21, 2023: Nature Reviews. Endocrinology
#74
REVIEW
Akanksha Garg, Agata P Zielinska, Arthur C Yeung, Rebecca Abdelmalak, Runzhi Chen, Aleena Hossain, Alisha Israni, Scott M Nelson, Andy V Babwah, Waljit S Dhillo, Ali Abbara
Infertility affects one in six couples, with in vitro fertilization (IVF) offering many the chance of conception. Compared to the solitary oocyte produced during the natural menstrual cycle, the supraphysiological ovarian stimulation needed to produce multiple oocytes during IVF results in a dysfunctional luteal phase that can be insufficient to support implantation and maintain pregnancy. Consequently, hormonal supplementation with luteal phase support, principally exogenous progesterone, is used to optimize pregnancy rates; however, luteal phase support remains largely 'black-box' with insufficient clarity regarding the optimal timing, dosing, route and duration of treatment...
December 18, 2023: Nature Reviews. Endocrinology
#75
Luca Valenti, Elena Corradini, Leon A Adams, Elmar Aigner, Saleh Alqahtani, Marco Arrese, Edouard Bardou-Jacquet, Elisabetta Bugianesi, Jose-Manuel Fernandez-Real, Domenico Girelli, Hannes Hagström, Benjamin Henninger, Kris Kowdley, Guido Ligabue, Donald McClain, Fabrice Lainé, Koji Miyanishi, Martina U Muckenthaler, Alessia Pagani, Patrizia Pedrotti, Antonello Pietrangelo, Daniele Prati, John D Ryan, Laura Silvestri, C Wendy Spearman, Per Stål, Emmanuel A Tsochatzis, Francesca Vinchi, Ming-Hua Zheng, Heinz Zoller
No abstract text is available yet for this article.
December 14, 2023: Nature Reviews. Endocrinology
#76
REVIEW
David Taïeb, Svenja Nölting, Nancy D Perrier, Martin Fassnacht, Jorge A Carrasquillo, Ashley B Grossman, Roderick Clifton-Bligh, George B Wanna, Zachary G Schwam, Laurence Amar, Isabelle Bourdeau, Ruth T Casey, Joakim Crona, Cheri L Deal, Jaydira Del Rivero, Quan-Yang Duh, Graeme Eisenhofer, Tito Fojo, Hans K Ghayee, Anne-Paule Gimenez-Roqueplo, Antony J Gill, Rodney Hicks, Alessio Imperiale, Abhishek Jha, Michiel N Kerstens, Ronald R de Krijger, André Lacroix, Ivica Lazurova, Frank I Lin, Charlotte Lussey-Lepoutre, Eamonn R Maher, Ozgur Mete, Mitsuhide Naruse, Naris Nilubol, Mercedes Robledo, Frédéric Sebag, Nalini S Shah, Akiyo Tanabe, Geoffrey B Thompson, Henri J L M Timmers, Jiri Widimsky, William J Young, Leah Meuter, Jacques W M Lenders, Karel Pacak
Adult and paediatric patients with pathogenic variants in the gene encoding succinate dehydrogenase (SDH) subunit B (SDHB) often have locally aggressive, recurrent or metastatic phaeochromocytomas and paragangliomas (PPGLs). Furthermore, SDHB PPGLs have the highest rates of disease-specific morbidity and mortality compared with other hereditary PPGLs. PPGLs with SDHB pathogenic variants are often less differentiated and do not produce substantial amounts of catecholamines (in some patients, they produce only dopamine) compared with other hereditary subtypes, which enables these tumours to grow subclinically for a long time...
December 14, 2023: Nature Reviews. Endocrinology
#77
JOURNAL ARTICLE
Mette M Rosenkilde
No abstract text is available yet for this article.
December 7, 2023: Nature Reviews. Endocrinology
#78
JOURNAL ARTICLE
Veronica A Cochrane, Matthias Hebrok
No abstract text is available yet for this article.
December 2023: Nature Reviews. Endocrinology
#79
REVIEW
Ibrahim AlZaim, Laura P M H de Rooij, Bilal N Sheikh, Emma Börgeson, Joanna Kalucka
Adipose tissue is an endocrine organ and a crucial regulator of energy storage and systemic metabolic homeostasis. Additionally, adipose tissue is a pivotal regulator of cardiovascular health and disease, mediated in part by the endocrine and paracrine secretion of several bioactive products, such as adipokines. Adipose vasculature has an instrumental role in the modulation of adipose tissue expansion, homeostasis and metabolism. The role of the adipose vasculature has been extensively explored in the context of obesity, which is recognized as a global health problem...
December 2023: Nature Reviews. Endocrinology
#80
JOURNAL ARTICLE
Ghulam Mehdi Dar
No abstract text is available yet for this article.
December 2023: Nature Reviews. Endocrinology
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