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REVIEW
Seppe Melis, Dana Trompet, Andrei S Chagin, Christa Maes
Skeletal stem cells (SSCs) and related progenitors with osteogenic potential, collectively termed skeletal stem and/or progenitor cells (SSPCs), are crucial for providing osteoblasts for bone formation during homeostatic tissue turnover and fracture repair. Besides mediating normal bone physiology, they also have important roles in various metabolic bone diseases, including osteoporosis. SSPCs are of tremendous interest because they represent prime future targets for osteoanabolic therapies and bone regenerative medicine...
October 8, 2024: Nature Reviews. Endocrinology
#2
JOURNAL ARTICLE
Senegal Carty
No abstract text is available yet for this article.
October 8, 2024: Nature Reviews. Endocrinology
#3
REVIEW
Rhonda D Kineman, Mercedes Del Rio-Moreno, David J Waxman
Metabolic dysfunction-associated steatotic liver disease (MASLD; also known as nonalcoholic fatty liver disease) is a chronic condition associated with metabolic syndrome, a group of conditions that includes obesity, insulin resistance, hyperlipidaemia and cardiovascular disease. Primary growth hormone (GH) deficiency is associated with MASLD, and the decline in circulating levels of GH with weight gain might contribute to the development of MASLD. Raising endogenous GH secretion or administering GH replacement therapy in the context of MASLD enhances insulin-like growth factor 1 (IGF1) production and reduces steatosis and the severity of liver injury...
September 25, 2024: Nature Reviews. Endocrinology
#4
REVIEW
Marysia Placzek, Kavitha Chinnaiya, Dong Won Kim, Seth Blackshaw
The tuberal hypothalamus regulates a range of crucial physiological processes, including energy homeostasis and metabolism. In this Review, we explore the intricate molecular mechanisms and signalling pathways that control the development of the tuberal hypothalamus, focusing on aspects that shape metabolic outcomes. Major developmental events are discussed in the context of their effect on the establishment of both functional hypothalamic neuronal circuits and brain-body interfaces that are pivotal to the control of metabolism...
September 23, 2024: Nature Reviews. Endocrinology
#5
REVIEW
Kylie D Hesketh, Miaobing Zheng, Karen J Campbell
The prevalence of obesity increases with age but is apparent even in early life. Early childhood is a critical period for development that is known to influence future health. Even so, the focus on obesity in this phase, and the factors that affect the development of obesity, has only emerged over the past two decades. Furthermore, there is a paucity of iterative work in this area that would move the field forward. Obesity is a complex condition involving the interplay of multiple influences at different levels: the individual and biological level, the sociocultural level, and the environmental and system levels...
September 23, 2024: Nature Reviews. Endocrinology
#6
REVIEW
Joanne Lysaght, Melissa J Conroy
Epidemiology studies have demonstrated a clear association between obesity and the development of several distinct malignancies, with excessive visceral adiposity being an increasingly prevalent feature in patients with cancer presenting for therapeutic intervention. Clinical trials and meta-analyses have helped to inform effective and safe dosing of traditional systemically administered anticancer agents in adult patients with cancer and obesity, but there remains much debate not only regarding the effect of obesity on the more novel targeted molecular and immune-based therapies, but also about how obesity is best defined and measured clinically...
September 23, 2024: Nature Reviews. Endocrinology
#7
JOURNAL ARTICLE
Pamela Fischer-Posovszky, Julia Zinngrebe
No abstract text is available yet for this article.
September 20, 2024: Nature Reviews. Endocrinology
#8
JOURNAL ARTICLE
Bandy Chen, Stephanie Lenck, Jean-Leon Thomas, Marc Schneeberger
No abstract text is available yet for this article.
September 20, 2024: Nature Reviews. Endocrinology
#9
JOURNAL ARTICLE
Claire Greenhill
No abstract text is available yet for this article.
September 19, 2024: Nature Reviews. Endocrinology
#10
JOURNAL ARTICLE
Olivia Tysoe
No abstract text is available yet for this article.
September 19, 2024: Nature Reviews. Endocrinology
#11
JOURNAL ARTICLE
David C D Hope, Tricia M-M Tan
No abstract text is available yet for this article.
September 18, 2024: Nature Reviews. Endocrinology
#12
JOURNAL ARTICLE
Varun Kumar, Ali Önder Yildirim, Peter P Nawroth
No abstract text is available yet for this article.
September 12, 2024: Nature Reviews. Endocrinology
#13
REVIEW
Alessandro Grattoni, Gregory Korbutt, Alice A Tomei, Andrés J García, Andrew R Pepper, Cherie Stabler, Michael Brehm, Klearchos Papas, Antonio Citro, Haval Shirwan, Jeffrey R Millman, Juan Melero-Martin, Melanie Graham, Michael Sefton, Minglin Ma, Norma Kenyon, Omid Veiseh, Tejal A Desai, M Cristina Nostro, Marjana Marinac, Megan Sykes, Holger A Russ, Jon Odorico, Qizhi Tang, Camillo Ricordi, Esther Latres, Nicholas E Mamrak, Jaime Giraldo, Mark C Poznansky, Paul de Vos
Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune destruction of pancreatic β cells, leading to a disruption in glucose homeostasis. Therapeutic intervention for T1DM requires a complex regimen of glycaemic monitoring and the administration of exogenous insulin to regulate blood glucose levels. Advances in continuous glucose monitoring and algorithm-driven insulin delivery devices have improved the quality of life of patients...
September 3, 2024: Nature Reviews. Endocrinology
#14
JOURNAL ARTICLE
Stefan R Bornstein, J Fraser Wright, Charlotte Steenblock
No abstract text is available yet for this article.
August 29, 2024: Nature Reviews. Endocrinology
#15
JOURNAL ARTICLE
Senegal Carty
No abstract text is available yet for this article.
August 29, 2024: Nature Reviews. Endocrinology
#16
Ruth T Casey, Emile Hendriks, Cheri Deal, Steven G Waguespack, Verena Wiegering, Antje Redlich, Scott Akker, Rathi Prasad, Martin Fassnacht, Roderick Clifton-Bligh, Laurence Amar, Stefan Bornstein, Letizia Canu, Evangelia Charmandari, Alexandra Chrisoulidou, Maria Currás Freixes, Ronald de Krijger, Luisa de Sanctis, Antonio Fojo, Amol J Ghia, Angela Huebner, Vasilis Kosmoliaptsis, Michaela Kuhlen, Marco Raffaelli, Charlotte Lussey-Lepoutre, Stephen D Marks, Naris Nilubol, Mirko Parasiliti-Caprino, Henri H J L M Timmers, Anna Lena Zietlow, Mercedes Robledo, Anne-Paule Gimenez-Roqueplo, Ashley B Grossman, David Taïeb, Eamonn R Maher, Jacques W M Lenders, Graeme Eisenhofer, Camilo Jimenez, Karel Pacak, Christina Pamporaki
No abstract text is available yet for this article.
August 27, 2024: Nature Reviews. Endocrinology
#17
JOURNAL ARTICLE
Yusman Manchanda, Alejandra Tomas
No abstract text is available yet for this article.
August 22, 2024: Nature Reviews. Endocrinology
#18
REVIEW
Giorgio Grani, Marialuisa Sponziello, Sebastiano Filetti, Cosimo Durante
Thyroid nodules, with a prevalence of almost 25% in the general population, are a common occurrence. Their prevalence varies considerably depending on demographics such as age and sex as well as the presence of risk factors. This article provides a comprehensive overview of the prevalence, risk stratification and current management strategies for thyroid nodules, with a particular focus on changes in diagnostic and therapeutic protocols that have occurred over the past 10 years. Several sonography-based stratification systems (such as Thyroid Imaging Reporting and Data Systems (TIRADS)) might help to predict the malignancy risk of nodules, potentially eliminating the need for biopsy in many instances...
August 16, 2024: Nature Reviews. Endocrinology
#19
REVIEW
Ruth T Casey, Emile Hendriks, Cheri Deal, Steven G Waguespack, Verena Wiegering, Antje Redlich, Scott Akker, Rathi Prasad, Martin Fassnacht, Roderick Clifton-Bligh, Laurence Amar, Stefan Bornstein, Letizia Canu, Evangelia Charmandari, Alexandra Chrisoulidou, Maria Currás Freixes, Ronald de Krijger, Luisa de Sanctis, Antonio Fojo, Amol J Ghia, Angela Huebner, Vasilis Kosmoliaptsis, Michaela Kuehlen, Marco Raffaelli, Charlotte Lussey-Lepoutre, Stephen D Marks, Naris Nilubol, Mirko Parasiliti-Caprino, Henri H J L M Timmers, Anna Lena Zietlow, Mercedes Robledo, Anne-Paule Gimenez-Roqueplo, Ashley B Grossman, David Taïeb, Eamonn R Maher, Jacques W M Lenders, Graeme Eisenhofer, Camilo Jimenez, Karel Pacak, Christina Pamporaki
Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70-80% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork...
August 15, 2024: Nature Reviews. Endocrinology
#20
REVIEW
Laszlo Hegedüs, Christina M Van Der Feltz-Cornelis, Enrico Papini, Endre V Nagy, Anthony P Weetman, Petros Perros
Persistent symptoms are common in the general population and even more so in people with hypothyroidism. When symptoms are unexplained and brought to medical attention, they can be referred to as medically not yet explained symptoms (MNYES), a term preferred to other descriptors by patients, care-givers and experts. MNYES might be neglected by endocrinologists or misattributed to hypothyroidism. Awareness of MNYES could open up more effective and less harmful interventions for patients who present to endocrinologists with unexplained symptoms than costly over-investigations and over-treatment with thyroid hormones (such as levothyroxine and liothyronine)...
August 13, 2024: Nature Reviews. Endocrinology
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