journal
https://read.qxmd.com/read/38179791/metabolic-profiling-identifies-1-methis-and-3-ipa-as-potential-diagnostic-biomarkers-for-patients-with-acute-and-chronic-heart-failure-with-reduced-ejection-fraction
#21
JOURNAL ARTICLE
Tom Kretzschmar, Julian Westphal, Sophie Neugebauer, Jasmine M F Wu, Max Zeller, Jurgen Bogoviku, Mohamed M Bekhite, Tarek Bekfani, Peter Schlattmann, Michael Kiehntopf, Marcus Franz, P Christian Schulze
BACKGROUND: Metabolomics has become a valuable tool for identifying potential new biomarkers and metabolic profiles. It has the potential to improve the diagnosis and prognosis of different phenotypes of heart failure. To generate a distinctive metabolic profile, we assessed and compared the metabolic phenotypes of patients with acute decompensated heart failure (ADHF), patients with chronic heart failure (CHF), and healthy controls. METHODS: Plasma metabolites were analyzed by liquid-chromatography mass spectrometry/mass spectrometry and the MxP Quant 500 kit in 15 patients with ADHF, 50 patients with CHF (25 with dilated cardiomyopathy, 25 with ischemic cardiomyopathy), and 13 controls...
January 5, 2024: Circulation. Heart Failure
https://read.qxmd.com/read/38179728/protocolized-natriuresis-guided-decongestion-improves-diuretic-response-the-multicenter-enact-hf-study
#22
JOURNAL ARTICLE
Jeroen Dauw, Kristina Charaya, Małgorzata Lelonek, Isabel Zegri-Reiriz, Samer Nasr, Cynthia P Paredes-Paucar, Attila Borbély, Fatih Erdal, Riad Benkouar, Marta Cobo-Marcos, Gonzalo Barge-Caballero, Varghese George, Cornelia Zara, Noel T Ross, Diane Barker, Annop Lekhakul, Simone Frea, Azmee M Ghazi, Dorit Knappe, Nawal Doghmi, Milka Klincheva, Inês Fialho, Virginia Bovolo, Hajo Findeisen, Imad A Alhaddad, Alessandro Galluzzo, Rafael de la Espriella, Ramzi Tabbalat, Òscar Miró, Jagdeep S Singh, Petra Nijst, Matthias Dupont, Pieter Martens, Wilfried Mullens
BACKGROUND: The use of urinary sodium to guide diuretics in acute heart failure is recommended by experts and the most recent European Society of Cardiology guidelines. However, there are limited data to support this recommendation. The ENACT-HF study (Efficacy of a Standardized Diuretic Protocol in Acute Heart Failure) investigated the feasibility and efficacy of a standardized natriuresis-guided diuretic protocol in patients with acute heart failure and signs of volume overload. METHODS: ENACT-HF was an international, multicenter, open-label, pragmatic, 2-phase study, comparing the current standard of care of each center with a standardized diuretic protocol, including urinary sodium to guide therapy...
January 5, 2024: Circulation. Heart Failure
https://read.qxmd.com/read/38126237/deep-learning-and-biased-prediction-more-questions-than-answers
#23
EDITORIAL
Michael A Rosenberg
No abstract text is available yet for this article.
December 21, 2023: Circulation. Heart Failure
https://read.qxmd.com/read/38126226/identification-of-clinical-drivers-of-left-atrial-enlargement-through-genomics-of-left-atrial-size
#24
JOURNAL ARTICLE
Vineet Agrawal, Ali Manouchehri, Nataraja S Vaitinadin, Mingjian Shi, Minoo Bagheri, Deepak K Gupta, Iftikhar J Kullo, Yuan Luo, Elizabeth M McNally, Megan J Puckelwartz, Jane F Ferguson, Quinn S Wells, Jonathan D Mosley
BACKGROUND: Greater left atrial size is associated with a higher incidence of cardiovascular disease and mortality, but the full spectrum of diagnoses associated with left atrial enlargement in sex-stratified clinical populations is not well known. Our study sought to identify genetic risk mechanisms affecting left atrial diameter (LAD) in a clinical cohort. METHODS: Using Vanderbilt deidentified electronic health record, we studied 6163 females and 5993 males of European ancestry who had at least 1 LAD measure and available genotyping...
December 21, 2023: Circulation. Heart Failure
https://read.qxmd.com/read/38126168/race-sex-and-age-disparities-in-the-performance-of-ecg-deep-learning-models-predicting-heart-failure
#25
JOURNAL ARTICLE
Dhamanpreet Kaur, J Weston Hughes, Albert J Rogers, Guson Kang, Sanjiv M Narayan, Euan A Ashley, Marco V Perez
BACKGROUND: Deep learning models may combat widening racial disparities in heart failure outcomes through early identification of individuals at high risk. However, demographic biases in the performance of these models have not been well-studied. METHODS: This retrospective analysis used 12-lead ECGs taken between 2008 and 2018 from 326 518 patient encounters referred for standard clinical indications to Stanford Hospital. The primary model was a convolutional neural network model trained to predict incident heart failure within 5 years...
December 21, 2023: Circulation. Heart Failure
https://read.qxmd.com/read/38073555/direct-vo-2-measurement-getting-the-fick-right-for-heart-transplant-eligibility
#26
JOURNAL ARTICLE
James W Schurr, Michael V Genuardi
No abstract text is available yet for this article.
December 11, 2023: Circulation. Heart Failure
https://read.qxmd.com/read/38054280/long-axis-biplane-echocardiography-sensitively-detects-the-progressing-functional-deterioration-of-mouse-heart
#27
JOURNAL ARTICLE
Ege Kacira, Mitchell Pittman, Dandan Yang, Sarah L Sturgill, Mark T Ziolo, Yuchi Han, Isabelle Deschênes, Ji-Dong Fu
No abstract text is available yet for this article.
December 6, 2023: Circulation. Heart Failure
https://read.qxmd.com/read/38250799/hierarchical-end-points-in-prior-heart-failure-trials-and-the-heart-fid-trial
#28
REVIEW
Josephine Harrington, Robert J Mentz, Frank W Rockhold, Jyotsna Garg, Javed Butler, Carmine G De Pasquale, Justin A Ezekowitz, Gregory D Lewis, Eileen O'Meara, Piotr Ponikowski, Richard W Troughton, Yee W Wong, Robert Adamczyk, Tatyana Storie, Nicole Blackman, Adrian F Hernandez
BACKGROUND: Clinical trials in heart failure (HF) traditionally use time-to-event analyses focusing on death and hospitalization for HF. These time-to-first event analyses may have more limited abilities to assess the probability of benefiting from a therapy, especially if that benefit manifests as improved functional status rather than reduced risk of death or HF hospitalization. Hierarchical end points including clinical outcomes and patient status measures allow for ranked evaluation of outcomes in 1 metric assessing whether patients randomized to intervention or control are more likely to derive an overall benefit while also allowing more patients to contribute to the primary outcome...
February 2024: Circulation. Heart Failure
https://read.qxmd.com/read/38227683/editors-and-editorial-board
#29
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2024: Circulation. Heart Failure
https://read.qxmd.com/read/38179720/natriuresis-guided-titration-of-loop-diuretics-in-heart-failure-another-brick-in-the-wall
#30
EDITORIAL
G Michael Felker
No abstract text is available yet for this article.
January 2024: Circulation. Heart Failure
https://read.qxmd.com/read/38108151/coronary-microvascular-dysfunction-in-patients-with-heart-failure-characterization-of-patterns-in-hfref-versus-hfpef
#31
JOURNAL ARTICLE
Pasquale Paolisso, Emanuele Gallinoro, Marta Belmonte, Dario Tino Bertolone, Konstantinos Bermpeis, Cristina De Colle, Monika Shumkova, Attilio Leone, Serena Caglioni, Giuseppe Esposito, Davide Fabbricatore, Ana Moya, Leen Delrue, Martin Penicka, Bernard De Bruyne, Emanuele Barbato, Jozef Bartunek, Marc Vanderheyden
BACKGROUND: Coronary microvascular dysfunction (CMD) is involved in heart failure (HF) onset and progression, independently of HF phenotype and obstructive coronary artery disease. Invasive assessment of CMD might provide insights into phenotyping and prognosis of patients with HF. We aimed to assess absolute coronary flow, absolute microvascular resistance, myocardial perfusion, coronary flow reserve, and microvascular resistance reserve in patients with HF with preserved ejection fraction and HF with reduced ejection fraction (HFrEF)...
January 2024: Circulation. Heart Failure
https://read.qxmd.com/read/38088175/case-implementing-2022-aha-acc-hfsa-guidelines-heart-failure-management-in-pregnancy-early-planning-close-surveillance-and-multidisciplinary-care
#32
JOURNAL ARTICLE
Neha V Chandra, Steven Stroud, Megan Y Kamath
No abstract text is available yet for this article.
January 2024: Circulation. Heart Failure
https://read.qxmd.com/read/38054337/heartmate-3-left-ventricular-assist-device-implant-and-repair-of-a-left-ventricular-pseudoaneurysm
#33
JOURNAL ARTICLE
Aryan Meknat, Manreet K Kanwar, Candice Y Lee, Masaki Tsukashita
No abstract text is available yet for this article.
January 2024: Circulation. Heart Failure
https://read.qxmd.com/read/38054278/rare-etiology-of-cardiogenic-shock-in-pregnancy
#34
JOURNAL ARTICLE
Lyana Labrada, Lindsay Panah, Joyce Johnson, Kaitlyn Brennan, Chetan Pasrija, Matthew Grace, Jonathan Menachem, Aniket S Rali
No abstract text is available yet for this article.
January 2024: Circulation. Heart Failure
https://read.qxmd.com/read/38113299/diastolic-tone-friend-and-foe-of-cardiac-performance
#35
EDITORIAL
Markus Meyer
No abstract text is available yet for this article.
December 2023: Circulation. Heart Failure
https://read.qxmd.com/read/38113298/increased-chamber-resting-tone-is-a-key-determinant-of-left-ventricular-diastolic-dysfunction
#36
JOURNAL ARTICLE
María Tamargo, Pablo Martínez-Legazpi, M Ángeles Espinosa, Aurore Lyon, Irene Méndez, Enrique Gutiérrez-Ibañes, Ana I Fernández, Raquel Prieto-Arévalo, Ana González-Mansilla, Theo Arts, Tammo Delhaas, Teresa Mombiela, Ricardo Sanz-Ruiz, Jaime Elízaga, Raquel Yotti, Carsten Tschöpe, Francisco Fernández-Avilés, Joost Lumens, Javier Bermejo
BACKGROUND: Twitch-independent tension has been demonstrated in cardiomyocytes, but its role in heart failure (HF) is unclear. We aimed to address twitch-independent tension as a source of diastolic dysfunction by isolating the effects of chamber resting tone (RT) from impaired relaxation and stiffness. METHODS: We invasively monitored pressure-volume data during cardiopulmonary exercise in 20 patients with hypertrophic cardiomyopathy, 17 control subjects, and 35 patients with HF with preserved ejection fraction...
December 2023: Circulation. Heart Failure
https://read.qxmd.com/read/38113297/nonsense-variant-prdm16-q187x-causes-impaired-myocardial-development-and-tgf-%C3%AE-signaling-resulting-in-noncompaction-cardiomyopathy-in-humans-and-mice
#37
JOURNAL ARTICLE
Bo Sun, Omid M T Rouzbehani, Ryan J Kramer, Rajeshwary Ghosh, Robin M Perelli, Sage Atkins, Amir Nima Fatahian, Kathryn Davis, Marta W Szulik, Michael A Goodman, Marissa A Hathaway, Ellenor Chi, Tarah A Word, Hari Tunuguntla, Susan W Denfield, Xander H T Wehrens, Kevin J Whitehead, Hala Y Abdelnasser, Junco S Warren, Mingfu Wu, Sarah Franklin, Sihem Boudina, Andrew P Landstrom
BACKGROUND: PRDM16 plays a role in myocardial development through TGF-β (transforming growth factor-beta) signaling. Recent evidence suggests that loss of PRDM16 expression is associated with cardiomyopathy development in mice, although its role in human cardiomyopathy development is unclear. This study aims to determine the impact of PRDM16 loss-of-function variants on cardiomyopathy in humans. METHODS: Individuals with PRDM16 variants were identified and consented...
December 2023: Circulation. Heart Failure
https://read.qxmd.com/read/38037817/neurocognitive-impairments-and-their-improvement-following-exercise-and-dietary-interventions-in-older-patients-with-heart-failure-with-preserved-ejection-fraction
#38
JOURNAL ARTICLE
Christopher L Schaich, Timothy M Hughes, Dalane W Kitzman, Youngkyoo Jung, Haiying Chen, Barbara J Nicklas, Denise K Houston, Peter H Brubaker, Anthony J A Molina, Christina E Hugenschmidt
No abstract text is available yet for this article.
December 1, 2023: Circulation. Heart Failure
https://read.qxmd.com/read/38010208/epicardial-fat-paradox-and-differential-effects-of-glp-1-receptor-agonists-across-heart-failure-phenotypes
#39
JOURNAL ARTICLE
Mainak Banerjee
No abstract text is available yet for this article.
December 2023: Circulation. Heart Failure
https://read.qxmd.com/read/37703079/hemodynamic-manifestations-of-concomitant-radiation-induced-tricuspid-regurgitation-and-pericardial-constriction-undergoing-transcatheter-tricuspid-valve-repair
#40
JOURNAL ARTICLE
Katie P Truong, Marcella Calfon Press, Peyman Benharash, Saibal Kar, Norman E Lepor, Gabriel Vorobiof, Eric H Yang
No abstract text is available yet for this article.
December 2023: Circulation. Heart Failure
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