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Circulation. Heart Failure

journal
https://read.qxmd.com/read/30744415/mitochondrial-morphology-dynamics-and-function-in-human-pressure-overload-or-ischemic-heart-disease-with-preserved-or-reduced-ejection-fraction
#1
Antoine H Chaanine, Lyle D Joyce, John M Stulak, Simon Maltais, David L Joyce, Joseph A Dearani, Katherine Klaus, K Sreekumaran Nair, Roger J Hajjar, Margaret M Redfield
BACKGROUND: The FOXO3a (forkhead box O3a)-BNIP3 (B-cell lymphoma 2/adenovirus E1B 19kDa interacting protein 3) pathway modulates mitochondrial dynamics and function and contributes to myocardial remodeling in rodent models of heart failure. We sought to investigate the expression of this pathway along with the expression of mitochondrial biogenesis (PGC-1α [peroxisome proliferator-activated receptor-γ coactivator-1α]), dynamics (DRP-1 [dynamin-related protein 1], OPA-1 [optic atrophy 1], and MFN 2 [mitofusin 2]), and oxidative phosphorylation (citrate synthase and electron transport chain complexes) markers and COX IV (cytochrome C oxidase) activity in myocardium from patients with valvular or ischemic heart disease and heart failure with preserved ejection fraction (HFpEF) or heart failure with reduced ejection fraction (HFrEF)...
February 2019: Circulation. Heart Failure
https://read.qxmd.com/read/30704292/correction-to-novel-model-to-predict-gastrointestinal-bleeding-during-left-ventricular-assist-device-support-the-utah-bleeding-risk-score
#2
(no author information available yet)
No abstract text is available yet for this article.
February 2019: Circulation. Heart Failure
https://read.qxmd.com/read/30704291/optimal-hemodynamics-during-left-ventricular-assist-device-support-are-associated-with-reduced-readmission-rates
#3
Teruhiko Imamura, Valluvan Jeevanandam, Gene Kim, Jayant Raikhelkar, Nitasha Sarswat, Sara Kalantari, Bryan Smith, Daniel Rodgers, Stephanie Besser, Ben Chung, Ann Nguyen, Nikhil Narang, Takeyoshi Ota, Tae Song, Colleen Juricek, Mandeep Mehra, Maria Rosa Costanzo, Ulrich P Jorde, Daniel Burkhoff, Gabriel Sayer, Nir Uriel
BACKGROUND: Left ventricular assist device (LVAD) therapy improves the hemodynamics of advanced heart failure patients. However, it is unknown whether hemodynamic optimization improves clinical outcomes. The aim of this study was to investigate whether hemodynamic optimization reduces hospital readmission rate in LVAD patients. METHODS AND RESULTS: LVAD patients undergoing an invasive hemodynamic ramp test were prospectively enrolled and followed for 1 year. LVAD speed was optimized using a ramp test, targeting the following goals: central venous pressure <12 mm Hg, pulmonary capillary wedge pressure <18 mm Hg, and cardiac index >2...
February 2019: Circulation. Heart Failure
https://read.qxmd.com/read/30688079/medical-misinformation
#4
EDITORIAL
Joseph A Hill, Stefan Agewall, Adrian Baranchuk, George W Booz, Jeffrey S Borer, Paolo G Camici, Peng-Sheng Chen, Anna F Dominiczak, Çetin Erol, Cindy L Grines, Robert Gropler, Tomasz J Guzik, Markus K Heinemann, Ami E Iskandrian, Bradley P Knight, Barry London, Thomas F Lüscher, Marco Metra, Kiran Musunuru, Brahmajee K Nallamothu, Andrea Natale, Sanjeev Saksena, Michael H Picard, Sunil V Rao, Willem J Remme, Robert S Rosenson, Nancy K Sweitzer, Adam Timmis, Christiaan Vrints
No abstract text is available yet for this article.
February 2019: Circulation. Heart Failure
https://read.qxmd.com/read/30630340/characteristics-of-acute-heart-failure-hospitalizations-based-on-presenting-severity
#5
Kishan S Parikh, Shubin Sheng, Bradley G Hammill, Clyde W Yancy, Gregg C Fonarow, Adrian F Hernandez, Adam D DeVore
BACKGROUND: Hospitalizations for acute heart failure (HF) are significant events with downstream implications for patients, as well as healthcare systems and payers. However, from anecdotal experience, both hospitalization and postdischarge courses vary significantly based on severity of presenting decompensation. METHODS AND RESULTS: We compared patient and hospitalization characteristics, resource utilization, and associated outcomes, among modern era acute HF patients enrolled in the GWTG-HF (Get With the Guidelines-Heart Failure) registry between 2011 and 2016, by varying severity of their acute HF...
January 2019: Circulation. Heart Failure
https://read.qxmd.com/read/30621511/of-parachutes-and-heart-pumps
#6
EDITORIAL
Eric D Adler
No abstract text is available yet for this article.
January 2019: Circulation. Heart Failure
https://read.qxmd.com/read/30621510/endothelial-leptin-receptor-deletion-promotes-cardiac-autophagy-and-angiogenesis-following-pressure-overload-by-suppressing-akt-mtor-signaling
#7
Rajinikanth Gogiraju, Astrid Hubert, Jörg Fahrer, Beate K Straub, Moritz Brandt, Philip Wenzel, Thomas Münzel, Stavros Konstantinides, Gerd Hasenfuss, Katrin Schäfer
BACKGROUND: Cardiac remodeling is modulated by overnutrition or starvation. The adipokine leptin mediates energy balance between adipose tissue and brain. Leptin and its receptors are expressed in the heart. METHODS AND RESULTS: To examine the importance of endothelial leptin signaling in cardiac hypertrophy, transverse aortic constriction was used in mice with inducible endothelium-specific deletion of leptin receptors (End.LepR-KO) or littermate controls (End...
January 2019: Circulation. Heart Failure
https://read.qxmd.com/read/30621509/standardized-psychosocial-assessment-before-left-ventricular-assist-device-implantation
#8
Brett W Sperry, Asad Ikram, Paulino A Alvarez, Antonio L Perez, Kay Kendall, Eiran Z Gorodeski, Randall C Starling
BACKGROUND: Before consideration of advanced cardiac therapies, guidelines recommend a comprehensive multidisciplinary examination, including psychosocial assessment. The Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT) has emerged as a highly reproducible tool to assess for psychosocial impairment and is associated with negative medical and psychosocial outcomes after transplantation. We sought to assess the association between SIPAT and outcomes after left ventricular assist device...
January 2019: Circulation. Heart Failure
https://read.qxmd.com/read/30616361/coupling-right-ventricular-pulmonary-arterial-research-to-the-pulmonary-hypertension-patient-bedside
#9
EDITORIAL
Steven Hsu
No abstract text is available yet for this article.
January 2019: Circulation. Heart Failure
https://read.qxmd.com/read/30616360/reserve-of-right-ventricular-arterial-coupling-in-the-setting-of-chronic-overload
#10
Khodr Tello, Antonia Dalmer, Jens Axmann, Rebecca Vanderpool, Hossein A Ghofrani, Robert Naeije, Fritz Roller, Werner Seeger, Natascha Sommer, Jochen Wilhelm, Henning Gall, Manuel J Richter
BACKGROUND: Right ventricular (RV) maladaptation and failure determine outcome in pulmonary hypertension. The adaptation of RV function to loading (RV-pulmonary arterial coupling) is defined by a ratio of end-systolic to arterial elastances (Ees/Ea). How RV-pulmonary arterial coupling relates to pulmonary hypertension severity and onset of RV failure (defined by excessive volume increase and ejection fraction [EF] decrease) is not exactly known. METHODS AND RESULTS: We performed cardiac magnetic resonance (CMR) imaging within 24 hours of a diagnostic right heart catheterization and invasive measurement of RV pressure-volume loops in 42 patients with pulmonary hypertension...
January 2019: Circulation. Heart Failure
https://read.qxmd.com/read/30562100/st2-in-heart-failure
#11
EDITORIAL
Antoni Bayés-Genis, Arantxa González, Josep Lupón
No abstract text is available yet for this article.
December 2018: Circulation. Heart Failure
https://read.qxmd.com/read/30562099/national-burden-of-heart-failure-events-in-the-united-states-2006-to-2014
#12
Sandra L Jackson, Xin Tong, Raymond J King, Fleetwood Loustalot, Yuling Hong, Matthew D Ritchey
BACKGROUND: Heart failure (HF)-a serious and costly condition-is increasingly prevalent. We estimated the US burden including emergency department (ED) visits, inpatient hospitalizations and associated costs, and mortality. METHODS AND RESULTS: We analyzed 2006 to 2014 data from the Healthcare Cost and Utilization Project Nationwide Emergency Department Sample, the Healthcare Cost and Utilization Project National (nationwide) Inpatient Sample, and the National Vital Statistics System...
December 2018: Circulation. Heart Failure
https://read.qxmd.com/read/30562098/increased-cardiac-uptake-of-ketone-bodies-and-free-fatty-acids-in-human-heart-failure-and-hypertrophic-left-ventricular-remodeling
#13
Gabor Voros, Joris Ector, Christophe Garweg, Walter Droogne, Johan Van Cleemput, Nele Peersman, Pieter Vermeersch, Stefan Janssens
BACKGROUND: Deranged energy metabolism contributes to the pathophysiology of heart failure (HF). Recent studies showed diminished free fatty acid (FFA) oxidation in experimental HF models with a shift towards oxidation of ketone bodies. However, conflicting clinical data on FFA metabolism and limited knowledge on ketone body metabolism in human HF mandate additional metabolic profiling studies. We, therefore, investigated cardiac uptake of FFAs and ketone bodies (β-hydroxybutyrate and acetoacetate) in patients with HF with reduced ejection fraction (HFrEF) or with aortic stenosis (AS)-induced left ventricular hypertrophy...
December 2018: Circulation. Heart Failure
https://read.qxmd.com/read/30562097/expanding-the-donor-pool-with-use-of-hepatitis-c-infected-hearts
#14
EDITORIAL
Michael M Givertz, Ann E Woolley, Lindsey R Baden
No abstract text is available yet for this article.
December 2018: Circulation. Heart Failure
https://read.qxmd.com/read/30562096/pulmonary-production-of-soluble-st2-in-heart-failure
#15
Domingo A Pascual-Figal, Maria T Pérez-Martínez, Maria C Asensio-Lopez, Jesús Sanchez-Más, Maria E García-García, Carlos M Martinez, Miriam Lencina, Ruben Jara, James L Januzzi, Antonio Lax
BACKGROUND: Serum concentrations of ST2 (interleukin-1 receptor-like 1) represent a meaningful prognostic marker in cardiac diseases. Production of soluble ST2 (sST2) may be partially extracardiac. Identification of sST2 sources is relevant to design strategies for modulating its signaling. METHODS AND RESULTS: An experimental model of ischemic heart failure was used. sST2, membrane-bound ST2 (ST2L), and IL-33 were measured in lungs, heart, kidney, and liver by quantifying mRNA and protein expression in tissue samples obtained at different times (1, 2, 4, and 24 weeks)...
December 2018: Circulation. Heart Failure
https://read.qxmd.com/read/30562095/thyroid-dysfunction-in-heart-failure-and-cardiovascular-outcomes
#16
Lakshmi Kannan, Pamela A Shaw, Michael P Morley, Jeffrey Brandimarto, James C Fang, Nancy K Sweitzer, Thomas P Cappola, Anne R Cappola
BACKGROUND: The effects of thyroid dysfunction in patients with preexisting heart failure have not been adequately studied. We examined the prevalence of thyroid dysfunction and associations with cardiovascular outcomes in a large, prospective cohort of outpatients with preexisting heart failure. METHODS AND RESULTS: We examined associations between thyroid dysfunction and New York Heart Association class, atrial fibrillation, and a composite end point of ventricular assist device placement, heart transplantation, or death in 1365 participants with heart failure enrolled in the Penn Heart Failure Study...
December 2018: Circulation. Heart Failure
https://read.qxmd.com/read/30562094/subendocardial-ischemia-because-of-coronary-artery-spasm-causes-transient-severe-mitral-regurgitation
#17
Mitsunobu Kaneko, Kazutaka Ueda, Ikiko Nishimae, Shuya Nitta, Masatoshi Suzuki, Masashi Kasao, Tetsuro Shirai
No abstract text is available yet for this article.
December 2018: Circulation. Heart Failure
https://read.qxmd.com/read/30562093/current-use-of-hearts-from-hepatitis-c-viremic-donors
#18
Yasbanoo Moayedi, Chun Po S Fan, Aliya F Gulamhusein, Cedric Manlhiot, Heather J Ross, Jeffrey J Teuteberg, Kiran K Khush
BACKGROUND: Strategies to improve donor heart utilization are required in the setting of limited donor availability. One innovative strategy is to consider the use of hepatitis C viremic (HCV) nucleic acid amplification test positive donors in hepatitis C-negative recipients, given the availability of highly effective direct acting antiviral agents. We utilized United Network for Organ Sharing data to evaluate the geographic distribution, clinical characteristics, and post-transplant outcomes of HCV+ donor hearts...
December 2018: Circulation. Heart Failure
https://read.qxmd.com/read/30537855/hungry-hearts
#19
EDITORIAL
Edoardo Bertero, Vasco Sequeira, Christoph Maack
No abstract text is available yet for this article.
December 2018: Circulation. Heart Failure
https://read.qxmd.com/read/30571199/lessons-from-the-first-202-rehab-hf-participants
#20
EDITORIAL
Kelsey M Flint, Daniel E Forman
No abstract text is available yet for this article.
November 2018: Circulation. Heart Failure
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