Harold I Salmons, Christopher Gow, Afton K Limberg, Jacob W Bettencourt, Mason F Carstens, Ashley N Payne, Mark E Morrey, Joaquin Sanchez-Sotelo, Daniel J Berry, Amel Dudakovic, Matthew P Abdel
AdipoRon is an adiponectin receptor 1, 2 (ADIPOR1 and ADIPOR2) agonist with numerous reported physiologic benefits in murine models of human disease, including a proposed reduction in fibrosis. However, AdipoRon has never been investigated in rabbits, which provide a robust model for orthopedic conditions. We examined the safety of intravenous (IV) AdipoRon in New Zealand White (NZW) female rabbits surgically-stressed by a procedure that mimics human arthrofibrosis. Fifteen female NZW rabbits were prospectively studied using increasing AdipoRon doses based on established literature...
March 16, 2023: Tissue Engineering. Part C, Methods