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Clinical Ophthalmology

Arnt-Ole Tvenning, Christian Hedels, Jørgen Krohn, Dordi Austeng
Purpose: To evaluate the use of aflibercept, triamcinolone acetonide, and photodynamic therapy (PDT) in the treatment of avascular pigment epithelium detachments (aPEDs). Patients and methods: Patients with treatment-naïve aPEDs ≥1,500 µm in diameter were randomized to treatment or observation. Treatment consisted of 6 monthly intravitreal injections of aflibercept. If the aPED persisted, the patients were treated with half-fluence PDT in combination with intravitreal triamcinolone acetonide and aflibercept...
2019: Clinical Ophthalmology
John L Bradley, Ipek Özer Stillman, Irina Pivneva, Annie Guerin, Amber M Evans, Reza Dana
Objectives: Dry eye disease (DED) is a complex multifactorial condition of the ocular surface characterized by symptoms of ocular discomfort, irritation, and visual disturbance. Data previously reported from this study showed an increase in prevalence and incidence of DED with age and over time. The objective of this study was to compare the ranking of DED prevalence among other ocular conditions that led patients to seek eye care. Methods: In this population-based study using the US Department of Defense Military Health System claims database of >9...
2019: Clinical Ophthalmology
Md Kaosar Yazdani-Ibn-Taz, Myint Myint Han, Sven Jonuscheit, Andrew Collier, Jane E Nally, Suzanne Hagan
Purpose: The purpose of the study was to assess the relationship between patient-reported severity of dry eye disease (DED), quality of life (QoL), presence of diabetic retinopathy (DR) and length of disease duration in people with type 1 diabetes mellitus (DM1) and type 2 diabetes mellitus (DM2). Patients and methods: A survey of 152 people (110 with and 42 without diabetes). All participants completed the Ocular Surface Disease Index (OSDI) and Dry Eye-related Quality of Life Score (DEQS) questionnaires...
2019: Clinical Ophthalmology
(no author information available yet)
[This corrects the article on p. 1921 in vol. 12, PMID: 30323548.].
2019: Clinical Ophthalmology
Mehdi Siddiqui, Joshua Iltis, Petar Yanev, John Sladic, Charles Huynh, Daniel Nolan, Michael Singer
Purpose: There is a limited understanding of factors that influence the efficacy of topical glaucoma medication. Our study is a long-term, case-control analysis of how systemic antihypertensive (anti-HTN) medications influence the change in IOP after initiating prostaglandin (PG) drop therapy. Materials and methods: A retrospective chart review of 3,781 patients was performed on patients with a diagnosis of glaucoma suspect that progressed to primary open-angle glaucoma (POAG) by ICD-9 codes over a 10-year period...
2019: Clinical Ophthalmology
Andreas F Borkenstein, Eva-Maria Borkenstein
Purpose: The purpose of this study was to describe our surgical experience and evaluate safety and postoperative outcomes of a fully preloaded, monofocal, hydrophobic acrylic intraocular lens (IOL) (CT LUCIA 611P) with a newly designed optic-haptic junction in severe cases of pseudoexfoliation (PXF) syndrome, phacodonesis, and small pupils. Setting: This study was conducted in Borkenstein & Borkenstein, private practice, Privatklinik der Kreuzschwestern Graz, Austria...
2019: Clinical Ophthalmology
David Badawi
Purpose: Evaluation of the safety and effectiveness of a TearCare® retreatment in adult subjects with clinically significant dry eye disease (DED). Patients and methods: This was an extension of an initial 6-month, prospective, single-center, randomized, parallel-group pilot study. In the initial study, subjects with DED were randomized to either a single TearCare® treatment or 4 weeks of daily warm compress therapy. The extension study involved retreatment of those subjects assigned to the TearCare® treatment group following the initial 6-month end point...
2019: Clinical Ophthalmology
Jacob Menzler, Aljoscha Steffen Neubauer, Christos Haritoglou, Timothy L Jackson
Purpose: Symptomatic vitreomacular adhesion (sVMA) comprises vitreomacular traction (VMT) and stage 1 and 2 full-thickness macular holes (MHs) associated with vitreomacular adhesion (VMA). We aimed to estimate the incidence and prevalence of sVMA in Germany. Materials and methods: A systematic literature review was conducted to identify the incidence and prevalence of sVMA based on international epidemiologic studies, weighted for study size and then averaged across eligible studies...
2019: Clinical Ophthalmology
Mukesh Dhariwal, Christine Bouchet, Shantanu Jawla
Purpose: The objective of this study was to estimate the cost impact of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy and its complications due to single-piece acrylic monofocal intraocular lenses (IOLs) in the healthcare setting of United Kingdom, Italy, and Denmark. Materials and methods: A hypothetical cost-consequence model was developed to estimate economic burden of Nd:YAG laser capsulotomy due to different single-piece acrylic monofocal IOLs...
2019: Clinical Ophthalmology
Steven R Sarkisian, Basil Mathews, Kai Ding, Aashka Patel, Zachary Nicek
Purpose: The purpose of this study was to evaluate the safety and efficacy of microinvasive glaucoma surgery (MIGS) with 360° ab-interno trabeculotomy using the TRAB360 device as a stand-alone procedure in patients with refractory primary open-angle glaucoma (POAG) and preoperative IOP ≥18 mmHg. Setting: This study evaluated patients treated in a tertiary-referral clinical practice setting. Design: This study is a retrospective analysis of 81 eyes...
2019: Clinical Ophthalmology
Edsel B Ing, Justine Philteos, Galina Sholohov, David Ta Kim, Navdeep Nijhawan, Patrick W Mark, Jaclyn Gilbert
This study discusses local anesthetic agents, administration techniques, ancillary considerations, and safety precautions for oculoplastic surgery including eyelid, lacrimal, orbital, and temporal artery biopsy procedures. Methods for reducing patient apprehension and discomfort including systemic premedication, topical pre-anesthetic, visual, auditory and tactile distraction techniques, regional blocks, small gauge needles, warmed lidocaine, and buffered lidocaine are discussed.
2019: Clinical Ophthalmology
Renan Rodrigues, Myrna Serapião Dos Santos, Rachel E Silver, Mauro Campos, Rachel Lr Gomes
Purpose: To evaluate anatomical differences between laser (VICTUS) and manual constructed phacoemulsification incisions. Setting: Study was conducted at the Hospital de Olhos Paulista, Sao Paulo, Brazil. Design: This is a prospective, observational, consecutive nonrandomized cohort. Patients and methods: Sixteen patients (18 eyes) had phacoemulsification surgery, nine eyes had manual incisions and nine eyes had femtosecond incisions...
2019: Clinical Ophthalmology
Christos Haritoglou, Ramin Tadayoni, Jean-Pierre Hubschman
Lamellar macular holes present distinct morphological features including tractional or non-tractional epimacular membranes, foveal tissue alterations, defects of the outer retinal layers, or a separation of the retinal layers. At present, degenerative lamellar holes are differentiated from tractional holes based on the morphological characteristics seen in OCT. The current treatment approach is based on this gross differentiation. Considering the recent developments in high-resolution imaging, this classification needs to be revisited since morphological features may present simultaneously, making it difficult to separate these entities...
2019: Clinical Ophthalmology
Gitansha Sachdev, Dandapani Ramamurthy
Purpose: To review the safety of the implantable phakic contact lens (IPCL V1, Caregroup Sight Solutions, India) for correction of myopia and myopic astigmatism. Methods: Retrospective interventional case series including 134 eyes which underwent IPCL implantation for correction of myopia and myopic astigmatism at a tertiary eye care hospital in South India. Intraoperative and postoperative complications were analyzed. The following parameters were analyzed at preoperative and 1, 6 and 12 month postoperative visits: visual acuity (in logMAR) and manifest refraction, slit lamp bio microscopy, dilated fundus examination, IOP and endothelial cell density measurement...
2019: Clinical Ophthalmology
Ali Abusharaha, Abdulaziz A Alturki, Saud A Alanazi, Raied Fagehi, Naji Al-Johani, Gamal A El-Hiti, Ali M Masmali
Objective: To assess the tear-evaporation rate in thyroid-gland patients using a VapoMeter. Methods: Twenty thyroid gland patients aged 18-43 years (mean 34.3±6.3 years) completed the study. Additionally, an age-matched control group of 20 patients aged 18-43 years (32.2±5.1 years) was enrolled in the study for comparison purposes. An Ocular Surface Disease Index dry-eye questionnaire was completed, followed by a test to determine the tear-evaporation rate using the VapoMeter...
2019: Clinical Ophthalmology
Christopher S Sáles, Edward E Manche
Purpose: The aim of this study was to report the 1-week and 6-month refractive outcomes of eyes treated with a novel silicone corneal shield designed to improve visual recovery after photorefractive keratectomy (PRK). Patients and methods: This prospective, observational clinical trial recruited 45 myopic eyes with or without astigmatism at a university eye clinic to undergo wavefront-guided PRK followed by application of an investigational silicone corneal shield that was removed on postoperative day 4...
2019: Clinical Ophthalmology
Harvey S Uy, Carolina Tesone-Coelho, Harilaos Ginis
Purpose: Eyes that have undergone phacoemulsification with implantation of a multicomponent intraocular lens (MCIOL) may further undergo an enhancement procedure for correction of residual refractive errors. The enhancement procedure is accomplished by exchanging the front lens used in the primary surgery with another lens containing the correct dioptric power. We evaluated the efficacy and safety of enhancement procedures among eyes that received an MCIOL. Methods: A total of 25 eyes that had undergone phacoemulsification with implantation of an MCIOL were found to have a residual error of refraction (spherical equivalent ≥0...
2019: Clinical Ophthalmology
Siegfried Wahl, Chengyang Song, Arne Ohlendorf
Introduction: The simulation of vision with intraocular lenses (IOLs) prior to the clinical validation is of great interest for manufacturers as well as clinicians. We have tested the influence of different IOLs on the perception of contrast using different devices. Materials and methods: A Rassow telescope and the VirtIOL have been used to assess the contrast sensitivity function (CSF) through monfocal IOL (CT Asphina 409 MP, IOL 1), multifocal IOL (AT LISA tri 839 MP, IOL 2) and extended-depth-of-focus-IOL (TECNIS Symfony ZXR00, IOL3) in 21 participants, aged between 22 and 29 years...
2019: Clinical Ophthalmology
Jay C Wang, Kenneth M McKay, Arjun B Sood, Inês Laíns, Lucia Sobrin, John B Miller
Purpose: To characterize and compare choroidal neovascularization (CNV) secondary to white dot syndromes (WDS) and age-related macular degeneration (AMD) using optical coherence tomography angiography (OCT-A). Methods: This is a cross-sectional study in which we imaged patients with CNV secondary to WDS and AMD with either the Zeiss Angioplex OCT-A or Optovue AngioVue OCT-A. Relevant demographic and clinical characteristics were collected and analyzed. CNV area and vessel density (VD) were measured by three independent graders, and linear regression analysis was subsequently performed...
2019: Clinical Ophthalmology
Yoshitaka Okuda, Masanori Fukumoto, Taeko Horie, Hidehiro Oku, Shinji Takai, Toyofumi Nakanishi, Kaori Matsuzaki, Hiroyuki Tsujimoto, Tsunehiko Ikeda
Purpose: Microparticle technology enables local administration of medication. The purpose of this study was to examine the inhibitory effect of locally administered candesartan (CAN)-encapsulated microparticles on experimental choroidal neovascularization (CNV). Methods: Laser photocoagulation was used to induce CNV in Brown Norway rats. The rats were pretreated with subconjunctival injections of CAN (5.0 mg/eye) or phosphate buffer saline for 3 days before photocoagulation...
2019: Clinical Ophthalmology
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