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International Journal of Laboratory Hematology

Xiaoan Zhang, Yanzi Ding, Yurong Zhang, Jinfang Xing, Yanpeng Dai, Enwu Yuan
INTRODUCTION: Reference intervals for pediatric laboratory tests need to be interpreted in the context of age- and sex-dependent dynamics. However, few reference intervals for healthy ethnic Han Chinese children have previously attempted to establish using large sample sizes. As such, there are no national hematological standards in China for pediatric reference intervals. METHODS: We used a direct method to enroll a total of 2164 healthy 1- to 7-year-old children from Henan province...
February 20, 2019: International Journal of Laboratory Hematology
Jean-François Naud, Sylvain Giraud, Neil Robinson, Philippe Desharnais, Magnus Ericsson, Martial Saugy, Tiia Kuuranne, Christiane Ayotte, Thierry Boghosian, Reid Aikin, Pierre-Edouard Sottas
INTRODUCTION: The percentage of circulating reticulocytes (RET%) is a useful marker of blood doping in the context of the Athlete Biological Passport (ABP). The viability of the ABP depends on the comparability of sample data obtained across multiple laboratories for a given athlete. With the recent introduction of a different technology for the measurement of reticulocytes, the goal of this study was to compare currently employed Sysmex XT/XE analyzers to the recently introduced Sysmex XN analyzer...
February 19, 2019: International Journal of Laboratory Hematology
Kathryn M Forwood, Edwin Lee, Philip J Crispin
INTRODUCTION: Bone marrow biopsies are a key diagnostic and monitoring intervention in haematology with manual bone marrow techniques the established method of choice. Powered biopsy devices are now available, but are not widely used in haematology. This study compared the quality of bone marrow trephines obtained with the Jamshidi needle and OnControl powered drill system. METHODS: Retrospective analysis was undertaken on trephine samples prior to and after implementation of the OnControl drill system...
February 19, 2019: International Journal of Laboratory Hematology
Tong Chen, ChunYan Liu, LiJuan Li, Hui Liu, Ting Wang, ZongHong Shao, Rong Fu
INTRODUCTION: CD56bright NK cells have been highlighted to serve immunoregulatory functions. However, their roles in severe aplastic anemia (SAA) have not been elucidated. METHODS: Here, we investigated the quantities, phenotypes, cytokine secretion abilities, and the cytotoxicities of peripheral CD56bright NK cells along with CD56dim NK cells obtained from patients with SAA, SAA in remission (R-SAA), and healthy controls (HC). RESULTS: We observed the decreased quantities of CD56bright NK cells in SAA compared with in R-SAA and HC...
February 19, 2019: International Journal of Laboratory Hematology
Sabrina Buoro, Michela Seghezzi, Paola Dominoni, Valentina Moioli, Barbara Manenti, Giulia Previtali, Cosimo Ottomano, Giuseppe Lippi
INTRODUCTION: Cellular analysis in body fluids (BFs) provides important diagnostic information in various pathological settings. This study was hence aimed at comparing automated cell count obtained with Mindray BC-6800 (BC-BF) vs Sysmex XN-series (XN-BF) and evaluating other quantitative and qualitative information provided by these analyzers in ascitic (AF), pleural (PF), synovial (SF), and cerebrospinal (CSF) fluids. METHODS: Three hundred and fifty-one samples (99 AFs, 45 PFs, 75 SFs, and 132 CSFs) were analyzed in parallel with BC-BF, XN-BF, and optical microscopy (OM)...
February 13, 2019: International Journal of Laboratory Hematology
Gabriel K Habermehl, Jason D Chesser, Karl S Theil, Heesun J Rogers
No abstract text is available yet for this article.
February 11, 2019: International Journal of Laboratory Hematology
Heidi Eilertsen, Per Christian Saether, Carola E Henriksson, Anne-Sofie Petersen, Tor-Arne Hagve
INTRODUCTION: The aim of the present study was to evaluate the diagnostic ability of blast flags generated by Sysmex instruments (XE/XN) by comparing with immunophenotyping by flow cytometry (IFCM). Additionally, the ability of manual microscopy and CellaVision DM96 (pre- and reclassification) to predict the presence of "true" blasts was investigated. METHODS: Blood samples (n = 240) with suspect pathology flags reported by the XE were collected from the daily workload and examined by the XN, by manual microscopy, by CellaVision DM96 and by IFCM (CytoDiff Panel)...
February 11, 2019: International Journal of Laboratory Hematology
Achuta K Guddati, Rachel P Rosovsky, Elizabeth M Van Cott, David J Kuter
INTRODUCTION: Patients with Type 1 von Willebrand disease (VWD) have reduced amounts of von Willebrand factor (VWF) in their blood. Desmopressin (DDAVP) has been used to raise the blood levels of VWF in these patients. However, not all patients with Type 1 VWD are known to respond to DDAVP therapy. We sought to compare the levels of Factor VIII, VWF antigen (VWF:Ag), VWF ristocetin cofactor (VWF:RCo), and fibrinogen at different time points after administration of DDAVP. METHODS: A retrospective analysis was conducted at a single institution on 89 patients with Type 1 VWD who received a single intravenous dose of 0...
February 8, 2019: International Journal of Laboratory Hematology
Nikolaos J Tsagarakis, Stefanos I Papadhimitriou, Dimitris Pavlidis, Theodoros Marinakis, Ioannis V Kostopoulos, Eftichia Stiakaki, Sofia Polychronopoulou, George Paterakis
INTRODUCTION: In B-acute lymphoblastic leukemia (B-ALL), the identification of cytogenetic prognostic factors is important for stratifying patients into risk groups and tailoring treatment accordingly. The purpose of this study was to propose flow cytometric (FCM) scoring systems (SSs) for predicting t(12;21)(p13;q22), t(9;22)(q34;q11), t(11q23), and t(1;19)(q23;p13.3) translocations. METHODS: We analyzed retrospectively the FCM immunophenotype of 377 patients with B-ALL with regard to the major cytogenetic findings revealed by interphase fluorescence in situ hybridization (i-FISH)...
February 7, 2019: International Journal of Laboratory Hematology
Estelle Cheli, Jocelyn Roze, Nadia Daouairi, Jessica Racine, Julien Guy, Khaldoun Ghazal, Véronique Picard, Francois Girodon
No abstract text is available yet for this article.
February 7, 2019: International Journal of Laboratory Hematology
Jonathan Evrard, Romain Siriez, Laure Morimont, Pauline Thémans, Julie Laloy, Céline Bouvy, Damien Gheldof, François Mullier, Jean-Michel Dogné, Jonathan Douxfils
INTRODUCTION: Clot waveform analysis (CWA), a new methodology to assess coagulation process, can be usefully applied in various clinical settings. However, its clinical use is limited mainly because of the absence of standardization. No consensus exists regarding the wavelengths at which CWA has to be performed what is crucial for the sensitivity of the CWA. OBJECTIVES: The primary aim of this study is to determine which wavelength is the most sensitive and specific for CWA...
February 7, 2019: International Journal of Laboratory Hematology
Laila Nomani, James R Cook, Heesun J Rogers
No abstract text is available yet for this article.
February 1, 2019: International Journal of Laboratory Hematology
Michela Cini, Cristina Legnani, Sophie Testa, Armando Tripodi, Benilde Cosmi, Gualtiero Palareti
INTRODUCTION: Co-administration of enoxaparin and a direct oral factor Xa inhibitor (xabans: apixaban, edoxaban, rivaroxaban) could give rise to the problem of overlapping the anti-Xa activity when measuring direct oral anticoagulant (DOAC) levels. We aimed to evaluate in vitro the degree of the interference of increasing enoxaparin concentrations on xaban plasma levels measured by different chromogenic anti-Xa assays with drug-specific calibrators and controls. METHODS: Seven plasma samples were spiked with apixaban, edoxaban, or rivaroxaban at fixed concentration, and enoxaparin at increasing concentrations (0, 0...
January 30, 2019: International Journal of Laboratory Hematology
Hazel Aggett, Patience Dabula, Elizabeth S Mayne, Susan Louw
INTRODUCTION: Laboratory quality assurance (QA) includes internal quality control (IQC), external quality assurance (EQA) and quality improvement (QI). EQA identifies quality deviations and training needs. D-dimers are breakdown products of thrombus and results guide various clinical decisions. METHODS: The National Health Laboratory Service (NHLS) in South Africa performs the pathology tests for more than 80% of the population. The NHLS Quality Assurance Department distributed 301 questionnaires to laboratories enquiring about D-dimer testing...
January 28, 2019: International Journal of Laboratory Hematology
Barbara De la Salle, Adrian D Stephens, Barbara J Wild, Cornelis L Harteveld, Keith Hyde
INTRODUCTION: The accurate determination of Hb A2 is a key marker when screening for a β-thalassaemia carrier. Data from external quality assessment (EQA) exercises have shown a lack of alignment of Hb A2 quantitation both within and between methods. The only reference material available for Hb A2 quantitative assay at the time of writing is the World Health Organization International Reference Reagent (89/666; WHO IRR) prepared in the 1980s and not validated for all current methodologies...
January 20, 2019: International Journal of Laboratory Hematology
Maria Lopez-Molina, Marc Sorigue, Alicia Martinez-Iribarren, Elisa Orna Montero, Xavier Tejedor Ganduxé, Alba Leis Sestayo, Maria Angels Sala Sanjaume, Maria-Antonia Llopis Díaz, Cristian Morales-Indiano
No abstract text is available yet for this article.
January 20, 2019: International Journal of Laboratory Hematology
Ahlem Achour, Elke de Grouw, Femke van Erp, Sandra Arkesteijn, Rianne Schaap, Jeanet Ter Huurne, Sharda Bisoen, Maaike Verschuren, Cornelis L Harteveld
No abstract text is available yet for this article.
January 20, 2019: International Journal of Laboratory Hematology
Deniz Gezgin Yıldırım, Zühre Kaya, Sevcan A Bakkaloglu
INTRODUCTION: Few data are available on the clinical utility of new red cell parameters for detecting anemia in children with inflammatory diseases. The aim was to investigate the utility of three new red cell parameters for distinguishing functional iron deficiency (FID) from absolute iron deficiency (AID) in children with familial Mediterranean fever (FMF). METHODS: The study involved 198 children with genetically confirmed FMF and 18 healthy-age and sex-matched controls...
January 9, 2019: International Journal of Laboratory Hematology
Elena Zerkalenkova, Svetlana Lebedeva, Anna Kazakova, Grigory Tsaur, Yulia Starichkova, Natalia Timofeeva, Olga Soldatkina, Evgenia Aprelova, Aleksandr Popov, Natalia Ponomareva, Ludmila Baidun, Claus Meyer, Galina Novichkova, Michael Maschan, Aleksey Maschan, Rolf Marschalek, Yulia Olshanskaya
INTRODUCTION: Translocations involving the KMT2A gene (also known as MLL) are frequently diagnosed in pediatric acute leukemia cases with either lymphoblastic or myeloid origin. KMT2A is translocated to multiple partner genes, including MLLT10/AF10 localizing at chromosomal band 10p12. KMT2A-MLLT10 is one of the common chimeric genes diagnosed in acute leukemia with KMT2A rearrangement (8%), especially in acute myeloid leukemia (AML; 18%). MLLT10 is localized in very close proximity to two other KMT2A partner genes at 10p11-12-NEBL and ABI1, so they could not be distinguished by conventional cytogenetics...
January 9, 2019: International Journal of Laboratory Hematology
Xianmin Guan, Xianhao Wen, Jianwen Xiao, Xizhou An, Jie Yu, Yuxia Guo
INTRODUCTION: To investigate the correlation of long noncoding RNA-SOX6-1 (lnc-SOX6-1) with clinicopathological features and treatment outcomes in pediatric acute myeloid leukemia (AML) patients, and further explore its function in AML cell proliferation and apoptosis. METHODS: A total of 146 de novo pediatric AML patients and 73 nonhematologic malignancy patients/donors were recruited. Bone marrow samples were obtained, followed by measurement of lnc-SOX6-1 expression by qPCR...
January 9, 2019: International Journal of Laboratory Hematology
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