journal
https://read.qxmd.com/read/39011313/impact-of-documented-fall-risk-self-reported-health-and-confidence-to-prevent-falls-on-concern-about-falling-among-community-dwelling-older-adults-secondary-analysis-of-a-randomized-clinical-trial
#1
RANDOMIZED CONTROLLED TRIAL
Hiroko Kiyoshi-Teo, Bryanna De Lima, Nathan F Dieckmann, Jennifer L Vincenzo, Elizabeth Eckstrom
PURPOSE: Individuals identified as high fall risk are expected to have high concern about falling. However, perception and individual factors that influence concern about falling have yet to be thoroughly studied. We aimed to understand factors that influence concern about falling among older adults with increased risk for falling. PATIENTS AND METHODS: This was a secondary analysis of a clinical trial among community-dwelling older adults (age ≥65 years old) at high risk for falls (n = 178)...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/39011312/bone-marrow-adipose-tissue-as-a-critical-regulator-of-postmenopausal-osteoporosis-a-concise-review
#2
REVIEW
Huifang Niu, Minfeng Zhou, Xiaoyun Xu, Xiaojuan Xu
Postmenopausal osteoporosis (PMOP) is a major health problem affecting millions of women worldwide. PMOP patients are often accompanied by abnormal accumulation of bone marrow adipose tissue (BMAT). BMAT is a critical regulator of bone homeostasis, and an increasing BMAT volume is negatively associated with bone mass reduction or fracture. BMAT regulates bone metabolism via adipokines, cytokines and the immune system, but the specific mechanisms are largely unknown. This review emphasizes the impact of estrogen deficiency on bone homeostasis and BMAT expansion, and the mechanism by which BMAT regulates PMOP, providing a promising strategy for targeting BMAT in preventing and treating PMOP...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/39006937/comparison-of-the-clinical-outcomes-between-reperfusion-and-non-reperfusion-therapy-in-elderly-patients-with-acute-ischemic-stroke
#3
COMPARATIVE STUDY
Xuanwen Luo, Suqin Chen, Weiliang Luo, Qingyun Li, Yening Zhu, Jiming Li
PURPOSE: To investigate the benefit (90-day mRS score) and rate of major complications (early symptomatic intracranial hemorrhage-SICH) after reperfusion therapy (RT) (including intravenous thrombolysis -IVT and mechanical thrombectomy -MT) in patients over 80 years with acute ischemic stroke (AIS). PATIENTS AND METHODS: AIS patients aged over 80 admitted to Huizhou Central People's Hospital from September 2018 to 2023 were included in this study. Data on SICH, NIHSS, and mRS were analyzed...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38978964/the-predictive-value-of-atherogenic-index-of-plasma-non-high-density-lipoprotein-cholesterol-non-hdl-c-non-hdl-c-hdl-c-and-lipoprotein-combine-index-for-stroke-incidence-and-prognosis-in-maintenance-hemodialysis-patients
#4
JOURNAL ARTICLE
Lijie Ma, Fang Sun, Kaiyi Zhu, Qiuxia Han, Qianmei Sun
PURPOSE: The serum lipid level is strongly associated with atherosclerosis. However, research on the relationship between lipid-derived indices and acute ischemic stroke (AIS) occurrence in hemodialysis populations is limited. This study aimed to explore the predictive value of lipid-derived indices, including atherogenic index of plasma (AIP), Non- high density lipoprotein cholesterol (Non-HDL-C), Non-HDL-C/HDL-C, and lipoprotein combine index (LCI) in clinical practice for the occurrence and prognosis of AIS in hemodialysis patients...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38974513/improving-lower-limb-function-and-frailty-in-frail-older-patients-with-acute-myocardial-infarction-after-percutaneous-coronary-intervention-a-randomized-controlled-study-of-neuromuscular-electrical-stimulation
#5
RANDOMIZED CONTROLLED TRIAL
Xiamin Pu, Houqiang Huang, Xiaolei Zhao, Feng Liu, Yebo Leng, Ya Deng, Lingyi Huang, Xingchen Zhou, Fen Xu, Yongli Huang, Shengmin Guo
BACKGROUND: A global public health problem, frailty is closely associated with poor prognosis after percutaneous coronary intervention (PCI) in older patients with acute myocardial infarction (AMI). Although exercise intervention is the most commonly used method to reverse and alleviate frailty, its application is restricted in patients with acute myocardial infarction following PCI due to cardiovascular instability and autonomic imbalance. Consequently, there is a need for a new practical intervention to address frailty syndrome in these patients...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38974512/longitudinal-analysis-of-renal-function-changes-in-elderly-populations-health-status-evaluation-and-risk-factor-assessment
#6
JOURNAL ARTICLE
Lengnan Xu, Chen Yu, Aiqun Chen, Chuanbao Li, Yonghui Mao
BACKGROUND: This study aims to investigate GFR decline in elderly subjects with varying physical conditions and analyze key risk factors impacting renal function changes. METHODS: We obtained data from patients between 2017 and 2019, and matched healthy elderly subjects based on gender and age. Data collected for all subjects included annual measurements of fast blood glucose (GLU), glycated hemoglobin (HbA1c), low-density lipoprotein cholesterol (LDL-c), blood albumin (ALB), blood uric acid (UA), urine protein (UP), and systolic blood pressure (SBP)...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38974511/potentially-inappropriate-use-of-medication-and-its-determinants-among-ambulatory-older-adults-in-six-community-chain-pharmacies-in-asmara-eritrea-a-cross-sectional-study-using-the-2023-american-geriatric-society-beers-criteria-%C3%A2
#7
JOURNAL ARTICLE
Saleh Idrisnur, Nuru Abdu, Filipos Yohannes, Tomas Tewelde, Natnael Russom, Eyasu H Tesfamariam
BACKGROUND: Potentially inappropriate medication (PIM) use is one of the main drug-related problems encountered in older adults. It is associated with adverse drug events, morbidity, mortality, increased economic costs, and negative effects on the quality of life that requires strict monitoring of prescriptions in older adults. Thus, the study aimed to assess potentially inappropriate medication use and its determinants among older adults. METHODS: A cross-sectional study was conducted among all outpatient prescriptions dispensed to older adults (aged 65 years and above) in six community chain pharmacies in Asmara, Eritrea...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38974510/enhancing-emergency-department-pain-management-for-older-adults-with-the-hip-fracture-fast-track-hfft-protocol-in-a-middle-income-country
#8
JOURNAL ARTICLE
Jiraporn Sri-On, Thitarat Worawiwat, Kitchai Luksameearunothai, Pornsak Nirunsuk, Alissara Vanichkulbodee, Yupadee Fusakul, Krit Phisaiphun, Pornsiri Kanokkarnjana, Danaiphat Lerdruttanasoontorn, Kwannapa Thong-On
PURPOSE: This study aimed to evaluate the impact of the Hip Fracture Fast-Track (HFFT) protocol, designed specifically for older patients at our hospital, which commenced on January 1, 2022, on the management of emergency department (ED) pain in older adults with hip fractures. PATIENTS AND METHODS: Retrospective pre- and post-study data from electronic health records (EHR) at our hospital, using the International Classification of Diseases (ICD)-10 codes S72.0, S72...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38974509/a-novel-mri-based-paravertebral-muscle-quality-pvmq-score-for-evaluating-muscle-quality-and-bone-quality-a-comparative-study-with-the-vbq-score
#9
COMPARATIVE STUDY
Song Wang, Xiang Zhang, Bo Qu, Kunhai Yang, Yongrong Hu, Hao Liu, Juntao Hong, Hao Niu, Hongsheng Yang
PURPOSE: This study aims to develop a novel MRI-based paravertebral muscle quality (PVMQ) score for assessing muscle quality and to investigate its correlation with the degree of fat infiltration (DFF) and the vertebral bone quality (VBQ) score of paravertebral muscles. Additionally, the study compares the effectiveness of the PVMQ score and the VBQ score in assessing muscle quality and bone quality. METHODS: PVMQ scores were derived from the ratio of paravertebral muscle signal intensity (SI) to L3 cerebrospinal fluid SI on T2-weighted MRI...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38974508/development-and-evaluation-of-content-validity-and-acceptance-of-a-multidomain-intervention-module-for-reversal-of-cognitive-frailty-among-older-adults
#10
JOURNAL ARTICLE
Norhayati Mustafa Khalid, Pavapriya Ponvel, Azianah Mohamad Ibrahim, A'isyah Mohd Safien, Nurul Hidayah Md Fadzil, Devinder Kaur Ajit Singh, Arimi Fitri Mat Ludin, Norhayati Ibrahim, Ponnusamy Subramaniam, Hasnah Haron, Roslee Rajikan, Divya Vanoh, Suzana Shahar
PURPOSE: There is a limited availability of multidomain interventions that target cognitive frailty. Thus, the aim of the present study was to develop and evaluate the content validity and acceptance of the multidomain intervention module to reverse cognitive frailty among older adults (iAGELESS). PATIENTS AND METHODS: This study was conducted in two phases: Phase I included the development of the multidomain intervention module iAGELESS and evaluation of content validity, while Phase II consisted of evaluating the acceptance of the module among 18 healthcare and social care providers, 13 older adults with cognitive frailty, and 13 caregivers...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38952872/an-analysis-of-optic-disc-parameters-in-patients-with-peripheral-retinal-tears-following-acute-posterior-vitreous-detachment-a-cross-sectional-study
#11
JOURNAL ARTICLE
Darko Batistic, Ante Kreso, Josip Vrdoljak, Jaksa Batistic, Ivan Paladin, Ivan Mizdrak, Sandro Glumac
BACKGROUND: To investigate association between optic disc parameters analyzed by optical coherence tomography (OCT) and occurrence of peripheral retinal tears in patients with symptomatic posterior vitreous detachment (PVD). METHODS: This cross-sectional study enrolled 75 patients with symptoms of acute PVD, who were allocated into two groups based on whether a peripheral retinal tear occurred or not. RESULTS: When comparing the average retinal nerve fiber layer (RNFL) thickness (μm) between retinal tear and control groups, it was shown that patients with a retinal tear have a significantly higher (87...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38948169/a-systematic-review-of-falls-risk-of-frail-patients-with-dementia-in-hospital-progress-challenges-and-recommendations
#12
JOURNAL ARTICLE
Naomi Davey, Eimear Connolly, Paul Mc Elwaine, Sean P Kennelly
This review article assesses the effectiveness and limitations of strategies to reduce falls among hospitalized older adults with frailty and dementia. It explores the efficacy of existing fall prevention strategies for a cohort that is acutely susceptible to falls and fall-related consequences. A systematic literature search was conducted across MEDLINE, Embase, CINAHL, and PsycINFO, employing Medical Subject Headings (MeSH) to identify studies on fall prevention strategies in hospitalized older adults with both dementia and frailty published from 2013 to 2023...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38948168/malondialdehyde-and-zinc-may-relate-to-severity-of-microvascular-complications-in-diabetes-a-preliminary-study-on-older-adults-with-type-2-diabetes-mellitus-in-northeast-china
#13
JOURNAL ARTICLE
Min Sun, Guanchi Yan, Siming Sun, Xiaonan Li, Wei Sun, Yuehui Wang
BACKGROUND: Serum trace elements and oxidative stress factors are related to diabetic microvascular complications. The study was to investigate the complex relationship between trace elements, oxidative stress factors, and the severity of microvascular complications of diabetes in older adults. METHODS: The present study included patients with or without type 2 diabetes, and blood glucose, blood lipids, trace elements (iron, magnesium, zinc), oxidative stress factors (malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC)) were evaluated...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38915432/efficacy-and-safety-of-rivaroxaban-for-extremely-aged-patients-with-venous-thromboembolism-a-retrospective-cross-sectional-real-world-study
#14
JOURNAL ARTICLE
Chun Wang, Xiaohong Fan, Li Nie, Qing Wang, Shanshan Li, Wen Zheng, Wei Zhang, Wangshu Dai, Minmin Chen
BACKGROUND: Rivaroxaban, a non-vitamin K antagonist oral anticoagulant, has become widely used for the management of venous thromboembolism (VTE) in adult patients. However, few trials have explored the efficacy and safety of rivaroxaban in VTE patients over 80 years of age. This necessitates further real-world studies of rivaroxaban across elderly populations. METHODS: We performed a retrospective single center study involving extremely aged VTE sufferers treated with rivaroxaban...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38911675/association-between-tcbi-triglycerides-total-cholesterol-and-body-weight-index-and-stroke-associated-pneumonia-in-acute-ischemic-stroke-patients
#15
JOURNAL ARTICLE
Yufeng Liu, Yan Chen, Zhongwen Zhi, Ping Wang, Mengchao Wang, Qian Li, Yuqian Wang, Liandong Zhao, Chun Chen
PURPOSE: Stroke-associated pneumonia (SAP) usually complicates stroke and is linked to adverse prognoses. Triglycerides, total cholesterol, and body weight index (TCBI) is a new and simple calculated nutrition index. This study seeks to investigate the association between TCBI and SAP incidence, along with its predictive value. PATIENTS AND METHODS: Nine hundred and sixty-two patients with acute ischemic stroke were divided into SAP group and Non-SAP group. The TCBI was divided into three layers: T1, TCBI < 948...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38911674/the-association-of-cerebral-oxygen-desaturation-with-postoperative-cognitive-dysfunction-in-older-patients-a-review
#16
REVIEW
Chun-Yan Zhang, Yu-Shen Yang, Meng-Qin Pei, Xin-Li Chen, Wei-Can Chen, He-Fan He
Postoperative cognitive dysfunction (POCD) is a neurological complication associated with surgery and anesthesia that is commonly observed in older patients, and it can significantly affect patient prognosis and survival. Therefore, predicting and preventing POCD is important. Regional cerebral oxygen saturation (rSO2 ) reflects cerebral perfusion and oxygenation, and decreased intraoperative cerebral oxygen saturation has been reported to increase the risk of POCD. In this review, we elucidated the important relationship between the decline in rSO2 and risk of POCD in older patients...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38911673/the-relationship-between-social-isolation-and-cognitive-frailty-among-community-dwelling-older-adults-the-mediating-role-of-depressive-symptoms
#17
JOURNAL ARTICLE
Yamei Bai, Yuqing Chen, Meng Tian, Jiaojiao Gao, Yulei Song, Xueqing Zhang, Haiyan Yin, Guihua Xu
PURPOSE: Social isolation and depression have an impact on cognitive frailty. However, the underlying mechanisms between these variables have not been well defined. This study aims to investigate the mediating role of depressive symptoms in the association between social isolation and cognitive frailty among older adults in China. METHODS: From Mar 2023 to Aug 2023, a cross-sectional study was conducted with 496 community-dwelling older adults aged ≥60 years in Nanjing, Jiangsu Province, China...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38911672/frailty-is-a-risk-factor-for-postoperative-complications-in-older-adults-with-lumbar-degenerative-disease-a-prospective-cohort-study
#18
JOURNAL ARTICLE
Yan Zhang, Qixing Wu, Mingming Han, Chengwei Yang, Fang Kang, Juan Li, Chengwen Hu, Xia Chen
OBJECTIVE: Frailty, representing the physiological reserve and tolerance of the body, serves as a crucial evaluation index of the overall status of the older adults. This study aimed to investigate the prevalence of preoperative frailty and its impact on postoperative outcomes among older adults with lumbar degenerative disease in China. PATIENTS AND METHODS: In this prospective study, a total of 280 patients aged 60 and above, diagnosed with lumbar degenerative disease and scheduled for surgical intervention were enrolled...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38894884/association-of-chat-gene-polymorphism-rs3793790-and-rs2177370-with-donepezil-response-and-the-risk-of-alzheimer-s-disease-continuum
#19
JOURNAL ARTICLE
Hongmei Sun, Chao Lv, Xiaoxue Zhang, Xuan Sun, Siyu Chen, Ke Li, Yazhuo Hu, Yuxin Feng, Tong Yin, Jianjun Jia
BACKGROUND: Genetic variation plays an important role in drug response, there are few relevant studies on patients with Alzheimer's disease continuum (ADC). OBJECTIVE: This study focused on the associations between two single nucleotide polymorphisms (SNPs) (rs3793790 and rs2177370) located in the CHAT gene and donepezil response in ADC patients, and further evaluated the associations between the two SNPs and ADC. MATERIAL AND METHODS: According to 2018 National Institute on Aging and Alzheimer's Association (NIA-AA) standard, amyloid β-protein positive (Aβ+) and negative (Aβ-) patients were recruited according to the Aβ-PET/CT standard...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38894883/erratum-addressing-the-missing-links-in-cardiovascular-aging-corrigendum
#20
(no author information available yet)
[This corrects the article DOI: 10.2147/CIA.S457180.].
2024: Clinical Interventions in Aging
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