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Clinical Journal of the American Society of Nephrology: CJASN

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https://read.qxmd.com/read/30765535/inadequate-dietary-potassium-and-progression-of-ckd
#1
EDITORIAL
Thomas D DuBose
No abstract text is available yet for this article.
February 14, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30765534/central-venous-stenosis-access-outcome-and-survival-in-patients-undergoing-maintenance-hemodialysis
#2
Anamika Adwaney, Charlotte Lim, Sarah Blakey, Neill Duncan, Damien R Ashby
BACKGROUND AND OBJECTIVES: Central venous catheters have traditionally provided access for urgent hemodialysis, but are also sometimes advocated as an option for older or more comorbid patients. Adverse effects of this type of dialysis access include central venous stenosis, for which the risk factors and consequences are incompletely understood. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted two studies within the same population cohort, comprising all patients starting hemodialysis in a single center from January 2006 to December 2013...
February 14, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30765533/urinary-potassium-excretion-and-progression-of-chronic-kidney-disease
#3
Hyung Woo Kim, Jung Tak Park, Tae-Hyun Yoo, Joongyub Lee, Wookyung Chung, Kyu-Beck Lee, Dong-Wan Chae, Curie Ahn, Shin-Wook Kang, Kyu Hun Choi, Seung Hyeok Han
BACKGROUND AND OBJECTIVES: Data on whether low or high urinary potassium excretion is associated with poor kidney outcome have been conflicting. The aim of this study was to clarify the association between urinary potassium excretion and CKD progression. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We investigated the relationship between lower urinary potassium excretion and CKD progression and compared three urinary potassium indices among 1821 patients from the Korean Cohort Study for Outcome in Patients with CKD...
February 14, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30755453/removal-of-protein-bound-uremic-toxins-during-hemodialysis-using-a-binding-competitor
#4
Magdalena Madero, Karla B Cano, Israel Campos, Xia Tao, Vaibhav Maheshwari, Jillian Brown, Beatriz Cornejo, Garry Handelman, Stephan Thijssen, Peter Kotanko
BACKGROUND AND OBJECTIVES: Current hemodialysis techniques fail to efficiently remove the protein-bound uremic toxins p-cresyl sulfate and indoxyl sulfate due to their high degree of albumin binding. Ibuprofen, which shares the same primary albumin binding site with p-cresyl sulfate and indoxyl sulfate, can be infused during hemodialysis to displace these toxins, thereby augmenting their removal. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We infused 800 mg ibuprofen into the arterial bloodline between minutes 21 and 40 of a conventional 4-hour high-flux hemodialysis treatment...
February 12, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30755452/efficacy-and-safety-of-imarikiren-in-patients-with-type-2-diabetes-and-microalbuminuria-a-randomized-controlled-trial
#5
Sadayoshi Ito, Tomoya Kagawa, Takuya Saiki, Kohei Shimizu, Shingo Kuroda, Yuhei Sano, Yuusuke Umeda
BACKGROUND AND OBJECTIVES: Imarikiren is a novel, potent, and selective direct renin inhibitor that has shown high oral availability during clinical development for the treatment of diabetic nephropathy. We evaluated the efficacy and safety of imarikiren in patients with type 2 diabetes mellitus and microalbuminuria. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was a randomized, multicenter, placebo-controlled, double-blind, phase 2, dose-finding trial...
February 12, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30745301/net-acid-excretion-and-urinary-organic-anions-in-idiopathic-uric-acid-nephrolithiasis
#6
I Alexandru Bobulescu, Sun K Park, L H Richie Xu, Francisco Blanco, John Poindexter, Beverley Adams-Huet, Taylor L Davidson, Khashayar Sakhaee, Naim M Maalouf, Orson W Moe
BACKGROUND AND OBJECTIVES: Idiopathic uric acid nephrolithiasis, which is closely associated with obesity and the metabolic syndrome, is increasing in prevalence. Unduly acidic urine pH, the quintessential pathophysiologic feature of this disease, is in part explained by inadequate excretion of the principal urinary buffer ammonium. The role of net acid excretion in the pathogenesis of uric acid nephrolithiasis is incompletely understood. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We compared acid-base parameters of patients with idiopathic uric acid nephrolithiasis with matched control subjects under controlled diets in an inpatient metabolic unit...
February 11, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30733224/serum-metabolomic-alterations-associated-with-proteinuria-in-ckd
#7
Shengyuan Luo, Josef Coresh, Adrienne Tin, Casey M Rebholz, Lawrence J Appel, Jingsha Chen, Ramachandran S Vasan, Amanda H Anderson, Harold I Feldman, Paul L Kimmel, Sushrut S Waikar, Anna Köttgen, Anne M Evans, Andrew S Levey, Lesley A Inker, Mark J Sarnak, Morgan Erika Grams
BACKGROUND AND OBJECTIVES: Data are scarce on blood metabolite associations with proteinuria, a strong risk factor for adverse kidney outcomes. We sought to investigate associations of proteinuria with serum metabolites identified using untargeted profiling in populations with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using stored serum samples from the African American Study of Kidney Disease and Hypertension (AASK; n =962) and the Modification of Diet in Renal Disease (MDRD) study ( n =620), two rigorously conducted clinical trials with per-protocol measures of 24-hour proteinuria and GFR, we evaluated cross-sectional associations between urine protein-to-creatinine ratio and 637 known, nondrug metabolites, adjusting for key clinical covariables...
February 7, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30728169/hypernatremia
#8
Qi Qian
No abstract text is available yet for this article.
February 6, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30728168/enhanced-removal-of-protein-bound-uremic-toxins-using-displacers-road-to-success
#9
EDITORIAL
Wim Van Biesen, Sunny Eloot
No abstract text is available yet for this article.
February 6, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30728167/a-conceptual-framework-of-palliative-care-across-the-continuum-of-advanced-kidney-disease
#10
Daniel Y Lam, Jennifer S Scherer, Mark Brown, Vanessa Grubbs, Jane O Schell
Kidney palliative care is a growing discipline within nephrology. Kidney palliative care specifically addresses the stress and burden of advanced kidney disease through the provision of expert symptom management, caregiver support, and advance care planning with the goal of optimizing quality of life for patients and families. The integration of palliative care principles is necessary to address the multidimensional impact of advanced kidney disease on patients. In particular, patients with advanced kidney disease have a high symptom burden and experience greater intensity of care at the end of life compared with other chronic serious illnesses...
February 6, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30728166/kidney-xenotransplantation-steps-toward-clinical-application
#11
Brian I Shaw, Allan D Kirk
No abstract text is available yet for this article.
February 6, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30723165/differences-in-dialysis-center-practices-in-determining-hemodialysis-patient-postdialysis-target-weight-and-patient-survival-and-hospitalizations
#12
EDITORIAL
Andrew Davenport
No abstract text is available yet for this article.
February 5, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30723164/associations-between-hemodialysis-facility-practices-to-manage-fluid-volume-and-intradialytic-hypotension-and-patient-outcomes
#13
Indranil Dasgupta, G Neil Thomas, Joanne Clarke, Alice Sitch, James Martin, Brian Bieber, Manfred Hecking, Angelo Karaboyas, Ronald Pisoni, Friedrich Port, Bruce Robinson, Hugh Rayner
BACKGROUND AND OBJECTIVES: Fluid overload and intradialytic hypotension are associated with cardiovascular events and mortality in patients on hemodialysis. We investigated associations between hemodialysis facility practices related to fluid volume and intradialytic hypotension and patient outcomes. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Data were analyzed from 10,250 patients in 273 facilities across 12 countries, from phase 4 of the Dialysis Outcomes and Practice Patterns Study (DOPPS; 2009-2012)...
February 5, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30696663/integrated-care-in-eskd-perspective-of-a-large-dialysis-organization
#14
Bryan N Becker, Allen R Nissenson
No abstract text is available yet for this article.
January 29, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30696662/integrated-care-in-eskd-a-perspective-of-nephrologists
#15
Brian M Brady, Kevin F Erickson
No abstract text is available yet for this article.
January 29, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30696661/integrated-care-for-people-with-kidney-disease-the-perspective-of-a-nonprofit-dialysis-provider
#16
Douglas S Johnson, Klemens B Meyer
No abstract text is available yet for this article.
January 29, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30696660/benefits-and-barriers-to-and-desired-outcomes-with-exercise-in-patients-with-eskd
#17
Danielle Moorman, Rita Suri, Swapnil Hiremath, Januvi Jegatheswaran, Teerath Kumar, Ann Bugeja, Deborah Zimmerman
BACKGROUND AND OBJECTIVES: Patients with ESKD are sedentary. When patient-identified barriers to exercise are addressed, recruitment and retention in exercise trials remain low, suggesting that the trial design may not resonate with them. Therefore, we conducted a survey of patients on dialysis to assess perceived benefits and barriers to exercise and discover preferred outcomes and exercise type by dialysis modality and age in anticipation of designing future randomized, controlled trials...
January 29, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30696659/a-patient-s-view-on-exercise-and-eskd
#18
EDITORIAL
Nichole M Jefferson
No abstract text is available yet for this article.
January 29, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30674459/complement-gene-variants-and-shiga-toxin-producing-escherichia-coli-associated-hemolytic-uremic-syndrome-retrospective-genetic-and-clinical-study
#19
Véronique Frémeaux-Bacchi, Anne-Laure Sellier-Leclerc, Paula Vieira-Martins, Sophie Limou, Theresa Kwon, Annie Lahoche, Robert Novo, Brigitte Llanas, François Nobili, Gwenaëlle Roussey, Mathilde Cailliez, Tim Ulinski, Georges Deschênes, Corinne Alberti, François-Xavier Weill, Patricia Mariani, Chantal Loirat
BACKGROUND AND OBJECTIVES: Inherited complement hyperactivation is critical for the pathogenesis of atypical hemolytic uremic syndrome (HUS) but undetermined in postdiarrheal HUS. Our aim was to investigate complement activation and variants of complement genes, and their association with disease severity in children with Shiga toxin-associated HUS. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Determination of complement biomarkers levels and next-generation sequencing for the six susceptibility genes for atypical HUS were performed in 108 children with a clinical diagnosis of post-diarrheal HUS (75 Shiga toxin-positive, and 33 Shiga toxin-negative) and 80 French controls...
January 23, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30665925/assessing-clinical-relevance-of-uremic-toxins
#20
EDITORIAL
Jennifer E Flythe, Thomas H Hostetter
No abstract text is available yet for this article.
January 21, 2019: Clinical Journal of the American Society of Nephrology: CJASN
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