journal
https://read.qxmd.com/read/38890652/a-retrospective-study-on-the-analysis-of-influencing-factors-of-neutropenia-in-endometrial-cancer-with-adjuvant-chemoradiotherapy
#1
JOURNAL ARTICLE
Mengsi Fan, Weiwei Zhang, Yuying Zhou, Mingzhuo Li, Dongyue Wang, Kexin Qiu, Mengzhen Li, Haoran Guo, Li Yan
OBJECTIVE: This retrospective study aimed to investigate the factors influencing the occurrence of neutropenia in patients with endometrial cancer (EC) following adjuvant chemoradiotherapy (CRT). METHODS: Retrospective analysis of EC patients who underwent adjuvant CRT from January 2012 to June 2023 in the Department of Gynecology and Oncology of the First Affiliated Hospital of Shandong First Medical University. Neutropenia was defined as an Absolute Neutrophil Count (ANC) of peripheral blood neutrophils below 2 × 109 /L...
June 18, 2024: Radiation Oncology
https://read.qxmd.com/read/38886727/possible-association-of-dose-rate-and-the-development-of-late-visual-toxicity-for-patients-with-intracranial-tumours-treated-with-pencil-beam-scanned-proton-therapy
#2
JOURNAL ARTICLE
Arturs Meijers, Juliane Daartz, Antje-Christin Knopf, Michelle van Heerden, Nicola Bizzocchi, Miriam Varela Vazquez, Barbara Bachtiary, Alessia Pica, Helen A Shih, Damien Charles Weber
BACKGROUND AND PURPOSE: Rare but severe toxicities of the optic apparatus have been observed after treatment of intracranial tumours with proton therapy. Some adverse events have occurred at unusually low dose levels and are thus difficult to understand considering dose metrics only. When transitioning from double scattering to pencil beam scanning, little consideration was given to increased dose rates observed with the latter delivery paradigm. We explored if dose rate related metrics could provide additional predicting factors for the development of late visual toxicities...
June 17, 2024: Radiation Oncology
https://read.qxmd.com/read/38880908/stereotactic-body-radiation-therapy-is-beneficial-for-a-subgroup-of-patients-with-urothelial-cancer-and-solitary-metastatic-disease-a-single-institution-real-world-experience
#3
JOURNAL ARTICLE
Fernanda Costa Svedman, Karin Holmsten, Faith Jawdat, Wehazit Hailom, Daniel Alm, Vitali Grozman, Anders Ullén
BACKGROUND: Standard treatment options for patients with metastatic urothelial cancer (mUC) include systemic platinum-based chemotherapy, immunotherapy, antibody-drug-conjugates, and targeted therapy. Oligometastatic disease (OMD) may be an intermediate state between localized and generalized cancer. The best treatment strategy for OMD and oligoprogressive (OPD) disease is poorly studied in mUC but local stereotactic body radiation therapy (SBRT) could be an option to avoid or delay systemic treatment...
June 16, 2024: Radiation Oncology
https://read.qxmd.com/read/38862982/impact-of-background-music-listening-on-anxiety-in-cancer-patients-undergoing-initial-radiation-therapy-a-randomized-clinical-trial
#4
RANDOMIZED CONTROLLED TRIAL
Huei-Fan Yang, Wen-Wei Chang, Ying-Hsiang Chou, Jing-Yang Huang, Yu-Shiun Liao, Ting-En Liao, Hsien-Chun Tseng, Shih-Tsung Chang, Hsin Lin Chen, Ya-Fang Ke, Pei-Fang Tsai, Hsiu-Man Chan, Bo-Jiun Chang, Yi-Ting Hwang, Hsueh-Ya Tsai, Yueh-Chun Lee
BACKGROUND: Patients undergoing radiation therapy (RT) often experience anxiety, which may jeopardize the treatment success. The efficacy of music interventions in reducing anxiety remains contentious. This randomized trial aimed to evaluate the impact of music listening on anxiety symptoms in patients undergoing initial RT. METHODS: First-time RT patients were randomly allocated to experimental and control groups. The Brief Symptom Rating Scale (BSRS-5), Distress Thermometer (DT), and Beck Anxiety Inventory (BAI-C) were administered pre- and post-RT...
June 11, 2024: Radiation Oncology
https://read.qxmd.com/read/38851718/radiation-pneumonitis-prediction-with-dual-radiomics-for-esophageal-cancer-underwent-radiotherapy
#5
JOURNAL ARTICLE
Chenyu Li, Ji Zhang, Boda Ning, Jiayi Xu, Zhixi Lin, Jicheng Zhang, Ninghang Tan, Xianwen Yu, Wanyu Su, Weihua Ni, Wenliang Yu, Jianping Wu, Guoquan Cao, Zhuo Cao, Congying Xie, Xiance Jin
BACKGROUND: To integrate radiomics and dosiomics features from multiple regions in the radiation pneumonia (RP grade ≥ 2) prediction for esophageal cancer (EC) patients underwent radiotherapy (RT). METHODS: Total of 143 EC patients in the authors' hospital (training and internal validation: 70%:30%) and 32 EC patients from another hospital (external validation) underwent RT from 2015 to 2022 were retrospectively reviewed and analyzed. Patients were dichotomized as positive (RP+) or negative (RP-) according to CTCAE V5...
June 8, 2024: Radiation Oncology
https://read.qxmd.com/read/38849900/compliance-of-volunteers-in-a-fully-enclosed-patient-rotation-system-for-mr-guided-radiation-therapy-a-prospective-study
#6
JOURNAL ARTICLE
Cedric Beyer, Katharina Maria Paul, Stefan Dorsch, Gernot Echner, Fabian Dinkel, Thomas Welzel, Katharina Seidensaal, Juliane Hörner-Rieber, Oliver Jäkel, Jürgen Debus, Sebastian Klüter
BACKGROUND: Particle therapy makes a noteworthy contribution in the treatment of tumor diseases. In order to be able to irradiate from different angles, usually expensive, complex and large gantries are used. Instead rotating the beam via a gantry, the patient itself might be rotated. Here we present tolerance and compliance of volunteers for a fully-enclosed patient rotation system in a clinical magnetic resonance (MR)-scanner for potential use in MR-guided radiotherapy, conducted within a prospective evaluation study...
June 8, 2024: Radiation Oncology
https://read.qxmd.com/read/38849839/-125-i-seed-brachytherapy-for-non-central-pelvic-recurrence-of-cervical-cancer-after-external-beam-radiotherapy
#7
JOURNAL ARTICLE
Xuemin Di, Zhen Gao, Huimin Yu, Xiaoli Liu, Jinxin Zhao, Juan Wang, Hongtao Zhang
OBJECTIVE: To investigate the efficacy of 125 I seed brachytherapy for non-central pelvic recurrence of cervical cancer after external beam radiotherapy, and to analyze the clinical influential factors. METHODS: Between June 2015 and April 2022, 32 patients with 41 lesions were treated with 125 I seed brachytherapy. The seeds were implanted under the guidance of CT and/or 3D-printed template images at a median dose of 100 Gy (range, 80-120 Gy), and the local control rate (LCR) and survival rates were calculated...
June 8, 2024: Radiation Oncology
https://read.qxmd.com/read/38822385/evaluation-of-multiple-vendor-ai-autocontouring-solutions
#8
JOURNAL ARTICLE
Lee Goddard, Christian Velten, Justin Tang, Karin A Skalina, Robert Boyd, William Martin, Amar Basavatia, Madhur Garg, Wolfgang A Tomé
BACKGROUND: Multiple artificial intelligence (AI)-based autocontouring solutions have become available, each promising high accuracy and time savings compared with manual contouring. Before implementing AI-driven autocontouring into clinical practice, three commercially available CT-based solutions were evaluated. MATERIALS AND METHODS: The following solutions were evaluated in this work: MIM-ProtégéAI+ (MIM), Radformation-AutoContour (RAD), and Siemens-DirectORGANS (SIE)...
May 31, 2024: Radiation Oncology
https://read.qxmd.com/read/38822369/a-survey-of-cancer-patients-interest-in-undertaking-exercise-to-promote-relaxation-during-radiotherapy-for-breast-cancer-and-metastatic-cancer
#9
JOURNAL ARTICLE
Rebecca Moser, Nina A Mayr, Jana Nano, Sophie T Behzadi, Sophia Kiesl, Stephanie E Combs, Kai J Borm
BACKGROUND: Approximately 25-50% of patients undergoing radiotherapy (RT) experience psychological distress and anxiety, which can detrimentally affect both their quality of life and treatment outcomes. While previous research has demonstrated that relaxation exercises can enhance the tolerability of RT and alleviate associated stress and anxiety, the specific needs for such therapies in radiation oncology remain under-explored. This study aims to investigate the demand for and preferences toward relaxation exercises among radiotherapy patients, addressing a critical gap in patient-centered care...
May 31, 2024: Radiation Oncology
https://read.qxmd.com/read/38816745/the-incidence-of-and-risk-factors-for-radiation-pneumonitis-in-patients-treated-with-simultaneous-bevacizumab-and-thoracic-radiotherapy
#10
JOURNAL ARTICLE
Feihu Chen, Jiling Niu, Min Wang, Hui Zhu, Zhijun Guo
BACKGROUND: First-line chemotherapy combined with bevacizumab is one of the standard treatment modes for patients with advanced non-small cell lung cancer (NSCLC). Thoracic radiotherapy (TRT) can provide significant local control and survival benefits to patients during the treatment of advanced NSCLC. However, the safety of adding TRT has always been controversial, especially because of the occurrence of radiation pneumonia (RP) during bevacizumab treatment. Therefore, in this study, we used an expanded sample size to evaluate the incidence of RP when using bevacizumab in combination with TRT...
May 30, 2024: Radiation Oncology
https://read.qxmd.com/read/38812040/early-outcomes-of-mr-guided-sbrt-for-patients-with-recurrent-pancreatic-adenocarcinoma
#11
JOURNAL ARTICLE
Spencer J Poiset, Sophia Shah, Louis Cappelli, Pramila Anné, Karen E Mooney, Maria Werner-Wasik, Talya S Laufer, James A Posey, Daniel Lin, Atrayee Basu Mallick, Harish Lavu, Babar Bashir, Charles J Yeo, Adam C Mueller
BACKGROUND: Local treatment options for locally recurrent pancreatic adenocarcinoma (LR-PAC) are limited, with median survival time (MST) of 9-13 months (mos) following recurrence. MRI-guided stereotactic body radiation therapy (MRgSBRT) provides the ability to dose escalate while sparing normal tissue. Here we report on the early outcomes of MRgSBRT for LR-PAC. METHODS: Patients with prior resection of pancreatic adenocarcinoma with local recurrence treated with MRgSBRT at a single tertiary referral center from 5-2021 to 2-2023 were identified from our prospective database...
May 29, 2024: Radiation Oncology
https://read.qxmd.com/read/38811994/uncertainty-estimation-and-attention-based-semi-supervised-models-for-automatically-delineate-clinical-target-volume-in-cbct-images-of-breast-cancer
#12
JOURNAL ARTICLE
Ziyi Wang, Nannan Cao, Jiawei Sun, Heng Zhang, Sai Zhang, Jiangyi Ding, Kai Xie, Liugang Gao, Xinye Ni
OBJECTIVES: Accurate segmentation of the clinical target volume (CTV) of CBCT images can observe the changes of CTV during patients' radiotherapy, and lay a foundation for the subsequent implementation of adaptive radiotherapy (ART). However, segmentation is challenging due to the poor quality of CBCT images and difficulty in obtaining target volumes. An uncertainty estimation- and attention-based semi-supervised model called residual convolutional block attention-uncertainty aware mean teacher (RCBA-UAMT) was proposed to delineate the CTV in cone-beam computed tomography (CBCT) images of breast cancer automatically...
May 29, 2024: Radiation Oncology
https://read.qxmd.com/read/38807176/the-impact-of-bolus-on-clinical-outcomes-for-post-mastectomy-breast-cancer-patients-treated-with-imrt-data-from-china
#13
JOURNAL ARTICLE
Tao Jiang, Jiao Tian, Peijie Lei, Chunliu Meng, Jialei Fu, Lianjing Cao, Jingjing Cheng, Fei Zhou, Hongjun Zhang, Hao Song, Haijun Lu, Xiaojuan Wei
PURPOSE: This study aims to investigate the effects of chest wall bolus in intensity-modulated radiotherapy (IMRT) technology on clinical outcomes for post-mastectomy breast cancer patients. MATERIALS AND METHODS: This retrospective study included patients with invasive carcinoma ((y)pT0-4, (y)pN0-3) who received photon IMRT after mastectomy at the Affiliated Hospital of Qingdao University from 2014 to 2019. The patients were divided into two groups based on whether they received daily bolus application or not, and the baseline characteristics were matched using propensity score matching (PSM)...
May 28, 2024: Radiation Oncology
https://read.qxmd.com/read/38802938/a-non-invasive-preoperative-prediction-model-for-predicting-axillary-lymph-node-metastasis-in-breast-cancer-based-on-a-machine-learning-approach-combining-ultrasonographic-parameters-and-breast-gamma-specific-imaging-features
#14
JOURNAL ARTICLE
Ranze Cai, Li Deng, Hua Zhang, Hongwei Zhang, Qian Wu
BACKGROUND: The most common route of breast cancer metastasis is through the mammary lymphatic network. An accurate assessment of the axillary lymph node (ALN) burden before surgery can avoid unnecessary axillary surgery, consequently preventing surgical complications. In this study, we aimed to develop a non-invasive prediction model incorporating breast specific gamma image (BSGI) features and ultrasonographic parameters to assess axillary lymph node status. MATERIALS AND METHODS: Cohorts of breast cancer patients who underwent surgery between 2012 and 2021 were created (The training set included 1104 ultrasound images and 940 BSGI images from 235 patients, the test set included 568 ultrasound images and 296 BSGI images from 99 patients) for the development of the prediction model...
May 27, 2024: Radiation Oncology
https://read.qxmd.com/read/38802888/hypofractionated-radiotherapy-with-simultaneous-tumor-bed-boost-hi-rise-in-breast-cancer-patients-receiving-upfront-breast-conserving-surgery-study-protocol-for-a-phase-iii-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Kairui Jin, Jurui Luo, Xiaoli Yu, Xiaomao Guo
BACKGROUND: The effectiveness and safety of moderately hypofractionated radiotherapy (HFRT) in patients undergoing breast-conserving surgery (BCS) has been demonstrated in several pivotal randomized trials. However, the feasibility of applying simultaneous integrated boost (SIB) to the tumor bed and regional node irradiation (RNI) using modern radiotherapy techniques with HFRT needs further evaluation. METHODS: This prospective, multi-center, randomized controlled, non-inferiority phase III trial aims to determine the non-inferiority of HFRT combined with SIB (HFRTsib) compared with conventional fractionated radiotherapy with sequential boost (CFRTseq) in terms of five-year locoregional control rate in breast cancer patients undergoing upfront BCS...
May 27, 2024: Radiation Oncology
https://read.qxmd.com/read/38773620/deformable-registration-of-magnetic-resonance-images-using-unsupervised-deep-learning-in-neuro-radiation-oncology
#16
JOURNAL ARTICLE
Alexander F I Osman, Kholoud S Al-Mugren, Nissren M Tamam, Bilal Shahine
PURPOSE: Accurate deformable registration of magnetic resonance imaging (MRI) scans containing pathologies is challenging due to changes in tissue appearance. In this paper, we developed a novel automated three-dimensional (3D) convolutional U-Net based deformable image registration (ConvUNet-DIR) method using unsupervised learning to establish correspondence between baseline pre-operative and follow-up MRI scans of patients with brain glioma. METHODS: This study involved multi-parametric brain MRI scans (T1, T1-contrast enhanced, T2, FLAIR) acquired at pre-operative and follow-up time for 160 patients diagnosed with glioma, representing the BraTS-Reg 2022 challenge dataset...
May 21, 2024: Radiation Oncology
https://read.qxmd.com/read/38773616/effect-of-adjuvant-radiotherapy-on-overall-survival-and-breast-cancer-specific-survival-of-patients-with-malignant-phyllodes-tumor-of-the-breast-in-different-age-groups-a-retrospective-observational-study-based-on-seer
#17
JOURNAL ARTICLE
Ping Yang, Gongyin Zhang, Yu Zhang, Wanying Zhao, Jinhai Tang, Siyuan Zeng, Xiupeng Lv, Li Lv
PURPOSE: Malignant phyllodes tumor of the breast (MPTB) is a rare type of breast cancer, with an incidence of less than 1%. The value of adjuvant radiotherapy (RT) for MPTB has been controversial. The aim of the study was to explore the effect of radiotherapy on the long-term survival of female patients with MPTB at different ages. METHODS: Female MPTB patients were selected from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2020...
May 21, 2024: Radiation Oncology
https://read.qxmd.com/read/38773605/a-survey-on-brachytherapy-training-of-gynecological-cancer-focusing-on-the-competence-of-residents-in-china
#18
JOURNAL ARTICLE
Mohan Dong, Changhao Liu, Junfang Yan, Yong Zhu, Yutian Yin, Jia Wang, Ying Zhang, Lichun Wei, Lina Zhao
BACKGROUND: The brachytherapy is an indispensable treatment for gynecological tumors, but the quality and efficiency of brachytherapy training for residents is still unclear. METHODS: An anonymous questionnaire was designed to collect information on gynecological brachytherapy (GBT) training for radiation oncology residents from 28 training bases in China. The questionnaire content was designed based on the principle of competency based medical education (CBME)...
May 21, 2024: Radiation Oncology
https://read.qxmd.com/read/38750577/correction-systematic-review-and-pooled-analysis-of-the-impact-of-treatment-induced-lymphopenia-on-survival-of-glioblastoma-patients
#19
Ali M Saeed, Søren M Bentzen, Haroon Ahmad, Lily Pham, Graeme F Woodworth, Mark V Mishra
No abstract text is available yet for this article.
May 15, 2024: Radiation Oncology
https://read.qxmd.com/read/38750501/correction-real-world-clinical-experience-using-daily-intelligence-assisted-online-adaptive-radiotherapy-for-head-and-neck-cancer
#20
Philip Blumenfeld, Eduard Arbit, Robert Den, Ayman Salhab, Tal Falick Michaeli, Marc Wygoda, Yair Hillman, Raphael M Pfeffer, Marcel Fang, Yael Misrati, Noam Weizman, Jon Feldman, Aron Popovtzer
No abstract text is available yet for this article.
May 15, 2024: Radiation Oncology
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