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Radiation Oncology

Seth Helfenstein, Oliver Riesterer, Urs R Meier, Alexandros Papachristofilou, Benjamin Kasenda, Miklos Pless, Sacha I Rothschild
BACKGROUND: Concurrent chemoradiotherapy with cisplatin is standard for patients (pts) with loco-regionally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) and for patients with resected SCCHN with high-risk features. The standard regimen includes 3-weekly cisplatin, but weekly regimens are often used to lower toxicity. Reaching a cumulative dose of ≥200 mg/m2 cisplatin was shown being associated with improved outcome. We herein investigated cumulative dose reached and toxicities between the 3-weekly and weekly cisplatin regimens with concurrent radiotherapy...
February 11, 2019: Radiation Oncology
Juan Huang, Fang-Fang Kong, Ronald Wihal Oei, Rui-Ping Zhai, Chao-Su Hu, Hong-Mei Ying
BACKGROUND: In patients with T4 nasopharyngeal carcinoma (NPC), death may occur prior to the occurrence of temporal lobe injury (TLI). Because such competing risk death precludes the occurrence of TLI and thus the competing risk analysis should be applied to TLI research. The aim was to investigate the incidence and predictive factors of TLI after intensity-modulated radiotherapy (IMRT) among T4 NPC patients. METHODS: From March 2008 to December 2014, T4 NPC patients treated with full-course radical IMRT at our center were reviewed retrospectively...
February 8, 2019: Radiation Oncology
Kai Dolde, Ye Zhang, Naved Chaudhri, Christian Dávid, Marc Kachelrieß, Antony John Lomax, Patrick Naumann, Nami Saito, Damien Charles Weber, Asja Pfaffenberger
BACKGROUND: Time-resolved volumetric magnetic resonance imaging (4DMRI) offers the potential to analyze 3D motion with high soft-tissue contrast without additional imaging dose. We use 4DMRI to investigate the interplay effect for pencil beam scanning (PBS) proton therapy of pancreatic cancer and to quantify the dependency of residual interplay effects on the number of treatment fractions. METHODS: Based on repeated 4DMRI datasets for nine pancreatic cancer patients, synthetic 4DCTs were generated by warping static 3DCTs with 4DMRI deformation vector fields...
February 7, 2019: Radiation Oncology
Sophie Jacob, Jérémy Camilleri, Sylvie Derreumaux, Valentin Walker, Olivier Lairez, Mathieu Lapeyre, Eric Bruguière, Atul Pathak, Marie-Odile Bernier, Dominique Laurier, Jean Ferrieres, Olivier Gallocher, Igor Latorzeff, Baptiste Pinel, Denis Franck, Christian Chevelle, Gaëlle Jimenez, David Broggio
BACKGROUND: Intra-individual heterogeneity of cardiac exposure is an issue in breast cancer (BC) radiotherapy that was poorly considered in previous cardiotoxicity studies mainly based on mean heart dose (MHD). This dosimetric study analyzes the distribution of individually-determined radiation doses to the heart and its substructures including coronary arteries and evaluate whether MHD is a relevant surrogate parameter of dose for these substructures. METHODS: Data were collected from the BACCARAT prospective study that included left or right unilateral BC patients treated with 3D-Conformal Radiotherapy (RT) between 2015 and 2017 and followed-up for 2 years with repeated cardiac imaging examinations...
February 7, 2019: Radiation Oncology
Motomasa Furuse, Naosuke Nonoguchi, Kei Yamada, Tohru Shiga, Jean-Damien Combes, Naokado Ikeda, Shinji Kawabata, Toshihiko Kuroiwa, Shin-Ichi Miyatake
INTRODUCTION: This systematic review aims to elucidate the diagnostic accuracy of radiological examinations to distinguish between brain radiation necrosis (BRN) and tumor progression (TP). METHODS: We divided diagnostic approaches into two categories as follows-conventional radiological imaging [computed tomography (CT) and magnetic resonance imaging (MRI): review question (RQ) 1] and nuclear medicine studies [single photon emission CT (SPECT) and positron emission tomography (PET): RQ2]-and queried...
February 6, 2019: Radiation Oncology
S Gwynne, E Higgins, A Poon King, G Radhakrishna, L Wills, S Mukherjee, Maria Hawkins, G Jones, J Staffurth, T Crosby
BACKGROUND: The SCOPE trials (SCOPE 1, NeoSCOPE and SCOPE 2) have been the backbone of oesophageal RT trials in the UK. Many changes in oesophageal RT techniques have taken place in this time. The SCOPE trials have, in addition to adopting these new techniques, been influential in aiding centres with their implementation. We discuss the progress made through the SCOPE trials and include details of a questionnaire sent to participating centres. to establish the role that trial participation played in RT changes in their centre...
February 4, 2019: Radiation Oncology
Nalee Kim, Hojin Cho, Mijin Yun, Kyung Ran Park, Chang Geol Lee
BACKGROUND: To identify whether early metabolic responses as determined using 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) during radiotherapy (RT) predict outcomes in patients with esophageal cancer. METHODS: Twenty-one patients with esophageal cancer who received pre-treatment 18 F-FDG PET/CT (PET1) and inter-fractional 18 F-FDG PET/CT (PET2) after 11 fractions of RT (median 23.1 Gy, 2.1 Gy per fraction) were retrospectively reviewed...
February 4, 2019: Radiation Oncology
Pascaline Nguemgo Kouam, Helmut Bühler, Thomas Hero, Irenäus A Adamietz
BACKGROUND: Radiotherapy is administered in more than 60% of all solid tumors. Most patients are cured but a significant number develops local recurrences or distant metastases. The question arises if irradiation might influence the metastatic process. In the present study we examined whether the adhesion of glioblastoma or breast cancer cells to endothelial cells, an important step in metastasis, is affected by photon irradiation. METHODS: U-87 MG, U-373 MG and MDA-MB-231 cancer cells as well as primary human endothelial cells were irradiated with 0, 2, 4, or 8 Gy photons at a dose rate of 5 Gy/min...
February 4, 2019: Radiation Oncology
G Vogin, A Wambersie, M Koto, T Ohno, M Uhl, P Fossati, J Balosso
BACKGROUND: Carbon ion radiotherapy (CIRT) has been delivered to more than 20,000 patients worldwide. International trials have been recommended in order to emphasize the actual benefits. The ULICE program (Union of Light Ion Centers in Europe) addressed the need for harmonization of CIRT practices. A comparative knowledge of the sources and magnitudes of uncertainties altering dose distribution and clinical effects during the whole CIRT procedure is required in that aim. METHODS: As part of ULICE WP2 task group, we sent a centrally reviewed questionnaire exploring candidate sources of uncertainties in dose deposition to the ten CIRT facilities in operation by February 2017...
February 1, 2019: Radiation Oncology
Giuseppe Sanguineti, Diana Giannarelli, Maria Grazia Petrongari, Stefano Arcangeli, Angelo Sangiovanni, Biancamaria Saracino, Alessia Farneti, Adriana Faiella, Mario Conte, Giorgio Arcangeli
BACKGROUND: To compare WBC counts during treatment of localized prostate cancer with either conventionally fractionated (CF) or moderately hypofractionated (HYPO) radiotherapy. METHODS: Weekly blood test results were extracted from the charts of patients treated within a phase III study comparing HYPO to CF. In order to compare WBC counts at the same nominal dose in both arms and thus to tease out the effect of fractionation, for each recorded WBC value the corresponding cumulative total dose was extracted as well...
January 30, 2019: Radiation Oncology
Sha Zhou, Liling Luo, Jibin Li, Maosheng Lin, Li Chen, Jianhui Shao, Shipei Lu, Yaru Ma, Yingting Zhang, Wenfen Chen, Mengzhong Liu, Shiliang Liu, Liru He
BACKGROUND: Three-dimensional ultrasound (3DUS) is an attractive option in image-guided radiotherapy (IGRT) for prostate cancer (PCa) patients. However, the potential factors influencing the accuracy of 3DUS in comparison with cone-beam CT (CBCT) in IGRT for PCa patients haven't been clearly identified. METHODS: The differences between US/US and CBCT/CT registrations were analyzed over 586 and 580 sessions for 24 and 25 PCa patients treated with or without pelvic lymph node irradiation, respectively...
January 29, 2019: Radiation Oncology
Slavisa Tubin, Helmut H Popper, Luka Brcic
BACKGROUND: Despite the advances in oncology, patients with bulky tumors have worse prognosis and often receive only palliative treatments. Bulky disease represents an important challenging obstacle for all currently available radical treatment options including conventional radiotherapy. The purpose of this study was to assess a retrospective outcome on the use of a newly developed unconventional stereotactic body radiation therapy (SBRT) for PArtial Tumor irradiation of unresectable bulky tumors targeting exclusively their HYpoxic segment (SBRT-PATHY) that exploits the non-targeted effects of radiotherapy: bystander effects (local) and the abscopal effects (distant)...
January 29, 2019: Radiation Oncology
Kaixin Du, Jinluan Li, Lirui Tang, Xiaoyi Lin, Xiangquan Kong, Xuehong Liao, Qingqin Peng, Yaping Dong, Junyan He, Yunxia Huang, Xueqing Zhang, Feifei Lin, Qingyang Zhuang, Junxin Wu
OBJECTIVE: This study aimed to evaluate the role of postoperative radiotherapy (RT) in dermatofibrosarcoma protuberans (DFSP) and identify the prognostic factors influencing the disease-free survival (DFS). METHODS: A total of 184 patients with DFSP were analyzed from 2000 to 2016. The regression model was used to examine the prognostic factors for DFS. Baseline covariates were balanced using a propensity score model. The role of RT was assessed by comparing the DFS of the surgery + RT group with that of the surgery group...
January 29, 2019: Radiation Oncology
Hakyoung Kim, Hongryull Pyo, Jae Myoung Noh, Woojin Lee, Byoungsuk Park, Hye Yun Park, Hongseok Yoo
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is associated with fatal complications after radiotherapy (RT) for lung cancer patients; however, the role of proton therapy to reduce the incidence of life-threatening complications is unclear. Herein, we present the preliminary results of early-stage lung cancer patients having IPF and treated with RT, with a focus on the comparison between X-ray and proton therapy. METHODS: From January 2010 to October 2017, we retrospectively reviewed the medical records of 264 patients with stage I-II non-small cell lung cancer (NSCLC) treated with definitive RT alone...
January 28, 2019: Radiation Oncology
Corey C Foster, David J Sher, Chad G Rusthoven, Vivek Verma, Michael T Spiotto, Ralph R Weichselbaum, Matthew Koshy
BACKGROUND: Preclinical studies suggest enhanced anti-tumor activity with combined radioimmunotherapy. We hypothesized that radiation (RT) + immunotherapy would associate with improved overall survival (OS) compared to immunotherapy or chemotherapy alone for patients with newly diagnosed metastatic non-small-cell lung cancer (NSCLC). METHODS: The National Cancer Database was queried for patients with stage IV NSCLC receiving chemotherapy or immunotherapy from 2013 to 2014...
January 28, 2019: Radiation Oncology
Chen-Hsi Hsieh, Hui-Ju Tien, Yuan-Bin Yu, Yuan-Hung Wu, Pei-Wei Shueng, Yueh-Feng Lu, Shan-Ying Wang, Li-Ying Wang
BACKGROUND: Helical irradiation of the total skin (HITS) was modified as simultaneous integrated boost (SIB)-helical arc radiotherapy of total skin (HEARTS) technique and applied to an acute myeloid leukemia (AML) patient with disseminated leukemia cutis. METHODS: The original HITS plan was revised for different regimens, i.e. HEARTS, low-dose HEARTS and SIB-HEARTS. The uniformity index (UI), conformity index (CI), and dose of organs at risk (OARs) were used to evaluate the plans...
January 28, 2019: Radiation Oncology
Jian Chen, Jiade J Lu, Ningyi Ma, Jingfang Zhao, Chang Chen, Min Fan, Guoliang Jiang, Jingfang Mao
BACKGROUND: To evaluate the safety and efficacy of particle therapy (PT) using pencil beam scanning (PBS) technique for early stage non-small cell lung cancer (NSCLC). METHODS: From 08/2014 to 03/2018, 31 consecutive patients with sum of the longest diameters of primary tumor and hilar lymph node < 5 cm, N0-1, M0 NSCLC treated with PT were retrospectively analyzed. Gating/active breathing control techniques were used to control tumor motion in 20 and 7 patients...
January 25, 2019: Radiation Oncology
Pedro Henrique Justino Oliveira Limirio, Priscilla Barbosa Ferreira Soares, Eduardo Tadashi Pinto Emi, Camila de Carvalho Almança Lopes, Flaviana Soares Rocha, Jonas Dantas Batista, Gustavo Davi Rabelo, Paula Dechichi
BACKGROUND: The aim of this study was to evaluate the ionizing radiation (IR) effects on rat bone 30 and 60 days after irradiation. METHODS: Wistar rats were submitted to IR (30 Gy) on the left leg and were euthanized after 30 and 60 days. The legs were divided into four groups according to the treatment and euthanization time: C30 and C60 (right leg-without IR), IR30 and IR60 (left leg-with IR). RESULTS: CT analysis showed more radiodensity in C60 compared with other groups, and IR60 showed more radiodensity than IR30...
January 22, 2019: Radiation Oncology
Mitsue Kawamura, Michio Yoshimura, Hiromi Asada, Mitsuhiro Nakamura, Yukinori Matsuo, Takashi Mizowaki
BACKGROUND AND PURPOSE: We created a scoring system incorporating dosimetric and clinical factors to assess the risk of severe, acute skin reactions in patients undergoing intensity-modulated radiation therapy (IMRT) to treat head and neck cancer (HNC). MATERIALS AND METHODS: A total of 101 consecutive patients who received definitive IMRT or volumetric modulated arc therapy (VMAT) with a prescription dose of 70 Gy to treat HNC between 2013 and 2017 in our hospital were enrolled...
January 21, 2019: Radiation Oncology
Hikaru Kubota, Toshinori Soejima, Nor Shazrina Sulaiman, Shuhei Sekii, Yoko Matsumoto, Yosuke Ota, Kayoko Tsujino, Ikuo Fujita, Takuya Fujimoto, Masayuki Morishita, Junichi Ikegaki, Koji Matsumoto, Ryohei Sasaki
BACKGROUND: The selection of radiation therapy dose fractionation schedules for bone metastases is often based on the estimation of life expectancy. Therefore, accurate prognosis prediction is an important issue. It is reported that the Katagiri scoring system can be used to predict the survival of patients with bone metastases. We aimed to assess prognostic factors and validate the Katagiri scoring system in patients who were treated with radiation therapy for bone metastases. MATERIALS/METHODS: We retrospectively reviewed data of all patients who were treated with radiation therapy for bone metastases between 2004 and 2013...
January 18, 2019: Radiation Oncology
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