Mohammad Sherif, Anja Schmidt, Jan Ragnar Path, Markus Rheinthaler, Tobias Daniel Trippel
No abstract text is available yet for this article.
October 2, 2023: EuroIntervention
Ioannis T Farmakis, Stefano Barco, George Giannakoulas, Karsten Keller, Luca Valerio, Tobias Tichelbäcker, Sasan Partovi, Ingo Ahrens, Stavros V Konstantinides, Lukas Hobohm
BACKGROUND: Reperfusion therapy is challenging in the elderly. Catheter-directed therapies are an alternative for higher-risk pulmonary embolism (PE) patients if systemic thrombolysis (ST) is contraindicated or has failed. Their safety has not been evaluated in specific vulnerable populations. AIMS: We aimed to assess the safety of reperfusion therapies in elderly and frail patients in the real world. METHODS: In the US Nationwide Inpatient Sample from 2016 to 2020, we identified hospitalisations of patients ≥65 years with PE and defined a frailty subgroup using the Johns Hopkins Adjusted Clinical Groups frailty-defining diagnosis indicator...
September 28, 2023: EuroIntervention
Mazen Albaghdadi, Michael N Young, Rasha Al-Bawardy, Peter Monteleone, Beau Hawkins, Ehrin Armstrong, Mohamad Kassab, Haitham Khraishah, Mohammed Chowdhury, Avnish Tripathi, Kevin K Kennedy, Eric A Secemsky
BACKGROUND: There is a paucity of real-world data on the in-hospital (IH) and post-discharge outcomes in patients undergoing lower extremity peripheral vascular intervention (PVI) with adjunctive atherectomy. AIMS: In this retrospective, registry-based study, we evaluated IH and post-discharge outcomes among patients undergoing PVI, treated with or without atherectomy, in the National Cardiovascular Data Registry PVI Registry. METHODS: The IH composite endpoint included procedural complications, bleeding or thrombosis...
September 25, 2023: EuroIntervention
Min Chul Kim, Sung Gyun Ahn, Kyung Hoon Cho, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Jun-Won Lee, Young-Jin Youn, Hee-Yeol Kim, Ki-Dong Yoo, Doo-Soo Jeon, Eun-Seok Shin, Young-Hoon Jeong, Kiyuk Chang, Youngkeun Ahn
BACKGROUND: The benefits of de-escalation of P2Y12 inhibition after percutaneous coronary intervention (PCI) may differ by high bleeding risk (HBR) status. AIMS: We investigated the efficacy and safety of de-escalation from ticagrelor to clopidogrel after PCI by HBR status. METHODS: This is a non-prespecified post hoc analysis of the TicAgrelor Versus CLOpidogrel in Stabilized Patients with Acute Myocardial Infarction (TALOS-AMI) trial. Net adverse clinical events (a composite of cardiovascular death, myocardial infarction, stroke, or Bleeding Academic Research Consortium [BARC] bleeding type 2, 3, or 5) at 1 year post-PCI were compared between the de-escalation (clopidogrel plus aspirin) and the active control (ticagrelor plus aspirin) groups by HBR status, as defined by the modification of the Academic Research Consortium (ARC) criteria...
September 19, 2023: EuroIntervention
Dejan Milasinovic, Salvatore Brugaletta, Dario Jelic, Goran Stankovic
No abstract text is available yet for this article.
September 7, 2023: EuroIntervention
Pier Pasquale Leone, Angelo Oliva, Damiano Regazzoli, Mauro Gitto, Laura Novelli, Ottavia Cozzi, Giulio Giuseppe Stefanini, Marco Luciano Rossi, Alessandro Sticchi, Francesco Tartaglia, Antonio Mangieri, Bernhard Reimers, Antonio Colombo
No abstract text is available yet for this article.
September 5, 2023: EuroIntervention
Moritz Seiffert, Reinhard Vonthein, Helmut Baumgartner, Michael A Borger, Yeong-Hoon Choi, Volkmar Falk, Norbert Frey, Andreas Hagendorff, Christian Hagl, Christian Hamm, Inke R König, Ulf Landmesser, Steffen Massberg, Hermann Reichenspurner, Holger Thiele, Raphael Twerenbold, Maren Vens, Thomas Walther, Andreas Ziegler, Jochen Cremer, Stefan Blankenberg
Transcatheter aortic valve implantation (TAVI) has become the preferred treatment option for patients with severe aortic stenosis at increased risk for surgical aortic valve replacement (SAVR) and for older patients irrespective of risk. However, in younger, low-risk patients for whom both therapeutic options, TAVI and SAVR, are applicable, the optimal treatment strategy remains controversial, as data on long-term outcomes remain limited. The DEDICATE-DZHK6 Trial is an investigator-initiated, industry-independent, prospective, multicentre, randomised controlled trial investigating the efficacy and safety of TAVI compared to SAVR in low- to intermediate-risk patients aged 65 years or older...
September 1, 2023: EuroIntervention
Clément Servoz, Jérôme Wintzer-Wehekind, Jean-Michel Paradis, Didier Champagnac, Gaetan Charbonnier, Julio Farjat, Mohamed Abdellaoui, Nicolas Dumonteil, Benjamin Faurie
No abstract text is available yet for this article.
August 29, 2023: EuroIntervention
Chiara Fraccaro, Nicole Karam, Helge Möllmann, Sabine Bleiziffer, Nikolaos Bonaros, Rui Campante Teles, Pedro Carrilho Ferreira, Alaide Chieffo, Martin Czerny, Erwan Donal, Dariusz Dudek, Nicolas Dumonteil, Giovanni Esposito, Stephane Fournier, Christian Hassager, Won-Keun Kim, Konstantin A Krychtiuk, Julinda Mehilli, Jerzy Pręgowski, Giulio G Stefanini, Julien Ternacle, Holger Thiele, Matthias Thielmann, Flavien Vincent, Ralph Stephan von Bardeleben, Giuseppe Tarantini
Valvular heart disease (VHD) is one of the most frequent causes of heart failure (HF) and is associated with poor prognosis, particularly among patients with conservative management. The development and improvement of catheter-based VHD interventions have broadened the indications for transcatheter valve interventions from inoperable/high-risk patients to younger/lower-risk patients. Cardiogenic shock (CS) associated with severe VHD is a clinical condition with a very high risk of mortality for which surgical treatment is often deemed a prohibitive risk...
August 25, 2023: EuroIntervention
Daijiro Tomii, Taishi Okuno, Dik Heg, Masaaki Nakase, Jonas Lanz, Fabien Praz, Stefan Stortecky, David Reineke, Stephan Windecker, Thomas Pilgrim
BACKGROUND: Both measured and predicted effective orifice area (EOA) indexed to the body surface area (EOAi) have been suggested to define prosthesis-patient mismatch (PPM) in patients undergoing transcatheter aortic valve replacement (TAVR). The impact of PPM on clinical outcomes may accumulate with extended follow-up and vary according to the definition used. AIMS: We aimed to investigate the long-term clinical impact of PPM in patients undergoing TAVR. METHODS: Patients in a prospective TAVR registry were stratified by the presence of moderate (0...
August 25, 2023: EuroIntervention
Ines Hribernik, John Thomson, Amit Bhan, Michael Mullen, Patrick Noonan, Benjamin Smith, Niki Walker, Antigoni Deri, James Bentham
The GORE CARDIOFORM atrial septal defect (ASD) Occluder (GCA) is composed of a platinum-filled nitinol wire frame covered with expanded polytetrafluoroethylene, making it softer and more conformable compared with nitinol mesh devices. After the ASSURED clinical study confirmed the efficacy and safety of the device, it received U.S. Food and Drug Administration approval and a European conformity mark. Our aim was to understand the learning curve implicated in using the GCA for ASD closure in paediatric and adult patients as well as to study the early outcomes...
August 23, 2023: EuroIntervention
Dirk-Jan van Ginkel, Willem L Bor, Christophe L F Dubois, Hugo M Aarts, Maxim J P Rooijakkers, Kees H van Bergeijk, Liesbeth Rosseel, Leo Veenstra, Ole De Backer, Nicolas M Van Mieghem, Frank van der Kley, Adriaan Wilgenhof, Remigio Leonora, Jonathan Halim, Carl E Schotborgh, Emanuele Barbato, Jan A S Van Der Heyden, Peter Frambach, Bert Ferdinande, Darren Mylotte, Enrico Fabris, Benno J W M Rensing, Leo Timmers, Martin J Swaans, Jorn Brouwer, Vincent J Nijenhuis, Joyce Peper, Pieter A Vriesendorp, Bas de Laat, Marisa Ninivaggi, Hendrik Stragier, Michiel Voskuil, Alexander J J IJsselmuiden, Renicus S Hermanides, Pierfrancesco Agostoni, Arnoud W J van 't Hof, Joanna J Wykrzykowska, Niels van Royen, Ronak Delewi, Jurrien M Ten Berg
About one-third of patients undergoing transcatheter aortic valve implantation (TAVI) use oral anticoagulants (OAC), mainly due to atrial fibrillation. General guidelines advise interrupting OAC in patients with a high risk of bleeding undergoing interventions. However, preliminary observational data suggest that the continuation of OAC during TAVI is safe and may reduce the risk of periprocedural thromboembolic events. The Periprocedural Continuation Versus Interruption of Oral Anticoagulant Drugs During Transcatheter Aortic Valve Implantation (POPular PAUSE TAVI) is a multicentre, randomised clinical trial with open-label treatment and blinded endpoint assessment...
August 22, 2023: EuroIntervention
Lisheng Jiang, Ziyong Hao, Xiaoyi Xie, Ke Xu, Lan Shen, Xin Pan, Cheng Wang, Lan Ma, Linghong Shen, Yiting Fan, Ben He
BACKGROUND: The current risk stratification schemes for stroke in patients with atrial fibrillation (AF) are insufficient for an accurate assessment of stroke risk. AIMS: This study evaluates the association between the mechanical function of the left atrial appendage (LAA), as assessed by angiography, and the risk of stroke. METHODS: We conducted a cross-sectional study to assess the mechanical function of the LAA by measuring the left atrial appendage ejection fraction (LAAEF) and grading the contrast retention (CR) using angiography...
August 18, 2023: EuroIntervention
Lars Jakobsen, Evald H Christiansen, Phillip Freeman, Johnny Kahlert, Karsten Veien, Michael Maeng, Bent Raungaard, Julia Ellert, Anton B Villadsen, Steen D Kristensen, Martin K Christensen, Christian J Terkelsen, Jens Aaroe, Troels Thim, Jens Flensted Lassen, Mikkel Hougaard, Ashkan Eftekhari, Rebekka V Jensen, Nicolaj B Støttrup, Jeppe G Rasmussen, Anders Junker, Svend E Jensen, Henrik S Hansen, Lisette O Jensen
BACKGROUND: Target lesion failure (TLF) remains an issue with contemporary drug-eluting stents. The dual-therapy sirolimus-eluting and CD34 antibody-coated COMBO stent (DTS) was designed to improve early healing. AIMS: We aimed to compare the 3-year outcomes of the DTS and the sirolimus-eluting Orsiro stent (SES) in all-comer patients treated with percutaneous coronary intervention. METHODS: The SORT OUT X trial is a prospective multicentre randomised clinical trial with a registry-based follow-up comparing DTS and SES...
August 16, 2023: EuroIntervention
Juan Pablo Sanchez-Luna, Pedro Martín, Antonio E Dager, Pablo D Charry, Javier R Beltrán, Ángel Sánchez-Recalde, Francesco Giannini, Antonio Gómez-Menchero, Manuel Pan, Alfonso Ielasi, Andrea Monastyrski, Marco Barbanti, Francisco Fernandez-Avilés, Marco Bruno Ancona, Abdurashid Mussayev, Juan Pablo De Brahi, Pablo Lamelas, Andrés Sánchez-Pérez, Melissa García Puerta, Miguel Ortiz, Jose Carlos Gonzalez-Gutiérrez, Giorgio Marengo, Javier Gómez, Esther Gonzalez-Bartol, Alexander Stepanenko, Itziar Gomez-Salvador, J Alberto San Román, Ignacio J Amat-Santos
BACKGROUND: Transcatheter aortic valve replacement (TAVR) in non-calcified aortic regurgitation (NCAR) is an off-label procedure. The balloon-expandable Myval includes extra-large sizes (30.5 mm and 32 mm) of interest in this setting. AIMS: We aimed to evaluate the safety and feasibility of Myval in NCAR. METHODS: This was an international, multicentre, observational study that enrolled all consecutive patients with symptomatic severe NCAR undergoing TAVR with the Myval device...
August 11, 2023: EuroIntervention
Sean Fitzgerald, Hannah Wilson, Maureen Brenan, Himanshu Rai, Nicoletta Begossi, Nial Blake, Hugh McCann, Gavin Blake, Roisin Colleran, Colm G Hanratty, Robert A Byrne
No abstract text is available yet for this article.
August 9, 2023: EuroIntervention
Kamil Bujak, Filippo Maria Verardi, Victor Arevalos, Rami Gabani, Francesco Spione, Pawel Rajwa, Dejan Milasinovic, Goran Stankovic, Mariusz Gasior, Manel Sabaté, Salvatore Brugaletta
BACKGROUND: Controversy still exists regarding the optimal treatment of coronary bifurcation lesions. AIMS: We aimed to analyse the evidence from randomised controlled trials (RCTs) to compare outcomes following different bifurcation stenting techniques. METHODS: We systematically searched for RCTs comparing different techniques published up to July 2022. We then conducted a pairwise meta-analysis to compare outcomes between provisional stenting (PS) versus upfront 2-stent techniques...
August 3, 2023: EuroIntervention
David Meier, Uri Landes, Lars Sondergaard, Ole De Backer, Georg Lutter, Thomas Puehler, Mariama Akodad, Georgios Tzimas, Philipp Blanke, Geoffrey W Payne, Althea Lai, Hacina Gill, David A Wood, John G Webb, Stephanie L Sellers, Janarthanan Sathananthan
BACKGROUND: When a balloon-expandable transcatheter heart valve (THV) is chosen to treat a failed balloon-expandable THV, there is a risk of underexpansion with a potential impact on performance. AIMS: We aimed to assess the impact of pre- and post-dilatation on the expansion of balloon-expandable THVs after redo-transcatheter aortic valve implantation (TAVI). METHODS: Redo-TAVI was performed on the bench with a 23 mm SAPIEN 3 (S3) implanted within a 23 mm SAPIEN XT (SXT) or a 23 mm S3, both of which served as the "failed" THVs...
July 31, 2023: EuroIntervention
Helge Struthoff, Lucas Lauder, Mathias Hohl, Alexander Hermens, Abraham Rami Tzafriri, Elazer R Edelman, Michael Kunz, Michael Böhm, Thomas Tschernig, Felix Mahfoud
BACKGROUND: Renal denervation is optimised when guided by knowledge of nerve distribution. AIMS: We aimed to assess sympathetic nerve distribution along the renal arteries, especially in post-bifurcation vessel segments. METHODS: Renal arteries and surrounding tissue from 10 body donors were collected and examined histologically. Immunohistochemical staining was used to analyse nerve distribution and to identify afferent and efferent sympathetic nerves...
July 28, 2023: EuroIntervention
Zhong-Kai Zhu, Zhen-Gang Zhao, Ting-Chao Zhang, Fei Chen, Xin Wei, Yu-Jia Liang, Yuan Feng, Mao Chen
No abstract text is available yet for this article.
July 24, 2023: EuroIntervention
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