Michael L Barta, John Hickey, Kyle E Kemege, Scott Lovell, Kevin P Battaile, P Scott Hefty
Chlamydia trachomatis is a major cause of various diseases, including blinding trachoma and pelvic inflammatory disease, and is the leading reported sexually transmitted bacterial infection worldwide. All pathogenic Chlamydiae spp. utilize a supramolecular syringe, or type III secretion system (T3SS), to inject proteins into their obligate host in order to propagate infection. Here, the structure of CT584, a T3SS-associated protein, that has been refined to a resolution of 3.05 Å is reported. The CT584 structure is a hexamer comprised of a trimer of dimers...
November 2013: Acta Crystallographica. Section F, Structural Biology and Crystallization Communications