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Current Neurovascular Research

Haiyan Ren, Weibin Qiu, Chen Peng, Ying Ding, Benju Zhu, Qiang Li, Xu Chen
INTRODUCTION: The purpose of this investigation was to elucidate whether miR-125b targeting p38MAPK could relieve cognitive impairment of obstructive sleep apnea hypopnea syndrome (OSAHS) mice models. MATERIAL AND METHODS: The mice models were categorized into untreated control (UC), 10% continuous hypoxic (CH), 10% chronic intermittent hypoxia (CIH) and 5% chronic intermittent hypoxia (CIH) groups. Morris Water Maze, spatial navigation test and spatial probe test were conducted to appraise the learning, memorizing and cognitive abilities of mice models...
February 11, 2019: Current Neurovascular Research
Yan He, Zhengbao Zhu, Daoxia Guo, Huan Zhang, Xiaowei Zheng, Nimei Zeng, Qiu Zhang, Hao Peng, Chongke Zhong, Aili Wang, Tan Xu, Jianhua Jin, Yonghong Zhang, Jiang He
INTRODUCTION: Methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms has been suggested to be associated with ischemic stroke. However, the association between serum MTHFR level and ischemic stroke has not yet been studied. We aimed to examine the association between them in patients with large-artery atherosclerotic stroke and community-based healthy controls. METHODS: Three hundred ninety-five patients with large-artery atherosclerotic stroke from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) and 395 age- and sex-matched healthy controls from communities in China were studied...
February 7, 2019: Current Neurovascular Research
Kenneth Maiese
No abstract text is available yet for this article.
February 7, 2019: Current Neurovascular Research
Yaoming Xu, Ran Meng, Gary B Rajah, Yuchuan Ding, Yan Wu, Yali Wu, Kangxiang Ji, Chuanjie Wu, Wenbo Zhao, Xunming Ji
Background and purpose Cerebral venous sinus stenosis has been identified as a potential etiology in a number of idiopathic intracranial hypertension (IIH ) patients. Stenting may immediately relieve intracranial hypertension. However, the long-term outcomes of patients treated with this modality are not clear. Methods A over 12 years single-center analyzed of 62 patients undergoing stenting for medically refactory IIH with non-thrombotic and non-external compression cerebral venous sinus stenosis. Results The mean age of the 62 patients was 40 (range 13~62) years, females accounted for 67...
February 6, 2019: Current Neurovascular Research
Rui Guo, Ruiqi Chen, Chao You, Lu Ma, Hao Li, Yuan Fang
OBJECTIVES: Hyperglycemia is reported to be associated with poor outcome in patients with spontaneous intracerebral hemorrhage (ICH), but the association between blood glucose level and outcomes in primary intraventricular hemorrhage (PIVH) remains unclear. We sought to identify the parameters associated with admission hyperglycemia and analyze the impact of hyperglycemia on clinical outcome in patients with PIVH. METHODS: Patients admitted to Department of Neurosurgery, West China Hospital with PIVH between 2010 and 2016 were retrospectively included in our study...
January 31, 2019: Current Neurovascular Research
Mirza Jusufovic, Karolina Skagen, Kirsten Krohg-Sørensen, Mona Skjelland
Carotid artery stenosis (CAS) is a marker of systemic atherosclerosis and patients with CAS are at high risk of vascular events in multiple vascular locations, including ipsilateral ischemic stroke. Both medical and surgical therapies have been demonstrated effective in reducing this risk. The optimal management for patients with asymptomatic carotid artery stenosis remains controversial. In patients with symptomatic CAS ≥70%, CEA has been demonstrated to reduce the risk of stroke. With risk of recurrent stroke being particularly high in the first 2 weeks after first event, CEA or carotid angioplasty with stenting provides maximal benefits to patients with symptomatic CAS ≥70% if performed within this «2-week» target...
January 31, 2019: Current Neurovascular Research
Ramazan Jabbarli, Thiemo Florin Dinger, Daniela Pierscianek, Marvin Darkwah Oppong, Bixia Chen, Philipp Dammann, Karsten H Wrede, Klaus Kaier, Martin Köhrmann, Michael Forsting, Christoph Kleinschnitz, Ulrich Sure
BACKGROUND: The exact causes of intracranial aneurysms (IAs) are still unknown. However, certain diseases are known to be associated with IAs. OBJECTIVE: To analyze the differences in IA characteristics in the general population and in individuals with sickle-cell disease (SCD). METHODS: We systematically searched PubMed, Scopus, Web of Science, and Cochrane Library for data on SCD patients with IAs. We compared IA characteristics of SCD patients with those from 2451 healthy IA carriers from our observational cohort...
January 31, 2019: Current Neurovascular Research
L Halbe, A Rami
ER stress leads to the activation of two protein degradation pathways, the ubiquitin-proteasome via ER-associated degradation and lysosome-mediated protein degradation via autophagy. ER-associated degradation involves translocation of unfolded ER proteins to the cytosol where they are ubiquitinated and degraded by the proteasome. When the accumulation of misfolded or unfolded proteins excels the ER capacity, autophagy can be activated in order to degrade accumulated proteins and thus attenuate ER stress. Autophagy is the process by which cellular macromolecules and organelles components are sequestered within double membrane vesicles and delivered to lysosomes for degradation and recycling of bioenergetics substrate...
January 31, 2019: Current Neurovascular Research
Pankaj Bhatia, Nirmal Singh
Cerebral hypoperfusion has been associated with increased risk of vascular dementia (VaD). The present study investigates the potential of Tadalafil, a phosphodiesterase-5 inhibitor, in rat model of bilateral common carotid artery occlusion (BCCAo) induced VaD. Wistar rats were subjected to BCCAo procedure under anesthesia to induce VaD. Morris water-maze (MWM) test (7thday onwards post-surgery) was employed to assess learning and memory whereby escape latency time, time spent in target quadrant, Path length and average swim speed taken as important parameters...
January 30, 2019: Current Neurovascular Research
Jianfeng Zheng, Rui Xu, Zongduo Guo, Xiaochuan Sun
OBJECTIVE: With the aging of the world population, a growing number of elderly patients suffered from aneurysmal subarachnoid hemorrhage (aSAH). We aim to investigate the potential association between plasma ALT level and clinical complications of elderly aSAH patients, and explore its predictive value for clinical outcomes of elderly aSAH patients. PATIENTS AND METHODS: Between January 2013 and March 2018, 152 elderly aSAH patients were analyzed in this study. Clinical information, imaging findings and laboratory data were reviewed...
January 29, 2019: Current Neurovascular Research
Monika Golab-Janowska, Edyta Paczkowska, Boguslaw Machalinski, Dariusz Kotlega, Agnieszka Meller, Przemyslaw Nowacki, Safranow Krzysztof, Wankowlcz Pawel
BACKGROUND: Endothelial progenitor cells (EPCs) are important players in neovascularization, mobilized through signalling by angiogenic growth factors (AGFs) such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF). In vitro, inflammatory parameters impair the function and influence of EPCs on AGFs. However, this connection is not clear in vivo. To understand the mechanisms of augmented arteriogenesis and angiogenesis in acute ischemic stroke (AIS) patients, we investigated whether circulating stem cells (CD133+), early endothelial progenitor cells (CD133+/VEGFR2+), and endothelial cells (ECs; CD34¯/CD133¯/VEGFR2+) were increasingly mobilized during AIS, and whether there were correlations between EPC levels, growth factor levels and inflammatory parameters...
January 29, 2019: Current Neurovascular Research
Elina Pucite, Ildze Krievina, Evija Miglane, Renars Erts, Dainis Krievins, Andrejs Millers
BACKGROUND: Although several studies have evaluated the change of cognitive performance after severe carotid artery stenosis (CAS), the results still remain elusive. The objective of this study was to assess changes in cognitive function, depressive symptoms and health-related quality of life (HRQoL) after CAS revascularisation and best medical treatment (BMT). METHODS: Study involved 213 patients with severe (≥70%) CAS who underwent assessment of cognitive function using Montreal Cognitive Assessment scale (MoCA), depressive symptoms - using Patient Health Questionnaire-9 (PHQ-9) and HRQoL - using Medical Outcome Survey Short Form version 2 (SF-36v2)...
January 29, 2019: Current Neurovascular Research
M D Rosenbaum, D M Heiferman, O A Raslan, B Martin, J F Dominguez, P M de la Peña, W W Ashley, J D Rosenblum, A V Germanwala
BACKGROUND: Intracranial aneurysms (IAs) are life-threatening lesions known within the literature to be found incidentally during routine angiographic workup for carotid artery stenosis (CAS). As IAs are associated with vascular shear stress, it is reasonable to expect that altered flow demands within the anterior circulation, such as with CAS, increase compensatory flow demands via the Circle of Willis (COW) and may induce similar stress at the basilar apex. OBJECTIVE: We present a series of nine unruptured basilar apex aneurysms (BAA) with CAS and a comparative radiographic analysis to BAA without CAS...
January 29, 2019: Current Neurovascular Research
Quhong Song, Yisong Li, Yanan Wang, Chenchen Wei, Junfeng Liu, Ming Liu
BACKGROUND AND PURPOSE: Leukocyte is currently known as a potential risk factor for symptomatic intracranial hemorrhage after reperfusion therapy, but there is little evidence on whether leukocyte is associated with the overall risk of hemorrhagic transformation (HT) after acute ischemic stroke (AIS). METHODS: Patients within seven days after stroke onset were included between January 2016 and October 2017. The laboratory data were collected within 24 hours after admission...
December 4, 2018: Current Neurovascular Research
Lulu Pei, Bo Song, Hui Fang, Yuan Gao, Yinan Guo, Kai Liu, Yapeng Li, Xiao Wang, Xuan Tian, Jun Wu, Shilei Sun, Yuming Xu
BACKGROUND: Recent studies indicated that multiple acute infarctions on diffusion-weighted imaging (DWI) were associated with a higher risk of stroke. OBJECTIVE: The study aims to estimate the association of different infarction patterns and ABCD2 score with the prognosis of transient ischemic attack (TIA). METHOD: We prospectively analyzed the data from TIA database of the First Affiliated Hospital of Zhengzhou University. The predictive outcome was 90-day ischemic stroke...
December 4, 2018: Current Neurovascular Research
Kenneth Maiese
The world's population continues to age at a rapid pace. By the year 2050, individuals over the age of 65 will account for sixteen percent of the world's population and life expectancy will increase well over eighty years of age. Accompanied with the aging of the global population is a significant rise in non-communicable diseases (NCDs). Neurodegenerative disorders will form a significant component for NCDs. Currently, dementia is the 7th leading cause of death and can be the result of multiple causes that include diabetes mellitus, vascular disease, and Alzheimer's disease (AD)...
November 28, 2018: Current Neurovascular Research
Bo Song, Kai Liu, Yuan Gao, Lu Zhao, Hui Fang, Yunchao Wang, Andrew Wang, Gillian Coates, Shen Li, Yusheng Li, Yuming Xu
BACKGROUND: Uric acid (UA) has been known to play a neuroprotective role in ischemic stroke patients. However, the relationship between UA levels and prognosis in patients with cerebral venous thrombosis (CVT) has not been investigated. METHOD: A total of 228 CVT patients were retrospectively identified and were divided into three groups according to UA levels. Functional outcome was evaluated by modified Rankin Scale (mRS). Multivariate logistic regression analysis was conducted to evaluate the relation between UA levels and functional outcome after CVT...
November 27, 2018: Current Neurovascular Research
Vincent M Tutino, Hamidreza Rajabzadeh-Oghaz, Anusha R Chandra, Liza C Gutierrez, Ferdinand Schweser, Marilena Preda, Aichi Chien, Kunal Vakharia, Ciprian Ionita, Adnan Siddiqui, John Kolega
BACKGROUND: The neurovasculature dynamically responds to changes in cerebral blood flow by vascular remodeling processes. Serial imaging studies in mouse models could help to characterize pathologic and physiologic flow-induced remodeling of the Circle of Willis (CoW). METHOD: We induced flow-driven pathologic cerebral vascular remodeling in the CoW of mice (n=3) by ligation of the left common carotid artery (CCA), and the right external carotid and pterygopalatine arteries, increasing blood flow through the basilar and the right internal carotid arteries...
November 27, 2018: Current Neurovascular Research
Chenhuan Zhang, Ping Huang, Peipei Zhang, Mo Zhou, Ya Gao, Yonghong Zhang, Yumei Guo, Liying Lv, Tan Xu
BACKGROUND: There was a lack of studies on the association between human cytomegalovirus (HCMV) infection and prognosis of ischemic stroke, although it was indicated that human cytomegalovirus DNA has played a role in several cardiovascular disorders. OBJECTIVE: To examine the association between HCMV IgM levels in the acute phase and death and major disability after 2 weeks of acute ischemic stroke. METHODS: Serum HCMV IgM levels were measured in 1150 participants in China...
November 23, 2018: Current Neurovascular Research
Min Tang, Fangping He, Li Ma, Ping Liu, Jianwen Wang, Xiongchao Zhu
Bradykinin(BK) is a major kinin substance in the kallikrein-kinin system (KKS) that acts in conjunction with target cell bradykinin receptors and is involved in a variety of systems and organs. Functional regulation and pathophysiological processes such as cardiovascular, renal, central nervous system regulation, glucose metabolism, cell proliferation, smooth muscle contraction, inflammation, pain, shock, and tissue damage processes, etc. The role and mechanism of receptors in the mediation of ischemic injury in tissues was reviewed...
November 23, 2018: Current Neurovascular Research
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