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Current Heart Failure Reports

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https://read.qxmd.com/read/30762178/diuretic-resistance-in-heart-failure
#1
REVIEW
Richa Gupta, Jeffrey Testani, Sean Collins
PURPOSE OF REVIEW: Diuretic resistance (DR) occurs along a spectrum of relative severity and contributes to worsening of acute heart failure (AHF) during an inpatient stay. This review gives an overview of mechanisms of DR with a focus on loop diuretics and summarizes the current literature regarding the prognostic value of diuretic efficiency and predictors of natriuretic response in AHF. RECENT FINDINGS: The pharmacokinetics of diuretics are impaired in chronic heart failure, but little is known about mechanisms of DR in AHF...
February 14, 2019: Current Heart Failure Reports
https://read.qxmd.com/read/30762177/cardiac-contractility-modulation-and-baroreflex-activation-therapy-in-heart-failure-patients
#2
REVIEW
James A Mann, William T Abraham
PURPOSE OF REVIEW: Despite advances in medical therapy, heart failure with reduced ejection fraction (HFrEF) is still a leading cause of mortality, hospitalizations, and healthcare costs. In this review, we describe two novel, implantable devices for the treatment of patients with HFrEF, cardiac contractility modulation (CCM), and baroreflex activation therapy (BAT), and summarize literature regarding these devices from the last 5 years. RECENT FINDINGS: CCM improves quality of life and functional capacity as assessed by the Minnesota Living with Heart Failure Questionnaire (MLHFQ) score, 6-min hall walk test (6MHWT) distance, New York Heart Association (NYHA) functional class, peak oxygen consumption (pVO2 ), heart failure (HF) hospitalizations, and mortality...
February 14, 2019: Current Heart Failure Reports
https://read.qxmd.com/read/30762176/the-role-of-troponin-for-acute-heart-failure
#3
REVIEW
Nicholas Harrison, Mark Favot, Phillip Levy
PURPOSE OF REVIEW: To review the mechanisms, clinical interpretation, prognostic role, and future research regarding cardiac troponin (cTn) in the assessment of acute heart failure (AHF) patients presenting to the emergency department (ED). RECENT FINDINGS: cTn has become a necessary component of the evaluation of AHF patients in the ED, largely because of its independently predictive value as a prognosticator of poor outcome. High-sensitivity assays (hs-cTn) may add risk stratification value beyond conventional assays, specifically with regard to identifying low-risk AHF patients...
February 14, 2019: Current Heart Failure Reports
https://read.qxmd.com/read/30762175/vasodilator-therapies-in-the-treatment-of-acute-heart-failure
#4
REVIEW
Daniel B Holt, Peter S Pang
PURPOSE OF REVIEW: Vasodilators are commonly recommended to treat acute heart failure (AHF), yet they are infrequently used. This review aims to evaluate the clinical utility of traditional, historical, and novel vasodilators in the treatment of AHF. RECENT FINDINGS: No traditional vasodilator (i.e., nitroglycerin) therapy definitely improves short- or long-term outcomes. Despite repeated efforts to develop new pharmacologic treatments, no novel therapy outperforms traditional management...
February 14, 2019: Current Heart Failure Reports
https://read.qxmd.com/read/30712146/implementation-of-heart-transplantation-program-to-advanced-heart-failure-patients-in-brazil
#5
REVIEW
Fabiana G Marcondes-Braga, Marcely Gimenes Bonatto, Caio Ribeiro Alves Andrade, Fernando Bacal
PURPOSE: Heart transplantation is the gold standard treatment for advanced heart failure. Left ventricular assist devices (LVADs), despite being a good option for these patients, are not quite available in developing countries. Time spent in heart transplant waiting list has increased lately even in regions where the number of transplants has also risen showing that a new strategy should be sought. RECENT FINDINGS: Transplant process organization combined with multidisciplinary work are linked to better outcomes while improvement in donor's care and in pre-transplant evaluation might be opportunities to change the long waiting list scenario...
February 2, 2019: Current Heart Failure Reports
https://read.qxmd.com/read/30712145/quality-measures-in-heart-failure-the-past-the-present-and-the-future
#6
REVIEW
Carisi A Polanczyk, Karen B Ruschel, Fabio Morato Castilho, Antonio L Ribeiro
PURPOSE OF REVIEW: This paper reviews performance measure in health, their importance, and methodologic issues, focusing on metrics for health failure patients. Quality measures are instruments to assess structural aspects or processes of care aiming to guarantee that optimal patient outcomes are achieved. As heart failure is a chronic condition in which established therapies reduce mortality and hospital admissions, there are quite a lot of initiatives that aim to monitor for quality of care and to coordinate the disease management...
February 2, 2019: Current Heart Failure Reports
https://read.qxmd.com/read/30421355/hyperkalaemia-in-heart-failure-pathophysiology-implications-and-therapeutic-perspectives
#7
REVIEW
Redi Llubani, Davor Vukadinović, Christian Werner, Nikolaus Marx, Stephen Zewinger, Michael Böhm
PURPOSE OF REVIEW: Hyperkalaemia is a frequent and sometimes life-threatening condition that may be associated with arrhythmia and cardiac dysfunction. Evaluating the prevalence of hyperkalaemia in patients with heart failure (HF) and potential treatments of this condition is essential for patients using renin-angiotensin-aldosterone system inhibitors or angiotensin receptor-neprilysin inhibitor and mineralocorticoid receptor antagonists, which represent the cornerstone and highly proven life-saving therapy...
December 2018: Current Heart Failure Reports
https://read.qxmd.com/read/30413991/who-benefits-from-a-defibrillator-balancing-the-risk-of-sudden-versus-non-sudden-death
#8
REVIEW
Simon A S Beggs, Roy S Gardner, John J V McMurray
PURPOSE OF REVIEW: Treatment with a defibrillator can reduce the risk of sudden death by terminating ventricular arrhythmias. The identification of patient groups in whom this function reduces overall mortality is challenging. In this review, we summarise the evidence for who benefits from a defibrillator. RECENT FINDINGS: Recent evidence suggests that contemporary pharmacologic and non-defibrillator device therapies are altering the potential risks and benefits of a defibrillator...
December 2018: Current Heart Failure Reports
https://read.qxmd.com/read/30402659/depression-anxiety-and-cognitive-impairment-comorbid-mental-health-disorders-in-heart-failure
#9
REVIEW
Christiane E Angermann, Georg Ertl
PURPOSE OF REVIEW: Depression, anxiety, and cognitive impairment constitute established risk markers for incident cardiovascular disease (CVD) and are associated with impaired life expectancy and quality of life and high hospitalization rates and healthcare expenditure. This review summarizes current knowledge about mental health disorders in patients with CVD and heart failure (HF). RECENT FINDINGS: Emerging evidence suggests various shared pathophysiological mechanisms between psychological comorbidities and CVD (e...
December 2018: Current Heart Failure Reports
https://read.qxmd.com/read/30353399/role-of-the-wearable-defibrillator-in-newly-diagnosed-heart-failure
#10
REVIEW
David Duncker, Christian Veltmann
PURPOSE OF REVIEW: The wearable defibrillator (WCD) was shown to be safe and effective in detecting and terminating ventricular tachyarrhythmias and therefore allows temporary protection from sudden cardiac death. This review gives an overview of the current data on WCD in newly diagnosed cardiomyopathy. RECENT FINDINGS: Patients with newly diagnosed heart failure and reduced LVEF appear to have an increased risk of ventricular tachyarrhythmias, which may decrease over time when heart failure medication is optimized and left ventricular function improves...
December 2018: Current Heart Failure Reports
https://read.qxmd.com/read/30251188/setting-up-a-heart-failure-program-in-2018-moving-towards-new-paradigm-s
#11
REVIEW
Nadia Bouabdallaoui, Anique Ducharme
PURPOSE OF REVIEW: Heart failure (HF) is the first cause of hospitalization in the elderly in Western countries, generating tremendous healthcare costs. Despite the spread of multidisciplinary post-discharge programs, readmission rates have remained unchanged over time. We review the recent developments in this setting. RECENT FINDINGS: Recent data plead for global reorganization of HF care, specifically targeting patients at high risk for further readmission, as well as a stronger involvement of primary care providers (PCP) in patients' care plan...
December 2018: Current Heart Failure Reports
https://read.qxmd.com/read/30238398/improving-provider-adherence-to-guideline-recommendations-in-heart-failure
#12
REVIEW
Katherine E Di Palo, Ileana L Piña, Hector O Ventura
PURPOSE OF REVIEW: Heart failure clinical practice guidelines are fundamental and serve as framework for providers to deliver evidence-based care that correlates with enhanced patient outcomes. However, adherence, particularly to guideline-directed medical therapy, remains suboptimal for a multitude of reasons. RECENT FINDINGS: Despite robust clinical trials, updated guidelines and an expert consensus statement from American Heart Association, American College of Cardiology, and Heart Failure Society of America registry data signal that heart failure patients do not receive appropriate pharmacotherapy and may receive an intracardiac device without prior initiation or optimization of medical therapy...
December 2018: Current Heart Failure Reports
https://read.qxmd.com/read/30238397/gene-therapy-for-heart-failure-new-perspectives
#13
REVIEW
Khatia Gabisonia, Fabio A Recchia
PURPOSE OF REVIEW: The current knowledge of pathophysiological and molecular mechanisms responsible for the genesis and development of heart failure (HF) is absolutely vast. Nonetheless, the hiatus between experimental findings and therapeutic options remains too deep, while the available pharmacological treatments are mostly seasoned and display limited efficacy. The necessity to identify new, non-pharmacological strategies to target molecular alterations led investigators, already many years ago, to propose gene therapy for HF...
December 2018: Current Heart Failure Reports
https://read.qxmd.com/read/30178183/impaired-exercise-tolerance-in-heart-failure-role-of-skeletal-muscle-morphology-and-function
#14
REVIEW
Wesley J Tucker, Mark J Haykowsky, Yaewon Seo, Elisa Stehling, Daniel E Forman
PURPOSE OF REVIEW: To discuss the impact of deleterious changes in skeletal muscle morphology and function on exercise intolerance in patients with heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), as well as the utility of exercise training and the potential of novel treatment strategies to preserve or improve skeletal muscle morphology and function. RECENT FINDINGS: Both HFrEF and HFpEF patients exhibit a reduction in percent of type I (oxidative) muscle fibers and oxidative enzymes coupled with abnormal mitochondrial respiration...
December 2018: Current Heart Failure Reports
https://read.qxmd.com/read/30171472/diastolic-stress-testing-along-the-heart-failure-continuum
#15
REVIEW
T Jake Samuel, Rhys Beaudry, Satyam Sarma, Vlad Zaha, Mark J Haykowsky, Michael D Nelson
PURPOSE OF REVIEW: This review summarizes recent developments highlighting the clinical utility of diastolic stress testing along the heart failure continuum. RECENT FINDINGS: Invasive hemodynamic assessment of cardiac filling pressures during physiological stress is the gold-standard technique for unmasking diastolic dysfunction. Non-invasive surrogate techniques, such as Doppler ultrasound, have shown excellent agreement with invasive approaches and are now recommended by the American Society of Echocardiography and the European Association of Cardiovascular Imaging...
December 2018: Current Heart Failure Reports
https://read.qxmd.com/read/30123941/cardiorenal-interactions-revisited-how-to-improve-heart-failure-outcomes-in-patients-with-chronic-kidney-disease
#16
REVIEW
Mattia Arrigo, Pietro E Cippà, Alexandre Mebazaa
PURPOSE OF THE REVIEW: To summarize current advances in the understanding and management of heart failure (HF) in patients with advanced chronic kidney disease (CKD). RECENT FINDINGS: Diagnosis of HF and treatment of congestion are crucial in the management of patients with advanced CKD to reduce symptoms, preserve organ function, and improve outcomes. Echocardiography and cardiovascular biomarkers may help to differentiate cardiac from non-cardiac components of overhydration...
October 2018: Current Heart Failure Reports
https://read.qxmd.com/read/30097910/non-response-to-cardiac-resynchronization-therapy
#17
REVIEW
Syed Yaseen Naqvi, Anas Jawaid, Ilan Goldenberg, Valentina Kutyifa
PURPOSE OF REVIEW: Cardiac resynchronization therapy (CRT) is an effective treatment option for therapy-refractory mild to severe heart failure (HF) patients with reduced ejection fraction and left ventricular (LV) conduction delay. Multiple clinical trials have shown that CRT improves cardiac function and overall quality of life, as well as reduces HF hospitalizations, health care costs, and mortality. RECENT FINDINGS: Despite its effectiveness, the "non-response" rate to CRT is around 30%, remaining a major challenge that faces electrophysiologists and researchers...
October 2018: Current Heart Failure Reports
https://read.qxmd.com/read/30062624/clinical-implications-of-serum-biomarkers-of-cardiac-stress-in-aortic-stenosis
#18
REVIEW
Nimesh Patel, Dharam J Kumbhani
PURPOSE OF REVIEW: The purpose of this review is to outline the relationship between serum biomarkers of cardiac stress and the pathophysiologic progression of aortic stenosis, to identify studies exploring the utility of biomarkers in the risk stratification and management of patients with aortic stenosis, and to highlight the biomarkers most practical to management of patients with aortic stenosis. RECENT FINDINGS: Several biomarkers have been identified that reflect various aspects of the pathogenesis of calcific aortic stenosis, subsequent hemodynamic obstruction leading to myocardial remodeling, oxidative stress and injury, and concomitant systemic inflammation...
October 2018: Current Heart Failure Reports
https://read.qxmd.com/read/30062623/heart-failure-and-stroke
#19
REVIEW
Katja Schumacher, Jelena Kornej, Eduard Shantsila, Gregory Y H Lip
PURPOSE: Ischemic stroke significantly contributes to morbidity and mortality in heart failure (HF). The risk of stroke increases significantly, with coexisting atrial fibrillation (AF). An aggravating factor could be asymptomatic paroxysms of AF (so-called silent AF), and therefore, the risk stratification in these patients remains difficult. This review provides an overview of stroke risk in HF, its risk stratification, and stroke prevention in these patients. RECENT FINDINGS: Stroke risk stratification in HF patients remains an important issue...
October 2018: Current Heart Failure Reports
https://read.qxmd.com/read/30051292/peripartum-cardiomyopathy-an-update
#20
REVIEW
Feriel Azibani, Karen Sliwa
PURPOSE OF REVIEW: Peripartum cardiomyopathy (PPCM) is an idiopathic disorder defined as heart failure occurring in women during the last month of pregnancy and up to 5 months postpartum. In this review, we outline recent reports about the disease pathogenesis and management and highlight the use of diagnosis and prognosis biomarkers. RECENT FINDINGS: Novel data strengthen the implication of endothelial function in PPCM pathogenesis. The first international registry showed that patient presentations were similar globally, with heterogeneity in patient management and outcome...
October 2018: Current Heart Failure Reports
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