journal
https://read.qxmd.com/read/38488965/hypertrophic-cardiomyopathy
#1
REVIEW
Jason N Dungu, Amy Hardy-Wallace, Anthony D Dimarco, Henry O Savage
PURPOSE OF REVIEW: Hypertrophic cardiomyopathy (HCM) is a common inherited cardiac condition with potential for severe complications including sudden cardiac death. Early diagnosis allows appropriate risk stratification and prompt intervention to minimise the potential for adverse outcomes. The implications of poorly coordinated screening are significant, either missing relatives at high-risk or burdening low-risk individuals with a diagnosis associated with reduced life expectancy. We aim to guide clinicians through the diagnostic pathway through to novel treatment options...
March 15, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38485860/non-coding-ribonucleic-acids-as-diagnostic-and-therapeutic-targets-in-cardiac-fibrosis
#2
REVIEW
Samuel R Olson, W H Wilson Tang, Chia-Feng Liu
PURPOSE OF REVIEW: Cardiac fibrosis is a crucial juncture following cardiac injury and a precursor for many clinical heart disease manifestations. Epigenetic modulators, particularly non-coding RNAs (ncRNAs), are gaining prominence as diagnostic and therapeutic tools. RECENT FINDINGS: miRNAs are short linear RNA molecules involved in post-transcriptional regulation; lncRNAs and circRNAs are RNA sequences greater than 200 nucleotides that also play roles in regulating gene expression through a variety of mechanisms including miRNA sponging, direct interaction with mRNA, providing protein scaffolding, and encoding their own products...
March 15, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38430308/cellular-alterations-in-immune-checkpoint-inhibitor-therapy-related-cardiac-dysfunction
#3
REVIEW
Lars Michel, Peter Ferdinandy, Tienush Rassaf
PURPOSE OF REVIEW: Immune checkpoint inhibitor (ICI) therapy has emerged as a pivotal advancement in cancer treatment, but the widespread adoption has given rise to a growing number of reports detailing significant cardiovascular toxicity. This review concentrates on elucidating the mechanisms behind ICI-related cardiovascular complications, emphasizing preclinical and mechanistic data. RECENT FINDINGS: Accumulating evidence indicates a more significant role of immune checkpoints in maintaining cardiac integrity than previously understood, and new key scientific data are available to improve our understanding of ICI-related cardiovascular toxicity, including hidden cardiotoxicity...
March 2, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38411885/evaluation-and-management-of-hyponatremia-in-heart-failure
#4
REVIEW
Giulio M Mondellini, Frederik H Verbrugge
PURPOSE OF REVIEW: To provide a contemporary overview of the pathophysiology, evaluation, and treatment of hyponatremia in heart failure (HF). RECENT FINDINGS: Potassium and magnesium losses due to poor nutritional intake and treatment with diuretics cause an intracellular sodium shift in HF that may contribute to hyponatremia. Impaired renal blood flow leading to a lower glomerular filtration rate and increased proximal tubular reabsorption lead to an impaired tubular flux through diluting distal segments of the nephron, compromising electrolyte-free water excretion...
February 27, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38363516/digital-solutions-to-optimize-guideline-directed-medical-therapy-prescriptions-in-heart-failure-patients-current-applications-and-future-directions
#5
REVIEW
Jelle P Man, Joanna Klopotowska, Folkert W Asselbergs, M Louis Handoko, Steven A J Chamuleau, Mark J Schuuring
PURPOSEOF REVIEW: Guideline-directed medical therapy (GDMT) underuse is common in heart failure (HF) patients. Digital solutions have the potential to support medical professionals to optimize GDMT prescriptions in a growing HF population. We aimed to review current literature on the effectiveness of digital solutions on optimization of GDMT prescriptions in patients with HF. RECENT FINDINGS: We report on the efficacy, characteristics of the study, and population of published digital solutions for GDMT optimization...
February 16, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38363515/impact-of-frailty-on-heart-failure-prognosis-is-sex-relevant
#6
REVIEW
Lara Aguilar-Iglesias, Ana Perez-Asensio, Lidia Vilches-Miguel, Cesar Jimenez-Mendez, Pablo Diez-Villanueva, Jose-Angel Perez-Rivera
PURPOSE OF REVIEW: Heart failure (HF) is one of the most frequent causes of hospital admission in elderly patients, especially in women, who present a high prevalence of geriatric syndromes like frailty. Studies have suggested that frailty and its impact may also differ between males and females. Understanding how frailty may differently affect HF patients depending on sex is therefore imperative for providing personalized care. The aim of this review is to summarize the role of sex in the prognostic impact of frailty in HF patients...
February 16, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38300391/diuretic-treatment-in-patients-with-heart-failure-current-evidence-and-future-directions-part-ii-combination-therapy
#7
REVIEW
Cuthbert J J, Cleland J G F, Clark A L
PURPOSE OF REVIEW: Fluid retention or congestion is a major cause of symptoms, poor quality of life, and adverse outcome in patients with heart failure (HF). Despite advances in disease-modifying therapy, the mainstay of treatment for congestion-loop diuretics-has remained largely unchanged for 50 years. In these two articles (part I: loop diuretics and part II: combination therapy), we will review the history of diuretic treatment and current trial evidence for different diuretic strategies and explore potential future directions of research...
February 1, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38300390/heart-failure-a-punch-from-the-gut
#8
REVIEW
Ajay Mahenthiran, Jennifer Wilcox, W H Wilson Tang
PURPOSE OF REVIEW: This article seeks to elucidate the mechanisms underlying the bidirectional relationship between the gut and the heart, focusing on the pathophysiology of heart failure. We have previously demonstrated that Heart failure (HF) has significant effects on splanchnic vasculature and leads to key alterations in the gut microbiome, portending greater comorbidity with HF. RECENT FINDINGS: A growing field of research is focused on the effects of a "leaky gut" in the development of disease across organ systems...
February 1, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38289538/fabry-disease-cardiac-implications-and-molecular-mechanisms
#9
REVIEW
David Weissman, Jan Dudek, Vasco Sequeira, Christoph Maack
PURPOSE OF REVIEW: This review explores the interplay among metabolic dysfunction, oxidative stress, inflammation, and fibrosis in Fabry disease, focusing on their potential implications for cardiac involvement. We aim to discuss the biochemical processes that operate in parallel to sphingolipid accumulation and contribute to disease pathogenesis, emphasizing the importance of a comprehensive understanding of these processes. RECENT FINDINGS: Beyond sphingolipid accumulation, emerging studies have revealed that mitochondrial dysfunction, oxidative stress, and chronic inflammation could be significant contributors to Fabry disease and cardiac involvement...
January 30, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38236485/the-role-of-the-wearable-defibrillator-in-heart-failure
#10
REVIEW
Thibault Lenormand, Alexandre Bodin, Laurent Fauchier
PURPOSE OF REVIEW: Wearable cardioverter defibrillators (WCDs) have been developed as a temporary measure for protecting patients at risk for sudden cardiac death that do not meet the indication for implantable cardioverter defibrillator (ICD), most notably in the early stages of heart failure with reduced ejection fraction before reassessment of their left ventricular ejection fraction. In this review, we report available evidence in the literature and guidelines regarding WCD use in order to try to define the role WCDs may have in heart failure...
January 18, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38231443/evolutions-in-combined-heart-kidney-transplant
#11
REVIEW
Rashmi Jain, Michelle M Kittleson
PURPOSE OF REVIEW: This review describes management practices, outcomes, and allocation policies in candidates for simultaneous heart-kidney transplantation (SHKT). RECENT FINDINGS: In patients with heart failure and concomitant kidney disease, SHKT confers a survival advantage over heart transplantation (HT) alone in patients with dialysis dependence or an estimated glomerular filtration rate (eGFR) < 40 mL/min/1.73 m2 . However, when compared to kidney transplantation (KT) alone, SHKT is associated with worse patient and kidney allograft survival...
January 17, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38224446/antiarrhythmic-treatment-in-heart-failure
#12
REVIEW
Hilke Könemann, Sati Güler-Eren, Christian Ellermann, Gerrit Frommeyer, Lars Eckardt
PURPOSE OF REVIEW: Arrhythmias are common in patients with heart failure (HF) and are associated with a significant risk of mortality and morbidity. Optimal antiarrhythmic treatment is therefore essential. Here, we review current approaches to antiarrhythmic treatment in patients with HF. RECENT FINDINGS: In atrial fibrillation, rhythm control and ventricular rate control are accepted therapeutic strategies. In recent years, clinical trials have demonstrated a prognostic benefit of early rhythm control strategies and AF catheter ablation, especially in patients with HF with reduced ejection fraction...
January 15, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38153611/novel-trial-designs-in-heart-failure-using-digital-health-tools-to-increase-pragmatism
#13
REVIEW
Adam D DeVore, Marat Fudim, Lars H Lund
PURPOSE OF REVIEW: Heart failure is an important clinical and public health issue. There is an urgent need to improve the efficiency of clinical trials in heart failure to rapidly identify new therapies and evidence-based implementation strategies for currently existing therapies. Electronic health (eHealth) platforms and digital health tools are being integrated into heart failure care. In this manuscript, we review opportunities to use these tools to potentially improve the design of and reduce the complexity of clinical trials in heart failure...
December 28, 2023: Current Heart Failure Reports
https://read.qxmd.com/read/38305851/contrast-echocardiography-in-heart-failure-update-2023
#14
REVIEW
Harald Becher, Waleed Alhumaid, Jonathan Windram, Jonathan Choy
PURPOSE OF REVIEW: The application of ultrasound-enhancing agents (contrast agents) has improved the accuracy and reproducibility of echocardiography. The review focuses on the currently approved and evolving indications for contrast echocardiography in patients with heart failure, specifically examining clinical studies conducted after the publication of the guidelines in 2017 and 2018. RECENT FINDINGS: The current ASE/EACVI recommendations for contrast echocardiography are based on its accuracy and reproducibility in comparison to non-enhanced echocardiography or other imaging modalities like cardiac MRI...
April 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38240883/diuretic-treatment-in-patients-with-heart-failure-current-evidence-and-future-directions-part-i-loop-diuretics
#15
REVIEW
Joseph James Cuthbert, Andrew L Clark
PURPOSE OF REVIEW: Fluid retention or congestion is a major cause of symptoms, poor quality of life, and adverse outcome in patients with heart failure (HF). Despite advances in disease-modifying therapy, the mainstay of treatment for congestion-loop diuretics-has remained largely unchanged for 50 years. In these two articles (part I: loop diuretics and part II: combination therapy), we will review the history of diuretic treatment and the current trial evidence for different diuretic strategies and explore potential future directions of research...
April 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38133864/appetite-and-its-regulation-are-there-palatable-interventions-for-heart-failure
#16
REVIEW
Matthew M Y Lee, Michael E J Lean, Naveed Sattar, Mark C Petrie
PURPOSE OF REVIEW: Obesity is a major driver of heart failure (HF) incidence, and aggravates its pathophysiology. We summarized key reported and ongoing randomized clinical trials of appetite regulation and/or dietary energy restriction in individuals with HF. RECENT FINDINGS: Weight loss can be achieved by structured supervised diet programs with behavioural change, medications, or surgery. The new glucagon-like peptide-1 receptor agonists alone or in combination with other agents (e...
February 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38060192/implications-of-sex-differences-on-the-treatment-effectiveness-in-heart-failure-with-reduced-ejection-fraction-related-to-clinical-endpoints-and-quality-of-life
#17
REVIEW
D Aydin, Y Allach, J J Brugts
PURPOSE OF THE REVIEW: This narrative review will emphasize the necessity for more female enrollment in heart failure (HF) trials and proposes future investigations regarding optimal dosages. Ultimately, a deeper understanding of the unique pathophysiology and medication responses in both men and women is crucial for effective HF management and may improve the quality of life in women. RECENT FINDINGS: An analysis of 740 cardiovascular studies reveals that women make up only 38...
December 7, 2023: Current Heart Failure Reports
https://read.qxmd.com/read/38060191/sex-differences-in-circulating-biomarkers-of-heart-failure
#18
REVIEW
Roopa A Rao, Anju Bhardwaj, Mrudula Munagala, Sonu Abraham, Sanjana Adig, Arden Shen, Eman Hamad
PURPOSE OF REVSIEW: Evidence is scaling up for sex differences in heart failure; however, clinical relevance of sex-specific differential thresholds for biomarkers is not clearly known. Current ambiguity warrants a further look into the sex-specific studies on cardiac biomarkers and may facilitate understanding of phenotypic presentations, clinical manifestations, and pathophysiologic pathway differences in men and women. RECENT FINDINGS: Recent studies have confirmed the fact that females have differential threshold for biomarkers, with lower troponin and higher NT proBNP levels...
December 7, 2023: Current Heart Failure Reports
https://read.qxmd.com/read/38047986/rethinking-the-impact-and-management-of-diabetes-in-heart-failure-patients
#19
REVIEW
Katharina Schütt
PURPOSE OF REVIEW: The following overview article summarizes the most important aspects of diagnosis and screening and provides an overview on the current evidence of glucose-lowering and heart failure treatment in patients with diabetes. RECENT FINDINGS: Patients with diabetes exhibit an increased risk to develop heart failure and the presence of both comorbidities has a major impact on the prognosis of these patients. Thus, it is of utmost importance to detect heart failure in patients with diabetes and to screen all patients with heart failure for the presence of diabetes...
December 4, 2023: Current Heart Failure Reports
https://read.qxmd.com/read/38038881/correction-to-differentiating-cardiac-troponin-levels-during-cardiac-myosin-inhibition-or-cardiac-myosin-activation-treatments-drug-effect-or-the-canary-in-the-coal-mine
#20
Matthew M Y Lee, Ahmad Masri
No abstract text is available yet for this article.
December 1, 2023: Current Heart Failure Reports
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