Journals Expert Review of Cardiovascula...

Expert Review of Cardiovascular Therapy
Ricardo Polman, John R Hurst, Omer Faruk Uysal, Swapna Mandal, Dominik Linz, Sami Simons
INTRODUCTION: Chronic Obstructive Pulmonary Disease (COPD) and cardiovascular diseases (CVD) commonly co-exist. Outcomes of people living with both conditions are poor in terms of symptom burden, receiving evidence-based treatment and mortality. Increased understanding of the underlying mechanisms may help to identify treatments to relieve this disease burden. This narrative review covers the overlap of COPD and CVD with a focus on clinical presentation, mechanisms, and interventions...
March 27, 2024: Expert Review of Cardiovascular Therapy
Seyed Younes Hosseini, Rahul Mallick, Petri Mäkinen, Seppo Ylä-Herttuala
INTRODUCTION: After understanding the genetic basis of cardiovascular disorders, the discovery of prime editing (PE), has opened new horizons for finding their cures. PE strategy is the most versatile editing tool to change cardiac genetic background for therapeutic interventions. The optimization of elements, prediction of efficiency, and discovery of the involved genes regulating the process have not been completed. The large size of the cargo and multi-elementary structure makes the in vivo heart delivery challenging...
March 17, 2024: Expert Review of Cardiovascular Therapy
Setor K Kunutsor, Jari A Laukkanen
INTRODUCTION: The evidence supporting the cardiovascular health benefits of physical activity and/or exercise training is well-established. While the role of physical activity in primary prevention is unequivocal, its significance in secondary prevention (among those with preexisting cardiovascular disease) is less definitive. Though guidelines universally recommend physical activity as part of the secondary preventive strategy, the empirical evidence underpinning these recommendations is not as robust as that for primary prevention...
March 15, 2024: Expert Review of Cardiovascular Therapy
Kosmas I Paraskevas, Alan Dardik, Marc L Schermerhorn, Christos D Liapis, Armando Mansilha, Brajesh K Lal, William A Gray, Martin M Brown, Piotr Myrcha, Carl J Lavie, Clark J Zeebregts, Eric A Secemsky, Luca Saba, Matthew Blecha, Victor Gurevich, Mauro Silvestrini, Ales Blinc, Alexei Svetlikov, Jose Fernandes E Fernandes, Peter A Schneider, Peter Gloviczki, Christopher J White, Ali F AbuRahma
INTRODUCTION: Two of the main reasons recent guidelines do not recommend routine population-wide screening programs for asymptomatic carotid artery stenosis (AsxCS) is that screening could lead to an increase of carotid revascularization procedures and that such mass screening programs may not be cost-effective. Nevertheless, selective screening for AsxCS could have several benefits. This article presents the rationale for such a program. AREAS COVERED: The benefits of selective screening for AsxCS include early recognition of AsxCS allowing timely initiation of preventive measures to reduce future myocardial infarction (MI), stroke, cardiac death and cardiovascular (CV) event rates...
March 13, 2024: Expert Review of Cardiovascular Therapy
Marie-A Chaix, Réda Ibrahim, Jean-Claude Tardif, Colombe Roy, François-Pierre Mongeon, Annie Dore, Blandine Mondésert, Paul Khairy
INTRODUCTION: The Fontan procedure is the palliative procedure of choice for patients with single ventricle physiology. Pulmonary vascular disease (PVD) is an important contributor to Fontan circulatory failure. AREAS COVERED: We review the pathophysiology of PVD in patients with Fontan palliation and share our initial experience with optical coherence tomography (OCT) in supplementing standard hemodynamics in characterizing Fontan-associated PVD. In the absence of a sub-pulmonary ventricle, low pulmonary vascular resistance (PVR; ≤2 WU/m2 ) is required to sustain optimal pulmonary blood flow...
March 13, 2024: Expert Review of Cardiovascular Therapy
Prashant D Bhave, Elsayed Soliman
No abstract text is available yet for this article.
March 10, 2024: Expert Review of Cardiovascular Therapy
Frederick Berro Rivera, Sung Whoy Cha, Mara Bernadette Liston, Sonny Redula, Nathan Ross B Bantayan, Nishant Shah, Mamas A Mamas, Annabelle Santos Volgman
BACKGROUND: Sex differences in clinical outcomes following acute myocardial infarction (AMI) are well known. However, data on sex differences among patients with familial hypercholesterolemia (FH) are limited. We aimed to explore sex differences in outcomes of AMI among patients with FH from a national administrative dataset. RESEARCH DESIGN AND METHODS: We utilized the National Inpatient Sample to identify admissions with a primary diagnosis of AMI and a secondary diagnosis of FH...
March 9, 2024: Expert Review of Cardiovascular Therapy
Eloi Vacher, Jean Baptiste Gourraud, Vincent Probst
INTRODUCTION: Mapping advances have expanded both the feasibility and benefits of ablation as a therapeutic approach, including in the treatment of two heart conditions that contribute to sudden cardiac death in young people: Brugada syndrome (BrS) and early repolarization syndrome (ERS). Although these conditions share a number of similarities, debates persist regarding the underlying pathophysiology and origin of the ventricular arrhythmias associated with them. AREAS COVERED: By synthesizing available data (PubMed), including current recommendations, pathophysiological insights and case reports, patient registries, our aim is to elucidate and establish the nuanced role of radiofrequency ablation (RFA) in therapeutic management...
March 1, 2024: Expert Review of Cardiovascular Therapy
Xavier García-Moll, Francesco Croci, Alexandra Solé, Elisabeth S Hartgers-Gubbels, Miguel A Calleja-Hernández
BACKGROUND: Heart failure (HF) is a chronic condition with considerable clinical burden for patients and economic burden for healthcare systems. Treatment for HF is typically based on ejection fraction (EF) phenotype. The cost-effectiveness of empagliflozin + standard of care (SoC) compared to SoC has been examined for HF phenotypes below or above 40% EF separately, but not across the full spectrum of EF in Spain. METHODS: The results of two preexisting, validated, and published phenotype-specific Markov cohort models were combined using a population-weighted approach, reflecting the incidence of each phenotype in the total HF population in Spain...
February 28, 2024: Expert Review of Cardiovascular Therapy
Kiera Liblik, Ioana Tereza Florica, Adrian Baranchuk
INTRODUCTION: Neglected tropical diseases (NTDs) introduce considerable morbidity and mortality on a global scale, directly impacting over 1 billion individuals as well as their families and communities. Afflicted individuals may have limited access to resources and care in these regions, contributing to a high proportion of chronic, progressive, and systemic disease. The cardiovascular system is at particular risk of demise for several NTDs, yet remains largely unstudied due in part to the lack of robust data collection mechanisms in the most impacted regions...
February 3, 2024: Expert Review of Cardiovascular Therapy
Frederick Berro Rivera, Faye Salva, Jacques Simon Gonzales, Sung Whoy Cha, Samantha Tang, Gurleen Kaur, Isabel Planek, Kyla Lara-Breitinger, Mark Dela Cruz, Tisha Marie B Suboc, Fareed Moses S Collado, Jonathan R Enriquez, Nishant Shah, Annabelle Santos Volgman
BACKGROUND: Mechanical complications (MC) are rare but significant sequelae of acute myocardial infarction (AMI). Current data on sex differences in AMI with MC is limited. METHODS: We queried the National Inpatient Sample database to identify adult patients with the primary diagnosis of AMI and MC. The main outcome of interest was sex difference in-hospital mortality. Secondary outcomes were sex differences in the incidence of acute kidney injury (AKI), major bleeding, use of inotropes, permanent pacemaker implantation (PPMI), performance of percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), surgery (VSD repair and MV surgery), pericardiocentesis, use of mechanical circulatory support (MCS), ischemic stroke, and mechanical ventilation...
January 29, 2024: Expert Review of Cardiovascular Therapy
Simran Singh Parmar, Mohamed O Mohamed, Mamas A Mamas, Ross Wilkie
OBJECTIVES: The prevalence of osteoarthritis (OA) and cardiovascular disease are increasing and both conditions share similar risk factors. We investigated the association between OA and receipt of invasive managements and clinical outcomes in patients with acute myocardial infarction (AMI). METHODS: Using the National Inpatient Sample, adjusted binary logistic regression determined the association between OA and each outcome variable. RESULTS: Of 6,561,940 AMI hospitalizations, 6...
January 29, 2024: Expert Review of Cardiovascular Therapy
Anthony S Wierzbicki
INTRODUCTION: Older adults form a fast-increasing proportion of the world population. However, gains in increasing quantity of life have not been accompanied by similar gains in quality of life. Older people frequently experience frailty, memory problems, and chronic diseases including cardiovascular disease (CVD) and neurodegenerative diseases. Recent trials have demonstrated the efficacy of anti-hypertensive therapy in older populations but failed to show benefits for aspirin. AREA COVERED: Statins clearly reduce CVD events in middle-aged populations...
January 23, 2024: Expert Review of Cardiovascular Therapy
Cayla Pichan, Adam D DeVore
No abstract text is available yet for this article.
2024: Expert Review of Cardiovascular Therapy
Sukhbir Randhawa, Subrat Da, Wilbert S Aronow
INTRODUCTION: Atrial fibrillation (AF) is a supraventricular arrhythmia characterized by fibrillatory waves in the atria with an irregular ventricular rhythm. It is the most common arrhythmia treated in clinical practice. AF is associated with approximately five-fold increase in risk of cerebrovascular accident (stroke) and two-fold increase in cognitive dysfunction and all-cause mortality. AREAS COVERED: Multiple risk factors have been identified for development of AF including age, hypertension, diabetes, and obesity...
December 18, 2023: Expert Review of Cardiovascular Therapy
Sadaf Fakhra, Mohammed Faisaluddin, Yasar Sattar, Danielle DeCicco, Asmaa Ahmed, Neel Patel, Senthil Balasubramanian, Dipesh Ludhwani, Hassan Masood, Sameer Raina, Karthik Gonuguntla, Scott C Feitell, Tushar Tarun, Sudarshan Balla
INTRODUCTION: Takotsubo syndrome (TTS), also known as stress-induced cardiomyopathy, can be complicated by shock. The outcomes of patients with TTS complicated with cardiogenic shock (CS) versus mixed cardiogenic and septic shock (MS) is not known. METHODS: We queried Nationwide Inpatient Sample (NIS) from 2009-2020 to compare TTS patients with CS and MS using International Classification of Disease, Ninth & Tenth Edition, Clinical Modification (ICD- 9 & 10-CM) coding...
December 18, 2023: Expert Review of Cardiovascular Therapy
Mohamed Khayata, Alejandro Sanchez Nadales, Bo Xu
INTRODUCTION: Infective endocarditis (IE) is an increasingly important condition with significant morbidity and mortality. With advancements in cardiovascular interventions including prosthetic valve implantation and utilization of intracardiac devices, the prevalence of IE is rising in the modern era. Early detection and management of this condition are critical. AREAS COVERED: This review presents a contemporary review of the applications of multi-modality imaging in IE, taking a comparative approach of the various imaging modalities...
November 23, 2023: Expert Review of Cardiovascular Therapy
Federica Agnello, Maria Sara Mauro, Carla Rochira, Davide Landolina, Simone Finocchiaro, Antonio Greco, Nicola Ammirabile, Carmelo Raffo, Placido Maria Mazzone, Marco Spagnolo, Giovanni Occhipinti, Antonino Imbesi, Daniele Giacoppo, Davide Capodanno
INTRODUCTION: Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of global mortality, imposing substantial healthcare economic burdens. Among the modifiable risk factors, hypercholesterolemia, especially elevated low-density lipoprotein cholesterol (LDL-C), plays a pivotal role in ASCVD development. Novel therapies such as PCSK9 (Proprotein Convertase Subtilisin/Kexin type 9) inhibitors are emerging to address this concern. These inhibitors offer the potential to reduce cardiovascular risk by directly targeting LDL-C levels...
November 23, 2023: Expert Review of Cardiovascular Therapy
Shreef Said, Alan Dardik, Cassius Iyad Ochoa Chaar
INTRODUCTION: The prevalence of carotid artery stenosis in the general population is approximately 3%, but approximately 20% among people with acute ischemic stroke. Statins are recommended by multiple international guidelines as the drug of choice for lipid control in people with asymptomatic or symptomatic carotid artery stenosis due to their lipid-lowering and other pleiotropic effects. AREAS COVERED: This review discusses the guidelines for statin usage as a cornerstone in the prevention and management of atherosclerotic carotid artery disease and the impact of statins on stroke incidence and mortality...
November 21, 2023: Expert Review of Cardiovascular Therapy
Rongfeng Xu, Zhenyu Cai, Jiandong Ding, Genshan Ma
INTRODUCTION: Tricuspid regurgitation (TR) is one of the most prevalent types of valvular heart disease linked to poor prognosis in patients with heart failure and is usually ignored. TR has received considerable attention due to the progressive advancements in transcatheter therapies in recent years. AREAS COVERED: With relatively solid data and rapid technological advancements, tricuspid transcatheter edge-to-edge repair (T-TEER) is the most frequently employed in a series of tricuspid transcatheter interventional treatments for TR...
November 20, 2023: Expert Review of Cardiovascular Therapy
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