Journals Expert Review of Cardiovascula...

Expert Review of Cardiovascular Therapy
Abraham Samuel Babu, Vibha Bhat, Prinu Jose, Sebastian Padickaparambil, Ramachandran Padmakumar, Panniyammakal Jeemon
BACKGROUND: Cardiac rehabilitation (CR) remains greatly underutilized, especially in low- and middle-income countries (LMIC). It is therefore important to explore factors that contribute to this, as perceived by health-care professionals (HCPs). RESEARCH DESIGN AND METHODS: This was a qualitative study using in-depth interviews that enrolled 18 HCPs (i.e. six each of physicians, physiotherapists, and nurses; mean experience in CR: 17.9 ± 11.8 yrs) working in cardiovascular care, and CR across private and government hospitals (both teaching and non-teaching) in India...
July 16, 2024: Expert Review of Cardiovascular Therapy
Robert J H Miller, Piotr J Slomka
INTRODUCTION: Myocardial perfusion imaging (MPI) is one of the most commonly ordered cardiac imaging tests. Accurate motion correction, image registration, and reconstruction is critical for high-quality imaging, but this can be technically challenging and traditionally has relied on expert manual processing. With accurate processing, there is a rich variety of clinical, stress, functional, and anatomic data that can be integrated to guide patient management. AREAS COVERED: Pubmed and Google Scholar were reviewed for articles related to artificial intelligence in nuclear cardiology published between 2020 and 2024...
July 13, 2024: Expert Review of Cardiovascular Therapy
Lin-Thiri Toon, John Paisey, Paul R Roberts
No abstract text is available yet for this article.
July 11, 2024: Expert Review of Cardiovascular Therapy
Carolina Montonati, Dario Pellegrini, Daniele Oreste d'Atri, Mariano Pellicano, Daniele Briguglia, Francesco Giannini, Giuseppe De Blasio, Giulio Guagliumi, Maurizio Tespili, Alfonso Ielasi
INTRODUCTION: Over the past two decades, transcatheter aortic valve replacement (TAVR) has expanded its application across all surgical risk levels, including low-risk patients, where, due to longer life expectancy, reducing common pitfalls of TAVR is essential. To address these needs, many technological advancements have been developed. Myval and the new generation Myval Octacor (Meril Life Sciences Pvt. Ltd) are novel balloon-expandable (BE) transcatheter heart valve (THV) systems designed for the treatment of severe aortic stenosis...
July 6, 2024: Expert Review of Cardiovascular Therapy
Mark A Sammut, Dwayne Conway, Javaid Iqbal, Arvindra Krishnamurthy, Kenneth P Morgan, Paul D Morris, James D Richardson, Alexander M K Rothman, Julian P Gunn, Robert F Storey
BACKGROUND: Triple antithrombotic therapy (TAT) with aspirin, a P2Y12 inhibitor, and oral anticoagulation in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) raises concerns about increased bleeding. Regimens incorporating more potent P2Y12 inhibitors over clopidogrel have not been investigated adequately. RESEARCH DESIGN AND METHODS: A retrospective observational study was performed on 387 patients with AF receiving TAT for 1 month ( n  = 236) or ≤1 week ( n  = 151) after PCI...
July 1, 2024: Expert Review of Cardiovascular Therapy
Bjørn Strøier Larsen, Tor Biering-Sørensen, Flemming Javier Olsen
INTRODUCTION: Ischemic stroke is a leading cause of morbidity and mortality worldwide. Emerging evidence suggests that left atrial (LA) dysfunction could play a role in the pathophysiology of ischemic stroke, as a possible contributor and as a predictive biomarker. AREAS COVERED: This narrative review details the intricate relationship between LA function, atrial fibrillation (AF), and ischemic stroke. We discuss imaging techniques used to assess LA function, the mechanisms by which impaired LA function may contribute to stroke, and its potential as a prognostic marker of stroke...
June 29, 2024: Expert Review of Cardiovascular Therapy
John Stone, Manish Kumar, Ariela R Orkaby
INTRODUCTION: Cardiovascular disease (CVD) is associated with significant morbidity, functional decline, and mortality in older adults. The role of statins for primary CVD prevention in older adults remains unclear, largely due to systematic exclusion of these individuals in trials that inform current practice guidelines, leading to conflicting national and international practice recommendations for statin use for primary prevention of CVD in adults aged 75 and older. AREAS COVERED: In this narrative review, we performed a literature review utilizing PubMed, and ultimately focus on seven major national and international guidelines of lipid lowering therapy...
June 28, 2024: Expert Review of Cardiovascular Therapy
Taylor R Anderson, Kasim Qureshi, Muhammad U Farooq, Philip B Gorelick
INTRODUCTION: Stroke is a significant public health challenge as it is the second most common cause of death and the third leading cause of disability globally. Additionally, stroke incidence and the number of stroke deaths has been rising. Efforts to prevent stroke have been made, including high-risk approaches where patients are screened for cardiovascular risk factors, and population-based approaches which attempt to reduce stroke rates by improving overall population health. AREAS COVERED: We summarize studies of population-based approaches to stroke prevention involving greater than 1,000 participants identified on a PubMed database search...
June 24, 2024: Expert Review of Cardiovascular Therapy
Ryosuke Sato, Stephan von Haehling
INTRODUCTION: Heart failure with preserved ejection fraction (HFpEF) is a highly heterogeneous syndrome, making it challenging to improve prognosis with pharmacotherapy. Obesity is one of the leading phenotypes of HFpEF, and its prevalence continues to grow worldwide. Consequently, obesity-targeted interventions have attracted attention as a novel treatment strategy for HFpEF. AREAS COVERED: The authors review the association between the pathogenesis of obesity and HFpEF and the potential for obesity-targeted pharmacotherapeutic strategies in HFpEF, together with the latest evidence...
June 13, 2024: Expert Review of Cardiovascular Therapy
Amanda R Bonikowske, Jenna L Taylor, Kathryn F Larson, Joel Hardwick, Cemal Ozemek, Matthew P Harber, Lenny A Kaminsky, Ross Arena, Carl J Lavie
INTRODUCTION: Considerable and convincing global data from cohorts across the health spectrum (i.e. apparently healthy to known disease) indicate that cardiorespiratory fitness (CRF) is a major predictor of overall and cardiovascular disease (CVD)-survival, seemingly with greater prognostic resolution compared to other traditional CVD risk factors. Therefore, the assessment of CRF in research and clinical settings is of major importance. AREAS COVERED: In this manuscript, we review the technology of measuring CRF assessed by the 'gold standard,' cardiopulmonary exercise testing (CPET), as well as with various other methods (e...
June 10, 2024: Expert Review of Cardiovascular Therapy
Steven G Chrysant
INTRODUCTION: The aim of the present study is to analyze the data indicating an association between high salt intake and the gastrointestinal microbiota in the development of salt sensitive hypertension in animals and man. It is also, to discuss the preventive effects of exercise on gut-induced hypertension by favorably modifying the composition of gut microbiota. AREAS COVERED: Salt sensitivity is quite common accounting for 30%-60% in hypertensive subjects. Recently, a novel cause for salt sensitive hypertension has been discovered through the action of gut microbiota by the secretion of several hormones and the action of short chain fatty acids (SCFAs)...
June 1, 2024: Expert Review of Cardiovascular Therapy
Elizabeth G Dieter, Aravinda Nanjundappa
No abstract text is available yet for this article.
May 30, 2024: Expert Review of Cardiovascular Therapy
Antonis A Manolis, Theodora A Manolis, Antonis S Manolis
INTRODUCTION: Chronic coronary syndrome (CCS) remains the leading cause of death worldwide with high admission/re-admission rates. Medical databases were searched on CCS & its management. AREAS COVERED: This review discusses phenotypes per stress-echocardiography, noninvasive/invasive testing (coronary computed-tomography angiography-CCTA; coronary artery calcium - CAC score; echocardiography assessing wall-motion, LV function, valvular disease; biomarkers), multidisciplinary management (risk factors/anti-inflammatory/anti-ischemic/antithrombotic therapies and revascularization), newer treatments (colchicine/ivabradine/ranolazine/melatonin), cardiac rehabilitation/exercise improving physical activity and quality-of-life, use of the implantable-defibrillator, and treatment with extracorporeal shockwave-revascularization for refractory symptoms...
May 20, 2024: Expert Review of Cardiovascular Therapy
Paul Jie Wen Tern, Khung Keong Yeo, Jack Wei Chieh Tan, Chee Tang Chin, Ru San Tan, Jonathan Yap
INTRODUCTION: Anticoagulants play a vital role as part of the antithrombotic therapy of myocardial infarction and are complementary to antiplatelet therapies. In the acute setting, the rationale for their use is to antagonize the ongoing clotting cascade including during percutaneous coronary intervention. Anticoagulation may be an important part of the longer-term antithrombotic strategy especially in patients who have other existing indications (e.g. atrial fibrillation) for their use...
May 14, 2024: Expert Review of Cardiovascular Therapy
Tom Wong
No abstract text is available yet for this article.
May 9, 2024: Expert Review of Cardiovascular Therapy
Taehwan Park, Monica Hwang
BACKGROUND: Recently FDA-approved drugs for cardiovascular disease (CVD) require robust post-marketing surveillance. The objective of this study was to assess their safety using a large pharmacovigilance database. RESEARCH DESIGN AND METHODS: We analyzed adverse event (AE) reports for 17 drugs approved from 2014 to 2021, utilizing the FDA Adverse Event Reporting System (FAERS). Descriptive and disproportionality analyses were conducted by estimating the reporting odds ratio (ROR) and its 95% confidence interval...
May 9, 2024: Expert Review of Cardiovascular Therapy
Marcos García-Guimarães, Teresa Bastante, David Del Val, Diego Fernández-Rodríguez, Teresa Guiberteau-Diaz, Jorge Salamanca, Fernando Rivero, Fernando Alfonso
INTRODUCTION: Spontaneous coronary artery dissection (SCAD) is arare but well-recognized cause of acute coronary syndrome, especially importantin women. Invasive coronary angiography (ICA) is the fundamental diagnostictechnique for the confirmation of SCAD. Knowing the angiographic patternssuggestive of SCAD is essential for the correct identification of patients withthis entity. AREAS COVERED: In this narrative review, the main angiographic characteristics ofSCAD lesions as detected by ICA are presented and discussed...
April 29, 2024: Expert Review of Cardiovascular Therapy
Yangfeng Wu, Yifang Yuan
No abstract text is available yet for this article.
April 27, 2024: Expert Review of Cardiovascular Therapy
Ricardo Polman, John R Hurst, Omer Faruk Uysal, Swapna Mandal, Dominik Linz, Sami Simons
INTRODUCTION: Chronic Obstructive Pulmonary Disease (COPD) and cardiovascular diseases (CVD) commonly co-exist. Outcomes of people living with both conditions are poor in terms of symptom burden, receiving evidence-based treatment and mortality. Increased understanding of the underlying mechanisms may help to identify treatments to relieve this disease burden. This narrative review covers the overlap of COPD and CVD with a focus on clinical presentation, mechanisms, and interventions...
March 27, 2024: Expert Review of Cardiovascular Therapy
Seyed Younes Hosseini, Rahul Mallick, Petri Mäkinen, Seppo Ylä-Herttuala
INTRODUCTION: After understanding the genetic basis of cardiovascular disorders, the discovery of prime editing (PE), has opened new horizons for finding their cures. PE strategy is the most versatile editing tool to change cardiac genetic background for therapeutic interventions. The optimization of elements, prediction of efficiency, and discovery of the involved genes regulating the process have not been completed. The large size of the cargo and multi-elementary structure makes the in vivo heart delivery challenging...
March 17, 2024: Expert Review of Cardiovascular Therapy
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