journal
https://read.qxmd.com/read/38700456/research-matters
#1
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
May 3, 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38699876/quantification-of-lymphangiogenesis-in-the-murine-lymphedema-tail-model-using-intravital-microscopy
#2
JOURNAL ARTICLE
Ganesh Mohan, Imran Khan, Stephanie M Diaz, Malgorzata M Kamocka, Luci A Hulsman, Shahnur Ahmed, Colby R Neumann, Miguel D Jorge, Gayle M Gordillo, Chandan K Sen, Mithun Sinha, Aladdin H Hassanein
Background: Lymphedema is chronic limb swelling resulting from lymphatic dysfunction. It affects an estimated five million Americans. There is no cure for this disease. Assessing lymphatic growth is essential in developing novel therapeutics. Intravital microscopy (IVM) is a powerful imaging tool for investigating various biological processes in live animals. Tissue nanotransfection technology (TNT) facilitates a direct, transcutaneous nonviral vector gene delivery using a chip with nanochannel poration in a rapid (<100 ms) focused electric field...
May 3, 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38662456/characteristic-single-photon-emission-computed-tomography-computed-tomography-findings-in-lower-extremity-lymphedema-comparison-to-indocyanine-green-lymphography
#3
JOURNAL ARTICLE
Hayahito Sakai, Toko Miyazaki, Maya Kanasaki, Reiko Tsukuura, Takumi Yamamoto
Introduction: Evaluation of lymph circulation is significant in lower extremity lymphedema (LEL) management. Single-photon emission computed tomography-computed tomography (SPECT-CT) has been introduced for lymphedema evaluation, but its characteristic findings are yet fully clarified. The purpose of this study was to reveal typical SPECT-CT findings in secondary LEL by contrasting with indocyanine green (ICG) lymphography findings. Methods: This is a single-center retrospective case-control study. Medical charts of cancer survivors who underwent SPECT-CT and ICG lymphography for secondary LEL were reviewed...
April 25, 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38648290/the-impact-of-sleep-on-the-lives-of-women-who-have-breast-cancer-related-lymphedema-a-qualitative-exploration
#4
JOURNAL ARTICLE
Karen J Bock, Kristen Kelly, Delainey R Pospichal, Catherine F Siengsukon, Jill Peltzer
Background: Breast cancer survivors (BCSs) have many lifelong symptoms of anxiety, depression, lymphedema, and fatigue that can be exacerbated by sleep disturbance. However, little is known about unique factors contributing to sleep disturbance among BCSs with lymphedema; this requires further investigation to offer appropriate support and treatment to these individuals. Therefore, the objective of this study was to capture perceptions and experiences of lymphedema and sleep among BCSs with lymphedema. Methods and Results: Qualitative description guided data collection and analysis as part of a mixed-methods investigation to characterize sleep disturbance among BCSs with and without lymphedema...
April 22, 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38608242/psychometric-evaluation-of-the-bahasa-malaysia-version-of-the-lymphedema-functioning-disability-and-health-questionnaire-for-upper-limb-lymphedema-in-patients-with-breast-cancer-related-lymphedema
#5
JOURNAL ARTICLE
Estu Meilani, Asfarina Zanudin, Nor Azlin Mohd Nordin
Background: Breast cancer-related lymphedema (BCRL) is the most prevalent comorbidity that occurs following breast cancer treatments and has negative impact on the patients' quality of life (QoL). The Lymphedema Functioning, Disability, and Health Questionnaire for Upper Limb Lymphedema (Lymph-ICF-UL) is a valid and reliable instrument in assessing the QoL of patients with BCRL. However, the Bahasa Malaysia (BM) version is not available yet. This study aimed to translate the Lymph-ICF-UL into BM and to evaluate its validity and reliability...
April 12, 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38593453/comparing-the-impact-of-diluents-and-injection-techniques-on-patient-comfort-during-indocyanine-green-lymphangiography-a-prospective-study
#6
JOURNAL ARTICLE
Ioannis Kyriazidis, Efterpi Demiri, Dimitrios Dionyssiou
Background: Indocyanine green (ICG) lymphography, a key diagnostic tool for lymphedema, is influenced by the dilution process of ICG dye, impacting patient experience. Methods and Results: In our study, we assessed three different ICG diluents-water for injection (WFI), normal saline (NS), and Dextrose® plus human albumin-in five healthy volunteer individuals undergoing superficial lymphography of the upper limb over 3 weeks. Results indicated that NS, as a diluent for ICG, caused the least discomfort during injection, in contrast to WFI, which led to the highest levels of discomfort...
April 8, 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38563976/time-dependent-changes-of-extremity-volume-and-tissue-alterations-in-swollen-arms-caused-by-taxanes
#7
JOURNAL ARTICLE
Kotaro Suehiro, Noriyasu Morikage, Takasuke Harada, Yuriko Takeuchi, Soichi Ike, Ryunosuke Sakamoto, Ryo Suzuki, Hiroshi Kurazumi, Toshiki Tanaka, Kimikazu Hamano
Background: We aimed to determine the course of arm swelling caused by the use of taxanes and to identify valid predictors of persistent swelling. Methods and Results: A total of 15 patients with unilateral arm swelling that developed during the course, or within 3 months after termination, of postoperative taxane-based chemotherapy were included in the present study. The patients attended follow-up appointments every 3-6 months for 24 months after their initial visit. Their arm circumference was measured at each follow-up appointment, while ultrasonography of the skin and subcutaneous tissues was performed at the 0-, 6-, 12-, and 24-month follow-ups...
April 2, 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38563697/positive-impact-of-a-new-compressive-garment-in-patients-with-genital-lymphedema-olympy-study
#8
JOURNAL ARTICLE
Sandrine Mestre, Stéphane Vignes, Julie Malloizel-Delaunay, Sarah Abba, Stéphanie Villet, Astrid Picolet, Eric Vicaut, Isabelle Quéré
Purpose: Genital lymphedema is a chronic debilitating condition associated with highly impaired health-related quality of life (QoL). This prospective multicenter study evaluated the use of a new compressive garment in patients with secondary and primary genital lymphedema. Methods: Thirty-two patients prospectively enrolled were advised to wear the compressive garment for 12 weeks (day and night). The primary endpoint was change in patient-reported QoL at 12 weeks via the patient global impression of change (PGI-C) instrument...
April 2, 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38546398/proposed-framework-for-research-case-definitions-of-lipedema
#9
JOURNAL ARTICLE
Leslyn Keith, Catherine Seo, Monika M Wahi, Siobhan Huggins, Matthew Carmody, Gabriele Faerber, Isabel Forner-Cordero, Sandro Michelini, Stefan Rapprich, Stanley G Rockson
Background: Our aim is to propose a framework for the development of a research case definition of lipedema, based on current available literature and those observations that can be applied to future lipedema research with the intent to standardize and strengthen the scientific evidence base. Methods and Results: We conducted a narrative review of the literature, and identified consensus characteristics and disputed characteristics that could be included in a research case definition of lipedema. After considering the strength of the evidence and how each characteristic might be measured in a research study, we recommended an approach for the development of a research case definition of lipedema that would be based on consideration of five agreed-upon characteristics, and five disputed, or less substantiated, characteristics as additional evidence to enhance specificity...
March 28, 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38630994/research-matters
#10
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38630993/sensitivity-of-each-index-of-doppler-cross-uncollapsible-parallel-and-superficial-fascia-in-lymphatic-ultrasound
#11
JOURNAL ARTICLE
Hisako Hara, Makoto Mihara
Background: Recently, the usefulness of lymphatic ultrasound has been reported. It is beneficial not only to identify lymphatic vessels but also to evaluate lymphatic degeneration and diagnose lymphedema. We previously proposed D-CUPS (Doppler, Cross, Uncollapsible, Parallel, and Superficial fascia) to identify the lymphatic vessels on ultrasound. The purpose of this study was to clarify the sensitivity of each index of D-CUPS. Methods: We performed a retrospective study of 27 patients (44 limbs, 98 sites) with lower extremity lymphedema, who underwent lymphaticovenous anastomosis (LVA)...
April 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38630992/focus-on-lipedema-unraveling-the-mysteries-through-research
#12
EDITORIAL
Stanley G Rockson
No abstract text is available yet for this article.
April 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38630991/update-april-2024
#13
JOURNAL ARTICLE
Francine Blei
No abstract text is available yet for this article.
April 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38593454/high-pressure-3%C3%A2-%C3%A3-%C3%A2-30-minute-compression-methods-for-advanced-lower-limb-lymphedema-patients
#14
JOURNAL ARTICLE
Marzanna T Zaleska, Natalia E Krzesniak
Introduction: In advanced lymphedema of lower limbs, stage III bandaging under the routinely applied pressure of 40-60 mmHg remains largely ineffective. This is caused by skin and subcutaneous tissue stiffness due to fibrosis. Edema fluid accumulates deep in the subcutaneous tissue. Evacuating this fluid requires a high external compression force to overcome the resistance of fibrous tissue. We aimed to investigate the effectiveness of the compression method, with high pressure lasting for 3 days. Methods and Results: Twenty-one patients with lower limb lymphedema, stage III, of the postinflammatory type were included...
April 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38394133/lymphactiv-a-digital-physical-activity-behavior-intervention-for-the-treatment-of-lymphedema-and-lipedema
#15
RANDOMIZED CONTROLLED TRIAL
Peter S Mortimer, Mark Pearson, Patryk Gawrysiak, Katie Riches, Vaughan Keeley, Kirstie F Tew, Ewan J Cranwell
Background: Lymphedema and lipedema are debilitating conditions with no proven drug or surgical therapy. Effective treatment requires self-management through movement and compression to reduce limb volume and the incidence of cellulitis. The addition of personalized everyday physical activity (PA) could be transformative, increasing the therapy window to include all waking hours per week and enabling an increased dose of PA. Aim: This service evaluation aimed to determine the feasibility of LymphActiv as a treatment option for lymphedema and lipedema patients...
April 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38407896/a-family-based-study-of-inherited-genetic-risk-in-lipedema
#16
JOURNAL ARTICLE
Steven Morgan, Isabella Reid, Charlotte Bendon, Musarat Ishaq, Ramin Shayan, Bernard Pope, Daniel Park, Tara Karnezis
Background: Lipedema is a progressive condition involving excessive deposition of subcutaneous adipose tissue, predominantly in the lower limbs, which severely compromises quality of life. Despite the impact of lipedema, its molecular and genetic bases are poorly understood, making diagnosis and treatment difficult. Historical evaluation of individuals with lipedema indicates a positive family history in 60%-80% of cases; however, genetic investigation of larger family cohorts is required. Here, we report the largest family-based sequencing study to date, aimed at identifying genetic changes that contribute to lipedema...
February 26, 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38394090/acknowledgment-of-reviewers-2023
#17
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38394089/update-february-2024
#18
JOURNAL ARTICLE
Francine Blei
No abstract text is available yet for this article.
February 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38394088/lipedema-focus-on-disease-magnitude-and-quality-of-life
#19
EDITORIAL
Stanley G Rockson
No abstract text is available yet for this article.
February 2024: Lymphatic Research and Biology
https://read.qxmd.com/read/38265788/evaluating-the-surgical-outcome-of-lymphovenous-anastomosis-in-breast-cancer-related-lymphedema-using-tc-99m-phytate-lymphoscintigraphy-preliminary-results
#20
JOURNAL ARTICLE
Yujin Myung, Junseo Yun, Jaewon Beom, Akitatsu Hayashi, Won Woo Lee, Yoo Sung Song, Joseph Kyu-Hyung Park
Background: Breast cancer-related lymphedema (BCRL) remains a significant postcancer treatment challenge with no definitive cure. Recent supermicrosurgical treatments, such as lymphovenous anastomosis (LVA), have shown promise but lack established objective indicators for outcome evaluation. We investigated the utility of Technetium-99m (Tc-99m) lymphoscintigraphy, an imaging technique providing objective information on lymphatic fluid flow, for assessing LVA surgical outcomes. Methods and Results: A retrospective cohort analysis of patients undergoing LVA for BCRL was conducted...
January 24, 2024: Lymphatic Research and Biology
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