journal
https://read.qxmd.com/read/38865161/sirtuin1-sirt1-regulates-the-glycolysis-pathway-and-decreases-cisplatin-chemotherapeutic-sensitivity-to-esophageal-squamous-cell-carcinoma
#1
JOURNAL ARTICLE
Xuewen Yang, Shisen Li, Chunsheng Xu, Shushang Liu, Xiang Zhang, Bo Lian, Mengbin Li
We aimed to evaluate the influence of sirtuin1 (sirt1) on the ESCC chemotherapeutic sensitivity to cisplatin. We used ESCC cell ablation sirt1 for establishing a xenograft mouse tumor model. The tumor volume was then detected. sirt1 was over-expressed significantly in ESCC patients and cells. Moreover, sirt1 knockdown raised ESCC sensitivity to cisplatin. Besides, glycolysis was associated with ESCC cell chemotherapy resistance to cisplatin. Furthermore, sirt1 increased ESCC cells' cisplatin chemosensitivity through HK2...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38860746/effects-of-combined-radiotherapy-with-immune-checkpoint-blockade-on-immunological-memory-in-luminal-like-subtype-murine-bladder-cancer-model
#2
JOURNAL ARTICLE
JiaMin Huang, Eva Michaud, Surashri Shinde-Jadhav, Sabina Fehric, Gautier Marcq, Jose Joao Mansure, Fabio Cury, Fadi Brimo, Ciriaco A Piccirillo, Wassim Kassouf
MIBC is a highly lethal disease, and the patient survival rate has not improved significantly over the last decades. UPPL is a cell line that can be used to recapitulate the luminal-like molecular subtype of bladder cancer and to discover effective treatments to be translated in patients. Here, we investigate the effects of combinational treatments of radiotherapy and immunotherapy in this recently characterized UPPL tumor-bearing mice. We first characterized the baseline tumor microenvironment and the effect of radiation, anti-PD-L1, and combinatorial treatments...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38857058/p4ha2-promotes-tumor-progression-and-is-transcriptionally-regulated-by-sp1-in-colorectal-cancer
#3
JOURNAL ARTICLE
Xuening Dang, Xiaojian Chen, Zhonglin Liang, Zhujiang Dai, Wenjun Ding, Jinglue Song, Jihong Fu
P4HA2 has been implicated in various malignant tumors; however, its expression and functional role in colorectal cancer (CRC) remain poorly elucidated. This study aims to investigate the involvement of P4HA2 in CRC metastasis and progression, uncovering the underlying mechanisms. In colorectal cancer (CRC), P4HA2 exhibited overexpression, and elevated levels of P4HA2 expression were associated with an unfavorable prognosis. Functional assays demonstrated P4HA2's regulation of cell proliferation, and epithelial-mesenchymal transition (EMT) both in vitro and in vivo...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38857055/role-of-transforming-growth-factor-%C3%AE-1-pathway-in-angiogenesis-induced-by-chronic-stress-in-colorectal-cancer
#4
JOURNAL ARTICLE
Jie Zhang, Yao-Tiao Deng, Jie Liu, Lu Gan, Yu Jiang
BACKGROUND: Chronic stress can induce stress-related hormones; norepinephrine (NE) is considered to have the highest potential in cancer. NE can stimulate the expression of hypoxia-inducible factor-1α (HIF-1α), which is associated with vascular endothelial growth factor (VEGF) secretion and tumor angiogenesis. However, the underlying mechanisms are poorly understood. METHODS: Tumor-bearing mice were subjected to chronic restraint stress and treated with normal saline, human monoclonal VEGF-A neutralizing antibody bevacizumab, or β-adrenergic receptor (β-AR) antagonist (propranolol)...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38816350/circ_rpph1-facilitates-progression-of-breast-cancer-via-mir-1296-5p-trim14-axis
#5
JOURNAL ARTICLE
Jing Jiang, Shenghong Shi, Wei Zhang, Chao Li, Long Sun, Qidong Ge, Xujun Li
Circular RNA Ribonuclease P RNA Component H1 ( circ_RPPH1 ) and microRNA (miRNA) miR-1296-5p play a crucial role in breast cancer (BC), but the molecular mechanism is vague. Evidence showed that miR-1296-5p can activate tripartite motif-containing 14 ( TRIM14 ). Clinical indications of eighty BC patients were collected and the circ_RPPH1 expression was detected using real-time quantitative PCR. MCF-7 and MDA-MB-231 cells were transfected with overexpression or knockdown of circ_RPPH1 , miR-1296-5p , or TRIM14 ...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38813753/nrs2002-score-as-a-prognostic-factor-in-solid-tumors-treated-with-immune-checkpoint-inhibitor-therapy-a-real-world-evidence-analysis
#6
JOURNAL ARTICLE
Wanfen Tang, Chenghui Li, Dong Huang, Shishi Zhou, Hongjuan Zheng, Qinghua Wang, Xia Zhang, Jianfei Fu
To observe the antitumour efficacy of programmed death 1 (PD-1) inhibitors in the real world and explore the relationship between NRS2002 score or other clinical characteristics and immunotherapy efficacy, we retrospectively analyzed 341 tumor patients who received immune checkpoint inhibitor (ICI) treatment at one center. A total of 341 solid tumor patients treated with ICIs from June 2018 to December 2021 were retrospectively included in this study. Patient characteristics, ICI responses, and survival status were documented, and the relationships between clinical factors and survival were analyzed...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38801069/t-cell-redirecting-bispecific-antibodies-a-review-of-a-novel-class-of-immuno-oncology-for-advanced-prostate-cancer
#7
REVIEW
Julia Palecki, Amman Bhasin, Andrew Bernstein, Patrick J Mille, William J Tester, Wm Kevin Kelly, Kevin K Zarrabi
Novel T-cell immunotherapies such as bispecific T-cell engagers (BiTEs) are emerging as promising therapeutic strategies for prostate cancer. BiTEs are engineered bispecific antibodies containing two distinct binding domains that allow for concurrent binding to tumor-associated antigens (TAAs) as well as immune effector cells, thus promoting an immune response against cancer cells. Prostate cancer is rich in tumor associated antigens such as, but not limited to, PSMA, PSCA, hK2, and STEAP1 and there is strong biologic rationale for employment of T-cell redirecting BiTEs within the prostate cancer disease space...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38782896/eif3a-mediates-malignant-biological-behaviors-in-colorectal-cancer-through-the-pi3k-akt-signaling-pathway
#8
JOURNAL ARTICLE
Chao Huo, Disheng Wu, Xiaodan Li, Yan Zhang, Baoguang Hu, Taoming Zhang, Jianwei Ren, Tianbao Wang, Yi Liu
Colorectal cancer (CRC) is among the most common gastrointestinal malignancies worldwide. eIF3a is highly expressed in a variety of cancer types, yet its role in CRC remains unclear. We introduced ectopic eIF3a expression in CRC cells to investigate its relevance to various malignant behaviors. Further, we silenced eIF3a to explore its effect on tumor growth in a nude mouse tumor xenograft model. Finally, the molecular mechanisms through which eIF3a regulates malignancy in CRC cells were explored through bioinformatics analysis combined with the use of a specific PI3K inhibitor (LY294002)...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38778753/the-prognostic-marker-krt81-is-involved-in-suppressing-cd8%C3%A2-%C3%A2-t-cells-and-predicts-immunotherapy-response-for-triple-negative-breast-cancer
#9
JOURNAL ARTICLE
Zhideng Yan, Zhihui Zhong, Chuanke Shi, Muyin Feng, Xiaoqiang Feng, Tong Liu
Triple-negative breast Cancer (TNBC) is an aggressive subtype lacking estrogen, progesterone, and HER2 receptors. Known for limited targeted therapies, it poses challenges and requires personalized treatment strategies. Differential analysis revealed a significant decrease in keratin 81 (KRT81) expression in non-TNBC samples and an increase in TNBC samples, lower KRT81 expression correlated with better TNBC patient outcomes. It emerged as an independent predictive factor for TNBC, with associations found between its expression and clinically relevant features...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38767879/the-interplay-between-the-tumor-microenvironment-and-tumor-derived-small-extracellular-vesicles-in-cancer-development-and-therapeutic-response
#10
REVIEW
Xuanyu Guo, Jiajun Song, Miao Liu, Xinyi Ou, Yongcan Guo
The tumor microenvironment (TME) plays an essential role in tumor cell survival by profoundly influencing their proliferation, metastasis, immune evasion, and resistance to treatment. Extracellular vesicles (EVs) are small particles released by all cell types and often reflect the state of their parental cells and modulate other cells' functions through the various cargo they transport. Tumor-derived small EVs (TDSEVs) can transport specific proteins, nucleic acids and lipids tailored to propagate tumor signals and establish a favorable TME...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38751019/correction
#11
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38742566/exosome-transmitted-circular-rna-circ-lmo7-facilitates-the-progression-of-osteosarcoma-by-regulating-mir-21-5p-arhgap24-axis
#12
JOURNAL ARTICLE
Anyu Luo, Hanlin Liu, Chen Huang, Sheng Wei
The potential function and mechanism of circRNAs in regulating malignant performances of Osteosarcoma (OS) cells have not been well investigated. The expression level of CircLMO7, miR-21-5p and ARHGAP24 were detected by RT-qPCR. The relationship between miR-21-5p and circ-LMO7, as well as between miR-21-5p and ARHGAP24, was predicted and examined through bioinformatics analysis and luciferase reporter gene experiments. Moreover, OS cell growth, invasion, migration, and apoptosis were detected using the cell counting kit-8 (CCK-8), transwell and flow cytometry assays, respectively...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38738555/mettl14-decreases-fth1-mrna-stability-via-m6a-methylation-to-promote-sorafenib-induced-ferroptosis-of-cervical-cancer
#13
JOURNAL ARTICLE
Lijie Li, Jie Zeng, Sili He, Yanfei Yang, Chen Wang
Cervical cancer (CC) is a prevalent malignancy among women worldwide. This study was designed to investigate the role of METTL14 in sorafenib-induced ferroptosis in CC. METTL14 expression and m6A methylation were determined in CC tissues, followed by analyzes correlating these factors with clinical features. Subsequently, METTL14 was knocked down in CC cell lines, and the effects on cell proliferation, mitochondrial morphology and ferroptosis were assessed using CCK-8, microscopy, and markers associated with ferroptosis, respectively...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38722731/comparative-analysis-of-the-tumor-microbiome-molecular-profiles-and-immune-cell-abundances-by-hpv-status-in-mucosal-head-and-neck-cancers-and-their-impact-on-survival
#14
COMPARATIVE STUDY
Rituraj Upadhyay, Aastha Dhakal, Caroline Wheeler, Rebecca Hoyd, Malvenderjit Jagjit Singh, Vidhya Karivedu, Priyanka Bhateja, Marcelo Bonomi, Sasha Valentin, Mauricio E Gamez, David J Konieczkowski, Sujith Baliga, John C Grecula, Dukagjin M Blakaj, Emile Gogineni, Darrion L Mitchell, Nicholas C Denko, Daniel Spakowicz, Sachin R Jhawar
Head and Neck Squamous Cell Carcinoma (HNSCC) comprises a diverse group of tumors with variable treatment response and prognosis. The tumor microenvironment (TME), which includes microbiome and immune cells, can impact outcomes. Here, we sought to relate the presence of specific microbes, gene expression, and tumor immune infiltration using tumor transcriptomics from The Cancer Genome Atlas (TCGA) and associate these with overall survival (OS). RNA sequencing (RNAseq) from HNSCC tumors in TCGA was processed through the exogenous sequences in tumors and immune cells (exotic) pipeline to identify and quantify low-abundance microbes...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38706149/correction
#15
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38680092/roles-of-trpm-channels-in-glioma
#16
REVIEW
Zhigang Chen, Han Xie, Jun Liu, JiaJia Zhao, Ruixiang Huang, Yufei Xiang, Haoyuan Wu, Dasheng Tian, Erbao Bian, Zhang Xiong
Gliomas are the most common type of primary brain tumor. Despite advances in treatment, it remains one of the most aggressive and deadly tumor of the central nervous system (CNS). Gliomas are characterized by high malignancy, heterogeneity, invasiveness, and high resistance to radiotherapy and chemotherapy. It is urgent to find potential new molecular targets for glioma. The TRPM channels consist of TRPM1-TPRM8 and play a role in many cellular functions, including proliferation, migration, invasion, angiogenesis, etc...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38678381/agent-based-modeling-in-cancer-biomedicine-applications-and-tools-for-calibration-and-validation
#17
REVIEW
Nicolò Cogno, Cristian Axenie, Roman Bauer, Vasileios Vavourakis
Computational models are not just appealing because they can simulate and predict the development of biological phenomena across multiple spatial and temporal scales, but also because they can integrate information from well-established in vitro and in vivo models and test new hypotheses in cancer biomedicine. Agent-based models and simulations are especially interesting candidates among computational modeling procedures in cancer research due to the capability to, for instance, recapitulate the dynamics of neoplasia and tumor - host interactions...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38659199/moics-a-novel-classier-deciphering-immune-heterogeneity-and-aid-precise-management-of-clear-cell-renal-cell-carcinoma-at-multiomics-level
#18
JOURNAL ARTICLE
Ying Liu, Lin Qi, Bicheng Ye, Anbang Wang, Juan Lu, Le Qu, Peng Luo, Linhui Wang, Aimin Jiang
Recent studies have indicated that the tumor immune microenvironment plays a pivotal role in the initiation and progression of clear cell renal cell carcinoma (ccRCC). However, the characteristics and heterogeneity of tumor immunity in ccRCC, particularly at the multiomics level, remain poorly understood. We analyzed immune multiomics datasets to perform a consensus cluster analysis and validate the clustering results across multiple internal and external ccRCC datasets; and identified two distinctive immune phenotypes of ccRCC, which we named multiomics immune-based cancer subtype 1 (MOICS1) and subtype 2 (MOICS2)...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38650446/significant-response-to-pembrolizumab-plus-lenvatinib-in-epstein-barr-virus-associated-intrahepatic-cholangiocarcinoma-a-case-report
#19
JOURNAL ARTICLE
Lisha Li, Dandan Yu, Jinru Yang, Fangyuan Zhang, Dejun Zhang, Zhenyu Lin, Menglan Zhai, Jing Wang, Tao Zhang, Lei Zhao
BACKGROUND: The prognosis for advanced intrahepatic cholangiocarcinoma (iCCA) is poor, and there remains an urgent need to develop efficient systemic therapy. The efficacy of Pembrolizumab immunotherapy combined with lenvatinibin in iCCA is still unclear. The role of Epstein-Barr-virus (EBV) as a biomarker in iCCA for response to immunotherapy needs further exploration. CASE PRESENTATION: We report a case of a 60-year-old female with EBV-associated advanced iCCA (EBVaiCCA) who progressed after first-line therapy...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38629578/understanding-and-overcoming-resistance-to-immunotherapy-in-genitourinary-cancers
#20
REVIEW
Sean T Evans, Yash Jani, Caroline S Jansen, Ahmet Yildirim, Ecem Kalemoglu, Mehmet Asim Bilen
The introduction of novel immunotherapies has significantly transformed the treatment landscape of genitourinary (GU) cancers, even becoming the standard of care in some settings. One such type of immunotherapy, immune checkpoint inhibitors (ICIs) like nivolumab, ipilimumab, pembrolizumab, and atezolizumab play a pivotal role by disturbing signaling pathways that limit the immune system's ability to fight tumor cells. Despite the profound impact of these treatments, not all tumors are responsive. Recent research efforts have been focused on understanding how cancer cells manage to evade the immune response and identifying the possible mechanisms behind resistance to immunotherapy...
December 31, 2024: Cancer Biology & Therapy
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