Gohar S Manzar, Molly B El Alam, Erica J Lynn, Tatiana V Karpinets, Timothy Harris, David Lo, Kyoko Yoshida-Court, Tatiana Cisneros Napravnik, Julie Sammouri, Daniel Lin, Lauren M Andring, Julianna Bronk, Xiaogang Wu, Travis T Sims, Geena Mathew, Kathleen M Schmeler, Patricia J Eifel, Anuja Jhingran, Lilie L Lin, Melissa M Joyner, Jianhua Zhang, Andrew Futreal, Ann H Klopp, Lauren E Colbert
BACKGROUND: Chemoradiation (CRT) may modulate the immune milieu as an in-situ vaccine. Rapid dose delivery of brachytherapy has unclear impact on T-cell repertoires. HPV-associated cancers express viral oncoproteins E6/E7, which enable tracking antigen/tumor-specific immunity during CRT. METHODS: Thirteen cervical cancer patients on a multi-institutional prospective protocol from 1/2020-1/2023 underwent standard-of-care CRT with pulsed-dose-rate brachytherapy boost (2 fractions)...
December 20, 2023: Brachytherapy