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Jie Li, Lijuan Zhang, Qigen Xie, Weiguo Wang, Yanyan Hua, Leyuan Zhou, Zongqiong Sun
PURPOSE: The effect of 125 I seed implantation for the treatment of local residual tumor of hepatocellular carcinoma located beneath the diaphragm (HCC-LBD) after transcatheter arterial chemoembolization (TACE) has not yet been reported. This retrospective study was performed to evaluate the safety and efficacy of 125 I seeds implantation (ISI) for the treatment of residual HCC-LBD after TACE. METHODS AND MATERIALS: A total of 18 patients treated with ISI between August 2012 and March 2018 for residual HCC-LBD after single or multiple TACE were enrolled...
February 7, 2019: Brachytherapy
Brandon A Dyer, Zilong Yuan, Jianfeng Qiu, Stanley H Benedict, Richard K Valicenti, Jyoti S Mayadev, Yi Rong
PURPOSE: To identify factors associated with MRI-to-CT image deformation accuracy and modes of failure for MRI-optimized intracavitary high-dose-rate treatment of locally advanced cervical cancer. METHODS AND MATERIALS: Twenty-six patients with locally advanced cervical cancer had preimplantation MRI registered and deformed to postimplantation CT images using anatomically constrained and biomechanical model-based deformable image registration (DIR) algorithms. Cervix (primary) and cervix plus 10-mm margin (secondary) were used as controlling regions of interest for deformation...
February 7, 2019: Brachytherapy
Ting Martin Ma, Matthew M Harkenrider, Catheryn M Yashar, Akila N Viswanathan, Jyoti S Mayadev
PURPOSE: To understand the reasons behind current low utilization of brachytherapy for locally advanced cervical cancer in the United States. METHODS AND MATERIALS: A 17-item survey was e-mailed to the American Brachytherapy Society (ABS) listserv of active members in 2018. Responses of attending physicians in the United States were included in the analysis. RESULTS: Among a total of 135 respondents, 81 completed the survey. Eighty-four percent agree/strongly agree that cervical brachytherapy is underutilized, and 46...
February 2, 2019: Brachytherapy
Stefanus C Maree, Ngoc Hoang Luong, Ernst S Kooreman, Niek van Wieringen, Arjan Bel, Karel A Hinnen, Henrike Westerveld, Bradley R Pieters, Peter A N Bosman, Tanja Alderliesten
PURPOSE: Bi-objective treatment planning for high-dose-rate prostate brachytherapy is a novel treatment planning method with two separate objectives that represent target coverage and organ-at-risk sparing. In this study, we investigated the feasibility and plan quality of this method by means of a retrospective observer study. METHODS AND MATERIALS: Current planning sessions were recorded to configure a bi-objective optimization model and to assess its applicability to our clinical practice...
February 1, 2019: Brachytherapy
Laura D'Alimonte, Ananth Ravi, Joelle Helou, David Morrison, Lucas C Mendez, Harry Easton, Gerard Morton
PURPOSE: To describe a technique of penile surface mold high-dose-rate (HDR) brachytherapy and early outcomes. METHODS AND MATERIALS: Five patients diagnosed with a T1aN0 squamous cell carcinoma of the penis were treated using a penile surface mold HDR brachytherapy technique. A negative impression of the penis was obtained using dental alginate. CT images were acquired of the penile impression; subsequently, a virtual model of the patient's penis was generated...
February 1, 2019: Brachytherapy
Christine H Holschneider, Daniel G Petereit, Christina Chu, I-Chow Hsu, Yevgeniya J Ioffe, Ann H Klopp, Bhavana Pothuri, Lee-May Chen, Catheryn Yashar
Brachytherapy is well-established as an integral component in the standard of care for treatment of patients receiving primary radiotherapy for cervical cancer. A decline in brachytherapy has been associated with negative impacts on survival in the era of modern EBRT techniques. Conformal external beam therapies such intensity modulated radiation therapy (IMRT) or stereotactic body radiation therapy (SBRT) should not be used as alternatives to brachytherapy in patients undergoing primary curative-intent radiation therapy for cervical cancer...
January 17, 2019: Brachytherapy
Chenyu Yan, M Saiful Huq, Dwight E Heron, Sushil Beriwal, Raymond Wynn
PURPOSE: The purpose of this study was to study the correlation between intraoperative and postimplant dosimetry. We investigated the correlation between prostate (V150 ) and urethra (D30 , D5 ) dose limits, and whether it is possible to increase prostate D90 and V100 in intraoperative planning without violating postimplant urethra and rectum dose limits. METHODS AND MATERIALS: Seventy-nine patients who underwent real-time ultrasound-guided prostate implants using intraoperative planning from 2013 to 2017 were analyzed...
January 14, 2019: Brachytherapy
Martin T King, David D Yang, Vinayak Muralidhar, Brandon Mahal, Santino Butler, Phillip M Devlin, Larissa J Lee, Kent W Mouw, Neil M Martin, Anthony V D'Amico, Paul L Nguyen, Peter F Orio
PURPOSE: External beam radiation therapy (EBRT) with low-dose-rate (LDR) brachytherapy boost has been associated with improved biochemical progression-free survival and overall survival (OS) compared with dose-escalated EBRT (DE-EBRT) alone for unfavorable-risk prostate cancer. However, it is not known whether high-dose-rate (HDR) boost provides a similar benefit. We compare HDR boost against LDR boost and DE-EBRT with respect to OS. METHODS: Using the National Cancer Database, we identified 122,896 patients who were diagnosed with National Comprehensive Cancer Network intermediate- or high-risk prostate cancer between 2004 and 2014 and treated with DE-EBRT (75...
January 9, 2019: Brachytherapy
Guo-Hao Zhang, Xiao-Ming Lv, Wen-Jie Wu, Zhi-Yuan Wu, Lei Zheng, Ming-Wei Huang, Yong Wang, Jian-Guo Zhang
PURPOSE: We sought to investigate the feasibility and accuracy of computer-assisted techniques in the interstitial brachytherapy of the deep regions of the head and neck. MATERIALS AND METHODS: A computer-assisted brachytherapy workflow was applied to 10 patients with tumors in the deep regions of the head and neck. Based on the brachytherapy treatment preplan, we constructed a digital stereotactic model to accurately transfer the virtual plan into the navigation system, and subsequently printed the individual templates...
January 9, 2019: Brachytherapy
Martin T King, Paul L Nguyen, Ninjin Boldbaatar, David D Yang, Vinayak Muralidhar, Clare M Tempany, Robert A Cormack, Mark D Hurwitz, W Warren Suh, Mark M Pomerantz, Anthony V D'Amico, Peter F Orio
PURPOSE: Although current Delphi Consensus guidelines do not recommend a specific definition of biochemical recurrence after partial gland therapy, these guidelines acknowledge that serial prostate-specific antigen (PSA) tests remain the best marker for monitoring disease after treatment. The purpose of this study was to determine whether PSA velocity at failure per the Phoenix (nadir + 2 ng/mL) definition is associated with metastasis and prostate cancer-specific mortality (PCSM) in a cohort of patients who experienced PSA failure after partial gland therapy...
January 9, 2019: Brachytherapy
Jared S Winoker, Olamide O Omidele, Richard G Stock, Nelson N Stone
PURPOSE: To evaluate the oncological and functional outcomes of young men treated with low-dose-rate brachytherapy (BT) for prostate cancer (PCa). MATERIALS AND METHODS: 423 men aged ≤60 years with clinically localized PCa were treated with BT ± external beam radiation. Biochemical failure was defined by Phoenix criteria. Freedom from biochemical failure (FFbF) and cancer-specific survival (CSS) at 10 and 15 years were estimated by the Kaplan-Meier method with the log-rank test to compare outcomes between National Comprehensive Cancer Network risk groups...
January 8, 2019: Brachytherapy
Arvind Kumar Shukla, Bhupendra Singh Rana, Narinder Paul Singh, Sanjeev Kumar
PURPOSE: The present work reports effects of source step sizes on dose distribution in patients treated with cobalt-60 (Co-60) high-dose-rate afterloading brachytherapy in carcinoma cervix (Ca-cx). METHODS AND MATERIALS: The retrospective study is based on data of 15 patients of Ca-cx treated with Co-60 high-dose-rate intracavitary brachytherapy with dose of 21 Gy in three fractions with source step size of 2.5 mm after external beam radiotherapy of 46 Gy. The effect of source step size on overall treatment procedure was evaluated from prescribed dose volume, dose to organ at risks, and treatment time for source step sizes of 1 mm, 2...
January 4, 2019: Brachytherapy
Zedef Dag, Burcak Yilmaz, Ayse Kutluhan Dogan, Donay Unluer Aksan, Huseyin Ozkurt, Hazim Orhan Kızılkaya, Deniz Arslan
PURPOSE: To evaluate the effect of metabolic parameters of pretreatment primary tumor and regional lymph nodes with F-18-FDG PET/CT compared with MRI findings for the prognostic value and disease-free survival (DFS) in locally advanced cervical cancer. MATERIAL AND METHODS: From 2011 to 2016, 112 patients with a diagnosis of cervical cancer stages IB2-IVA treated with concomitant chemoradiation therapy with 3D intracavitary brachytherapy were analyzed. From this group, 50 patients who underwent pretreatment and posttreatment FDG PET/CT and MRI were enrolled...
December 26, 2018: Brachytherapy
Vinicius Toloti Moschini da Silva, Ana Paula Fortuna Diniz, Jumara Martins, Kleber Cursino, Sergio Carlos Barros Esteves, Julio Cesar Teixeira
PURPOSE: The purpose of this study was to evaluate clinical response, postrecurrence survival, disease-free survival (DFS), and toxicity related to reirradiation in pelvic recurrence of cervical carcinoma. METHODS AND MATERIALS: A retrospective cohort study of 45 women undergoing high-dose-rate interstitial brachytherapy (HDR-IB) was conducted from 1998 to 2014. Clinical information, as well as data on the malignancy, primary treatment, HDR-IB technique, and toxicity, was collected...
December 24, 2018: Brachytherapy
Philip Yuguang Wu, Terry Pang Wai Wong, Yan Yee Chloe Yip, Tien Yee Amy Chang, Lai Kwan Lucy Chan, Michael Chi Hang Lee, Lai Yau Ada Law, Mei Wan Rebecca Yeung, Sung Inda Soong
BACKGROUND: Paradigm has shifted from 2D to image-guided adaptive brachytherapy (IGABT) for locally advanced cervix cancer (LACC). Increasing reports from pioneering institutions and large retrospective multicenter series have demonstrated improvements in outcome and reduction in toxicity with IGABT. However, there is scarcity of data on magnetic resonance (MR)-IGABT in Chinese patients. PURPOSE: To evaluate the clinical outcome of MR-IGABT for LACC in a single institution in Hong Kong...
December 20, 2018: Brachytherapy
Alexander J Lin, Comron Hassanzadeh, Stephanie Markovina, Julie Schwarz, Perry Grigsby
PURPOSE: Small cell cancer involving the cervix and uterus is considered the same rare disease, but management is controversial and disparate. Patterns of care and outcomes in the United States are unclear. METHODS AND MATERIALS: Clinical data from patients with small cell cancer of the cervix and uterus were abstracted from the National Cancer Database from 2004 to 2014. Patients with missing clinical stage, incomplete followup, or receiving treatment >90 days from diagnosis were excluded...
December 15, 2018: Brachytherapy
Marc Gaudet, Mathieu Pharand-Charbonneau, Debbie Wright, Jonathan Nguyen, Jade Trudel-Sabourin, Mustapha Chelfi
PURPOSE: The purpose of this study was to report the long-term results of women treated in one center with accelerated partial-breast irradiation (APBI) with interstitial high-dose-rate (HDR) brachytherapy. MATERIALS AND METHODS: We analyzed data from women treated in one center with adjuvant interstitial HDR brachytherapy for early-stage breast cancer. Treatment regimen was homogeneous for all women with treatment dose 32Gy in 8 fractions twice daily given to the tumor bed with interstitial HDR brachytherapy...
December 13, 2018: Brachytherapy
So-Yeon Park, Seonghee Kang, Jong Min Park, Hyun Joon An, Do Hoon Oh, Jung-In Kim
PURPOSE: The purpose of this study was to develop a patient-specific elastic skin applicator and to evaluate its dosimetric characteristics for high-dose-rate (HDR) brachytherapy. METHODS AND MATERIALS: We simulated the treatment of a nonmelanoma skin cancer on the nose. An elastic skin applicator was manufactured by pouring the Dragon Skin (Smooth-On Inc., Easton, PA) with a shore hardness of 10A into an applicator mold. The rigid skin applicator was printed using high-impact polystyrene with a shore hardness of 73D...
December 6, 2018: Brachytherapy
Gerson M Struik, Jean-Philippe Pignol, Inger-Karine Kolkman-Deurloo, Jeremy Godart, Gerda M Verduijn, Linetta B Koppert, Erwin Birnie, Ali Ghandi, Taco M Klem
PURPOSE: Accelerated partial breast irradiation is a treatment option for selected patients with early-stage breast cancer. Some accelerated partial breast irradiation techniques lead to skin toxicity with the skin dose as a main risk factor. Biodegradable spacers are effective and safe in prostate brachytherapy to protect the rectum. We hypothesize that a subcutaneous spacer injection reduces the skin dose in breast brachytherapy. METHODS AND MATERIALS: Ultrasound-guided spacer injections, either hyaluronic acid (HA) or iodined polyethylene glycol (PEG), were performed on fresh mastectomy specimens...
December 5, 2018: Brachytherapy
Jessica L Conway, Rachel Gerber, Kathy Han, Haiyan Jiang, Jason Xie, Akbar Beiki-Ardakani, Anthony Fyles, Michael Milosevic, Deborah Williamson, Jennifer Croke
PURPOSE: The treatment of locally advanced cervical cancer with definitive chemoradiation (CRT) is associated with vaginal toxicity and altered sexual satisfaction. This prospective study assessed patient-reported sexual adjustment, vaginal dosimetry, and physician-reported vaginal toxicity in patients with cervical cancer treated with CRT and MR-guided brachytherapy (BT). MATERIALS AND METHODS: Between 2008 and 2010, International Federation of Gynecologists and Obstetricians stage IB-IVA patients with cervical cancer receiving definitive CRT were enrolled in a feasibility study assessing MR-guided BT...
November 30, 2018: Brachytherapy
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