Brandon Stretton, Joshua Kovoor, Stephen Bacchi, Shantel Chang, Benjamin Ngoi, Tess Murray, Thomas Cameron Bristow, Jonathan Heng, Aashray Gupta, Christopher Ovenden, Guy Maddern, Campbell H Thompson, Leonie Heilbronn, Mark Boyd, Christopher Rayner, Nicholas J Talley, Michael Horowtiz
INTRODUCTION: GLP-1 receptor agonists (GLP-1 RAreduce elevated blood glucose levels and induce weight loss. Multiple GLP-1 RAs and one combined GLP-1/GIP agonist currently available. This review was conducted with the aim of summarising direct comparisons between subcutaneous semaglutide and other GLP-1 RAs in individuals with type 2 diabetes(T2DM), particularly with respect to efficacy for inducing weight loss and improving other markers of metabolic health. METHODS: This systematic review of PubMed and Embase from inception to early 2022 was registered on PROSPERO, and was conducted in accordance with the PRISMA and MOOSE guidelines...
May 15, 2023: Internal Medicine Journal