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Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]

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https://read.qxmd.com/read/30765164/the-product-value-of-serum-albumin-and-prothrombin-time-activity-could-be-a-useful-biomarker-for-severity-prediction-in-ap-an-ordinal-retrospective-study
#1
Shoukang Li, Zhiqiang Liu, Heshui Wu
AIM: To appraise the predictive function of 'the product value of serum albumin and prothrombin time activity' (PAA) on admission for the organ failure related events of acute pancreatitis (AP). BACKGROUND: 789 patients with AP were included in this retrospective study. 468 patients generated transient organ failure (TOF). 242 were diagnosed with persistent organ failure (POF), of which 63 patients died. STUDY: All the values of laboratory parameters were measured upon admission to hospital...
February 5, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30737189/ca19-9-elevation-as-an-indication-to-start-salvage-treatment-in-surveillance-after-pancreatic-cancer-resection
#2
Jiarui Li, Zhe Li, Haoxuan Kan, Zhao Sun, Jiazhang Xing, Yuejuan Cheng, Chunmei Bai
BACKGROUND: CA19-9 is the most commonly used tumor marker in the diagnosis, prognosis and surveillance of pancreatic cancer. We hypothesized that CA19-9 elevation can be taken as an indication to start salvage treatment in surveillance after resection. METHODS: From January 2014 and July 2017, 80 pancreatic cancer patients who underwent R0 surgical resection and received adjuvant chemotherapy were included. RESULTS: Twenty-six (32.5%) patients started salvage treatment at the time of CA19-9 elevation without radiological evidence of recurrence...
February 1, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30733164/chronic-asymptomatic-pancreatic-hyperenzymemia-caph-meta-analysis-of-pancreatic-findings-at-second-level-imaging
#3
Giuseppe Vanella, Paolo Giorgio Arcidiacono, Gabriele Capurso
BACKGROUND/OBJECTIVES: Data estimating the prevalence of significant findings during the investigation of patients with Chronic Asymptomatic Pancreatic Hyperenzymemia (CAPH) are scanty and heterogeneous, and the diagnostic approach is therefore uncertain. The aim of this study was to meta-analyze pancreatic abnormalities detected at second-level imaging in patients with CAPH. METHODS: Pubmed database was searched until September 2018 for articles evaluating CAPH patients through MRI-Cholangio-Pancreatography with/without secretin (MRCP or s-MRCP) or Endoscopic Ultrasound (EUS)...
January 31, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30718188/bacterial-smear-test-of-drainage-fluid-after-pancreaticoduodenectomy-can-predict-postoperative-pancreatic-fistula
#4
Masaki Morimoto, Soichiro Honjo, Teruhisa Sakamoto, Takuki Yagyu, Ei Uchinaka, Masataka Amisaki, Joji Watanabe, Manabu Yamamoto, Yoji Fukumoto, Naruo Tokuyasu, Keigo Ashida, Hiroaki Saito, Yoshiyuki Fujiwara
OBJECTIVES: It is widely accepted that postoperative pancreatic fistula (POPF) accompanied by bacterial infection results in a worse outcome than POPF alone. However, few studies evaluating predictive indicators of POPF have focused on bacterial infection. METHODS: A consecutive 100 patients who underwent pancreaticoduodenectomy at our institute for periampullary disease were enrolled. POPF was assessed according to the International Study Group of Pancreatic Fistula consensus guidelines; grades B and C were defined as clinically relevant POPF (CR-POPF)...
January 29, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30713129/short-chain-fatty-acids-pancreatic-dysfunction-and-type-2-diabetes
#5
REVIEW
Dipeeka K Mandaliya, Sriram Seshadri
The microbiota living in gut influence the immune response, metabolism, mood and behavior. The diet plays a pivotal role in maintaining healthy gut microbiota composition and its fermentation leads to production of Short Chain Fatty Acids (SCFAs) mainly acetate, propionate and butyrate. During pancreatic dysfunction, insulin mediated suppression of glucagon is impaired leading to uncontrolled glucose production by liver and state of hyperglycemia. Insulin and glucagon balance is as important as insulin sensitivity which is reduced during Type 2 Diabetes (T2D)...
January 28, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30738764/the-clinical-impact-of-portal-venous-patency-ratio-on-prognosis-of-patients-with-pancreatic-ductal-adenocarcinoma-undergoing-pancreatectomy-with-combined-resection-of-portal-vein-following-preoperative-chemoradiotherapy
#6
Warakorn Jaseanchiun, Hiroyuki Kato, Aoi Hayasaki, Takehiro Fujii, Yusuke Iizawa, Akihiro Tanemura, Yasuhiro Murata, Yoshinori Azumi, Naohisa Kuriyama, Masashi Kishiwada, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai, Shuji Isaji
We analyzed the significance of portal vein (PV) patency ratio (minimum diameter/maximum diameter) during preoperative chemoradiotherapy (CRT) on the outcomes of patients with pancreatic-ductal adenocarcinoma (PDAC). METHODS: The 261 PDAC patients had been prospectively registered to our CRT protocol (Gemcitabine or S1+Gemcitabine) from 2005 to 2015. Among them, the subjects were the 84 PDAC- patients with preoperative PV contact who underwent pancreatectomy with PV resection. RESULTS: The 3- and 5-year disease-specific survival (DSS) rates of all 84 patients were 44% and 39%, respectively...
January 25, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30713128/clinical-relevance-of-pancreatobiliary-and-intestinal-subtypes-of-ampullary-and-duodenal-adenocarcinoma-pattern-of-recurrence-chemotherapy-and-survival-after-pancreatoduodenectomy
#7
Inger Marie Bowitz Lothe, Dyre Kleive, Ewa Pomianowska, Milada Cvancarova, Elin Kure, Svein Dueland, Ivar P Gladhaug, Knut Jørgen Labori
BACKGROUND: The clinical relevance of the classification of ampullary adenocarcinoma (AC) into pancreatobiliary (PB) or intestinal (Int) subtypes has not been resolved. METHODS: Clinicopathological factors, survival, and localization and treatment of recurrence were investigated for patients with AC and duodenal adenocarcinoma (DC) treated by pancreatoduodenectomy from 2000 to 2015. RESULTS: A total of 109 AC (45 PB, 64 Int) and 71 DC (all Int) were identified...
January 25, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30718187/prognostic-evaluation-of-pancreatic-ductal-adenocarcinoma-associations-between-molecular-biomarkers-and-ct-imaging-findings
#8
Yoshifumi Noda, Satoshi Goshima, Yusuke Tsuji, Hiroyuki Tomita, Akira Hara, Masaya Kawaguchi, Hiroshi Kawada, Nobuyuki Kawai, Yukichi Tanahashi, Masayuki Matsuo
OBJECTIVES: To investigate association between molecular biomarkers and computed tomography (CT) imaging findings in patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: Fifty-three consecutive patients with PDAC (34 men and 19 women; mean age, 70.6 ± 8.1 years; range, 56-86 years) who underwent dynamic contrast-enhanced CT prior to pancreatectomy were included. The Ki-67 index and expressions of E-cadherin, Vimentin, and TWIST were immunohistochemically evaluated...
January 24, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30704851/cystic-pancreatic-neuroendocrine-tumors-a-more-favorable-lesion
#9
Rosalie A Carr, Panagiotis Bletsis, Alexandra M Roch, Michael G House, Nicholas J Zyromski, Attila Nakeeb, C Max Schmidt, Eugene P Ceppa
BACKGROUND: Pancreatic neuroendocrine tumors (PNETs) are predominantly solid lesions with malignant potential. Cystic PNETs are a small subset in which data are scarce. The aim of this study was to compare clinical and biologic differences between cystic and solid PNETs. METHODS: Patients with PNETs undergoing pancreatectomy between 1988 and 2016 at a high-volume center were reviewed retrospectively. Demographic, clinical, and histopathologic data were collected and analyzed...
January 22, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30704852/folfirinox-is-a-cost-effective-combination-chemotherapy-in-first-line-for-advanced-pancreatic-ikcancer
#10
Jacopo Giuliani, Andrea Bonetti
OBJECTIVES: The analysis was conducted to assess the effect of front-line combination chemotherapies on progression free survival (PFS). METHODS: The analysis was restricted to phase III randomized controlled trials (RCTs) in first-line therapy for advanced pancreatic cancer. The European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) was applied to the above phase III RCTs. We have also calculated differences in PFS between the different arms of each trial and the pharmacological costs necessary to get the benefit in PFS, for each trial...
January 19, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30685120/plasma-ifn-%C3%AE-inducible-chemokines-cxcl9-and-cxcl10-correlate-with-survival-and-chemotherapeutic-efficacy-in-advanced-pancreatic-ductal-adenocarcinoma
#11
Ling Qian, Shulin Yu, Chengqian Yin, Bo Zhu, Zhen Chen, Zhiqiang Meng, Peng Wang
OBJECTIVES: Recent studies have suggested that the CXCL9, 10, 11/CXCR3 axis is significant in immune regulation and therapeutic efficacy in human cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) remains unknown. This study serves to evaluate the prognostic prediction value of plasma IFN-γ-inducible chemokines, CXCL9 and CXCL10, in advanced PDAC. METHODS: Two hundred patients with advanced PDAC receiving palliative chemotherapy were retrospectively recruited...
January 19, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30683515/can-we-predict-recurrence-in-who-g1-g2-pancreatic-neuroendocrine-neoplasms-results-from-a-multi-institutional-spanish-study
#12
F Ausania, P Senra Del Rio, M A Gomez-Bravo, E Martin-Perez, J A Pérez-Daga, D Dorcaratto, T González-Nicolás, S Sanchez-Cabus, A Tardio-Baiges
INTRODUCTION: Pancreatic neuroendocrine neoplasms (PNEN) are rare tumours and well differentiated PNEN are associated with relatively indolent physiological behaviour. For this reason, only few studies have investigated those factors associated with recurrence in this group of patients. The aim of this study is to analyse whether it is possible to predict tumour recurrence in World Health Organization (WHO) 2017 G1-G2 PNEN patients. METHODS: This is a retrospective multi-institutional study...
January 19, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30685119/menadione-vitamin-k3-inhibits-hydrogen-sulfide-and-substance-p-via-nf-%C3%B0%C2%BAb-pathway-in-caerulein-induced-acute-pancreatitis-and-associated-lung-injury-in-mice
#13
Amiti, Ramasamy Tamizhselvi, Venkatraman Manickam
OBJECTIVE: We aim to study the protective effect of menadione on caerulein-induced acute pancreatitis (AP) and associated lung injury and to explore the possible mechanism. METHODS: Male Swiss mice randomized into control and different experimental groups. AP was induced in mice by six hourly intraperitoneal (i.p) injections of caerulein (50 μg/kg at 1 h interval). Menadione (10 mg/kg) was administered one hour (i.p, 10 mg/kg) after the first caerulein injection and control animals were given hourly intraperitoneal (i...
January 18, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30683516/early-local-drug-therapy-for-pancreatic-contusion-and-laceration
#14
Cong Feng, Hao Yang, Sai Huang, Xuan Zhou, Lili Wang, Xiang Cui, Li Chen, Faqin Lv, Tanshi Li
OBJECTIVES: To study the therapeutic effect of early local drug therapy on pancreatic contusion and laceration. METHODS: Twenty pigs were divided into 4 groups: model(PL), 1 ml of saline; medical protein glue (EC), 1 ml of medical protein glue; ulinastatin (UL), 50000U of ulinastatin; combined treatment (UE), 1 ml of medical protein glue and 50000U of ulinastatin. 30 min after model establishment, different groups received different local drug treatments...
January 17, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30670333/hdac3-modulates-cancer-immunity-via-increasing-pd-l1-expression-in-pancreatic-cancer
#15
Guofu Hu, Nan He, Chuanqi Cai, Fei Cai, Ping Fan, Zhikun Zheng, Xin Jin
Pancreatic ductal adenocarcinoma (PDAC) is the second leading cause of cancer-related deaths worldwide. Despite immune checkpoints based immunotherapy highlights a new therapeutic strategy and achieves a remarkable therapeutic effect in various types of malignant tumors. Pancreatic cancer is one of the non-immunogenic cancers and is resistant to immunotherapy. Programmed death ligand 1 (PD-L1) is expressed on the surface of tumor cells and its level is a key determinant of the checkpoint immunotherapy efficacy...
January 16, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30665702/sarcopenia-associates-with-increased-hospitalization-rates-and-reduced-survival-in-patients-with-chronic-pancreatitis
#16
Søren S Olesen, Alev Büyükuslu, Marianne Køhler, Henrik Højgaard Rasmussen, Asbjørn M Drewes
BACKGROUND: Objectives: Malnutrition is a well-known complication of chronic pancreatitis and alterations in body composition are common in this context. We investigated the prevalence of sarcopenia in patients with chronic pancreatitis, its associated risk factors and health-related outcome. METHODS: This was a prospective cohort study of chronic pancreatitis outpatients. Bioelectric impedance was used to measure body composition, and a handheld dynamometer and the timed-up-and-go test characterized muscle function...
January 14, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30665701/can-endogenous-gastric-acid-and-bile-facilitate-chemical-debridement-of-walled-off-necrosis
#17
LETTER
Surinder Singh Rana, Ravi Sharma, Rajesh Gupta
No abstract text is available yet for this article.
January 14, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30733163/fear-stress-enhanced-xenograft-pancreatic-tumor-growth-through-activating-epithelial-mesenchymal-transition
#18
Min Li, Huilan Xu
OBJECTIVE: Cancer patients often experience multiple emotional distresses, particularly the fear of death. However, there are rare studies to assess the direct effect of the fear of death on disease progression. METHODS: Xenograft pancreatic cancer animal models were established in nude mice. Fear stress was induced to tumor bearing mice by closely housing with a cat and depressive behaviors were measured using open field test, forced swimming test, and sucrose consumption test...
January 11, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30679137/should-we-regard-all-main-duct-type-intraductal-papillary-mucinous-neoplasms-of-the-pancreas-md-ipmn-as-an-indication-of-surgery-a-retrospective-study-in-29-patients-with-md-ipmn-showing-mural-nodules
#19
Yoshiharu Masaki, Shinsuke Koshita, Yutaka Noda, Yoshihide Kanno, Takahisa Ogawa, Kaori Masu, Takashi Sawai, Kei Ito
PURPOSE: To elucidate predictive factors for malignant main duct type IPMN (MD-IPMN). METHODS: All 29 subjects had mural nodules (MNs) in the main pancreatic duct (MPD) on preoperative endoscopic ultrasonography and underwent surgery (19, malignant; 10, benign). Possible predictive factors for malignancy such as background, imaging, and histological factors including histological subtype (HS), were evaluated. RESULTS: Multivariate analysis revealed an MPD diameter of ≥12 mm (p = 0...
January 11, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30660392/n-acetylcysteine-enhances-the-therapeutic-efficacy-of-bone-marrow-derived-mesenchymal-stem-cell-transplantation-in-rats-with-severe-acute-pancreatitis
#20
Zhilong Ma, Guodong Song, Dalu Liu, Daohai Qian, Yuxiang Wang, Jia Zhou, Jian Gong, Hongbo Meng, Bo Zhou, Tingsong Yang, Zhenshun Song
BACKGROUND: Severe acute pancreatitis (SAP) is a high mortality disease, for which there is a lack of effective therapies. Previous research has demonstrated that bone marrow-derived mesenchymal stem cells (BMSCs), which have immunomodulatory and antioxidant properties, have potential for the treatment of SAP. It remains unclear, however, whether the free radical scavenger N-acetylcysteine (NAC) can enhance the therapeutic efficacy of BMSC transplantation in SAP. In this study, we investigated the effect of combining treatment with NAC and BMSCs in a rat model of SAP...
January 11, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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