journal
Journals Pancreatology : Official Journ...

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]

https://read.qxmd.com/read/37723006/bone-health-in-children-with-recurrent-and-chronic-pancreatitis-a-multi-center-cross-sectional-analysis
#1
JOURNAL ARTICLE
Maisam Abu-El-Haija, Lindsey Hornung, Kate Ellery, Douglas S Fishman, Tanja Y Gonska, Cheryl Gariepy, Mark Lowe, Katie Larson Ode, Asim Maqbool, Maria Mascarenhas, Veronique D Morinville, Chee Y Ooi, Emily R Perito, Sarah Jane Schwarzenberg, Zachary M Sellers, Babette S Zemel, Ying Yuan, Fuchenchu Wang, Aliye Uc, Heidi J Kalkwarf
BACKGROUND/OBJECTIVES: Bone health of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) is not well studied. METHODS: This retrospective study was performed at three sites and included data from INSPPIRE-2. RESULTS: Of the 87 children in the study: 46 had ARP (53%), 41 had CP (47%). Mean age was 13.6 ± 3.9 years at last DXA scan. The prevalence of low height-for-age (Z-score < -2) (13%, 10/78) and low bone mineral density (BMD) adjusted for height (Z-score < -2) (6...
August 31, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37696729/greater-cost-without-greater-benefit-the-need-to-refine-transfer-criteria-for-patients-with-severe-acute-pancreatitis
#2
JOURNAL ARTICLE
Melike N Harfouche, Mira Ghneim, Nariman Nezami, Roumen Vesselinov, Jose J Diaz
BACKGROUND: Appropriate and timely care is essential in the management of severe acute pancreatitis (SAP). We hypothesized that transferred patients with SAP undergoing procedural intervention would have higher mortality compared to those managed directly at academic centers. METHODS: This was a retrospective analysis of Maryland's statewide claims database from 2009 to 2022 of adult patients admitted with a primary diagnosis of SAP (acute pancreatitis with organ failure)...
August 30, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37666733/development-and-external-validation-of-a-nomogram-for-prediction-of-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis
#3
JOURNAL ARTICLE
Rintaro Fukuda, Ryunosuke Hakuta, Yousuke Nakai, Tsuyoshi Hamada, Shinya Takaoka, Yurie Tokito, Yukari Suzuki, Hiroki Oyama, Sachiko Kanai, Kensaku Noguchi, Tatsunori Suzuki, Kazunaga Ishigaki, Kei Saito, Tomotaka Saito, Naminatsu Takahara, Suguru Mizuno, Yukiko Ito, Hirofumi Kogure, Mitsuhiro Fujishiro
BACKGROUND AND AIMS: Endoscopic retrograde cholangiopancreatography (ERCP) is widely performed for management of pancreatobiliary diseases; however, post-ERCP pancreatitis (PEP) remains as an unsolved problem. Although various risk factors for PEP have been reported, the prediction of PEP remains controversial. This study aimed to develop a predictive model for PEP. METHODS: Consecutive patients undergoing ERCP for biliary indications at two centers were retrospectively studied...
August 29, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37661465/increased-slamf7-cd8-t-cells-are-associated-with-the-pathogenesis-of-experimental-autoimmune-pancreatitis-in-mice
#4
JOURNAL ARTICLE
Jia Liu, Hui Peng, Tingfeng Yu, Yanlin Huang, Ning Tan, Li Pang, Yongtong Wu, Lingyun Wang
BACKGROUND: IgG4-related autoimmune pancreatitis (AIP) is considered to be a T cell-mediated autoimmune disease. However, CD8+ T cells have only received brief mention, and have yet to be completely studied. The study aimed to investigate the expression of signaling lymphocytic activation molecule family 7 (SLAMF7) on CD8+ T cells and the features of SLAMF7+ CD8+ T cells in MRL/Mp mice with AIP. METHODS: A murine model of AIP was established by intraperitoneal injection with polyinosinic:polycytidylic acid (poly I:C) for 8 weeks...
August 28, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37659916/pancreatic-ductal-adenocarcinoma-with-acinar-to-ductal-metaplasia-like-cancer-cells-shows-increased-cellular-proliferation
#5
JOURNAL ARTICLE
Reiji Nishimon, Koji Yoshida, Fumiaki Sanuki, Yoshihiro Nakashima, Tomoo Miyake, Tatsuki Sato, Yasuyuki Tomiyama, Sohji Nishina, Takuya Moriya, Akiko Shiotani, Keisuke Hino
BACKGROUND/OBJECTIVES: Acinar-to-ductal metaplasia (ADM) has been shown to contribute to the development of pancreatic ductal adenocarcinoma (PDAC) in genetically engineered mouse models, but little is known about whether acinar cell plasticity contributes to carcinogenesis in human PDAC. We aimed to assess whether cancer cells that stain positive for amylase and CK19 (ADM-like cancer cells) are present in human resected PDAC and to investigate their role in tumor progression. METHODS: We immunohistochemically investigated the presence of ADM-like cancer cells, and compared the clinical and histological parameters of PDAC patients with and without ADM-like cancer cells...
August 26, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37604733/substrate-specificity-of-human-chymotrypsin-like-protease-ctrl-characterized-by-phage-display-selected-small-protein-inhibitors
#6
JOURNAL ARTICLE
Bálint Zoltán Németh, Zoltán Attila Nagy, Bence Kiss, Gabriella Gellén, Gitta Schlosser, Alexandra Demcsák, Andrea Geisz, Eszter Hegyi, Miklós Sahin-Tóth, Gábor Pál
Chymotrypsin-like protease (CTRL) is one of the four chymotrypsin isoforms expressed in the human exocrine pancreas. Human genetic and experimental evidence indicate that chymotrypsins B1, B2, and C (CTRB1, CTRB2 and CTRC) are important not only for protein digestion but also for protecting the pancreas against pancreatitis by degrading potentially harmful trypsinogen. CTRL has not been reported to play a similar role, possibly due to its low abundance and/or different substrate specificity. To address this problem, we investigated the specificity of the substrate-binding groove of CTRL by evolving the substrate-like canonical loop of the Schistocerca gregaria proteinase inhibitor 2 (SGPI-2), a small-protein reversible chymotrypsin inhibitor to bind CTRL...
August 17, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37599170/the-differential-effect-of-neoadjuvant-chemotherapy-and-chemoradiation-on-nodal-downstaging-in-pancreatic-adenocarcinoma
#7
JOURNAL ARTICLE
Marc Altimari, Amy Wells, John Abad, Akhil Chawla
BACKGROUND/OBJECTIVES: Neoadjuvant chemotherapy (NCT) and chemoradiotherapy (NCRT) enhance resectability in patients with pancreatic adenocarcinoma (PDAC). This study compares the effect of NCT and NCRT on lymph nodal downstaging and survival. METHODS: The 2004-2016 National Cancer Database Pancreas Participant User File was used to identify patients who underwent surgery for PDAC. Fisher's exact, Wilcoxon rank-sum, multivariate logistic regression, and log-rank were used...
August 16, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37604731/systematic-review-of-challenging-issues-in-pathology-of-intraductal-papillary-mucinous-neoplasms
#8
JOURNAL ARTICLE
Laura D Wood, N Volkan Adsay, Olca Basturk, Lodewijk A A Brosens, Noriyoshi Fukushima, Seung-Mo Hong, Sung-Joo Kim, Jae W Lee, Claudio Luchini, Michaël Noë, Martha B Pitman, Aldo Scarpa, Aatur D Singhi, Mariko Tanaka, Toru Furukawa
BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are a cystic precursor to pancreatic cancer. IPMNs deemed clinically to be at high-risk for malignant progression are frequently treated with surgical resection, and pathological examination of the pancreatectomy specimen is a key component of the clinical care of IPMN patients. METHODS: Systematic literature reviews were conducted around eight topics of clinical relevance in the examination of pathological specimens in patients undergoing resection of IPMN...
August 11, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37567847/female-patients-delay-seeking-medical-care-with-alcohol-associated-acute-pancreatitis
#9
JOURNAL ARTICLE
Christie Y Jeon, Esther Adeniran, Connor Stewart, Georgios I Papachristou, Joseph R Pisegna, Alma A Kuc, James L Buxbaum, Stephen J Pandol, Dhiraj Yadav
BACKGROUND/OBJECTIVE: Alcohol consumption is increasing in women, who more frequently report abdominal symptoms compared to men. We aimed to examine differences in presentation of acute pancreatitis [AP] in male and female patients hospitalized with alcohol-associated AP. METHODS: We analyzed 138 patients enrolled in an ongoing case-crossover study of alcohol-associated AP conducted across 5 medical centers in the U.S. Patients meeting the Revised Atlanta Classification of AP and who scored 3 or higher on the AUDIT-C instrument were invited to participate in the study and were interviewed while hospitalized with AP...
August 5, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37604732/pancreatic-ductal-adenocarcinomas-concomitant-with-intraductal-papillary-mucinous-neoplasms-of-the-pancreas-a-investigation-of-those-clinicopathological-features-by-analyzing-48-patients-who-underwent-surgery-for-those-lesions
#10
JOURNAL ARTICLE
Yujiro Kawakami, Shinsuke Koshita, Yoshihide Kanno, Takahisa Ogawa, Hiroaki Kusunose, Toshitaka Sakai, Keisuke Yonamine, Kazuaki Miyamoto, Fumisato Kozakai, Takaho Okada, Masaya Oikawa, Takashi Tsuchiya, Yutaka Noda, Takashi Sawai, Hiroshi Nakase, Kei Ito
BACKGROUND: Differences between pancreatic ductal adenocarcinomas (PDACs) concomitant with intraductal papillary mucinous neoplasm (IPMN) (C-PDACs), those without IPMN (NC-PDACs) and invasive cancers derived from IPMN (IC-Ds) have not been fully clarified. METHODS: Forty-eight patients with C-PDAC were included to investigate the differences in 1) clinicopathological features and 2) post-operative courses among the three invasive cancer groups. RESULTS: 1) Characteristics of C-PDACs were mostly similar to those of NC-PDACs; whereas, between C-PDACs and IC-Ds, the rate of mucinous carcinoma (2%/25%, p = 0...
August 2, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37574438/surgical-anatomy-of-the-dorsal-pancreatic-artery-considering-embryonic-development
#11
JOURNAL ARTICLE
Masahiro Yamane, Yoshiya Ishikawa, Daisuke Asano, Shuichi Watanabe, Hiroki Ueda, Keiichi Akahoshi, Hiroaki Ono, Atsushi Kudo, Shinji Tanaka, Yuzuki Sugiyama, Satoru Muro, Keiichi Akita, Minoru Tanabe
OBJECTIVES: The dorsal pancreatic artery (DPA) is a pancreatic branch with various anatomical variations. Previous studies mostly focused on the origin of the DPA, and its pathways and branching patterns have rarely been examined. The purpose of this study was to investigate the branching patterns and pathways of the DPA. METHODS: This study included 110 patients who underwent computed tomography scans. We examined the pathways and branching patterns of the DPA...
August 1, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37541802/dynamics-of-intestinal-and-intratumoral-microbiome-signatures-in-genetically-engineered-mice-and-human-pancreatic-ductal-adenocarcinoma
#12
JOURNAL ARTICLE
Nina Pfisterer, Christoph Ammer-Herrmenau, Kai Antweiler, Stefan Küffer, Volker Ellenrieder, Albrecht Neesse
BACKGROUND: Emerging evidence has recently revealed a prominent role of the microbiome in pancreatic ductal adenocarcinoma (PDAC). However, while most observations were made in patients, mouse models still require a precise characterization of their disease-related microbiome to employ them for mechanistic and interventional preclinical studies. METHODS: To investigate the fecal and tumoral microbiome of LSL-KrasG12D/+ ;LSL-Trp53R172H/+ ;Pdx-1-Cre (KPC) and control (CTRL) mice, Oxford Nanopore sequencing was applied...
July 31, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37507301/is-surgical-resection-justified-for-pancreatic-ductal-adenocarcinoma-with-distant-abdominal-organ-metastasis-a-position-paper-by-experts-in-pancreatic-surgery-at-the-joint-meeting-of-the-international-association-of-pancreatology-iap-the-japan-pancreas-society
#13
REVIEW
Daisuke Hashimoto, Sohei Satoi, Tsutomu Fujii, Masayuki Sho, Jin He, Thilo Hackert, Marco Del Chiaro, Jin-Young Jang, Aiste Gulla, Yoo-Seok Yoon, Yan-Shen Shan, Wenhui Lou, Roberto Valente, Junji Furuse, Atsushi Oba, Minako Nagai, Taichi Terai, Haruyoshi Tanaka, Ayano Sakai, Tomohisa Yamamoto, So Yamaki, Ippei Matsumoto, Yoshiaki Murakami, Kyoichi Takaori, Yoshifumi Takeyama
Pancreatic ductal adenocarcinoma (PDAC) is a typical refractory malignancy, and many patients have distant organ metastases at diagnosis, such as liver metastasis and peritoneal dissemination. The standard treatment for unresectable PDAC with distant organ metastasis (UR-M) is chemotherapy, but the prognosis remained poor. However, with recent dramatic developments in chemotherapy, the prognosis has gradually improved, and some patients have experienced marked shrinkage or disappearance of their metastatic lesions...
July 20, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37532635/the-impact-of-intra-and-postoperative-fluid-balance-in-pancreatic-surgery-a-retrospective-cohort-study
#14
JOURNAL ARTICLE
Patricia Marie Doll, Louisa Bolm, Ruediger Braun, Kim C Honselmann, Steffen Deichmann, Birte Kulemann, Iurii Kuchyn, Sergii Zemskov, Dirk Bausch, Tobias Keck, Ulrich Friedrich Wellner, Hryhoriy Lapshyn
BACKGROUND/OBJECTIVES: The aim of this study was to evaluate the impact of perioperative fluid administration in pancreatic surgery. METHODS: Patients who underwent pancreatic resections were identified from our institution's prospectively maintained database. Fluid balances were recorded intraoperatively and at 24hr postoperatively. Patients were stratified into tertiles of fluid administration (low, medium, high). Adjusted multivariable analysis was performed and outcome measures were postoperative complications...
July 17, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37481340/estimation-of-exocrine-pancreatic-insufficiency-in-children-with-acute-pancreatitis-using-the-13-c-mixed-triglyceride-breath-test
#15
JOURNAL ARTICLE
Shalini G Hegde, Sindhu Kashyap, Sarita Devi, Prasanna Kumar, John Michael Raj A, Anura V Kurpad
BACKGROUND: /Objective: The extent of exocrine pancreatic insufficiency (EPI) in the paediatric population with acute pancreatitis (AP) is unknown. The primary objective was to use a 6 h stable-isotope breath test to determine the prevalence of EPI in children with AP. The secondary objective was to determine the diagnostic ability of a 4 h abbreviated breath test in the detection of EPI. METHODS: 13 C-mixed triglyceride (MTG) breath test was used to measure fat digestibility in 12 children with AP and 12 normal children...
July 17, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37468364/serum-cytokine-profiles-in-patients-with-pancreatic-cancer-and-chronic-pancreatitis
#16
JOURNAL ARTICLE
Mira Lanki, Harri Mustonen, Marko Salmi, Sirpa Jalkanen, Caj Haglund, Hanna Seppänen
BACKGROUND: Chronic pancreatitis (CP) may cause tumor-like lesions, creating a challenge in distinguishing between CP and pancreatic ductal adenocarcinoma (PDAC) in a patient. Given that invasive surgery is a standard cancer treatment, we aimed to examine whether a noninvasive diagnostic tool utilizing serum cytokines could safely differentiate between PDAC and CP. METHODS: A pre-operative serum panel comprising 48 inflammatory cytokines, CA19-9, and C-reactive protein (CRP) was analyzed, consisting of 231 patients, 186 with stage I-III PDAC and 45 with CP...
July 13, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37460341/involvement-of-ataxin-3-atxn3-in-the-malignant-progression-of-pancreatic-cancer-via-deubiquitinating-hdac6
#17
JOURNAL ARTICLE
Xin Wu, Xin Zhang, Peng Liu, Yao Wang
BACKGROUND: Pancreatic cancer is a common digestive system cancer and one of the most lethal malignancies worldwide. Ataxin-3 (ATXN3) protein is a deubiquitinating enzyme implicated in the occurrence of diverse human cancers. The potential role of ATXN3 in pancreatic cancer still remains unclear. METHODS: ATXN3 was screened from differentially-upregulated genes of GSE71989, GSE27890 and GSE40098 datasets. The mRNA and protein levels of ATXN3 was evaluated in pancreatic cancer samples and cell lines...
July 7, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37438173/kynurenine-pathway-alteration-in-acute-pancreatitis-and-its-role-as-a-biomarker-of-infected-necrosis
#18
JOURNAL ARTICLE
Aparna Jakkampudi, Priyanka Sarkar, Misbah Unnisa, Aashish Patil, Chandrakanth Koutarapu, Shashidhar Jaggaiahgari, Pragathi Naik, Subhaleena Sarkar, Ambika Prasanna, Sreelekha Chintaluri, D Nageshwar Reddy, Sashidhar Rao Beedu, Rupjyoti Talukdar
INTRODUCTION: Infected pancreatic necrosis (IPN) is a major cause of mortality in acute pancreatitis (AP). Currently, no specific strategies are available to predict the development of IPN. Earlier we reported that persistent down-regulation of HLA-DR increases risk of developing IPN. Altered kynurenine pathway (KP) metabolites showed poor prognosis in sepsis. Here we evaluated the role of HLA-DR and KP in IPN. METHODS: Patients with ANP and healthy controls were enrolled...
July 5, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37453848/clinical-impact-of-multimodal-treatment-including-chemoradiotherapy-conversion-surgery-and-postoperative-chemotherapy-for-borderline-resectable-and-unresectable-locally-advanced-pancreatic-cancer-without-disease-progression-after-gemcitabine-plus-nab-paclitaxel
#19
JOURNAL ARTICLE
Rei Umezawa, Masamichi Mizuma, Kei Nakagawa, Takaya Yamamoto, Noriyoshi Takahashi, Yu Suzuki, Keita Kishida, So Omata, Michiaki Unno, Keiichi Jingu
BACKGROUND: The purpose of this study was to investigate treatment outcomes of chemoradiotherapy (CRT) using S-1 with or without conversion surgery after gemcitabine plus nab-paclitaxel (GnP) for borderline resectable (BR) and unresectable locally advanced (UR-LA) pancreatic cancer. METHODS: From 2016 to 2020, patients without disease progression after GnP for BR or UR-LA pancreatic cancer underwent CRT with S-1. If distant metastasis was not detected after CRT, conversion surgery and oral administration of S-1 as postoperative adjuvant chemotherapy for at least 6 months was performed...
July 4, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37422338/risk-of-pancreatic-cancer-in-people-with-new-onset-diabetes-a-danish-nationwide-population-based-cohort-study
#20
JOURNAL ARTICLE
Morten Hasselstrøm Jensen, Simon Lebech Cichosz, Ole Hejlesen, Stine Dam Henriksen, Asbjørn Mohr Drewes, Søren Schou Olesen
BACKGROUND: New onset diabetes (NOD) in people 50 years or older may indicate underlying pancreatic ductal adenocarcinoma (PDAC). The cumulative incidence of PDAC among people with NOD remains uncertain on a population-based level. METHODS: This was a nationwide population-based retrospective cohort study based on the Danish national health registries. We investigated the 3-year cumulative incidence of PDAC in people 50 years or older with NOD. We further characterised people with pancreatic cancer-related diabetes (PCRD) in relation to demographic and clinical characteristics, including trajectories of routine biochemical parameters, using people with type 2 diabetes (T2D) as a comparator group...
July 3, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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