journal
https://read.qxmd.com/read/37729796/tripartite-motif-containing-59-mediates-protective-anti-oxidative-effects-in-intestinal-injury-through-nrf2-signaling
#1
JOURNAL ARTICLE
Bing Liu, Yongsheng Gao, Xin Liu, Qin Lian, Yanliang Li
Elevated evidence has reported the important role of oxidative stress injury and inflammatory response in the progression of colitis. Tumor Suppressor TSBF1, TRIM59, is a ubiquitin E3 ligase and mediates immune response. However, the underlying molecular function of TRIM59 on regulation of colitis is still not understood. In the current study, we identify the TRIM59 as a critical and novel endogenous suppressor of kelch-like ECH-associated protein 1 (KEAP1), and we also determine that TRIM59 is a KEAP1-interacting partner protein that catalyses its ubiquitination and degradation in intestinal epithelial cells (IEC)...
September 18, 2023: International Immunopharmacology
https://read.qxmd.com/read/37725848/micrornas-in-equine-endometritis-a-review-of-pathophysiology-and-molecular-insights-for-diagnostic-and-therapeutic-strategies
#2
REVIEW
Sana Asif, Talha Umar, Zaima Umar, Huma Jamil, Huili Feng, Peipei Zhang, Saqib Umer
Endometritis plays an important role in mare infertility. Certain infectious agents interfere with the innate immune system of endometrium, causing a systemic inflammatory response that lasts for a long time and circulates via the blood or cellular degeneration, leading to endometritis due to bacterial endotoxins. Different small, non-coding RNA molecules are involved in many biological functions. For instance, microRNAs (miRNAs) are involved in the post-transcriptional regulation of gene expression. These miRNAs are important regulators of gene expression, primarily via inhibiting transcription and translation processes...
September 17, 2023: International Immunopharmacology
https://read.qxmd.com/read/37725847/efficacy-of-montelukast-as-an-adjuvant-therapy-in-rheumatoid-arthritis-patients-a-randomized-controlled-study
#3
JOURNAL ARTICLE
Basma M Ahmed, Noha O Mansour, Rehab A Sallam, Moetaza M Soliman
OBJECTIVE: This study aimed to evaluate the efficacy of montelukast in conjunction with non-biologic disease modifying anti-rheumatic drugs (nDMARDs) in rheumatoid arthritis (RA) patients. METHODS: This study was a single-center randomized double-blinded placebo-controlled study. Adult RA patients were included if they had moderate to severe disease activity and were receiving monotherapy or combination of nDMARDs. Eligible patients were randomized, in 1:1 ratio, to receive either 10 mg montelukast or placebo, once daily for 16 weeks...
September 17, 2023: International Immunopharmacology
https://read.qxmd.com/read/37725846/anti-cd1d-treatment-suppresses-immunogenic-maturation-of-lung-dendritic-cells-dependent-on-lung-invariant-natural-killer-t-cells-in-asthmatic-mice
#4
JOURNAL ARTICLE
Qibin Lin, Tong Wang, Xiaoshu Zuo, Haiyang Ni, Jieying Zhong, Liying Zhan, Hong Cheng, Yi Huang, Xuhong Ding, Hongying Yu, Hanxiang Nie
Our previous findings show that invariant natural killer T (iNKT)cells can promote immunogenic maturation of lung dendritic cells (LDCs) to enhance Th2 cell responses in asthma. It has been accepted that recognition of glycolipid antigens presented by CD1d molecules by the T cell receptors of iNKT cells leads to iNKT cell activation. Therefore, we examine the immunoregulatory influences of anti-CD1d treatment on Th2 cell response and immunogenic maturation of LDCs and subsequently explored whether these influences were dependent on lung iNKT cells in asthmatic mice...
September 17, 2023: International Immunopharmacology
https://read.qxmd.com/read/37725845/induction-immunochemotherapy-followed-by-radiotherapy-for-patients-with-unresectable-locally-advanced-or-metastatic-esophageal-cancer-a-propensity-score-matched-analysis
#5
JOURNAL ARTICLE
Wei Deng, Xiao Chang, Xin Dong, Yuting Zhao, Dan Yang, Leilei Jiang, Anhui Shi, Huiming Yu, Rong Yu, Zefen Xiao, Weihu Wang
BACKGROUND: The study aimed to investigate the efficacy of induction immunochemotherapy before radiotherapy (RT) for patients with locally advanced or metastatic esophageal cancer. METHODS: Patients with unresectable locally advanced or metastatic esophageal cancer who received induction immunochemotherapy followed by RT (ICIs + RT group) and RT alone (RT group) were retrospectively identified in two cancer centers, respectively. Propensity score matching (PSM) was used to balance the potential confounders between the two groups...
September 17, 2023: International Immunopharmacology
https://read.qxmd.com/read/37722262/the-negative-effect-of-concomitant-medications-on-immunotherapy-in-non-small-cell-lung-cancer-an-umbrella-review
#6
REVIEW
Jixin Chen, Shuqi Chen, Huiyan Luo, Shunqin Long, Xiaobing Yang, Wenfeng He, Wanyin Wu, Sumei Wang
BACKGROUND: Conflicting results about the effect of concomitant medications on immunotherapy in non-small cell lung cancer (NSCLC) were reported by many meta-analyses (MAs), and the certainty of evidence linking concomitant medications with immunotherapy efficacy has not been quantified, which may cause some evidence to be misinterpreted. METHODS: Four databases including Embase, Cochrane Library, PubMed, and Web of Science were searched from inception to January 2023 in English...
September 16, 2023: International Immunopharmacology
https://read.qxmd.com/read/37722261/periodontal-health-status-porphyromonas-gingivalis-and-anti-cyclic-citrullinated-peptide-antibodies-among-rheumatoid-arthritis-patients
#7
JOURNAL ARTICLE
Tan Wan Jiun, Haslina Taib, Wan Majdiah Wan Mohamad, Suharni Mohamad, Wan Syamimee Wan Ghazali
Porphyromonas gingivalis (P. gingivalis) is the primary periodontal pathogen involved in protein citrullination, which triggers the production of anti-cyclic citrullinated peptide (anti-CCP) antibodies, exacerbating rheumatoid arthritis (RA). This study aims to evaluate the amount of P. gingivalis and its association with anti-CCP antibodies in RA patients with periodontitis. This cross-sectional study involves 100 RA patients with a mean age of 52.36 (SD 13.90) years. Smokers and patients with other uncontrolled systemic diseases were excluded...
September 16, 2023: International Immunopharmacology
https://read.qxmd.com/read/37722260/cxcl1-enhances-cox-ii-expression-in-rheumatoid-arthritis-synovial-fibroblasts-by-cxcr2-plc-pkc-and-nf-%C3%AE%C2%BAb-signal-pathway
#8
JOURNAL ARTICLE
Chun-Han Hou, Po-Chun Chen, Ju-Fang Liu
Rheumatoid arthritis (RA) is the most common autoimmune disease, affecting the joints of the hands and feet. Several chemokines and their receptors are crucial in RA pathogenesis through immune cell recruitment. C-X-C Motif Chemokine Ligand 1 (CXCL1), a chemokine for the recruitment of various immune cells, can be upregulated in patients with RA. However, the discussion on the role of CXCL1 in RA pathogenesis is insufficient. Here, we found that CXCL1 promoted cyclooxygenase-2 (COX-II) expression in a dose- and time-dependent manner in rheumatoid arthritis synovial fibroblasts (RASFs)...
September 16, 2023: International Immunopharmacology
https://read.qxmd.com/read/37722259/the-contribution-of-il-17a-dependent-low-lcn2-levels-to-helicobacter-pylori-infection-insights-from-clinical-and-experimental-studies
#9
JOURNAL ARTICLE
Mingjing Cheng, Yong Zheng, Yujuan Fan, Ping Yan, Weidong Zhao
BACKGROUND: Helicobacter pylori (H. pylori) infection is a common bacterial infection that is widespread globally. It is crucial to comprehend the molecular mechanisms that underlie the infection caused by H. pylori in order to devise successful therapeutic approaches. The objective of this study was to examine the involvement of Lipocalin-2 (LCN2) in the development of H. pylori infection. METHODS: LCN2 expression levels in human gastric mucosa and H. pylori-infected mouse models were analyzed using quantitative PCR and immunohistochemistry methods...
September 16, 2023: International Immunopharmacology
https://read.qxmd.com/read/37722258/a-collagen-binding-sirp%C3%AE-fc-fusion-protein-for-targeted-cancer-immunotherapy
#10
JOURNAL ARTICLE
Jiayang Liu, Tongyang Xu, Danjie Pan, Jiajun Fan, Yuan Fu, Xiting Huang, Weili Zhao, Xiaochun Dong, Shaohui Zhang, Kudelaidi Kuerban, Xuan Huang, Songna Wang, Huaning Chen, Yunpeng He, Yi Zhun Zhu, Congjun Wang, Li Ye
Collagen is abundant but exposed in tumor due to the abnormal tumor blood vessels, thus is considered as a tumor-specific target. The A3 domain of von Willebrand factor (vWF A3) is a kind of collagen-binding domain (CBD) which could bind collagen specifically. Previously we reported a chemosynthetic CBD-SIRPαFc conjugate, which could block CD47 and derived tumor-targeting ability by CBD. CBD-SIRPαFc conjugate represented improved anti-tumor efficacy with increased MHC II+ M1 macrophages, but the uncertain coupling ratio remained a problem...
September 16, 2023: International Immunopharmacology
https://read.qxmd.com/read/37718175/corrigendum-to-rapamycin-regulates-osteogenic-differentiation-through-parkin-mediated-mitophagy-in-rheumatoid-arthritis-int-immunopharmacol-113-part-b-2022-109407
#11
Qiyue Chen, Kai Fan, Guangbao Song, Xinqiong Wang, Jinwei Zhang, Huan Chen, Xuan Qin, Yao Lu, Weizhong Qi
No abstract text is available yet for this article.
September 15, 2023: International Immunopharmacology
https://read.qxmd.com/read/37717372/boningmycin-induces-ampk-mediated-endoplasmic-reticulum-associated-degradation-of-pd-l1-protein-in-human-cancer-cells
#12
JOURNAL ARTICLE
Juan Zhang, Jincai Wang, Yue Shang, Yang Chen, Shuzhen Chen, Qiyang He
Anti-PD-1/PD-L1 monoclonal antibodies have displayed remarkable clinical benefits and revolutionized the treatment of multiple tumor types, but the low response rates and immune-related adverse events limit their application, which promoting the development of small molecule agents to improve the efficacy of PD-1/PD-L1 blockade therapy. Boningmycin (BON), a new small molecule belonging to bleomycin (BLM) family, exhibits potent anticancer activity in vitro and in vivo, as well as negligible lung toxicity, thereby can be an alternative of BLM...
September 15, 2023: International Immunopharmacology
https://read.qxmd.com/read/37717320/chimeric-cns-targeting-peptide-engineered-exosomes-for-experimental-autoimmune-encephalomyelitis-therapy
#13
JOURNAL ARTICLE
Ying-Kai Wang, Yun-Peng Zhao, Ming-Zhu Ye, Ling Wang, Tian-Shu Lan, Yue Wang, Zhong-Quan Qi
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) that causes demyelination, neuronal damage and white matter loss, but there is still no known cure. Exosomes are 30-200 nm-sized double-layered membrane vesicles that can easily cross the blood-brain barrier (BBB). Exosomes from umbilical cord mesenchymal stem cells(UMSCs) have been found to treat experimental autoimmune encephalomyelitis (EAE) through the action of anti-inflammatory and immunomodulatory, but its clinical translation has been hampered by their inefficacious accumulation in CNS...
September 15, 2023: International Immunopharmacology
https://read.qxmd.com/read/37717319/potential-value-of-interleukin-6-as-a-diagnostic-biomarker-in-human-mdd-and-the-antidepressant-effect-of-its-receptor-antagonist-tocilizumab-in-lipopolysaccharide-challenged-rats
#14
JOURNAL ARTICLE
Dandan Xu, Yayun Xu, Xinran Gao, Mengyu Yan, Chen Zhang, Xian Wu, Qingrong Xia, Jinfang Ge
Depression is a common mental disease with disastrous effect on the health and wealth globally. Focusing on the role for inflammation and immune activation in the pathogenesis of depression, many tries have been taken into effect targeting at the blockage of inflammatory cytokines, among which interleukin- 6 (IL-6) and its receptor antagonist tocilizumab attracts more attention, with inconsistent findings. Moderate to severe depressive disorder (MSDD) patients were enrolled and the serum concentrations of IL-6 and tumor necrosis factor-α (TNF-α) measured, their correlation with the Hamilton Depression Rating Scale-24 (HAMD-24) scores was analyzed, and their role in discriminating MSDD patients from the health controls were evaluated...
September 15, 2023: International Immunopharmacology
https://read.qxmd.com/read/37717318/identifying-immuno-related-diagnostic-genes-and-immune-infiltration-signatures-for-periodontitis-and-alopecia-areata
#15
JOURNAL ARTICLE
Haoyu Wang, Ruoqu Wei, Tanjun Deng, Jie Zhang, Zhengyu Shen
BACKGROUND: Although there have been indications that periodontitis (PD) may be susceptible to alopecia areata (AA), the underlying mechanism of its pathogenesis remains poorly understood. The objective of our study is to conduct further research into the occurrence of this complication. METHODS: The gene expression omnibus (GEO) database was the source of acquisition for both PD and AA datasets. Various methods, including the differentially expressed genes (DEGs) analysis, functional enrichment analysis, protein-protein interaction (PPI) network construction, Cytohubba algorithms, and RandomForest algorithms, were utilized to identify candidate hub immuno-related genes (IRGs) for diagnosing AA with PD...
September 15, 2023: International Immunopharmacology
https://read.qxmd.com/read/37717317/balb-c-and-c57bl-6-mice-differ-in-oxidant-and-antioxidant-responses-in-innate-and-adaptive-immune-cells-in-an-asthma-model-induced-by-cockroach-allergens
#16
JOURNAL ARTICLE
Layla A Al-Kharashi, Saleh A Alqarni, Sheikh F Ahmad, Naif O Al-Harbi, Sary Alsanea, Khalid E Ibrahim, Mohammad M Algahtani, Khalid Alhazzani, Gamal A Shazly, Mohammad M Al-Harbi, Ahmed Nadeem
Asthma is a complex and heterogenous disease affected by a multitude of factors. Several phenotypes of asthma exist which are influenced by various molecular mechanisms that include presence of antioxidant and oxidant enzymes in different immune cells such as dendritic cells (DCs), alveolar macrophages (AMs), neutrophils, and T cells. Close interaction between epithelial cells and dendritic cells initiates complex pathogenesis of asthma followed by involvement of other innate and adaptive immune cells. In chronic phase of the disease, these immune cells support each other in amplification of airway inflammation where oxidant-antioxidant balance is known to be an important contributing factor...
September 15, 2023: International Immunopharmacology
https://read.qxmd.com/read/37717316/a-novel-drug-combination-of-tofacitinib-and-iguratimod-alleviates-rheumatoid-arthritis-and-secondary-osteoporosis
#17
JOURNAL ARTICLE
Jie Chen, Qincheng Che, Yuying Kou, Xing Rong, Xiaojie Zhang, Minqi Li, Qiang Shu
BACKGROUND: The inadequate response of some patients with rheumatoid arthritis (RA) to current therapies is an issue that needs to be addressed. Patients with refractory RA (RRA) are often accompanied by high Tumor necrosis factor (TNF) expression. We evaluated the synergistic therapeutic effects of the combination of Iguratimod (IGU) and Tofacitinib (TOF) on RRA and secondary osteoporosis. METHODS: Pathological changes in the ankle joints of collagen-induced arthritis (CIA) + TNF model rats were assessed using hematoxylin and eosin (HE) staining...
September 15, 2023: International Immunopharmacology
https://read.qxmd.com/read/37717315/avian-safety-guardian-luteolin-restores-mycoplasma-gallisepticum-induced-immunocompromise-to-improve-production-performance-via-inhibiting-the-il-17-nf-kb-pathway
#18
JOURNAL ARTICLE
Tengfei Wang, Guangyang Jiang, Shan Lv, Yufei Xiao, Changyong Fan, Mengyun Zou, Yingjie Wang, Qiao Guo, Md Ahsanul Kabir, Xiuli Peng
Mycoplasma gallisepticum (MG) is a major pathogen causing chronic respiratory disease (CRD) in chickens. Exposure to MG poses a constant threat to chicken health and causes substantial economic losses. Antibiotics are the main treatment for MG infections, but have to struggle with antibiotic residues and MG resistance. To date, no safe and more effective prevention or treatment for MG infections has been identified. Luteolin (Lut) is a natural flavonoid compound known for its excellent anti-viral, anti-bacterial, immunoregulatory, and anti-inflammatory pharmacological activities...
September 15, 2023: International Immunopharmacology
https://read.qxmd.com/read/37717314/brevilin-a-attenuates-cartilage-destruction-in-osteoarthritis-mouse-model-by-inhibiting-inflammation-and-ferroptosis-via-sirt1-nrf2-gpx4-signaling-pathway
#19
JOURNAL ARTICLE
Qing Ruan, Cuijie Wang, Yunfeng Zhang, Jiayang Sun
Osteoarthritis (OA) is a serious orthopedic disease that affects people's quality of life. Although there are many treatment methods, the treatment effect is still not good. Brevilin A is a bioactive compound isolated from the medicinal herbCentipeda minima. The potential efficacy of brevilin A on OA was explored in this study. Mouse chondrocytes were isolated and stimulated by IL-1β and mouse OA model was induced by destabilization of the medial meniscus (DMM). The results demonstrated that brevilin A markedly inhibited IL-1β-induced MMP1 and MMP3 production...
September 15, 2023: International Immunopharmacology
https://read.qxmd.com/read/37716165/the-effect-of-artesunate-to-reverse-clp-induced-sepsis-immunosuppression-mice-with-secondary-infection-is-tightly-related-to-reducing-the-apoptosis-of-t-cells-via-decreasing-the-inhibiting-receptors-and-activating-mapk-erk-pathway
#20
JOURNAL ARTICLE
Yue Yuan, Ling Hua, Jun Zhou, Dan Liu, Fumin Ouyang, Xuemin Chen, Shujuan Long, Yasi Huang, Xin Liu, Jiang Zheng, Hong Zhou
T cells play an important role in regulating immune system balance. Sepsis-associated immunosuppression causes apoptosis of T cells and a decrease in their number. Previously, artesunate was found to have an immunomodulatory effect on immunosuppression in model mice with cecal ligation and puncture (CLP)-induced sepsis. In the present study, mouse sepsis models of CLP and CLP with secondary infection were established and treated with artesunate in order to examine the effect of artesunate on adaptive immune response in sepsis-related immunosuppression...
September 14, 2023: International Immunopharmacology
journal
journal
35181
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.