Sangeeta Kumari, Neelam Bodhale, Aditya Sarode, Mukesh Kumar Jha, Sagar Bhadange, Surya Prakash Pandey, Sathishkumar Selvaraj, Ajit G Chande, Robin Mukhopadhyaya, Soumya Kanti Ghosh, Shailza Singh, Debasri Mukherjee, Rebekah Duffin, Philip Andrews, Bhaskar Saha
The parasite Leishmania resides as amastigotes within the macrophage parasitophorous vacuoles inflicting the disease Leishmaniasis. Leishmania selectively modulates mitogen-activated protein kinase (MAPK) phosphorylation subverting CD40-triggered anti-leishmanial functions of macrophages. The mechanism of any pathogen-derived molecule induced host MAPK modulation remains poorly understood. Herein, we show that of the fifteen MAPKs, LmjMAPK4 expression is higher in virulent L. major. LmjMAPK4- detected in parasitophorous vacuoles and cytoplasm- binds MEK-1/2, but not MKK-3/6...
May 9, 2024: International Immunopharmacology