journal
https://read.qxmd.com/read/38636375/icariin-inhibits-chondrocyte-ferroptosis-and-alleviates-osteoarthritis-by-enhancing-the-slc7a11-gpx4-signaling
#1
JOURNAL ARTICLE
Juan Xiao, Chenggen Luo, Anmao Li, Fanglan Cai, Yu Wang, Xiaoli Pan, Liu Xu, Zihong Wang, Zhouxiong Xing, Limei Yu, Yong Chen, Mei Tian
BACKGROUND: Chondrocyte ferroptosis plays a critical role in the pathogenesis of osteoarthritis (OA), regulated by the SLC7A11/GPX4 signaling pathway. Icariin (ICA), a flavonoid glycoside, exhibits strong anti-inflammatory and antioxidant activities. This study investigated whether ICA could modulate the SLC7A11/GPX4 signaling to inhibit chondrocyte ferroptosis and alleviate OA. PURPOSE: The objective was to explore the impact of ICA on chondrocyte ferroptosis in OA and its modulation of the SLC7A11/GPX4 signaling pathway...
April 17, 2024: International Immunopharmacology
https://read.qxmd.com/read/38636373/periplogenin-inhibits-pyroptosis-of-fibroblastic-synoviocytes-in-rheumatoid-arthritis-through-the-nlrp3-caspase-1-gsdmd-signaling-pathway
#2
JOURNAL ARTICLE
Xi Ma, YuZheng Yang, Hao Li, ZeHong Luo, QiuYi Wang, XueMing Yao, Fang Tang, Ying Huang, Yi Ling, WuKai Ma
Although the pathogenesis of rheumatoid arthritis (RA) remains unclear, an increasing number of studies have confirmed that pyroptosis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) is an important factor affecting the progression of RA. Periplogenin (PPN) is a natural cardiac glycoside; reportedly, it exerts anti-inflammatory and analgesic effects in diseases by inhibiting cell growth and migration. This study aimed to determine the effect of PPN on the growth, migration, and invasion of RA-FLS and the potential mechanism of pyroptosis regulation...
April 17, 2024: International Immunopharmacology
https://read.qxmd.com/read/38636372/ivermectin-ameliorates-acute-myocarditis-via-the-inhibition-of-importin-mediated-nuclear-translocation-of-nf-%C3%AE%C2%BAb-p65
#3
JOURNAL ARTICLE
Xu Gao, Yunling Xuan, Zhou Zhou, Chen Chen, Dao Wen Wang, Zheng Wen
BACKGROUND: Myocarditis is an important clinical issue which lacks specific treatment by now. Ivermectin (IVM) is an inhibitor of importin α/β-mediated nuclear translocation. This study aimed to explore the therapeutic effects of IVM on acute myocarditis. METHODS: Mouse models of coxsackie B3 virus (CVB3) infection-induced myocarditis and experimental autoimmune myocarditis (EAM) were established to evaluate the effects of IVM. Cardiac functions were evaluated by echocardiography and Millar catheter...
April 17, 2024: International Immunopharmacology
https://read.qxmd.com/read/38636371/klrb1-defines-an-activated-phenotype-of-cd4-%C3%A2-t-cells-and-shows-significant-upregulation-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#4
JOURNAL ARTICLE
Zhonghui Zhang, Ayibaota Bahabayi, Danni Liu, Ainizati Hasimu, Yangyang Zhang, Siyu Guo, Ruiqing Liu, Ke Zhang, Qi Li, Ziqi Xiong, Pingzhang Wang, Chen Liu
OBJECTIVE: This study aimed to investigate the role of KLRB1 (CD161) in human CD4+ T cells and elucidate its significance in primary Sjögren's syndrome (pSS). METHODS: Peripheral blood samples from 37 healthy controls and 44 pSS patients were collected. The publicly available single-cell RNA-Seq data from pSS patient PBMCs were utilized to analyse KLRB1 expression in T cells. KLRB1-expressing T lymphocyte subset proportions in pSS patients and healthy controls were determined by flow cytometry...
April 17, 2024: International Immunopharmacology
https://read.qxmd.com/read/38636370/identification-of-m6a-related-lncrnas-linc02471-and-dock9-dt-as-potential-biomarkers-for-thyroid-cancer
#5
JOURNAL ARTICLE
Dengwang Chen, Hongyuan Zhao, Zhanwen Guo, Zixuan Dong, Yuanning Yu, Jishan Zheng, Yunyan Ma, Hongqin Sun, Qian Zhang, Jidong Zhang, Yuqi He, Tao Song
Thyroid cancer (THCA) is the most common endocrine malignancy worldwide and has been rising at the fastest rate in recent years. Long-stranded non-coding RNAs (lncRNAs) and N6-methyladenosine (m6A) have been associated with immunotherapy efficacy and cancer prognosis. However, how m6A-associated lncRNAs (mrlncRNAs) affect the prognosis of patients with thyroid cancer is unclear. Therefore, this study utilized The Cancer Genome Atlas (TCGA) database to provide thyroid cancer-related transcriptomic data and related clinical data...
April 17, 2024: International Immunopharmacology
https://read.qxmd.com/read/38636369/phloridzin-reduces-synovial-hyperplasia-and-inflammation-in-rheumatoid-arthritis-rat-by-modulating-mtor-pathway
#6
JOURNAL ARTICLE
Liuyu Wang, Xiangkun Wu, Quanhui Wan, Yuqiang Yang, Chaojie Gao
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease and management of it still a challenge. Given report evaluates protective effect of phlorizin on RA and also postulates the molecular mechanism of its action. Bovine type II collagen (CIA) and Freund's incomplete adjuvant (1:1 and 1 mg/ml) was administered on 1st and 8th day of protocol to induce RA in rats and treatment with phlorizin 60 and 120 mg/kg was started after 4th week of protocol. Level of inflammatory cytokines and expression of proteins were estimated in phlorizin treated RA rats...
April 17, 2024: International Immunopharmacology
https://read.qxmd.com/read/38636374/csf1r-blockade-slows-progression-of-cerebral-hemorrhage-by-reducing-microglial-proliferation-and-increasing-infiltration-of-cd8%C3%A2-%C3%A2-cd122-t-cells-into-the-brain
#7
JOURNAL ARTICLE
Fangyuan Cheng, Conglin Wang, Bo Yan, Zhenyu Yin, Yaru Liu, Lan Zhang, Meimei Li, Pan Liao, Han Gao, Zexi Jia, Dai Li, Qiang Liu, Ping Lei
Microglia play a pivotal role in the neuroinflammatory response after brain injury, and their proliferation is dependent on colony-stimulating factors. In the present study, we investigated the effect of inhibiting microglia proliferation on neurological damage post intracerebral hemorrhage (ICH) in a mouse model, an aspect that has never been studied before. Using a colony-stimulating factor-1 receptor antagonist (GW2580), we observed that inhibition of microglia proliferation significantly ameliorated neurobehavioral deficits, attenuated cerebral edema, and reduced hematoma volume after ICH...
April 16, 2024: International Immunopharmacology
https://read.qxmd.com/read/38631221/relationship-between-chemokine-chemokine-receptor-and-glioma-prognosis-and-outcomes-systematic-review-and-meta-analysis
#8
REVIEW
Shaobo Yang, Minjie Luo, Shun Yang, Min Yuan, Hu Zeng, Jun Xia, Nianhua Wang
BACKGROUND: Glioma is a primary tumor originating from the central nervous system, and despite ongoing efforts to improve treatment, its overall survival rate remains low. There are a limited number of reports regarding the clinical grading, prognostic impact, and utility of chemokines. Therefore, conducting a meta-analysis is necessary to obtain convincing and conclusive results. METHODS: A comprehensive literature search was conducted using various databases, including PubMed, Web of Science, The Cochrane Library, Embase, Ovid Medline, CNKI, Wanfang Database, VIP, and CBM...
April 16, 2024: International Immunopharmacology
https://read.qxmd.com/read/38631220/angiogenesis-related-immune-response-may-be-the-prelude-to-the-syndesmophyte-formation-in-ankylosing-spondylitis
#9
JOURNAL ARTICLE
Chunmei Cai, Yuye Huang, Liyan Li, Kai Kei Miu, Zhangting Wang, Yujie Deng, Yanzhen Cai, Jinxiu Li, Liang Wu, Hepeng Zhu, Yang Gao, Jun Chen, Wende Xiao, Li Lu
BACKGROUND: Ankylosing spondylitis (AS) is a chronic autoimmune arthritis that mainly affects spine joints. To date, the pathogenesis of AS remains unclear, although immune cells and innate immune response cytokines have been suggested to be crucial players. METHODS: By adopting a single-cell RNA sequencing approach in the AS cynomolgus model, we profiled and characterized PBMC proportions along disease progression. RESULTS: Here, our primary focus was on the activation of an immune cascade-initiating lymphocyte subtype known as CD4+ CXCR5+ T follicular helper (Tfh) cells...
April 16, 2024: International Immunopharmacology
https://read.qxmd.com/read/38631219/elevated-microrna-214-3p-level-ameliorates-neuroinflammation-after-spinal-cord-ischemia-reperfusion-injury-by-inhibiting-nmb-cav3-2-pathway
#10
JOURNAL ARTICLE
Guo-Qiang Xia, Miao Xu, Cong Sun, Zai-Li Zhang, Xiao-Qian Li
BACKGROUND: Neuromedin B (Nmb) plays a pivotal role in the transmission of neuroinflammation, particularly during spinal cord ischemia-reperfusion injury (SCII). However, the detailed molecular mechanisms underlying this process remain elusive. METHODS: The SCII model was established by clamping the abdominal aorta of male Sprague-Dawley (SD) rats for 60 min. The protein expression levels of Nmb, Cav3.2, and IL-1β were detected by Western blotting, while miR-214-3p expression was quantified by qRT-PCR...
April 16, 2024: International Immunopharmacology
https://read.qxmd.com/read/38626551/honokiol-suppress-the-pd-l1-expression-to-improve-anti-tumor-immunity-in-lung-cancer
#11
JOURNAL ARTICLE
Lianxiang Luo, Tong Wu, Miaorong Ji, Jing Xiang, Youwen Zou, Yinglin Liao
Lung cancer is a serious health issue globally, and current treatments have proven to be inadequate. Therefore, immune checkpoint inhibitors (ICIs) that target the PD-1/PD-L1 pathway have become a viable treatment option in lun cancer. Honokiol, a lignan derived from Magnolia officinalis, has been found to possess anti-inflammatory, antioxidant, and antitumor properties. Our research found that honokiol can effectively regulate PD-L1 through network pharmacology and transcriptome analysis. Cell experiments showed that honokiol can significantly reduce PD-L1 expression in cells with high PD-L1 expression...
April 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38626550/neutrophil-extracellular-traps-nets-and-fibrotic-diseases
#12
REVIEW
Xiaojiao Wu, Yang Yang
Fibrosis, a common cause and serious outcome of organ failure that can affect any organ, is responsible for up to 45% of all deaths in various clinical settings. Both preclinical models and clinical trials investigating various organ systems have shown that fibrosis is a highly dynamic process. Although many studies have sought to gain understanding of the mechanism of fibrosis progression, their findings have been mixed. In recent years, increasing evidence indicates that neutrophil extracellular traps (NETs) are involved in many inflammatory and autoimmune disorders and participate in the regulation of fibrotic processes in various organs and systems...
April 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38626549/immunomodulatory-effects-of-kaempferol-on-microglial-and-macrophage-cells-during-the-progression-of-diabetic-retinopathy
#13
JOURNAL ARTICLE
Fahad Eid Albalawi, Ifat Alsharif, Mamdoh S Moawadh, Abdulaziz Alkhoshaiban, Faez Falah Alshehri, Aishah E Albalawi, Norah A Althobaiti, Zeyad M Alharbi, Hailah M Almohaimeed
BACKGROUND: Diabetic retinopathy (DR) stands as a prevalent secondary complication of diabetes, notably Type 1 Diabetes Mellitus (T1D), characterized by immune system involvement potentially impacting the retinal immune response mediated by microglia. Early stages of DR witness blood-retinal barrier permeabilization, facilitating peripheral immune cell interaction with the retinal immune system. Kaempferol (Kae), known for its potent anti-inflammatory activity, presents a promising avenue in DR treatment by targeting the immune mechanisms underlying its onset and progression...
April 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38626548/melatonin-pretreatment-improves-endometrial-regenerative-cell-mediated-therapeutic-effects-in-experimental-colitis
#14
JOURNAL ARTICLE
Jingpeng Hao, Ai Ma, Chenglu Sun, Hong Qin, Yanglin Zhu, Guangming Li, Hongda Wang, Hao Wang
BACKGROUND: Endometrial regenerative cells (ERCs) have been proven to be an effective strategy for attenuating experimental colitis, but the complex in vivo microenvironment such as oxidative stress may largely limit and weaken ERC efficacy. Melatonin (MT) works as an anti-oxidative agent in a variety of preclinical diseases, and has been identified to promote mesenchymal stem cell-mediated therapeutic effects in different diseases. However, the ability of MT to enhance ERC-mediated effects in colitis is currently poorly understood...
April 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38626547/a-review-mechanisms-and-molecular-pathways-of-signaling-lymphocytic-activation-molecule-family-3-slamf3-in-immune-modulation-and-therapeutic-prospects
#15
REVIEW
Tong Zhou, Yanjie Guan, Lin Sun, Wentao Liu
The signaling lymphocytic activation molecule (SLAM) family participates in the modulation of various innate and adaptive immune responses. SLAM family (SLAMF) receptors include nine transmembrane glycoproteins, of which SLAMF3 (also known as CD229 or Ly9) has important roles in the modulation of immune responses, from the fundamental activation and suppression of immune cells to the regulation of intricate immune networks. SLAMF3 is mainly expressed in immune cells, such as T, B, and natural killer cells. It has a unique molecular structure, including four immunoglobulin-like domains in the extracellular domain and two immunoreceptor tyrosine-based signaling motifs in the intracellular structural domains...
April 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38626546/ire1%C3%AE-regulates-macrophage-polarization-in-type-2-diabetic-periodontitis-through-promoting-endoplasmic-reticulum-stress
#16
JOURNAL ARTICLE
Yang Zhang, Yanan Zhang, Miao Lu, Xulei Yuan, Guangyue Li, Ling Xu, Tingwei Zhang, Jinlin Song
OBJECTIVES: The aim of this study was to investigate the effect of 4μ8c, an inhibitor targeting the endoplasmic reticulum stress-associated factor IRE1α, on macrophage polarization in an experimental model of diabetic periodontitis through ex vivo experiments. MATERIALS AND METHODS: Local alveolar bone parameters were evaluated using Micro-CT following intraperitoneal administration of 4μ8c in mice with experimental diabetic periodontitis. Surface markers indicating macrophage polarization were identified using immunofluorescence...
April 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38626545/reniformin-a-suppresses-non-small-cell-lung-cancer-progression-by-inducing-tlr4-nlrp3-caspase-1-gsdmd-dependent-pyroptosis
#17
JOURNAL ARTICLE
Huiyu Zhu, Yifei Guan, Wei Wang, Xinhui Liu, Sijia Wang, Ran Zheng, Yihan Li, Lei Liu, Hua Huang
Pyroptosis is an inflammatory form of programmed cell death that plays an important role in regulating tumor progression. Reniformin A (RA) is a natural compound isolated from the medicinal herb Isodon excisoides that has been applied as folk medicine in the treatment of esophageal cancer. However, whether RA has an individual function in cancer and the molecular mechanisms remain unclear. Here, we show that in non-small-cell lung cancer (NSCLC), RA inhibits tumor growth by functioning as a pyroptosis inducer to promote TLR4/NLRP3/caspase-1/GSDMD axis...
April 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38626544/dipeptidase-1-promotes-ferroptosis-in-renal-tubular-epithelial-cells-in-diabetic-nephropathy-via-inhibition-of-the-gsh-gpx4-axis
#18
JOURNAL ARTICLE
Yan Li, Xueqi Wang, Qidong Zhang, Dongli Tian, Yu Bai, Yiduo Feng, Wenhu Liu, Zongli Diao
Renal tubular injury is an important pathological change associated with diabetic nephropathy (DN), in which ferroptosis of renal tubular epithelial cells is critical to its pathogenesis. Inhibition of the glutathione/glutathione peroxidase 4 (GSH/GPX4) axis is the most important mechanism in DN tubular epithelial cell ferroptosis, but the underlying reason for this is unclear. Our biogenic analysis showed that a zinc-dependent metalloproteinase, dipeptidase 1 (DPEP1), is associated with DN ferroptosis. Here, we investigated the role and mechanism of DPEP1 in DN tubular epithelial cell ferroptosis...
April 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38626543/chondroprotective-effects-of-apolipoprotein-d-in-knee-osteoarthritis-mice-through-the-pi3k-akt-mtor-signaling-pathway
#19
JOURNAL ARTICLE
Gang Zhang, Chao Huang, Ren Wang, Jiangrong Guo, Yong Qin, Songcen Lv
BACKGROUND: Because the pathophysiology of osteoarthritis (OA) has not been fully elucidated, targeted treatments are lacking. In this study, we assessed the role and underlying mechanism apolipoprotein D (APOD) on the development of OA. METHODS: To establish an in vitro OA model, we extracted primary chondrocytes from the cartilage of C57BL/6 mice and stimulated the chondrocytes with IL-1β. After APOD intervention or incubation with an overexpressing plasmid, we detected inflammatory-related markers using RT-qPCR, Western blotting, and ELISA...
April 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38621337/duration-of-antibody-response-to-the-receptor-binding-domain-of-sars-cov-2-in-infected-or-vaccinated-individuals-a-one-year-retrospective-cohort-study
#20
JOURNAL ARTICLE
Martin Pasev, Angelina Trifonova, Andrey Velichkov, Velislava Terzieva
The 2019 coronavirus (COVID-19) pandemic raised many scientific and medical questions. Of interest are the duration and effectiveness of the humoral immune response, especially since part of the pandemic occurred in the presence of anti-SARS-CoV-2 vaccines. We retrospectively studied 564 serum samples from 393 post-infected and vaccinated individuals to investigate the longevity and magnitude of the anti-spike IgG response. Our results showed that SARS-CoV-2 anti-spike IgG antibodies are retained for nine-twelve months, in both groups...
April 14, 2024: International Immunopharmacology
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