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Digestive and Liver Disease

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https://read.qxmd.com/read/30770201/potential-biomarkers-to-predict-outcome-of-faecal-microbiota-transfer-for-recurrent-clostridioides-difficile-infection
#1
Fedja Farowski, Philipp Solbach, Anastasia Tsakmaklis, Susanne Brodesser, M Rebeca Cruz Aguilar, Oliver A Cornely, Katja Dettmer, Paul G Higgins, Sebastian Suerbaum, Nathalie Jazmati, Peter J Oefner, Maria J G T Vehreschild
BACKGROUND & AIMS: Faecal microbiota transplantation (FMT) has proven high clinical efficacy in the management of recurrent Clostridioides difficile infection (rCDI) with cure rates of over 80% after a single treatment. Nevertheless, the reasons for failure in the remaining 20% remain elusive. The aim of the present study was to investigate different potential predictors of response to FMT. METHODS: Faecal specimens of sixteen patients undergoing FMT for rCDI, as well as samples from the respective donors were collected and analyzed by 16S rRNA gene profiling, bile acid-inducible (baiCD) gene specific qPCR, and liquid chromatography tandem-mass spectrometry (LC-MS/MS) to quantify the concentrations of primary and secondary bile acids...
January 26, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30765220/albumin-bilirubin-albi-as-an-accurate-and-simple-prognostic-score-for-chronic-hepatitis-b-related-liver-cirrhosis
#2
Jian Wang, Zhaoping Zhang, Xiaomin Yan, Ming Li, Juan Xia, Yong Liu, Yuxin Chen, Bei Jia, Li Zhu, Chuanwu Zhu, Rui Huang, Chao Wu
BACKGROUND: The Albumin-Bilirubin (ALBI) score was developed to predict the long-term prognosis of hepatocellular carcinoma patients. We aimed to investigate the performance of ALBI for predicting severity and long-term prognosis of chronic hepatitis B-related liver cirrhosis (CHB-LC). METHODS: CHB-LC patients were enrolled from two medical centers between 2011 and 2017. The prognostic performance of ALBI was evaluated and compared with Child-Turcotte-Pugh (CTP), model of end-stage liver disease (MELD) and MELD integrating sodium (MELD-Na) scores...
January 26, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30755347/comparison-of-eus-guided-versus-percutaneous-and-transjugular-approaches-for-the-performance-of-liver-biopsies
#3
Asim Shuja, Ahmad Alkhasawneh, Andre Fialho, Andrea Fialho, Amal Shukri, Ciel Harris, Carmen Smotherman, Miguel Malespin, Silvio W de Melo
BACKGROUND: Liver biopsy through endoscopic ultrasound (EUS) has become a novel approach for tissue acquisition. We aim to evaluate the adequacy of EUS-guided liver biopsies in comparison to those obtained through interventional radiology (IR) techniques. METHODS: A retrospective single-center analysis was performed of all IR (transjugular or image-guided percutaneous) and EUS-guided liver biopsies performed at an academic medical center from January 2016 to January 2018...
January 22, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30723019/the-size-of-well-differentiated-pancreatic-neuroendocrine-tumors-correlates-with-ki67-proliferative-index-and-is-not-associated-with-age
#4
Stefano Partelli, Francesca Muffatti, Paola Maria Vittoria Rancoita, Valentina Andreasi, Gianpaolo Balzano, Stefano Crippa, Claudio Doglioni, Corrado Rubini, Giuseppe Zamboni, Massimo Falconi
BACKGROUND: Concerns exist about a conservative management of well-differentiated nonfunctioning small pancreatic neuroendocrine tumors (NF-PanNET) in young patients and when preoperative Ki67 proliferative index is ≥3%. AIM: To evaluate an association between age, tumor size and grading in patients with sporadic NF-PanNET who underwent curative resection. METHODS: Patients who underwent surgery for sporadic NF-PanNET (excluding G3) were retrospectively analyzed...
January 22, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30718202/correlation-between-endoscopic-and-histological-validated-scoring-indices-in-crohn-s-disease
#5
Wenbin Gong, Kun Guo, Tao Zheng, Miao Fang, Haohao Xie, Weijie Li, Zhiwu Hong, Huajian Ren, Guosheng Gu, Gefei Wang, Xiuwen Wu, Zhiming Wang, Jianan Ren, Jieshou Li
BACKGROUND: It is of crucial importance to evaluate disease activity by means of endoscopy and histopathology in Crohn's disease (CD). Nonetheless, correlation between endoscopic and histological validated indices has not been verified. AIMS: We aim to correlate the Simple Endoscopic Score for Crohns disease (SES-CD) with two validated widely used histological indices in patients with established CD. METHODS: The SES-CD at the worst affected area was scored and histological disease activity using Global Histologic Disease Activity Score (GHAS or D'Haens score) and the Naini and Cortina Score (NCS) was scored independently by two pathologists blinded to the clinical information and endoscopic results...
January 22, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30770202/clinical-outcomes-of-endoscopic-treatment-for-gastric-epithelial-neoplasm-in-remnant-stomach-after-distal-gastrectomy
#6
Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
BACKGROUNDS/AIM: We aimed to evaluate the feasibility of endoscopic treatment for gastric epithelial neoplasm in the remnant stomach after distal gastrectomy and compared the clinical outcomes by tumor location and endoscopic treatment modality. METHODS: We reviewed the data of patients who underwent endoscopic treatment for gastric epithelial neoplasms in the remnant stomach after distal gastrectomy between January 1996 and August 2013. The treatments included endoscopic resection or argon plasma coagulation...
January 17, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30718203/prospective-evaluation-of-ercp-performance-in-an-italian-regional-database-study
#7
Alberto Mariani, Simone Segato, Andrea Anderloni, Gianpaolo Cengia, Marco Parravicini, Teresa Staiano, Gian Eugenio Tontini, Davide Lochis, Paolo Cantù, Guido Manfredi, Arnaldo Amato, Stefano Bargiggia, Giordano Bernasconi, Fausto Lella, Marcella Berni Canani, Paolo Beretta, Luca Ferraris, Sergio Signorelli, Giuseppe Pantaleo, Gianpiero Manes, Pier Alberto Testoni
BACKGROUND: Prospective studies about endoscopic retrograde cholangio-pancreatography (ERCP) in a community setting are rare. AIM: To assess success and complication rates of routinely-performed ERCP in a regional setting, and the priority quality indicators for ERCP practice. METHODS: Prospective region wide observational study on consecutive patients undergoing ERCP during a 6-month period. A centralized online ERCP questionnaire was built and used for data storage...
January 17, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30712953/lesson-from-epidemiology-of-paediatric-crohn-s-disease
#8
EDITORIAL
Salvatore Cucchiara, Sara Isoldi, Valerio Nobili
No abstract text is available yet for this article.
January 17, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30723020/a-new-algorithm-for-predicting-long-term-survival-in-chronic-hepatitis-b-patients-with-variceal-bleeding-after-endoscopic-therapy
#9
Lingling He, Ping Li, Yu Jiang, Julong Hu, Jiali Ma, Xiaohui Ye, Junru Yang, Yuling Zhou, Xiuxia Liang, Zhenglin Ai, Yijun Lin, Hongshan Wei
BACKGROUND AND AIMS: A predictive algorithm for survival is urgently needed in clinical practice. This study aimed to establish an algorithm to predict long-term survival in chronic hepatitis B (CHB) patients with hepatic cirrhosis and variceal bleeding after endoscopic therapy. METHODS: This was a retrospective study in which 603 patients who followed-up for three years were randomly assigned into a training cohort and a validation cohort in a 2:1 ratio. A new score model was devised based on the result of Cox regression analysis in the training cohort, and was verified in the validation cohort...
January 14, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30712954/quality-of-life-during-one-year-of-postoperative-prophylactic-drug-therapy-after-intestinal-resection-in-crohn-s-patients-results-of-the-apprecia-trial
#10
Carlos Taxonera, Antonio López-Sanromán, Isabel Vera-Mendoza, Eugeni Domènech, Vicente Vega Ruiz, Ignacio Marín-Jiménez, Jordi Guardiola, Luisa Castro, María Esteve, Eva Iglesias, Daniel Ceballos, Pilar Martínez-Montiel, Javier P Gisbert, Miguel Mínguez, Ana Echarri, Xavier Calvet, Jesús Barrio, Joaquín Hinojosa, María Dolores Martín-Arranz, Lucía Márquez-Mosquera, Fernando Bermejo, Jordi Rimola, Cristina Alba, Vicente Pons, Pilar Nos
BACKGROUND: In APPRECIA trial, Crohn's disease (CD) patients undergoing intestinal resection were randomized to postoperative adalimumab (ADA) or azathioprine (AZA). AIMS: To evaluate health-related quality of life (HRQoL) in APPRECIA trial. METHODS: HRQoL was evaluated using disease-specific shortened Spanish version of the IBDQ (SIBDQ-9) and generic European Quality of Life-5 Dimensions (EQ-5D) questionnaires, completed at baseline and at weeks 24 and 52...
January 14, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30691776/micro-elimination-of-hepatitis-c-virus-infection-in-%C3%AE-thalassaemia-major-patients-positively-moving-towards-the-world-health-organisation-2030-eradication-goal
#11
EDITORIAL
Edoardo G Giannini, Alessio Aghemo
No abstract text is available yet for this article.
January 14, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30686714/hybrid-resection-with-esd-and-ftrd-could-this-be-a-rescue-treatment-in-the-presence-of-severe-submucosal-fibrosis
#12
LETTER
Gianluca Andrisani, Francesco Maria Di Matteo
No abstract text is available yet for this article.
January 14, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30691777/evaluation-of-three-beyond-baveno-vi-criteria-to-safely-spare-endoscopies-in-compensated-advanced-chronic-liver-disease
#13
Giulia Tosetti, Massimo Primignani, Vincenzo La Mura, Roberta D'Ambrosio, Elisabetta Degasperi, Nicolò Mezzina, Mauro Viganò, Mariagrazia Rumi, Anna Ludovica Fracanzani, Rosa Lombardi, Silvia Fargion, Mirella Fraquelli, Alessio Aghemo, Pietro Lampertico
BACKGROUND: Liver stiffness measurement (LSM) <20 kPa and platelet count >150,000/mm3 exclude varices needing treatment (VNT) in viral compensated advanced chronic liver disease (cACLD), saving-up to 20-25% endoscopies (Baveno VI criteria). Refinements of such criteria to further reduce endoscopies and an approach without LSM (Platelet 150/MELD 6) were later proposed. AIMS: To assess LSM 25/platelet 125, LSM 25/platelet 110 (Expanded-Baveno VI) and Platelet 150/MELD 6 accuracy versus Baveno VI criteria, and the impact of platelet count variability on criteria accuracy in all-etiologies cACLD...
January 11, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30691775/uncommon-appearance-of-concurrent-liver-cirrhosis-and-chronic-pancreatitis-the-alcohol-metabolism-theory
#14
Katalin Márta, Péter Hegyi
No abstract text is available yet for this article.
January 11, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30686716/nonalcoholic-fatty-liver-disease-is-associated-with-breast-cancer-in-nonobese-women
#15
Min-Sun Kwak, Jeong Yoon Yim, Ann Yi, Goh-Eun Chung, Jong In Yang, Donghee Kim, Joo Sung Kim, Dong-Young Noh
BACKGROUND: Growing evidence supports that nonalcoholic fatty liver disease (NAFLD) is associated with extrahepatic cancers. Nonalcoholic fatty liver disease (NAFLD) and breast cancer share similar risk factors, including obesity. AIM: The aim of this case-control study was to investigate the association between NAFLD and breast cancer. METHODS: Subjects who received health screening, including mammography and breast and hepatic ultrasonography simultaneously, were included...
January 9, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30683615/association-of-vitamin-d-levels-and-vitamin-d-related-gene-polymorphisms-with-liver-fibrosis-in-patients-with-biopsy-proven-nonalcoholic-fatty-liver-disease
#16
Taeang Arai, Masanori Atsukawa, Akihito Tsubota, Mai Koeda, Yuji Yoshida, Tomomi Okubo, Ai Nakagawa, Norio Itokawa, Chisa Kondo, Katsuhisa Nakatsuka, Takushi Masu, Keizo Kato, Noritomo Shimada, Tsutomu Hatori, Naoya Emoto, Masayoshi Kage, Katsuhiko Iwakiri
BACKGROUND: Vitamin D has promising anti-proliferative and anti-fibrotic properties, but its clinical utility in nonalcoholic fatty liver disease (NAFLD) is unclear. AIMS: This study aimed to clarify the association between vitamin D levels, single nucleotide polymorphisms (SNPs) in vitamin D-related genes, and the histopathological severity of disease in patients with biopsy-proven NAFLD. METHODS: SNPs in CYP2R1, DHCR7, vitamin D binding protein (GC), CYP27B1, and vitamin D receptor (VDR) were determined for 229 consecutive patients with biopsy-proven NAFLD...
January 9, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30685416/epidemiological-features-and-disease-related-concerns-of-a-large-cohort-of-italian-patients-with-active-crohn-s-disease
#17
Alessandro Armuzzi, Gabriele Riegler, Federica Furfaro, Monia Baldoni, Francesco Costa, Manuela Fortuna, Gaetano Iaquinto, Pietro Paese, Claudio Papi, Fabrizio Bossa, Gian Eugenio Tontini, Sara Di Fino, Giuliana Gualberti, Rocco Merolla, Fernando Rizzello
BACKGROUND-AIMS: The SOLE study was conducted on a large cohort of Italian patients with moderate-severe Crohn's disease (CD) to assess epidemiological and disease characteristics and their correlation with disease-related worries, treatment satisfaction and adherence, workability. METHODS: The following tools were used over 12 months to assess: Results were correlated with demographic and clinical variables with linear regression models. RESULTS: 552 patients with active CD (51% men) were recruited...
January 3, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30683616/time-to-revise-the-definition-of-nafld-a-purist-vision
#18
LETTER
Alessandro Mantovani
No abstract text is available yet for this article.
January 3, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30658941/feasibility-and-reproducibility-of-liver-and-pancreatic-stiffness-in-patients-with-alcohol-related-liver-disease
#19
Clara Benedetta Conti, Nina Weiler, Giovanni Casazza, Christopher Schrecker, Maximillian Schneider, Marcus M Mücke, Alexander Queck, Eva Herrmann, Dario Conte, Massimo Colombo, Stefan Zeuzem, Mirella Fraquelli, Mireen Friedrich-Rust
BACKGROUND: To date no studies evaluated liver stiffness and pancreatic stiffness by shear-wave elastography, in alcoholic liver disease setting. AIMS: To assess feasibility and reproducibility of Shear-wave elastrography in measuring liver and pancreatic stiffness in alcoholic liver disease and investigate the correlation among liver and pancreatic stiffness and clinical data. METHODS: Liver and pancreatic stiffness were measured by elastography (2 examiners) in patients with alcoholic liver disease and in healthy volunteers, for reference values...
January 3, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30658940/impact-of-the-direct-acting-antiviral-agents-daas-on-chronic-hepatitis-c-in-sardinian-patients-with-transfusion-dependent-thalassemia-major
#20
Maria Laura Ponti, Federica Comitini, Debora Murgia, Roberto Ganga, Roberto Canu, Carlo Dessì, Maria Loreta Foschini, GianBattista Leoni, Maddalena Morittu, Maria Perra, Maria Paola Pilia, Maria Rosaria Casini, Antonietta Zappu, Raffaella Origa
BACKGROUND AND AIMS: Direct antiviral agents (DAAs) have revolutionised the standard of care for the treatment of hepatitis even in patients with hemoglobinopathies. The aim of this study is to show how, thanks to DAAs, HCV infection has been substantially eradicated in one of the biggest Centres for the management of Thalassemia in Europe. METHODS: Thalassemia major patients regularly transfused and iron chelated in Cagliari (Italy) who were HCV-RNA positive were evaluated for the potential prescription of antiviral therapy...
January 3, 2019: Digestive and Liver Disease
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