Elisabetta Esposito, Nadia Eblovi, Silvia Rasi, Markus Drechsler, Giordano M Di Gregorio, Enea Menegatti, Rita Cortesi
This article describes the production and characterization of monoglyceride-based supramolecular systems by a simple processing technique, avoiding time-consuming procedures, high energy input, and the use of organic solvents. A preformulatory study was performed to study the influence of the experimental parameters on the production of monoglyceride-based disperse systems. In particular the effects of (1) stirring speed, (2) type and concentration of monoglyceride mixture, and (3) type and concentration of surfactant were investigated on the recovery, fraction of larger particles, mean diameter, and shape of smaller particles (so called nanosomes)...
November 18, 2003: AAPS PharmSci