Maíra Barbosa E Reis, Açucena Imparato Maximo, Jessica Maria Magno, Daniel de Lima Bellan, João Luiz Aldinucci Buzzo, Fernanda Fogagnoli Simas, Hugo Alexandre Oliveira Rocha, Edvaldo da Silva Trindade, Carolina Camargo de Oliveira
Natural substances are strategic candidates for drug development in cancer research. Marine-derived molecules are of special interest due to their wide range of biological activities and sustainable large-scale production. Melanoma is a type of skin cancer that originates from genetic mutations in melanocytes. BRAF, RAS, and NF1 mutations are described as the major melanoma drivers, but approximately 20% of patients lack these mutations and are included in the triple wild-type (tripleWT) classification. Recent advances in targeted therapy directed at driver mutations along with immunotherapy have only partially improved patients' overall survival, and consequently, melanoma remains deadly when in advanced stages...
January 26, 2024: Marine Biotechnology